CDK10 Gene (Protein Coding)

Cyclin Dependent Kinase 10

GC16P089680
GIFtS:
44
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-... See more...

Aliases for CDK10 Gene

Aliases for CDK10 Gene

  • Cyclin Dependent Kinase 10 2 3 5
  • Cyclin-Dependent Kinase (CDC2-Like) 10 2 3
  • Cell Division Protein Kinase 10 3 4
  • Cyclin-Dependent Kinase 10 3 4
  • EC 2.7.11.22 4 51
  • PISSLRE 2 3
  • Cyclin-Dependent Kinase Related Protein 3
  • Serine/Threonine Protein Kinase PISSLRE 3
  • Serine/Threonine-Protein Kinase PISSLRE 4
  • CDC2-Related Protein Kinase 3
  • EC 2.7.11 51
  • ALSAS 3
  • CDK10 5

External Ids for CDK10 Gene

Previous GeneCards Identifiers for CDK10 Gene

  • GC16P081075
  • GC16P090742
  • GC16P089455
  • GC16P089496
  • GC16P088280
  • GC16P089753
  • GC16P075448

Summaries for CDK10 Gene

Entrez Gene Summary for CDK10 Gene

  • The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

GeneCards Summary for CDK10 Gene

CDK10 (Cyclin Dependent Kinase 10) is a Protein Coding gene. Diseases associated with CDK10 include Al Kaissi Syndrome and Fanconi Anemia, Complementation Group A. Among its related pathways are GADD45 Pathway and Cell Cycle Control of Chromosomal Replication. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK11B.

UniProtKB/Swiss-Prot Summary for CDK10 Gene

  • Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747).

Gene Wiki entry for CDK10 Gene

Additional gene information for CDK10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDK10 Gene

Genomics for CDK10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CDK10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDK10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDK10

Top Transcription factor binding sites by QIAGEN in the CDK10 gene promoter:
  • AML1a
  • Arnt
  • CUTL1
  • ITF-2
  • Olf-1

Genomic Locations for CDK10 Gene

Genomic Locations for CDK10 Gene
chr16:89,680,737-89,696,354
(GRCh38/hg38)
Size:
15,618 bases
Orientation:
Plus strand
chr16:89,747,145-89,762,772
(GRCh37/hg19)
Size:
15,628 bases
Orientation:
Plus strand

Genomic View for CDK10 Gene

Genes around CDK10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CDK10 Gene

Proteins for CDK10 Gene

Products:

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  2. Protein
  3. Assay

  • Protein details for CDK10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15131-CDK10_HUMAN
    Recommended name:
    Cyclin-dependent kinase 10
    Protein Accession:
    Q15131
    Secondary Accessions:
    • A8K370
    • A8K8I6
    • A8MXU6
    • B3KQJ3
    • B7Z420
    • D3DX82
    • D3DX83
    • Q0VGZ7
    • Q15130
    • Q6PJC0

    Protein attributes for CDK10 Gene

    Size:
    360 amino acids
    Molecular mass:
    41038 Da
    Quaternary structure:
    • Heterodimer with CCNQ, the interaction is required for kinase activity. Interacts with ETS2. Interacts with PRK2 (PubMed:27104747).

    Alternative splice isoforms for CDK10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK10 Gene

Protein Expression for CDK10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for CDK10 Gene

Q15131:
  • TDEIVALK
  • DFGLARA
  • TDEIVALKKVRMDKEKDG
  • QYSLRKQPYNNLKHKFPWLSEAGLRL
  • VVTLWYR
  • DLIVQLLGTPSENIWPGFS
  • LQVLRGLQYLHR
  • YRAPELLL
  • IGEGTYG

Post-translational modifications for CDK10 Gene

  • Ubiquitination at Lys76
  • Modification sites at PhosphoSitePlus

Other Protein References for CDK10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CDK10 Gene

Gene Families for CDK10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for CDK10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDK10 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ78380, highly similar to Homo sapiens cyclin-dependent kinase (CDC2-like) 10, mRNA (A8K8I6_HUMAN)
  • cDNA FLJ90555 fis, clone OVARC1000916, highly similar to Cell division protein kinase 10 (EC 2.7.11.22) (B3KQJ3_HUMAN)
  • Serine/threonine-protein kinase PISSLRE (CDK10_HUMAN)
  • Cyclin-dependent kinase related protein (Q9UHL7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15131

UniProtKB/Swiss-Prot:

CDK10_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK10: view

Function for CDK10 Gene

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Molecular function for CDK10 Gene

UniProtKB/Swiss-Prot Function:
Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence={ECO:0000269|PubMed:24218572};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence={ECO:0000269|PubMed:24218572};.
GENATLAS Biochemistry:
cyclin dependent kinase (CDC2-like) related protein kinase,with several isoforms resulting from complex splicing,acting in G2 phase of the cell cycle,not deleted in sporadic breast carcinoma

Enzyme Numbers (IUBMB) for CDK10 Gene

Phenotypes From GWAS Catalog for CDK10 Gene

Gene Ontology (GO) - Molecular Function for CDK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IDA 27104747
GO:0004693 cyclin-dependent protein serine/threonine kinase activity TAS,IBA 21873635
GO:0005515 protein binding IPI 18242510
genes like me logo Genes that share ontologies with CDK10: view
genes like me logo Genes that share phenotypes with CDK10: view

Human Phenotype Ontology for CDK10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CDK10 Gene

MGI Knock Outs for CDK10:

Animal Model Products

CRISPR Products

miRNA for CDK10 Gene

miRTarBase miRNAs that target CDK10

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK10

Clone Products

  • Addgene plasmids for CDK10

No data available for Transcription Factor Targets and HOMER Transcription for CDK10 Gene

Localization for CDK10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK10 Gene

Cytoplasm, cytoskeleton, cilium basal body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK10 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Midbody (1)
  • Midbody ring (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11006117
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0036064 ciliary basal body IDA 27104747
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with CDK10: view

Pathways & Interactions for CDK10 Gene

PathCards logo

SuperPathways for CDK10 Gene

SuperPathway Contained pathways
1 DNA Damage
DNA Damage
-
2 Cell Cycle Control of Chromosomal Replication
Cell Cycle Control of Chromosomal Replication
-
3 GADD45 Pathway
GADD45 Pathway
-
genes like me logo Genes that share pathways with CDK10: view

Pathways by source for CDK10 Gene

2 Qiagen pathways for CDK10 Gene
  • Cell Cycle Control of Chromosomal Replication
  • GADD45 Pathway
1 Cell Signaling Technology pathway for CDK10 Gene
1 GeneTex pathway for CDK10 Gene

SIGNOR curated interactions for CDK10 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for CDK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IBA 21873635
GO:0007089 traversing start control point of mitotic cell cycle TAS 8208557
GO:0007346 regulation of mitotic cell cycle IBA 21873635
GO:0008285 negative regulation of cell proliferation TAS 8208557
GO:0010468 regulation of gene expression IBA 21873635
genes like me logo Genes that share ontologies with CDK10: view

Drugs & Compounds for CDK10 Gene

Products:

  1. Drug

(2) Drugs for CDK10 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alvocidib Experimental, Investigational Pharma inhibitor Pan-cdk inhibitor, Kinase Inhibitors 64
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(1) Additional Compounds for CDK10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with CDK10: view

Transcripts for CDK10 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
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mRNA/cDNA for CDK10 Gene

5 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK10

Clone Products

  • Addgene plasmids for CDK10

Alternative Splicing Database (ASD) splice patterns (SP) for CDK10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - -
SP9: - - - - - - -
SP10: - - - - - -
SP11: - - - -
SP12: - - - -
SP13: - - - - - -
SP14: - - -
SP15:
SP16:
SP17:
SP18:

ExUns: 11c · 11d ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c · 15d · 15e
SP1: - - - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - - - - -
SP16:
SP17: - - -
SP18:

Relevant External Links for CDK10 Gene

GeneLoc Exon Structure for
CDK10

Expression for CDK10 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDK10 Gene

mRNA expression in normal human tissues for CDK10 Gene
mRNA expression by GTEx for CDK10 GenemRNA expression by BioGPS for CDK10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Colon (Gastrointestinal Tract)

Protein differential expression in normal tissues from HIPED for CDK10 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDK10 Gene



Protein tissue co-expression partners for CDK10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDK10

SOURCE GeneReport for Unigene cluster for CDK10 Gene:

Hs.699177

Evidence on tissue expression from TISSUES for CDK10 Gene

  • Nervous system(4.7)
  • Intestine(4.4)
  • Lung(4.4)
  • Skin(2.6)
  • Kidney(2.2)
  • Lymph node(2.2)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with CDK10: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK10 Gene

Orthologs for CDK10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia CDK10 30 31
  • 92.46 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia CDK10 31
  • 92 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia CDK10 30 31
  • 89.85 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia CDK10 30 31
  • 88.15 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Cdk10 30
  • 87.41 (n)
Mouse
(Mus musculus)
 Mammalia Cdk10 30 17 31
  • 87.04 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia CDK10 31
  • 79 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves CDK10 30 31
  • 79.57 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia CDK10 31
  • 73 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia cdk10 30
  • 75.15 (n)
Str.19111 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.12757 30
Zebrafish
(Danio rerio)
 Actinopterygii cdk10 30 31
  • 71.55 (n)
 OneToOne
Dr.16835 30
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.10159 30
Fruit Fly
(Drosophila melanogaster)
 Insecta cdc2rk 30 31 32
  • 65.13 (n)
 OneToOne
CG6800 32
  • 35 (a)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP005851 30
  • 62.91 (n)
Worm
(Caenorhabditis elegans)
 Secernentea H01G02.2 32
  • 36 (a)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes CTK1 31
  • 25 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 67 (a)
 OneToOne
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.13995 30
Species where no ortholog for CDK10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CDK10 Gene

ENSEMBL:
Gene Tree for CDK10 (if available)
TreeFam:
Gene Tree for CDK10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDK10: view image

Paralogs for CDK10 Gene

Paralogs for CDK10 Gene

(126) SIMAP similar genes for CDK10 Gene using alignment to 10 proteins:

  • CDK10_HUMAN
  • A8K8I6_HUMAN
  • B3KQJ3_HUMAN
  • D6RA59_HUMAN
  • D6REZ2_HUMAN
  • D6RHH3_HUMAN
  • F8W872_HUMAN
  • H3BSN8_HUMAN
  • H3BT74_HUMAN
  • Q9UHL7_HUMAN
genes like me logo Genes that share paralogs with CDK10: view

Variants for CDK10 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDK10 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
813896 Likely Pathogenic: AL KAISSI SYNDROME 89,693,407(+) GCCTGGCC/G FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
916087 Pathogenic: not provided 89,694,227(+) CAT/C FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs1060499745 Likely Pathogenic: Abnormality of brain morphology 89,694,721(+) C/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs1555516716 Pathogenic: AL KAISSI SYNDROME 89,689,302(+) AG/A FRAMESHIFT_VARIANT,FIVE_PRIME_UTR_VARIANT
rs767176610 Pathogenic: AL KAISSI SYNDROME 89,694,172(+) G/A SPLICE_ACCEPTOR_VARIANT

Additional dbSNP identifiers (rs#s) for CDK10 Gene

Structural Variations from Database of Genomic Variants (DGV) for CDK10 Gene

Variant ID Type Subtype PubMed ID
esv2762221 CNV gain+loss 21179565
esv3639592 CNV gain 21293372
nsv1057351 CNV loss 25217958
nsv428331 CNV gain+loss 18775914
nsv457623 CNV gain 19166990
nsv482951 CNV loss 15286789
nsv509639 CNV insertion 20534489
nsv516241 CNV loss 19592680
nsv573739 CNV gain 21841781
nsv573743 CNV gain 21841781
nsv833330 CNV loss 17160897
nsv952079 CNV deletion 24416366

Variation tolerance for CDK10 Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDK10 Gene

Human Gene Mutation Database (HGMD)
CDK10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK10 Gene

Disorders for CDK10 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CDK10 Gene - From: OMIM, ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
al kaissi syndrome
  • alkas
fanconi anemia, complementation group a
  • fanca
chromosome 2q35 duplication syndrome
  • syndactyly, type i; sdty1
- elite association - COSMIC cancer census association via MalaCards
Search CDK10 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CDK10_HUMAN
  • Al Kaissi syndrome (ALKAS) [MIM:617694]: An autosomal recessive developmental disorder characterized by growth retardation, spine malformation, facial dysmorphisms, and developmental delay. {ECO:0000269 PubMed:28886341}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for CDK10

Genetic Association Database
(GAD)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CDK10: view

No data available for Genatlas for CDK10 Gene

Publications for CDK10 Gene

  1. PISSLRE, a human novel CDC2-related protein kinase. (PMID: 8208557) Graña X … Giordano A (Oncogene 1994) 2 3 4
  2. Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases. (PMID: 8084611) Brambilla R … Draetta G (Oncogene 1994) 2 3 4
  3. CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays. (PMID: 28886341) Windpassinger C … Kaldis P (American journal of human genetics 2017) 3 4
  4. STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis. (PMID: 27104747) Guen VJ … Colas P (Cell cycle (Georgetown, Tex.) 2016) 3 4
  5. CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. (PMID: 24218572) Guen VJ … Colas P (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 4

ExternalLinks

View latest publications for CDK10 gene in Mastermind

Products for CDK10 Gene

  • Addgene plasmids for CDK10
  • Signalway Proteins for CDK10

Sources for CDK10 Gene