Aliases for CDK10 Gene
External Ids for CDK10 Gene
Previous GeneCards Identifiers for CDK10 Gene
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
GeneCards Summary for CDK10 Gene
CDK10 (Cyclin Dependent Kinase 10) is a Protein Coding gene. Diseases associated with CDK10 include Al Kaissi Syndrome and Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations. Among its related pathways are GADD45 Pathway and DNA Damage. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK11B.
UniProtKB/Swiss-Prot Summary for CDK10 Gene
Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747).