CDK1 Gene (Protein Coding)

Cyclin Dependent Kinase 1

GC10P060772
GIFtS:
47
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The ... See more...

Aliases for CDK1 Gene

Aliases for CDK1 Gene

  • Cyclin Dependent Kinase 1 2 3 5
  • Cell Division Cycle 2, G1 To S And G2 To M 2 3
  • Cell Division Control Protein 2 Homolog 3 4
  • Cell Division Protein Kinase 1 3 4
  • Cyclin-Dependent Kinase 1 3 4
  • P34 Protein Kinase 3 4
  • P34CDC2 3 4
  • CDC28A 3 4
  • CDC2 3 4
  • Cell Cycle Controller CDC2 3
  • EC 2.7.11.22 4
  • EC 2.7.11.23 4
  • CDKN1 4

External Ids for CDK1 Gene

Previous HGNC Symbols for CDK1 Gene

  • CDC2

Previous GeneCards Identifiers for CDK1 Gene

  • GC10P062205
  • GC10P062539
  • GC10P056527

Summaries for CDK1 Gene

Entrez Gene Summary for CDK1 Gene

  • The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for CDK1 Gene

CDK1 (Cyclin Dependent Kinase 1) is a Protein Coding gene. Diseases associated with CDK1 include Retinoblastoma and Breast Cancer. Among its related pathways are Oocyte meiosis and ERK Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK2.

UniProtKB/Swiss-Prot Summary for CDK1 Gene

  • Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2 and RUNX2. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. Essential for early stages of embryonic development. During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation. Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis. Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair. Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression. In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons. The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis. NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis. The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis. In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis. This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration. CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230). Regulates the amplitude of the cyclic expression of the core clock gene ARNTL/BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (PubMed:27238018).
  • (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry.

Gene Wiki entry for CDK1 Gene

Additional gene information for CDK1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDK1 Gene

Genomics for CDK1 Gene

GeneHancer (GH) Regulatory Elements for CDK1 Gene

Promoters and enhancers for CDK1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH10J060731 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.3 -45.7 -45730 3.6 CTCF PHF8 ZFX POLR2A ZBTB26 EZH2 ZEB1 HDAC2 SIN3A MYC ANK3 lnc-RHOBTB1-2 CDK1 ANK3-DT
GH10J060777 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +1.4 1370 4.2 ZBTB40 ZSCAN5C SIN3A TCF12 NRF1 USF1 POLR2G SP1 NCOR1 PHF8 CDK1 ANK3 lnc-CDK1-4
GH10J060769 Enhancer 0.7 ENCODE 0.4 -9.3 -9289 0 CTCF ZSCAN5C ZNF639 CUX1 RAD21 SMC3 ZSCAN18 IRF1 KLF8 GATA3 ANK3 ANK3-DT CDK1
GH10J060770 Enhancer 0.7 Ensembl 0.4 -8.8 -8831 0.6 CTCF ZSCAN5C ZNF639 CUX1 ZSCAN18 IRF1 KLF8 ZFHX2 GATA3 ZNF335 ANK3 ANK3-DT CDK1
GH10J060762 Enhancer 0.7 Ensembl ENCODE 0.4 -15.3 -15331 1.2 HDAC2 NANOG TCF12 ZNF407 ZNF416 CHD7 EP300 SP1 POU5F1 REST ANK3-DT ANK3 CDK1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDK1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDK1

Genomic Locations for CDK1 Gene

Genomic Locations for CDK1 Gene
chr10:60,778,331-60,794,852
(GRCh38/hg38)
Size:
16,522 bases
Orientation:
Plus strand
chr10:62,538,089-62,554,610
(GRCh37/hg19)
Size:
16,522 bases
Orientation:
Plus strand

Genomic View for CDK1 Gene

Genes around CDK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CDK1 Gene

Proteins for CDK1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CDK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06493-CDK1_HUMAN
    Recommended name:
    Cyclin-dependent kinase 1
    Protein Accession:
    P06493
    Secondary Accessions:
    • A8K7C4
    • C9J497
    • O60764

    Protein attributes for CDK1 Gene

    Size:
    297 amino acids
    Molecular mass:
    34095 Da
    Quaternary structure:
    • Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cyclins-B (CCNB1, CCNB2 and CCNB3) to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Can also form CDK1-cylin-D and CDK1-cyclin-E complexes that phosphorylate RB1 in vitro. Binds to RB1 and other transcription factors such as FOXO1 and RUNX2. Promotes G2-M transition when in complex with a cyclin-B. Interacts with DLGAP5. Binds to the CDK inhibitors CDKN1A/p21 and CDKN1B/p27. Isoform 2 is unable to complex with cyclin-B1 and also fails to bind to CDKN1A/p21. Interacts with catalytically active CCNB1 and RALBP1 during mitosis to form an endocytotic complex during interphase. Associates with cyclins-A and B1 during S-phase in regenerating hepatocytes. Interacts with FANCC. Interacts with CEP63; this interaction recruits CDK1 to centrosomes. Interacts with CENPA (PubMed:25556658). Interacts with NR1D1 (PubMed:27238018).
    Miscellaneous:
    • As a key regulator of the cell cycle, CDK1 is a potent therapeutic target for inhibitors in cancer treatment.
    SequenceCaution:
    • Sequence=EAW54204.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDK1 Gene

    Alternative splice isoforms for CDK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK1 Gene

Protein Expression for CDK1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CDK1 Gene

  • Phosphorylation at Thr-161 by CAK/CDK7 activates kinase activity. Phosphorylation at Thr-14 and Tyr-15 by PKMYT1 prevents nuclear translocation. Phosphorylation at Tyr-15 by WEE1 and WEE2 inhibits the protein kinase activity and acts as a negative regulator of entry into mitosis (G2 to M transition). Phosphorylation by PKMYT1 and WEE1 takes place during mitosis to keep CDK1-cyclin-B complexes inactive until the end of G2. By the end of G2, PKMYT1 and WEE1 are inactivated, but CDC25A and CDC25B are activated. Dephosphorylation by active CDC25A and CDC25B at Thr-14 and Tyr-15, leads to CDK1 activation at the G2-M transition. Phosphorylation at Tyr-15 by WEE2 during oogenesis is required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, leading to prevent meiotic reentry. Phosphorylation by WEE2 is also required for metaphase II exit during egg activation to ensure exit from meiosis in oocytes and promote pronuclear formation. Phosphorylated at Tyr-4 by PKR/EIF2AK2 upon genotoxic stress. This phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest. In response to UV irradiation, phosphorylation at Tyr-15 by PRKCD activates the G2/M DNA damage checkpoint.
  • Polyubiquitinated upon genotoxic stress.
  • Ubiquitination at Lys6, Lys9, Lys20, Lys24, Lys33, Lys34, Lys130, Lys139, Lys143, Lys201, Lys238, Lys245, Lys254, Lys266, Lys274, Lys279, and Lys295
  • Modification sites at PhosphoSitePlus

Other Protein References for CDK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CDK1

No data available for DME Specific Peptides for CDK1 Gene

Domains & Families for CDK1 Gene

Gene Families for CDK1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for CDK1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDK1 Gene

GenScript: Design optimal peptide antigens:
  • p34 protein kinase (CDK1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P06493

UniProtKB/Swiss-Prot:

CDK1_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK1: view

Function for CDK1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CDK1 Gene

UniProtKB/Swiss-Prot Function:
Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2 and RUNX2. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. Essential for early stages of embryonic development. During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation. Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis. Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair. Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression. In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons. The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis. NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis. The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis. In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis. This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration. CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230). Regulates the amplitude of the cyclic expression of the core clock gene ARNTL/BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (PubMed:27238018).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase]; Xref=Rhea:RHEA:10216, Rhea:RHEA-COMP:11321, Rhea:RHEA-COMP:11322, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43176, ChEBI:CHEBI:68546, ChEBI:CHEBI:456216; EC=2.7.11.23;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it. Activated through a multistep process; binding to cyclin-B is required for relocation of cyclin-kinase complexes to the nucleus, activated by CAK/CDK7-mediated phosphorylation on Thr-161, and CDC25-mediated dephosphorylation of inhibitory phosphorylation on Thr-14 and Tyr-15. Inhibited by flavopiridol and derivatives, pyrimidine derivatives, pyridine derivatives, purine derivatives, staurosporine, paullones, oxoindoles, indazole analogs, indolin-2-ones, pyrazolo[3,4-b]pyridines, imidazo[1,2-a]pyridine (AZ703), thiazolinone analogs(RO-3306), thiazol urea, macrocyclic quinoxalin-2-one, pyrrolo[2,3-a]carbazole, pyrazolo[1,5-a]-1,3,5-triazine, pyrazolo[1,5-a]pyrimidine (Dinaciclib, SCH 727965), 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine), olomoucine, AG-024322, AT-7519, P276-00, R547/Ro-4584820 and SNS-032/BMS-387032. Repressed by the CDK inhibitors CDKN1A/p21 and CDKN1B/p27 during the G1 phase and by CDKN1A/p21 at the G1-S checkpoint upon DNA damage. Transient activation by rapid and transient dephosphorylation at Tyr-15 triggered by TGFB1.
UniProtKB/Swiss-Prot Induction:
Follows a cyclic expression; during interphase, accumulates gradually following G1, S to reach a critical threshold at the end of G2, which promotes self-activation and triggers onset of mitosis. Induced transiently by TGFB1 at an early phase of TGFB1-mediated apoptosis, but later repressed. Triggered by CKS1B during mitotic entry in breast cancer cells. Down-regulated under genotoxic stresses triggered by PKR/EIF2AK2-mediated phosphorylation.

Enzyme Numbers (IUBMB) for CDK1 Gene

Phenotypes From GWAS Catalog for CDK1 Gene

Gene Ontology (GO) - Molecular Function for CDK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001618 virus receptor activity IEA --
GO:0003682 chromatin binding IEA --
GO:0004672 protein kinase activity IDA,IEA 22854038
GO:0004674 protein serine/threonine kinase activity TAS,IEA --
genes like me logo Genes that share ontologies with CDK1: view
genes like me logo Genes that share phenotypes with CDK1: view

Animal Models for CDK1 Gene

MGI Knock Outs for CDK1:
  • Cdk1 Cdk1<tm1(Cdk2)Kald>
  • Cdk1 Cdk1<tm2.2Kald>

Animal Model Products

CRISPR Products

miRNA for CDK1 Gene

miRTarBase miRNAs that target CDK1

Clone Products

  • Addgene plasmids for CDK1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDK1 Gene

Localization for CDK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK1 Gene

Nucleus. Cytoplasm. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK1 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
nucleus 5
cytosol 5
endoplasmic reticulum 4
plasma membrane 2
extracellular 2
peroxisome 2
endosome 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA 1312467
GO:0000784 nuclear chromosome, telomeric region HDA 19135898
GO:0005634 nucleus IBA,IDA 16109376
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CDK1: view

Pathways & Interactions for CDK1 Gene

PathCards logo

SuperPathways for CDK1 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins
.95
Cdc20-Phospho-APC/C mediated degradation of Cyclin A
.95
APC/C-mediated degradation of cell cycle proteins
.93
Regulation of APC/C activators between G1/S and early anaphase
.93
Regulation of mitotic cell cycle
.93
APC/C-Cdc20 mediated degradation of mitotic proteins
.89
APC-Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
.89
The role of GTSE1 in G2/M progression after G2 checkpoint
.81
MAPK6/MAPK4 signaling
.57
Phosphorylation of the APC/C
.01
2 Regulation of PLK1 Activity at G2/M Transition
Centrosome maturation
.88
Loss of Nlp from mitotic centrosomes
.88
Loss of proteins required for interphase microtubule organization from the centrosome
.88
Recruitment of mitotic centrosome proteins and complexes
.88
AURKA Activation by TPX2
.85
Regulation of PLK1 Activity at G2/M Transition
.80
Anchoring of the basal body to the plasma membrane
.72
G2/M Transition
.49
Mitotic G2-G2/M phases
.49
Recruitment of NuMA to mitotic centrosomes
.01
3 Transport of the SLBP independent Mature mRNA
Nuclear Pore Complex (NPC) Disassembly
.78
Nuclear Envelope Breakdown
.67
Activation of NIMA Kinases NEK9, NEK6, NEK7
.01
Depolymerisation of the Nuclear Lamina
.01
4 Cyclin A/B1 associated events during G2/M transition
Cyclin B2 mediated events
.01
G2/M DNA replication checkpoint
.01
Phosphorylation of proteins involved in the G2/M transition by Cyclin A-Cdc2 complexes
.01
Cyclin A/B1 associated events during G2/M transition
-
5 DNA Damage Response
DNA Damage Response
.74
miRNA Regulation of DNA Damage Response
.74
p53 signaling pathway
.37
genes like me logo Genes that share pathways with CDK1: view

Pathways by source for CDK1 Gene

1 PharmGKB pathway for CDK1 Gene
10 GeneGo (Thomson Reuters) pathways for CDK1 Gene
  • Apoptosis and survival BAD phosphorylation
  • Apoptosis and survival Role of CDK5 in neuronal death and survival
  • Cell cycle Cell cycle (generic schema)
  • Cell cycle Role of 14-3-3 proteins in cell cycle regulation
  • Cell cycle Role of SCF complex in cell cycle regulation
14 Qiagen pathways for CDK1 Gene
  • 14-3-3 and Cell Cycle Regulation
  • ATM Pathway
  • Breast Cancer Regulation by Stathmin1
  • Calpain Protease Regulates Cellular Mechanics
  • Cell Cycle Control by BTG Proteins
1 Cell Signaling Technology pathway for CDK1 Gene
1 GeneTex pathway for CDK1 Gene

SIGNOR curated interactions for CDK1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000187 activation of MAPK activity TAS --
GO:0000226 microtubule cytoskeleton organization TAS 21655336
GO:0000278 mitotic cell cycle IEA --
GO:0006260 DNA replication TAS 21655336
genes like me logo Genes that share ontologies with CDK1: view

Drugs & Compounds for CDK1 Gene

Products:

  1. Drug

(131) Drugs for CDK1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Deferasirox Approved, Investigational Pharma Oral iron chelator 98
Alvocidib Experimental, Investigational Pharma Target, inhibitor Pan-cdk inhibitor, Kinase Inhibitors 64
Olomoucine Experimental Pharma Target, binder Cyclin-dependent kinase inhibitor 0
Alsterpaullone Experimental Pharma Target, inhibitor 0

(50) Additional Compounds for CDK1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(R)-CR8
294646-77-8
Arcyriaflavin A
118458-54-1

(5) Tocris Compounds for CDK1 Gene

Compound Action Cas Number
(R)-CR8 Dual cdk1/cdk5 inhibitor; also inhibits CK1 294646-77-8
Arcyriaflavin A Potent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV) 118458-54-1
AZD 5438 Potent cyclin-dependent kinase (cdk) 1, 2 and 9 inhibitor 602306-29-6
Olomoucine Cyclin-dependent kinase inhibitor 101622-51-9
SU 9516 Potent cdk2 inhibitor 377090-84-1

(29) ApexBio Compounds for CDK1 Gene

Compound Action Cas Number
(R)-DRF053 dihydrochloride cdk/CK1 inhibitor,potent and ATP-competitive 1241675-76-2
Aminopurvalanol A 220792-57-4
AT7519 Multi-CDK inhibitor 844442-38-2
AT7519 Hydrochloride Multi-CDK inhibitor 902135-91-5
AT7519 trifluoroacetate CDK/cyclin inhibitor 1431697-85-6
AZD-5438 Potent CDK1/2/9 inhibitor 602306-29-6
AZD-5597 Potent CDK inhibitor 924641-59-8
BMS265246 CDK1/2 inhibitor,potent and selective 582315-72-8
BS-181 HCl CDK7 inhibitor,highly selective 1397219-81-6
CDK inhibitor II 1269815-17-9
CGP60474 CDKs and PKC inhibitor, potent 164658-13-3
Deferasirox Oral iron chelator 201530-41-8
Dinaciclib (SCH727965) Potent CDK inhibitor 779353-01-4
Flavopiridol Pan-cdk inhibitor 146426-40-6
Flavopiridol hydrochloride 131740-09-5
Kenpaullone 142273-20-9
LDC000067 1073485-20-7
Nocodazole Tubulin production inhibitor,anti-neoplastic agent 31430-18-9
NSC 693868 40254-90-8
Nu 6027 ATR/CDK inhibitor, potent and selective 220036-08-8
NVP-LCQ195 CDK1/CDK2/CDK5 inhibitor 902156-99-4
P276-00 CDK-1/CDK4/CDK9 inhibitor 920113-03-7
PF 4800567 hydrochloride 1391052-28-0
PHA-793887 Pan-Cdk inhibitor 718630-59-2
PHA-848125 CDK inhibitor,potent and ATP-competitive 802539-81-7
Purvalanol B CDK1/CDK2/CDK4 inhibitor 212844-54-7
R547 CDK1/2/4 inhibitor,ATP-competitive 741713-40-6
Ro 3306 An ATP-competitive, potent CDK1 inhibitor 872573-93-8
TMCB 905105-89-7
genes like me logo Genes that share compounds with CDK1: view

Transcripts for CDK1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CDK1 Gene

6 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for CDK1

Alternative Splicing Database (ASD) splice patterns (SP) for CDK1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6:
SP7:

Relevant External Links for CDK1 Gene

GeneLoc Exon Structure for
CDK1

Expression for CDK1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDK1 Gene

mRNA expression in normal human tissues for CDK1 Gene
mRNA expression by GTEx for CDK1 GenemRNA expression by BioGPS for CDK1 Gene

mRNA differential expression in normal tissues according to GTEx for CDK1 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.4).

Protein differential expression in normal tissues from HIPED for CDK1 Gene

This gene is overexpressed in Bone (13.4), Ovary (7.7), Lymph node (7.4), and Testis (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDK1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDK1

SOURCE GeneReport for Unigene cluster for CDK1 Gene:

Hs.732435

mRNA Expression by UniProt/SwissProt for CDK1 Gene:

P06493-CDK1_HUMAN
Tissue specificity: Isoform 2 is found in breast cancer tissues.

Evidence on tissue expression from TISSUES for CDK1 Gene

  • Skin(4.4)
  • Intestine(2.9)
  • Blood(2.6)
  • Bone marrow(2.3)
  • Liver(2)
  • Lung(2)
genes like me logo Genes that share expression patterns with CDK1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK1 Gene

Orthologs for CDK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CDK1 31 30
  • 99.89 (n)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CDK1 31
  • 96 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 96 (a)
 OneToMany
-- 31
  • 96 (a)
 OneToMany
dog
(Canis familiaris)
 Mammalia CDK1 31 30
  • 95.74 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia CDK1 31 30
  • 95.29 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Cdk1 17 31 30
  • 86.08 (n)
rat
(Rattus norvegicus)
 Mammalia Cdk1 30
  • 84.62 (n)
chicken
(Gallus gallus)
 Aves CDK1 31 30
  • 80.36 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia CDK1 31
  • 84 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia cdk1 30
  • 75.71 (n)
MGC76203 30
African clawed frog
(Xenopus laevis)
 Amphibia cdc2-prov 30
zebrafish
(Danio rerio)
 Actinopterygii cdk1 31 30
  • 73.65 (n)
 OneToOne
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.631 30
fruit fly
(Drosophila melanogaster)
 Insecta cdc2 31 30
  • 63.08 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP009459 30
  • 60.71 (n)
worm
(Caenorhabditis elegans)
 Secernentea cdk-1 31 30
  • 61.64 (n)
 OneToOne
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes CDC28 31
  • 59 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.2145 31
  • 73 (a)
 OneToOne
Cin.2773 30
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.2773 30
Species where no ortholog for CDK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK1 Gene

ENSEMBL:
Gene Tree for CDK1 (if available)
TreeFam:
Gene Tree for CDK1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDK1: view image

Paralogs for CDK1 Gene

Paralogs for CDK1 Gene

(100) SIMAP similar genes for CDK1 Gene using alignment to 2 proteins:

  • CDK1_HUMAN
  • E5RIU6_HUMAN
genes like me logo Genes that share paralogs with CDK1: view

Variants for CDK1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDK1 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
710938 Benign: not provided 60,792,042(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for CDK1 Gene

Variation tolerance for CDK1 Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDK1 Gene

Human Gene Mutation Database (HGMD)
CDK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CDK1 Gene

Disorders for CDK1 Gene

MalaCards: The human disease database

(37) MalaCards diseases for CDK1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
retinoblastoma
  • rb1
breast cancer
  • breast cancer, familial
polyploidy
bloom syndrome
  • bls
hepatitis c virus
  • hepatitis c virus, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search CDK1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CDK1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CDK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDK1 Gene

Publications for CDK1 Gene

  1. New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses. (PMID: 20395957) Yoon CH … Bae YS (EMBO reports 2010) 3 4 23 54
  2. Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. (PMID: 16407259) Qiao M … Passaniti A (The Journal of biological chemistry 2006) 3 4 23 54
  3. Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1. (PMID: 16371510) Fourest-Lieuvin A … Job D (Molecular biology of the cell 2006) 3 4 23 54
  4. The Fanconi anemia polypeptide, FAC, binds to the cyclin-dependent kinase, cdc2. (PMID: 9242535) Kupfer GM … D'Andrea AD (Blood 1997) 3 4 23 54
  5. Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2. (PMID: 3553962) Lee MG … Nurse P (Nature 1987) 2 3 4 54

ExternalLinks

View latest publications for CDK1 gene in Mastermind

Products for CDK1 Gene