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The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
CDK1 (Cyclin Dependent Kinase 1) is a Protein Coding gene. Diseases associated with CDK1 include Retinoblastoma and Breast Cancer. Among its related pathways are ATM Pathway and Cell cycle_Spindle assembly and chromosome separation. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0001618 | virus receptor activity | IEA | -- |
GO:0003682 | chromatin binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA,IDA | 22854038 |
GO:0004674 | protein serine/threonine kinase activity | IEA,TAS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | IDA | 1312467 |
GO:0000784 | nuclear chromosome, telomeric region | HDA | 19135898 |
GO:0005634 | nucleus | IDA | 15767402 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IDA | 15767402 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000086 | G2/M transition of mitotic cell cycle | TAS | -- |
GO:0000187 | activation of MAPK activity | TAS | -- |
GO:0000226 | microtubule cytoskeleton organization | TAS | 21655336 |
GO:0000278 | mitotic cell cycle | IEA | -- |
GO:0006260 | DNA replication | TAS | 21655336 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
Deferasirox | Approved, Investigational | Pharma | Oral iron chelator | 100 | ||
Alvocidib | Experimental, Investigational | Pharma | Target, inhibitor | Pan-cdk inhibitor, Kinase Inhibitors | 64 | |
Olomoucine | Experimental | Pharma | Target, binder | Cyclin-dependent kinase inhibitor | 0 | |
Alsterpaullone | Experimental | Pharma | Target, inhibitor | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
(R)-CR8 |
|
294646-77-8 |
|
|
||
Arcyriaflavin A |
|
118458-54-1 |
|
|
Compound | Action | Cas Number |
---|---|---|
(R)-CR8 | Dual cdk1/cdk5 inhibitor; also inhibits CK1 | 294646-77-8 |
Arcyriaflavin A | Potent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV) | 118458-54-1 |
AZD 5438 | Potent cyclin-dependent kinase (cdk) 1, 2 and 9 inhibitor | 602306-29-6 |
Olomoucine | Cyclin-dependent kinase inhibitor | 101622-51-9 |
SU 9516 | Potent cdk2 inhibitor | 377090-84-1 |
Compound | Action | Cas Number |
---|---|---|
(R)-DRF053 dihydrochloride | cdk/CK1 inhibitor,potent and ATP-competitive | 1241675-76-2 |
Aminopurvalanol A | 220792-57-4 | |
AT7519 | Multi-CDK inhibitor | 844442-38-2 |
AT7519 Hydrochloride | Multi-CDK inhibitor | 902135-91-5 |
AT7519 trifluoroacetate | CDK/cyclin inhibitor | 1431697-85-6 |
AZD-5438 | Potent CDK1/2/9 inhibitor | 602306-29-6 |
AZD-5597 | Potent CDK inhibitor | 924641-59-8 |
BMS265246 | CDK1/2 inhibitor,potent and selective | 582315-72-8 |
BS-181 HCl | CDK7 inhibitor,highly selective | 1397219-81-6 |
CDK inhibitor II | 1269815-17-9 | |
CGP60474 | CDKs and PKC inhibitor, potent | 164658-13-3 |
Deferasirox | Oral iron chelator | 201530-41-8 |
Dinaciclib (SCH727965) | Potent CDK inhibitor | 779353-01-4 |
Flavopiridol | Pan-cdk inhibitor | 146426-40-6 |
Flavopiridol hydrochloride | 131740-09-5 | |
Kenpaullone | 142273-20-9 | |
LDC000067 | 1073485-20-7 | |
Nocodazole | Tubulin production inhibitor,anti-neoplastic agent | 31430-18-9 |
NSC 693868 | 40254-90-8 | |
Nu 6027 | ATR/CDK inhibitor, potent and selective | 220036-08-8 |
NVP-LCQ195 | CDK1/CDK2/CDK5 inhibitor | 902156-99-4 |
P276-00 | CDK-1/CDK4/CDK9 inhibitor | 920113-03-7 |
PF 4800567 hydrochloride | 1391052-28-0 | |
PHA-793887 | Pan-Cdk inhibitor | 718630-59-2 |
PHA-848125 | CDK inhibitor,potent and ATP-competitive | 802539-81-7 |
Purvalanol B | CDK1/CDK2/CDK4 inhibitor | 212844-54-7 |
R547 | CDK1/2/4 inhibitor,ATP-competitive | 741713-40-6 |
Ro 3306 | An ATP-competitive, potent CDK1 inhibitor | 872573-93-8 |
TMCB | 905105-89-7 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||
SP7: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CDK1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CDK1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | CDK1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CDK1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cdk1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cdk1 30 |
|
||
Chicken (Gallus gallus) |
Aves | CDK1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CDK1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cdk1 30 |
|
||
MGC76203 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | cdc2-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cdk1 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.631 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | cdc2 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009459 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | cdk-1 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CDC28 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2145 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2773 30 |
|
SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
710938 | Benign: not provided | 60,792,042(+) | C/T | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
retinoblastoma |
|
|
breast cancer |
|
|
polyploidy |
|
|
bloom syndrome |
|
|
hepatitis c virus |
|
|