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Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
CDIPT (CDP-Diacylglycerol--Inositol 3-Phosphatidyltransferase) is a Protein Coding gene. Diseases associated with CDIPT include Alpha-1-Antitrypsin Deficiency and Dentin Caries. Among its related pathways are Inositol phosphate metabolism (KEGG) and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and manganese ion binding. An important paralog of this gene is TMEM269.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003881 | CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity | IBA,IDA | 8110188 |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0016740 | transferase activity | IEA | -- |
GO:0016780 | phosphotransferase activity, for other substituted phosphate groups | IEA | -- |
GO:0019992 | diacylglycerol binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | IEA | -- |
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
GO:0005794 | Golgi apparatus | IBA | 21873635 |
GO:0005886 | plasma membrane | IEA | -- |
SuperPathway | Contained pathways | ||
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1 | Inositol phosphate metabolism (KEGG) | ||
2 | Glycerophospholipid biosynthesis |
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3 | Metabolism |
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4 | Glycerophospholipid Biosynthetic Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006661 | phosphatidylinositol biosynthetic process | IDA,TAS | -- |
GO:0008654 | phospholipid biosynthetic process | IEA | -- |
GO:0046341 | CDP-diacylglycerol metabolic process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
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Inositol | Approved, Investigational, Withdrawn | Pharma | 110 | |||
Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
Manganese | Approved | Nutra | 56 | |||
Cytidine monophosphate | Experimental | Pharma | 0 | |||
scyllo-inositol | Investigational | Pharma | Target, inhibitor | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
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CDP-DG(16:0/16:0) |
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CDP-DG(16:0/18:0) |
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CDP-DG(16:0/18:1(11Z)) |
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CDP-DG(16:0/18:1(9Z)) |
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CDP-DG(16:0/18:2(9Z,12Z)) |
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ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e |
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SP1: | - | ||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||||||||||||||
SP7: | - | ||||||||||||||||||||||||||||||||||||
SP8: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
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Chimpanzee (Pan troglodytes) |
Mammalia | CDIPT 30 31 |
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OneToOne | |
Cow (Bos Taurus) |
Mammalia | CDIPT 30 31 |
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OneToOne | |
Dog (Canis familiaris) |
Mammalia | CDIPT 30 31 |
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OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cdipt 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CDIPT 31 |
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OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cdipt 30 |
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Platypus (Ornithorhynchus anatinus) |
Mammalia | CDIPT 31 |
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OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CDIPT 31 |
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OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cdipt 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | cdipt 30 31 |
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OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003478 30 |
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Fruit Fly (Drosophila melanogaster) |
Insecta | Pis 30 31 |
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OneToOne | |
CG9245 32 |
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Worm (Caenorhabditis elegans) |
Secernentea | pisy-1 30 31 |
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OneToOne | |
Y46G5A.5 32 |
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A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AAR037W 30 |
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Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PIS1 30 31 33 |
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OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D15037g 30 |
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Thale Cress (Arabidopsis thaliana) |
eudicotyledons | PIS1 30 |
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Rice (Oryza sativa) |
Liliopsida | Os02g0123600 30 |
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Bread mold (Neurospora crassa) |
Ascomycetes | NCU09192 30 |
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Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
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OneToMany | |
-- 31 |
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OneToMany | |||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | pis1 30 |
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SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
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rs1802002 | - | p.Arg199Cys |
Disorder | Aliases | PubMed IDs |
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alpha-1-antitrypsin deficiency |
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dentin caries |
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fibromuscular dysplasia |
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bicipital tenosynovitis |
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plasma protein metabolism disease |
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