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Aliases for CDIP1 Gene

Aliases for CDIP1 Gene

  • Cell Death Inducing P53 Target 1 2 3 5
  • Cell Death Involved P53-Target 2 3 4
  • Lipopolysaccharide-Induced Tumor Necrosis Factor-Alpha-Like Protein 3 4
  • Transmembrane Protein I1 3 4
  • LITAF-Like Protein 3 4
  • C16orf5 3 4
  • LITAFL 3 4
  • CDIP 3 4
  • Lipopolysaccharide-Induced TNF Factor-Like 2
  • Cell Death-Inducing P53-Target Protein 1 3
  • Chromosome 16 Open Reading Frame 5 2
  • Cell Death-Inducing P53 Target 1 2
  • Cell Death Inducing Protein 3
  • Cell Death-Inducing Protein 4
  • I1 3

External Ids for CDIP1 Gene

Previous HGNC Symbols for CDIP1 Gene

  • C16orf5

Previous GeneCards Identifiers for CDIP1 Gene

  • GC16M004560

Summaries for CDIP1 Gene

GeneCards Summary for CDIP1 Gene

CDIP1 (Cell Death Inducing P53 Target 1) is a Protein Coding gene. Diseases associated with CDIP1 include Cervical Dystonia and Focal Dystonia. Among its related pathways are Apoptosis and Autophagy and NF-kappaB Signaling. An important paralog of this gene is LITAF.

UniProtKB/Swiss-Prot for CDIP1 Gene

  • Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner.

Additional gene information for CDIP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDIP1 Gene

Genomics for CDIP1 Gene

GeneHancer (GH) Regulatory Elements for CDIP1 Gene

Promoters and enhancers for CDIP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J004536 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 687.7 +0.6 637 2.6 HDGF PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 CDIP1 C16orf96 NMRAL1 ZNF500 CREBBP EEF2KMT HMOX2 ENSG00000261938 MGRN1 PPL
GH16J004473 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 17.3 +62.7 62660 5.4 CLOCK MLX DMAP1 YY1 E2F8 ZNF143 ZNF548 SP3 NFYC GLIS1 NMRAL1 HMOX2 ZNF500 CREBBP ENSG00000261938 UBN1 CDIP1 NUDT16L1 MGRN1 GC16P004473
GH16J004485 Enhancer 1.1 Ensembl ENCODE dbSUPER 30.1 +50.4 50436 6.2 TFAP4 MAX RAD21 YY1 ZNF121 POLR2A EGR1 RFX1 ZNF362 RXRA NMRAL1 CDIP1 HMOX2 NUDT16L1 CORO7 MGRN1
GH16J005032 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 11.2 -496.2 -496220 5 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 NAGPA ALG1 ZNF500 C16orf89 UBN1 CDIP1 PPL NAGPA-AS1
GH16J004252 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.5 +285.2 285179 1.7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B LINC01569 LOC105371063 SRL CREBBP ZNF500 ZNF263 ENSG00000261938 ZNF597 UBN1 ZNF75A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDIP1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CDIP1 Gene

Genomic Locations for CDIP1 Gene
chr16:4,510,675-4,538,828
(GRCh38/hg38)
Size:
28,154 bases
Orientation:
Minus strand
chr16:4,560,676-4,588,829
(GRCh37/hg19)
Size:
28,154 bases
Orientation:
Minus strand

Genomic View for CDIP1 Gene

Genes around CDIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDIP1 Gene

Proteins for CDIP1 Gene

  • Protein details for CDIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H305-CDIP1_HUMAN
    Recommended name:
    Cell death-inducing p53-target protein 1
    Protein Accession:
    Q9H305
    Secondary Accessions:
    • A8K7M1
    • B4DFU1
    • B4DY75
    • D3DUD6
    • Q96ID8
    • Q9H0Q4
    • Q9P112

    Protein attributes for CDIP1 Gene

    Size:
    208 amino acids
    Molecular mass:
    21892 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF26619.1; Type=Frameshift; Positions=200; Evidence={ECO:0000305};

    Alternative splice isoforms for CDIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDIP1 Gene

Post-translational modifications for CDIP1 Gene

  • Ubiquitination at posLast=205205, Lys198, and Lys21
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDIP1 Gene

Domains & Families for CDIP1 Gene

Gene Families for CDIP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CDIP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H305

UniProtKB/Swiss-Prot:

CDIP1_HUMAN :
  • The LITAF domain is stabilized by a bound zinc ion. The LITAF domain contains an amphiphatic helix that mediates interaction with lipid membranes.
  • Belongs to the CDIP1/LITAF family.
Domain:
  • The LITAF domain is stabilized by a bound zinc ion. The LITAF domain contains an amphiphatic helix that mediates interaction with lipid membranes.
Family:
  • Belongs to the CDIP1/LITAF family.
genes like me logo Genes that share domains with CDIP1: view

Function for CDIP1 Gene

Molecular function for CDIP1 Gene

UniProtKB/Swiss-Prot Function:
Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner.
UniProtKB/Swiss-Prot Induction:
Up-regulated by p53/TP53.

Phenotypes From GWAS Catalog for CDIP1 Gene

Gene Ontology (GO) - Molecular Function for CDIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21516116
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CDIP1: view

Phenotypes for CDIP1 Gene

genes like me logo Genes that share phenotypes with CDIP1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDIP1

CRISPR Products

miRNA for CDIP1 Gene

miRTarBase miRNAs that target CDIP1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDIP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDIP1 Gene

Localization for CDIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDIP1 Gene

Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDIP1 gene
Compartment Confidence
nucleus 5
lysosome 5
endosome 5
plasma membrane 3
cytoskeleton 2
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,NAS 10570909
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CDIP1: view

Pathways & Interactions for CDIP1 Gene

genes like me logo Genes that share pathways with CDIP1: view

Pathways by source for CDIP1 Gene

3 Cell Signaling Technology pathways for CDIP1 Gene

Gene Ontology (GO) - Biological Process for CDIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IGI 17599062
GO:0033209 tumor necrosis factor-mediated signaling pathway IGI 17599062
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP 17599062
genes like me logo Genes that share ontologies with CDIP1: view

No data available for SIGNOR curated interactions for CDIP1 Gene

Drugs & Compounds for CDIP1 Gene

No Compound Related Data Available

Transcripts for CDIP1 Gene

mRNA/cDNA for CDIP1 Gene

Unigene Clusters for CDIP1 Gene

Cell death-inducing p53 target 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDIP1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDIP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d
SP1: - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4:
SP5: - - - - - - -
SP6: - - - - - -
SP7: - -
SP8: - - -

Relevant External Links for CDIP1 Gene

GeneLoc Exon Structure for
CDIP1
ECgene alternative splicing isoforms for
CDIP1

Expression for CDIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDIP1 Gene

This gene is overexpressed in Frontal cortex (39.0) and Peripheral blood mononuclear cells (24.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDIP1 Gene



Protein tissue co-expression partners for CDIP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDIP1 Gene:

CDIP1

SOURCE GeneReport for Unigene cluster for CDIP1 Gene:

Hs.654653

mRNA Expression by UniProt/SwissProt for CDIP1 Gene:

Q9H305-CDIP1_HUMAN
Tissue specificity: Highly expressed in brain. Expressed at lower level in heart, skeletal muscle, kidney, pancreas and liver. Weakly or not expressed in placenta and lung.

Evidence on tissue expression from TISSUES for CDIP1 Gene

  • Nervous system(4.9)
  • Eye(4.3)
  • Lung(4.2)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with CDIP1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDIP1 Gene

Orthologs for CDIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C16H16ORF5 34
  • 100 (a)
OneToOne
C16H16orf5 33
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia CDIP1 34
  • 96 (a)
OneToOne
C6H16orf5 33
  • 89.9 (n)
cow
(Bos Taurus)
Mammalia CDIP1 34 33
  • 90.38 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdip1 33
  • 88.46 (n)
mouse
(Mus musculus)
Mammalia Cdip1 16 34 33
  • 88.14 (n)
oppossum
(Monodelphis domestica)
Mammalia CDIP1 34
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDIP1 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves C16ORF5 34 33
  • 67.5 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5174 33
African clawed frog
(Xenopus laevis)
Amphibia MGC52765 33
zebrafish
(Danio rerio)
Actinopterygii zgc:165666 33
  • 62.4 (n)
CDIP1 34
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG32280 34
  • 35 (a)
ManyToMany
CG13559 34
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F36G3.3 34
  • 26 (a)
OneToMany
Species where no ortholog for CDIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDIP1 Gene

ENSEMBL:
Gene Tree for CDIP1 (if available)
TreeFam:
Gene Tree for CDIP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDIP1: view image

Paralogs for CDIP1 Gene

Paralogs for CDIP1 Gene

genes like me logo Genes that share paralogs with CDIP1: view

Variants for CDIP1 Gene

Sequence variations from dbSNP and Humsavar for CDIP1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000046113 -- 4,537,465(-) G/A intron_variant
rs1000322333 -- 4,513,962(-) T/A intron_variant
rs1000546731 -- 4,518,435(-) G/A intron_variant
rs1000656835 -- 4,512,751(-) C/G/T intron_variant
rs1000690968 -- 4,519,029(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CDIP1 Gene

Variant ID Type Subtype PubMed ID
nsv1046986 CNV gain 25217958

Variation tolerance for CDIP1 Gene

Residual Variation Intolerance Score: 49.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDIP1 Gene

Human Gene Mutation Database (HGMD)
CDIP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDIP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDIP1 Gene

Disorders for CDIP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CDIP1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
cervical dystonia
  • spasmodic torticollis
focal dystonia
  • dystonia, focal, task-specific
- elite association - COSMIC cancer census association via MalaCards
Search CDIP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CDIP1

genes like me logo Genes that share disorders with CDIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDIP1 Gene

Publications for CDIP1 Gene

  1. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. (PMID: 17599062) Brown L … Lee SW (The EMBO journal 2007) 2 3 4 58
  2. C16orf5, a novel proline-rich gene at 16p13.3, is highly expressed in the brain. (PMID: 10570909) Bhalla K … Callen DF (Journal of human genetics 1999) 2 3 4 58
  3. The Charcot Marie Tooth disease protein LITAF is a zinc-binding monotopic membrane protein. (PMID: 27582497) Qin W … Woodman PG (The Biochemical journal 2016) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58

Products for CDIP1 Gene

Sources for CDIP1 Gene

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