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Aliases for CDHR4 Gene

Aliases for CDHR4 Gene

  • Cadherin Related Family Member 4 2 3 5
  • Cadherin-Related Family Member 4 2 3
  • Cadherin-Like Protein 29 3 4
  • Cadherin-Like 29 2 3
  • CDH29 3 4
  • Cadherin-Like Protein UNQ9392/PRO34300 3
  • PRO34300 3
  • VLLR9392 3

External Ids for CDHR4 Gene

Previous HGNC Symbols for CDHR4 Gene

  • CDH29

Previous GeneCards Identifiers for CDHR4 Gene

  • GC03M049828

Summaries for CDHR4 Gene

GeneCards Summary for CDHR4 Gene

CDHR4 (Cadherin Related Family Member 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CDHR3.

UniProtKB/Swiss-Prot for CDHR4 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity).

Additional gene information for CDHR4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDHR4 Gene

Genomics for CDHR4 Gene

GeneHancer (GH) Regulatory Elements for CDHR4 Gene

Promoters and enhancers for CDHR4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J049799 Promoter/Enhancer 1.1 EPDnew ENCODE 650.7 +3.2 3233 1.1 KLF1 RFX1 NFIA CEBPB RFX5 ZFHX2 NFIC PRDM10 FOS FOSL2 CDHR4 IP6K1 GC03P049763 GC03P049762 GC03P049421
GH03J049802 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 35.4 -2.6 -2614 7.2 HDGF CLOCK ARID4B SIN3A YBX1 DMAP1 ZNF2 ZNF766 ZNF207 ZNF143 INKA1 MIR5193 CDHR4 AMT WDR6 UBA7 GC03P049763 GC03P049762 GC03P049421
GH03J049812 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 34.7 -10.8 -10791 2.5 ELF3 FOXA2 ARID4B RAD21 ETS1 ZNF766 IKZF2 THAP11 HCFC1 RXRA UBA7 CDHR4 MIR5193 GC03P049763 GC03P049762 GC03P049421
GH03J049784 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 31.7 +16.6 16604 3.2 HDGF PKNOX1 CLOCK SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 IP6K1 QRICH1 CDHR4 RBM5 USP19 INKA1 CCDC36 ENSG00000225399 AMT ENSG00000235236
GH03J049855 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 27.8 -53.3 -53330 1.6 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 BRCA1 ZNF48 ETS1 SLC30A9 GC03M049858 GC03M049859 TRAIP UBA7 QRICH1 USP19 CDHR4 CCDC36 ENSG00000225399 SEMA3F-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDHR4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CDHR4 Gene

Genomic Locations for CDHR4 Gene
12,433 bases
Minus strand
9,104 bases
Minus strand

Genomic View for CDHR4 Gene

Genes around CDHR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDHR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDHR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDHR4 Gene

Proteins for CDHR4 Gene

  • Protein details for CDHR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cadherin-related family member 4
    Protein Accession:
    Secondary Accessions:
    • Q6UXT0

    Protein attributes for CDHR4 Gene

    788 amino acids
    Molecular mass:
    85827 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDHR4 Gene


neXtProt entry for CDHR4 Gene

Post-translational modifications for CDHR4 Gene

  • Glycosylation at Asn242
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDHR4 Gene

Domains & Families for CDHR4 Gene

Gene Families for CDHR4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CDHR4 Gene

Suggested Antigen Peptide Sequences for CDHR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDHR4: view

No data available for UniProtKB/Swiss-Prot for CDHR4 Gene

Function for CDHR4 Gene

Molecular function for CDHR4 Gene

UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity).

Phenotypes From GWAS Catalog for CDHR4 Gene

Gene Ontology (GO) - Molecular Function for CDHR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CDHR4: view
genes like me logo Genes that share phenotypes with CDHR4: view

Animal Model Products

miRNA for CDHR4 Gene

miRTarBase miRNAs that target CDHR4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDHR4 Gene

Localization for CDHR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDHR4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDHR4 gene
Compartment Confidence
plasma membrane 5
extracellular 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CDHR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDHR4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CDHR4 Gene

Pathways & Interactions for CDHR4 Gene

SuperPathways for CDHR4 Gene

No Data Available

Interacting Proteins for CDHR4 Gene

Gene Ontology (GO) - Biological Process for CDHR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IBA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007267 cell-cell signaling IBA --
GO:0007399 nervous system development IBA --
genes like me logo Genes that share ontologies with CDHR4: view

No data available for Pathways by source and SIGNOR curated interactions for CDHR4 Gene

Drugs & Compounds for CDHR4 Gene

(1) Drugs for CDHR4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with CDHR4: view

Transcripts for CDHR4 Gene

mRNA/cDNA for CDHR4 Gene

(9) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDHR4 Gene

Cadherin-related family member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDHR4 Gene

No ASD Table

Relevant External Links for CDHR4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDHR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDHR4 Gene

mRNA differential expression in normal tissues according to GTEx for CDHR4 Gene

This gene is overexpressed in Fallopian Tube (x15.7), Cervix - Endocervix (x10.4), Testis (x8.0), and Lung (x5.5).

NURSA nuclear receptor signaling pathways regulating expression of CDHR4 Gene:


SOURCE GeneReport for Unigene cluster for CDHR4 Gene:

genes like me logo Genes that share expression patterns with CDHR4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDHR4 Gene

Orthologs for CDHR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDHR4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDHR4 34 33
  • 98.88 (n)
(Bos Taurus)
Mammalia CDHR4 34 33
  • 82.86 (n)
(Canis familiaris)
Mammalia CDHR4 34 33
  • 81.51 (n)
(Rattus norvegicus)
Mammalia Cdhr4 33
  • 79.3 (n)
(Mus musculus)
Mammalia Cdhr4 16 34 33
  • 79.17 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 42 (a)
-- 34
  • 37 (a)
(Monodelphis domestica)
Mammalia CDHR4 34
  • 41 (a)
(Gallus gallus)
Aves CDHR4 34 33
  • 50.2 (n)
(Anolis carolinensis)
Reptilia CDHR4 34
  • 34 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdhr4 33
  • 48.61 (n)
Species where no ortholog for CDHR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CDHR4 Gene

Gene Tree for CDHR4 (if available)
Gene Tree for CDHR4 (if available)
Evolutionary constrained regions (ECRs) for CDHR4: view image

Paralogs for CDHR4 Gene

Paralogs for CDHR4 Gene

genes like me logo Genes that share paralogs with CDHR4: view

Variants for CDHR4 Gene

Sequence variations from dbSNP and Humsavar for CDHR4 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000345506 -- 49,792,062(-) T/A genic_downstream_transcript_variant, intron_variant
rs1001005784 -- 49,802,427(-) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001071331 -- 49,804,000(-) C/A upstream_transcript_variant
rs1001100350 -- 49,797,073(-) G/C intron_variant
rs1001266151 -- 49,797,857(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CDHR4 Gene

Variant ID Type Subtype PubMed ID
nsv834688 CNV loss 17160897

Variation tolerance for CDHR4 Gene

Gene Damage Index Score: 3.26; 52.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDHR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDHR4 Gene

Disorders for CDHR4 Gene

Additional Disease Information for CDHR4

No disorders were found for CDHR4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDHR4 Gene

Publications for CDHR4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PMID: 20307617) Morgan AR … Ferguson LR (Human immunology 2010) 3 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for CDHR4 Gene

Sources for CDHR4 Gene

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