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Aliases for CDHR3 Gene

Aliases for CDHR3 Gene

  • Cadherin Related Family Member 3 2 3 5
  • Cadherin-Related Family Member 3 2 3
  • Cadherin-Like Protein 28 3 4
  • CDH28 3 4

External Ids for CDHR3 Gene

Previous GeneCards Identifiers for CDHR3 Gene

  • GC07P105517
  • GC07P099964

Summaries for CDHR3 Gene

GeneCards Summary for CDHR3 Gene

CDHR3 (Cadherin Related Family Member 3) is a Protein Coding gene. Diseases associated with CDHR3 include Asthma. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CDHR4.

UniProtKB/Swiss-Prot for CDHR3 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

  • (Microbial infection) Acts as a receptor for rhinovirus C.

Additional gene information for CDHR3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDHR3 Gene

Genomics for CDHR3 Gene

GeneHancer (GH) Regulatory Elements for CDHR3 Gene

Promoters and enhancers for CDHR3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I105875 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 563.2 +0.2 212 2.9 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 CDHR3 ATXN7L1
GH07I105962 Promoter/Enhancer 1.1 EPDnew ENCODE dbSUPER 557.6 +86.3 86335 1 RFX1 GLIS1 RFX5 CDHR3 GC07P105932 ENSG00000280439
GH07I105980 Promoter 0.5 EPDnew 550.1 +103.8 103771 0.1 CDHR3 GC07P105932 ENSG00000280439
GH07I105775 Enhancer 1.1 Ensembl ENCODE 19.1 -100.3 -100259 2.9 FOXA2 SIN3A ETS1 ZNF766 FOS MAFF STAT3 NR2C1 HNF4A FOXP1 CDHR3 ATXN7L1 PIR36718 RPL13AP16
GH07I105689 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 11 -186.2 -186162 4.2 FOXA2 CLOCK NEUROD1 SIN3A FEZF1 ZNF2 YY1 ZNF121 ZNF213 ZNF302 ATXN7L1 RINT1 KMT2E PUS7 CDHR3 PIR36718 EFCAB10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CDHR3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CDHR3 Gene

Genomic Locations for CDHR3 Gene
chr7:105,876,796-106,036,431
(GRCh38/hg38)
Size:
159,636 bases
Orientation:
Plus strand
chr7:105,517,242-105,676,877
(GRCh37/hg19)

Genomic View for CDHR3 Gene

Genes around CDHR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDHR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDHR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDHR3 Gene

Proteins for CDHR3 Gene

  • Protein details for CDHR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZTQ4-CDHR3_HUMAN
    Recommended name:
    Cadherin-related family member 3
    Protein Accession:
    Q6ZTQ4
    Secondary Accessions:
    • Q8TCI7

    Protein attributes for CDHR3 Gene

    Size:
    885 amino acids
    Molecular mass:
    97977 Da
    Quaternary structure:
    • (Microbial infection) Interacts with rhinovirus C capsid proteins.

    Alternative splice isoforms for CDHR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDHR3 Gene

Post-translational modifications for CDHR3 Gene

  • Glycosylation at Asn186, posLast=257257, and posLast=624624
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDHR3 Gene

Domains & Families for CDHR3 Gene

Gene Families for CDHR3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CDHR3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CDHR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDHR3: view

No data available for UniProtKB/Swiss-Prot for CDHR3 Gene

Function for CDHR3 Gene

Molecular function for CDHR3 Gene

UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for rhinovirus C.

Phenotypes From GWAS Catalog for CDHR3 Gene

Gene Ontology (GO) - Molecular Function for CDHR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CDHR3: view

Phenotypes for CDHR3 Gene

genes like me logo Genes that share phenotypes with CDHR3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDHR3

miRNA for CDHR3 Gene

miRTarBase miRNAs that target CDHR3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDHR3 Gene

Localization for CDHR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDHR3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDHR3 gene
Compartment Confidence
plasma membrane 5
nucleus 3
endoplasmic reticulum 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDHR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,IDA 24241537
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDHR3: view

Pathways & Interactions for CDHR3 Gene

SuperPathways for CDHR3 Gene

No Data Available

Interacting Proteins for CDHR3 Gene

Gene Ontology (GO) - Biological Process for CDHR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0016032 viral process IEA --
GO:0046718 viral entry into host cell IEA --
genes like me logo Genes that share ontologies with CDHR3: view

No data available for Pathways by source and SIGNOR curated interactions for CDHR3 Gene

Drugs & Compounds for CDHR3 Gene

(1) Drugs for CDHR3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with CDHR3: view

Transcripts for CDHR3 Gene

Unigene Clusters for CDHR3 Gene

Cadherin-related family member 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDHR3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
SP1:
SP2: - - -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for CDHR3 Gene

GeneLoc Exon Structure for
CDHR3
ECgene alternative splicing isoforms for
CDHR3

Expression for CDHR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDHR3 Gene

mRNA differential expression in normal tissues according to GTEx for CDHR3 Gene

This gene is overexpressed in Fallopian Tube (x5.7).

Protein differential expression in normal tissues from HIPED for CDHR3 Gene

This gene is overexpressed in Pancreatic juice (51.5) and Tonsil (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDHR3 Gene



Protein tissue co-expression partners for CDHR3 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDHR3 Gene:

CDHR3

SOURCE GeneReport for Unigene cluster for CDHR3 Gene:

Hs.150120

mRNA Expression by UniProt/SwissProt for CDHR3 Gene:

Q6ZTQ4-CDHR3_HUMAN
Tissue specificity: Expressed in bronchial epithelium from adults and in fetal lung tissue.

Evidence on tissue expression from TISSUES for CDHR3 Gene

  • Intestine(4.1)
  • Lung(3.2)
genes like me logo Genes that share expression patterns with CDHR3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDHR3 Gene

Orthologs for CDHR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDHR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDHR3 34 33
  • 99.13 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CDHR3 33 34
  • 84.18 (n)
dog
(Canis familiaris)
Mammalia CDHR3 34 33
  • 83.65 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cdhr3 33 16 34
  • 81.49 (n)
rat
(Rattus norvegicus)
Mammalia LOC686932 33
  • 77.28 (n)
oppossum
(Monodelphis domestica)
Mammalia CDHR3 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDHR3 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDHR3 34 33
  • 58.94 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDHR3 34
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdhr3 33
  • 58.32 (n)
Species where no ortholog for CDHR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CDHR3 Gene

ENSEMBL:
Gene Tree for CDHR3 (if available)
TreeFam:
Gene Tree for CDHR3 (if available)

Paralogs for CDHR3 Gene

Paralogs for CDHR3 Gene

genes like me logo Genes that share paralogs with CDHR3: view

Variants for CDHR3 Gene

Sequence variations from dbSNP and Humsavar for CDHR3 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000003068 -- 105,992,888(+) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000013714 -- 106,030,492(+) C/A genic_downstream_transcript_variant, intron_variant
rs1000036629 -- 105,914,778(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000044626 -- 105,942,454(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000116059 -- 105,881,071(+) T/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CDHR3 Gene

Variant ID Type Subtype PubMed ID
esv3336173 CNV insertion 20981092
nsv1027213 CNV gain 25217958
nsv5891 CNV deletion 18451855
nsv820197 CNV loss 19587683

Variation tolerance for CDHR3 Gene

Residual Variation Intolerance Score: 80.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.63; 94.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDHR3 Gene

Human Gene Mutation Database (HGMD)
CDHR3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDHR3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDHR3 Gene

Disorders for CDHR3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDHR3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
asthma
  • asthma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search CDHR3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CDHR3_HUMAN
  • Note=Asthma susceptibility may be associated with variations affecting the gene represented in this entry in early childhood asthma with severe exacerbations occurring between 2 and 6 years of age. {ECO:0000269 PubMed:24241537}.

Additional Disease Information for CDHR3

genes like me logo Genes that share disorders with CDHR3: view

No data available for Genatlas for CDHR3 Gene

Publications for CDHR3 Gene

  1. Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication. (PMID: 25848009) Bochkov YA … Gern JE (Proceedings of the National Academy of Sciences of the United States of America 2015) 3 4 58
  2. A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. (PMID: 24241537) Bønnelykke K … Bisgaard H (Nature genetics 2014) 3 4 58
  3. Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese. (PMID: 20833655) Cha PC … Nakamura Y (Human molecular genetics 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58

Products for CDHR3 Gene

Sources for CDHR3 Gene

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