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Aliases for CDH7 Gene

Aliases for CDH7 Gene

  • Cadherin 7 2 3 5
  • Cadherin 7, Type 2 2 3
  • CDH7L1 3 4
  • Cadherin-7 3

External Ids for CDH7 Gene

Previous GeneCards Identifiers for CDH7 Gene

  • GC18P063262
  • GC18P063390
  • GC18P061566
  • GC18P061568
  • GC18P060120

Summaries for CDH7 Gene

Entrez Gene Summary for CDH7 Gene

  • This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types. Mutations in this gene may be associated with bipolar disease in human patients. This gene is present in a gene cluster on chromosome 18. [provided by RefSeq, May 2016]

GeneCards Summary for CDH7 Gene

CDH7 (Cadherin 7) is a Protein Coding gene. Among its related pathways are ERK Signaling and Neural Crest Differentiation. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH20.

UniProtKB/Swiss-Prot for CDH7 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Additional gene information for CDH7 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH7 Gene

Genomics for CDH7 Gene

GeneHancer (GH) Regulatory Elements for CDH7 Gene

Promoters and enhancers for CDH7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I065752 Promoter 1 EPDnew 550.8 +1.3 1272 0.1 ZBTB10 ZNF10 ZSCAN4 ZFP37 SIN3A ZEB2 ZNF501 PRDM2 ZNF335 CTBP2 CDH7 GC18M065700
GH18I065751 Promoter 0.9 EPDnew 550.8 +0.7 741 0.1 ZBTB8A ZIC2 ZNF335 GLIS2 GLIS1 CTBP2 ZBTB26 ZXDB EZH2 ZBTB20 CDH7 GC18M065700
GH18I065753 Promoter 0.7 EPDnew 550.8 0.0 -48 0.1 ZNF362 ZNF600 CDH7 GC18M065700 ENSG00000265217
GH18I065750 Enhancer 0.6 ENCODE 550.8 +0.3 298 0.1 MXI1 MAZ ZNF362 BCL11B GLIS2 POLR2A GLIS1 ZBTB26 EGR2 EZH2 CDH7 GC18M065700
GH18I065768 Enhancer 0.8 ENCODE 8.4 +18.4 18350 1.1 INSM2 FEZF1 ZNF2 ZBTB40 ZEB1 GTF3C2 ZNF335 ZNF366 FOS ZNF362 CDH7 GC18M065700
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CDH7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDH7 gene promoter:

Genomic Locations for CDH7 Gene

Genomic Locations for CDH7 Gene
chr18:65,750,252-65,890,341
(GRCh38/hg38)
Size:
140,090 bases
Orientation:
Plus strand
chr18:63,417,488-63,548,638
(GRCh37/hg19)

Genomic View for CDH7 Gene

Genes around CDH7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH7 Gene

Proteins for CDH7 Gene

  • Protein details for CDH7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULB5-CADH7_HUMAN
    Recommended name:
    Cadherin-7
    Protein Accession:
    Q9ULB5
    Secondary Accessions:
    • Q9H157

    Protein attributes for CDH7 Gene

    Size:
    785 amino acids
    Molecular mass:
    87086 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CDH7 Gene

Post-translational modifications for CDH7 Gene

  • Glycosylation at Asn449 and Asn530

Other Protein References for CDH7 Gene

No data available for DME Specific Peptides for CDH7 Gene

Domains & Families for CDH7 Gene

Gene Families for CDH7 Gene

Suggested Antigen Peptide Sequences for CDH7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULB5

UniProtKB/Swiss-Prot:

CADH7_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
genes like me logo Genes that share domains with CDH7: view

Function for CDH7 Gene

Molecular function for CDH7 Gene

GENATLAS Biochemistry:
BH-cadherin chicken cadherin 7-like,transmembrane glycoprotein component of adherens junction,with two alternatively spliced isoforms,the major transcript predominantly expressed in the brain,putatively involved in synaptic adhesion,axon outgrowth and guidance,heart,the minor expressed in several cancer lines
UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Phenotypes From GWAS Catalog for CDH7 Gene

Gene Ontology (GO) - Molecular Function for CDH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CDH7: view

Phenotypes for CDH7 Gene

genes like me logo Genes that share phenotypes with CDH7: view

miRNA for CDH7 Gene

miRTarBase miRNAs that target CDH7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDH7 Gene

Localization for CDH7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH7 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDH7 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CDH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDH7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CDH7 Gene

Pathways & Interactions for CDH7 Gene

genes like me logo Genes that share pathways with CDH7: view

Gene Ontology (GO) - Biological Process for CDH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0034332 adherens junction organization TAS --
GO:0098609 cell-cell adhesion NAS 10861224
genes like me logo Genes that share ontologies with CDH7: view

No data available for SIGNOR curated interactions for CDH7 Gene

Drugs & Compounds for CDH7 Gene

(1) Drugs for CDH7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with CDH7: view

Transcripts for CDH7 Gene

mRNA/cDNA for CDH7 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDH7 Gene

Cadherin 7, type 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDH7 Gene

No ASD Table

Relevant External Links for CDH7 Gene

GeneLoc Exon Structure for
CDH7
ECgene alternative splicing isoforms for
CDH7

Expression for CDH7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDH7 Gene

mRNA differential expression in normal tissues according to GTEx for CDH7 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x12.2), Brain - Cerebellum (x8.9), and Nerve - Tibial (x6.9).

Protein differential expression in normal tissues from HIPED for CDH7 Gene

This gene is overexpressed in Plasma (55.2) and Heart (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDH7 Gene



Protein tissue co-expression partners for CDH7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDH7 Gene:

CDH7

SOURCE GeneReport for Unigene cluster for CDH7 Gene:

Hs.657522

Evidence on tissue expression from TISSUES for CDH7 Gene

  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with CDH7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDH7 Gene

Orthologs for CDH7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDH7 33 34
  • 99.62 (n)
oppossum
(Monodelphis domestica)
Mammalia CDH7 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDH7 33 34
  • 91.85 (n)
cow
(Bos Taurus)
Mammalia CDH7 33 34
  • 89.6 (n)
mouse
(Mus musculus)
Mammalia Cdh7 33 16 34
  • 88.83 (n)
rat
(Rattus norvegicus)
Mammalia Cdh7 33
  • 88.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDH7 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDH7 33 34
  • 83.44 (n)
lizard
(Anolis carolinensis)
Reptilia CDH7 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh7 33
  • 76.46 (n)
zebrafish
(Danio rerio)
Actinopterygii cdh7 33 34
  • 67.7 (n)
CDH7 (1 of 2) 34
  • 58 (a)
OneToMany
Species where no ortholog for CDH7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH7 Gene

ENSEMBL:
Gene Tree for CDH7 (if available)
TreeFam:
Gene Tree for CDH7 (if available)

Paralogs for CDH7 Gene

Paralogs for CDH7 Gene

(25) SIMAP similar genes for CDH7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CDH7: view

Variants for CDH7 Gene

Sequence variations from dbSNP and Humsavar for CDH7 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000039196 -- 65,761,628(+) T/G intron_variant
rs1000041233 -- 65,864,617(+) A/G downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000058661 -- 65,864,840(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000062656 -- 65,792,761(+) G/A intron_variant
rs1000072487 -- 65,809,603(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CDH7 Gene

Variant ID Type Subtype PubMed ID
nsv954961 CNV deletion 24416366
nsv954124 CNV deletion 24416366
nsv833676 CNV gain 17160897
nsv833675 CNV gain 17160897
nsv828267 CNV gain 20364138
nsv577157 CNV loss 21841781
nsv510462 OTHER sequence alteration 20534489
nsv458102 CNV loss 19166990
nsv1123188 CNV deletion 24896259
nsv1071856 CNV deletion 25765185
nsv1067311 CNV loss 25217958
esv6192 CNV loss 19470904
esv3893118 CNV gain 25118596
esv3642844 CNV loss 21293372
esv3584946 CNV gain 24956385
esv3583120 CNV loss 25503493
esv3555529 CNV deletion 23714750
esv3413 CNV loss 18987735
esv3364230 CNV insertion 20981092
esv3304720 CNV mobile element insertion 20981092
esv3119346 CNV deletion 24192839
esv2717231 CNV deletion 23290073
esv2521787 CNV deletion 19546169
esv1954972 CNV deletion 18987734
esv1389809 CNV deletion 17803354
esv1064517 CNV insertion 17803354
esv1005846 CNV deletion 20482838
esv1000701 CNV deletion 20482838
dgv1625n106 CNV deletion 24896259

Variation tolerance for CDH7 Gene

Residual Variation Intolerance Score: 3.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDH7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDH7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH7 Gene

Disorders for CDH7 Gene

Additional Disease Information for CDH7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CDH7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDH7 Gene

Publications for CDH7 Gene

  1. Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7. (PMID: 10995570) Kools P … van Roy F (Genomics 2000) 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Cadherin-7 interacts with melanoma inhibitory activity protein and negatively modulates melanoma cell migration. (PMID: 19200257) Winklmeier A … Bosserhoff AK (Cancer science 2009) 3 22 58
  4. Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. (PMID: 10861224) Shimoyama Y … Natori M (The Biochemical journal 2000) 3 4 58
  5. Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. (PMID: 9615235) Kremmidiotis G … Callen DF (Genomics 1998) 2 3 58

Products for CDH7 Gene

Sources for CDH7 Gene

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