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This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to ... See more...
Aliases for CDH5 Gene
Aliases for CDH5 Gene
External Ids for CDH5 Gene
- HGNC: 1764
- NCBI Entrez Gene: 1003
- Ensembl: ENSG00000179776
- OMIM®: 601120
- UniProtKB/Swiss-Prot: P33151
Previous GeneCards Identifiers for CDH5 Gene
- GC16P056984
- GC16P066658
- GC16P066136
- GC16P066176
- GC16P064958
- GC16P066400
- GC16P052277
Summaries for CDH5 Gene
-
This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015]
GeneCards Summary for CDH5 Gene
CDH5 (Cadherin 5) is a Protein Coding gene. Diseases associated with CDH5 include Epithelioid Sarcoma and Periapical Granuloma. Among its related pathways are Presenilin-Mediated Signaling and Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview. Gene Ontology (GO) annotations related to this gene include calcium ion binding and ion channel binding. An important paralog of this gene is CDH7.
UniProtKB/Swiss-Prot Summary for CDH5 Gene
-
Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:21269602). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (PubMed:10861224). Acts in concert with KRIT1 and MPP5 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (PubMed:20332120). Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (PubMed:20332120).
Additional gene information for CDH5 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDH5 Gene
Genomics for CDH5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CDH5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CDH5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDH5
- Top Transcription factor binding sites by QIAGEN in the CDH5 gene promoter:
-
- AML1a
- AP-1
- ATF-2
- c-Jun
Genomic Locations for CDH5 Gene
Latest Assembly
- chr16:66,366,622-66,404,784
- (GRCh38/hg38)
- Size:
- 38,163 bases
- Orientation:
- Plus strand
Previous Assembly
- chr16:66,400,594-66,438,687
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 38,094 bases
- Orientation:
- Plus strand
Genomic View for CDH5 Gene
Genes around CDH5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q21 by HGNC
- 16q21 by Entrez Gene
- 16q21 by Ensembl
CDH5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CDH5 Gene
Proteins for CDH5 Gene
-
Protein details for CDH5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P33151-CADH5_HUMAN
- Recommended name:
- Cadherin-5
- Protein Accession:
- P33151
- Q4VAI5
- Q4VAI6
Protein attributes for CDH5 Gene
- Size:
- 784 amino acids
- Molecular mass:
- 87528 Da
- Quaternary structure:
-
- Interacts (via cadherin 5 domain) with PTPRB (By similarity). Interacts with TRPC4 (PubMed:19996314). Interacts with KRIT1 (PubMed:20332120). Interacts with PARD3 (By similarity). Interacts with RTN4 (isoform B) (PubMed:21183689). Interacts with MPP5; the interaction promotes MPP5 localization to cell junctions and is required for CDH5-mediated vascular lumen formation and endothelial cell (PubMed:27466317).
Protein Expression for CDH5 Gene
Post-translational modifications for CDH5 Gene
Other Protein References for CDH5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences CD144 / CDH5 / VE Cadherin Monoclonal Antibody
- NSJ Bioreagents VE-Cadherin Antibody
-
BioLegend
- CD144 (VE-Cadherin) Antibody (348506)
- CD144 (VE-Cadherin) Antibody (348501)
- CD144 (VE-Cadherin) Antibody (348505)
- CD144 (VE-Cadherin) Antibody (348502)
- CD144 (VE-Cadherin) Antibody (348507)
- CD144 (VE-Cadherin) Antibody (348508)
- PerCP/Cyanine5.5 CD144 (VE-Cadherin) Antibody (348509)
- PerCP/Cyanine5.5 CD144 (VE-Cadherin) Antibody (348510)
- CD144 (VE-Cadherin) Antibody (348512)
- CD144 (VE-Cadherin) Antibody (348513)
- CD144 (VE-Cadherin) Antibody (348514)
- CD144 (VE-Cadherin) Antibody (348515)
- CD144 (VE-Cadherin) Antibody (348516)
- CD144 (VE-Cadherin) Antibody (348519)
- CD144 (VE-Cadherin) Antibody (348520)
- TotalSeq(TM)-A0400 CD144 (VE-Cadherin) Antibody
- Novus Biologicals Antibodies for CDH5
-
Abcam antibodies for CDH5
- Invitrogen Antibodies for CDH5 (AFLGC-CDH5)
- antibodies-online: Show 102 available Cadherin 5 Antibodies ranked by validation data
- Compare Top Cadherin 5 Antibodies
-
Recommended
- 105 WB Antibodies (anti-mouse)
- 29 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 5 IHC (fro) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 32 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 158 WB Antibodies (anti-human)
- 51 FACS Antibodies (anti-human)
- 11 IF (p) Antibodies (anti-human)
- 10 IHC Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 3 EIA Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
-
Boster Bio Antibodies for CDH5
-
Santa Cruz Biotechnology (SCBT) Antibodies for CDH5
- Sino Biological Antibodies for CDH5
Protein products for research
-
OriGene Purified Proteins for CDH5
- Search Origene for MassSpec and Protein Over-expression Lysates for CDH5
- Origene Custom Protein Services for CDH5
- Sino Biological Recombinant Proteins for CDH5
- Sino Biological Cell Lysates for CDH5
- ProSpec Recombinant Proteins for CDH5
-
Abcam proteins for CDH5
Assay products for research
- G Biosciences Immunotag™ Human CDH5 (Cadherin-5 ) ELISA and Immunotag™ Cadherin-5 ELISA Kit
- antibodies-online: Show 79 available Cadherin 5 Elisa Kits ranked by validation data
- Compare Top Cadherin 5 Elisa Kits
-
Quality Products:
- ABIN416976
- ABIN367068
- ABIN2859329
- ABIN1568912
- ABIN1117763
- ABIN5521996
- ABIN5668839
- ABIN5592932
- ABIN509901
- ABIN456772
- ABIN1113870
- ABIN812342
- ABIN424785
- ABIN2859330
- ABIN1568913
- ABIN5521997
- ABIN5596310
- ABIN5669939
- ABIN627657
- ABIN1381585
- ABIN1113868
- ABIN432081
- ABIN1568914
- ABIN5670597
- ABIN626836
- ABIN5652453
- ABIN2542308
- ABIN2952355
- ABIN6209603
- ABIN2043041
- ABIN989640
- ABIN1124630
-
Abcam assays for CDH5
- Sino Biological Assays for CDH5
No data available for DME Specific Peptides for CDH5 Gene
Domains & Families for CDH5 Gene
Gene Families for CDH5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for CDH5 Gene
- InterPro:
- Blocks:
-
- Cadherin cytoplasmic region
- Cadherin
Suggested Antigen Peptide Sequences for CDH5 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ51088, highly similar to Cadherin-5 (B4DTR2_HUMAN)
- Vascular endothelial cadherin (CADH5_HUMAN)
- CDH5 protein (Q4VAI4_HUMAN)
- CDH5 protein (Q4VAI5_HUMAN)
- CDH5 protein (Q4VAI6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P33151UniProtKB/Swiss-Prot:
CADH5_HUMAN :- Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
- Domain:
-
- Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Function for CDH5 Gene
Molecular function for CDH5 Gene
- UniProtKB/Swiss-Prot Function:
- Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:21269602). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (PubMed:10861224). Acts in concert with KRIT1 and MPP5 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (PubMed:20332120). Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (PubMed:20332120).
- GENATLAS Biochemistry:
- cadherin 5,VE-cadherin,transmembrane glycoprotein component of adherens junction,expressed in vascular endothelium,integrity and normal organ function required for vascular
Phenotypes From GWAS Catalog for CDH5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | IPI | 12088286 |
| GO:0005509 | calcium ion binding | IEA,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 15985432 |
| GO:0008013 | beta-catenin binding | IPI | 18287330 |
| GO:0019903 | protein phosphatase binding | IEA,IPI | 28926625 |
Phenotypes for CDH5 Gene
- MGI mutant phenotypes for CDH5:
-
inferred from 13 alleles
- normal phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- immune system phenotype
- mortality/aging
- liver/biliary system phenotype
- hematopoietic system phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- integument phenotype
- embryo phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for CDH5:
-
- Reduced mammosphere formation
- no effect
- Decreased viability ratio
- Decreased vaccinia virus (VACV) infection
- Increased IL-8 secretion
- Synthetic lethal with Ras
- Increased shRNA abundance (Z-score > 2)
- Increased mitotic delay (prometaphase or metaphase alignment problems, MAP)
- Multipolar spindles
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability with paclitaxel
- Inhibition of centrosomal clustering
- Decreased viability with carboplatin
Animal Models for CDH5 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CDH5 - Starting at $85 >
- * CDH5 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CDH5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDH5
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDH5
miRNA for CDH5 Gene
- miRTarBase miRNAs that target CDH5
-
- hsa-miR-211-5p (MIRT006257)
- mmu-miR-362-5p (MIRT008872)
- hsa-miR-335-5p (MIRT017265)
- hsa-miR-128-3p (MIRT021947)
- hsa-miR-26b-5p (MIRT029178)
- hsa-miR-125b-5p (MIRT052977)
- hsa-miR-101-3p (MIRT053051)
- hsa-miR-544a (MIRT710468)
- hsa-miR-6721-5p (MIRT710469)
- hsa-miR-4763-3p (MIRT710470)
- hsa-miR-1207-5p (MIRT710471)
- hsa-miR-5581-5p (MIRT710472)
- hsa-miR-4297 (MIRT710473)
- hsa-miR-6836-5p (MIRT710474)
- hsa-miR-6132 (MIRT710475)
- hsa-miR-4708-3p (MIRT710476)
- hsa-miR-2276-3p (MIRT710477)
- hsa-miR-4772-3p (MIRT710478)
- hsa-miR-1915-5p (MIRT710479)
- hsa-miR-1237-3p (MIRT710480)
- hsa-miR-3918 (MIRT710481)
- hsa-miR-4761-5p (MIRT710482)
- hsa-miR-4512 (MIRT710483)
- hsa-miR-7843-5p (MIRT710484)
- hsa-miR-6879-5p (MIRT710485)
- hsa-miR-6735-5p (MIRT710486)
- hsa-miR-4632-5p (MIRT710487)
- hsa-miR-4436b-3p (MIRT710488)
- hsa-miR-27b-3p (MIRT734860)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDH5
- Browse OriGene Inhibitory RNA Products For CDH5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDH5
Clone products for research
- Applied Biological Materials (abm): Clones for CDH5 - Starting at $45 >
- * CDH5 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CDH5
- Addgene plasmids for CDH5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDH5
Cell Lines for research
-
Horizon Cell Lines for CDH5
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDH5 Gene
Localization for CDH5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CDH5 Gene
- Cell junction. Cell membrane. Single-pass type I membrane protein. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions. {ECO:0000269 PubMed:20332120}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| extracellular | 3 |
| cytoskeleton | 3 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Plasma membrane (3)
- Nuclear membrane (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005886 | plasma membrane | IDA,TAS | -- |
| GO:0005911 | cell-cell junction | IEA,IDA | 15572031 |
| GO:0005912 | adherens junction | IEA,IMP | 26923917 |
| GO:0005923 | bicellular tight junction | IEA,IBA | 21873635 |
Pathways & Interactions for CDH5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways | ||
| 2 | Cell junction organization | ||
| 3 | Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview | ||
| 4 | ERK Signaling |
Rho Family GTPases
.61
|
ILK Signaling
.49
|
| 5 | RET signaling | ||
Pathways by source for CDH5 Gene
1 Sino Biological pathway for CDH5 Gene
2 BioSystems pathways for CDH5 Gene
8 Reactome pathways for CDH5 Gene
3 KEGG pathways for CDH5 Gene
2 GeneGo (Thomson Reuters) pathways for CDH5 Gene
- Cell adhesion_Cadherin-mediated cell adhesion
- Cell adhesion_Endothelial cell contacts by junctional mechanisms
8 R&D Systems pathways for CDH5 Gene
- Blood-Brain Barrier and Immune Cell Transmigration: CCL2/MCP-1 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview
- Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: VEGF Signaling Pathways
8 Qiagen pathways for CDH5 Gene
- G12-G13 in Cellular Signaling
- GSK3 Signaling
- ILK Signaling
- Presenilin-Mediated Signaling
- Rho Family GTPases
2 Cell Signaling Technology pathways for CDH5 Gene
Interacting Proteins for CDH5 Gene
Selected Interacting proteins:
P33151-CADH5_HUMAN
ENSP00000344115
for CDH5 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CDH5
SIGNOR curated interactions for CDH5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000902 | cell morphogenesis | IBA | 21873635 |
| GO:0001932 | regulation of protein phosphorylation | IDA | 23159740 |
| GO:0001944 | vasculature development | IBA | 21873635 |
| GO:0001955 | blood vessel maturation | IEA | -- |
| GO:0006874 | cellular calcium ion homeostasis | IDA | 23159740 |
Drugs & Compounds for CDH5 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for CDH5 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Cadherin Peptide, avian | Role in cell adhesion | 127650-08-2 |
Transcripts for CDH5 Gene
mRNA/cDNA for CDH5 Gene
- 2 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000341529 4057 nts (view in UCSC)
- ENST00000539168 1672 nts (view in UCSC)
- ENST00000562048 615 nts (view in UCSC)
- ENST00000563425 1932 nts (view in UCSC)
- ENST00000565334 2138 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CDH5 - Starting at $85 >
- * CDH5 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CDH5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDH5
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDH5
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDH5
- Browse OriGene Inhibitory RNA Products For CDH5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDH5
Clone products for research
- Applied Biological Materials (abm): Clones for CDH5 - Starting at $45 >
- * CDH5 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CDH5
- Addgene plasmids for CDH5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDH5
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
Relevant External Links for CDH5 Gene
- GeneLoc Exon Structure for
- CDH5
Expression for CDH5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Endothelium (Cardiovascular System)
- Arterial Endothelial Cells Paired Dorsal Aorta
- Hemangioblasts Posterior Primitive Streak
- Angioblasts Embryonic Capillary Plexus
- Extraembryonic Angioblasts Extraembryonic Blood Islands
- Umbilical vein endothelial cells Umbilical Veins
- NULL (Nervous System)
- Umbilical Cord (Extraembryonic Tissues)
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- Hemangioblasts Posterior Primitive Streak
- Angiogenic cell precursors
- Hematopoietic progenitor cells(Takayama N et. al. 2012)
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Arterial Endothelial Cells Paired Dorsal Aorta
- Angioblasts Embryonic Capillary Plexus
- Angioblasts Embryonic Blood Islands
- Angioblasts Proepicardium
-
Skeletal Muscle (Muscoskeletal System)
- Myoblasts Mandibular Arch Muscles
- Muscle Progenitor Cells Mandibular Arch Muscles
- Myoblasts Hyoid Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
- Brain (Nervous System)
-
Adipose (Muscoskeletal System)
- Stromal Cells Subcutaneous White Adipose
- Body Subcutaneous White Adipose
- Visceral White Adipose
- Heart (Cardiovascular System)
- Kidney (Urinary System)
- Dermis (Integumentary System)
- Lymph (Hematopoietic System)
- Lung (Respiratory System)
- Epithelial Cells (Uncategorized)
- Eye (Sensory Organs)
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
-
Mesenchymal Stem Cells
- Bone Marrow Stromal Cells Pelvic Girdle
-
Primitive Streak (Early Embryonic Tissues)
- Hemangioblasts Posterior Primitive Streak
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Blood Islands
- Ovary (Reproductive System)
- Liver (Hepatobiliary System)
- Lower Urinary Tract (Urinary System)
- Intestine (Gastrointestinal Tract)
- Epiblast (Early Embryonic Tissues)
- Germ Cells (Reproductive System)
- Gonad
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for CDH5 Gene
This gene is overexpressed in Adipose - Visceral (Omentum) (x4.5) and Lung (x4.2).
This gene is overexpressed in Serum (53.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDH5 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDH5
SOURCE GeneReport for Unigene cluster for CDH5 Gene:
Hs.76206mRNA Expression by UniProt/SwissProt for CDH5 Gene:
P33151-CADH5_HUMAN
Tissue specificity:
Endothelial tissues and brain.
Evidence on tissue expression from TISSUES for CDH5 Gene
- Nervous system(4.8)
- Heart(4.8)
- Bone marrow(4.5)
- Muscle(3.4)
- Lung(3.1)
- Blood(3)
- Liver(2.8)
- Kidney(2.8)
- Skin(2.7)
- Eye(2.6)
- Spleen(2.6)
- Intestine(2.5)
- Lymph node(2.4)
- Thyroid gland(2.2)
- Pancreas(2)
- Bone(2)
Primer products for research
-
OriGene qPCR primer pairs for CDH5
Gene Expression Assays for research
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDH5 Gene
Orthologs for CDH5 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CDH5 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CDH5 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CDH5 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cdh5 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Cdh5 29 16 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CDH5 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CDH5 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CDH5 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cdh5 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | cdh5 29 30 |
|
OneToOne |
- Species where no ortholog for CDH5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CDH5 Gene
- ENSEMBL:
- Gene Tree for CDH5 (if available)
- TreeFam:
- Gene Tree for CDH5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CDH5: view image
- Alliance of Genome Resources:
- Additional Orthologs for CDH5
Paralogs for CDH5 Gene
Paralogs for CDH5 Gene
(21) SIMAP similar genes for CDH5 Gene using alignment to 8 proteins:
- CADH5_HUMAN
- B4DTR2_HUMAN
- H3BPG1_HUMAN
- H3BQ82_HUMAN
- H3BR11_HUMAN
- H3BR64_HUMAN
- I3L1J2_HUMAN
- Q4VAI4_HUMAN
Variants for CDH5 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDH5 Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs140545178 | Benign: not provided | 66,390,419(+) |
C/T NM_001795.5(CDH5):c.798C>T (p.Val266=) |
SYNONYMOUS | |
| rs143548008 | Likely Benign: not provided | 66,390,488(+) |
G/C NM_001795.5(CDH5):c.867G>C (p.Gln289His) |
MISSENSE | |
| rs1596937199 | Uncertain Significance: Marfanoid habitus and intellectual disability | 66,386,863(+) |
G/A NM_001795.5(CDH5):c.265G>A (p.Val89Met) |
MISSENSE | |
| rs1049970 | -- |
p.Ile517Thr |
|||
| rs16956504 | -- |
p.Ile503Thr |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2468646 | CNV | deletion | 19546169 |
| esv2714642 | CNV | deletion | 23290073 |
| esv2714643 | CNV | deletion | 23290073 |
| esv3448646 | CNV | duplication | 20981092 |
| esv4828 | CNV | loss | 18987735 |
| nsv572902 | CNV | loss | 21841781 |
| nsv833264 | CNV | gain | 17160897 |
| nsv958050 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
36.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.62;
56.58% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CDH5 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH5 Gene
Disorders for CDH5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| epithelioid sarcoma |
|
|
| periapical granuloma |
|
|
| acute myocardial infarction |
|
|
| melanoma, uveal |
|
|
| spastic paraplegia 3, autosomal dominant |
|
|
Search CDH5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CDH5
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CDH5 Gene
Publications for CDH5 Gene
- Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion. (PMID: 9219219) Ali J … Muller WA (Microcirculation (New York, N.Y. : 1994) 1997) 3 4 22
- Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin. (PMID: 7627717) Breviario F … Dejana E (Arteriosclerosis, thrombosis, and vascular biology 1995) 3 4 22
- Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. (PMID: 2059658) Suzuki S … Tanihara H (Cell regulation 1991) 2 3 4
- Endothelial reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation. (PMID: 21183689) Di Lorenzo A … Sessa WC (Blood 2011) 3 4
- Src-induced tyrosine phosphorylation of VE-cadherin is not sufficient to decrease barrier function of endothelial monolayers. (PMID: 20048167) Adam AP … Vincent PA (The Journal of biological chemistry 2010) 3 22
ExternalLinks
Products for CDH5 Gene
- View all 32 R&D Systems CDH5 (VE-Cadherin) Products
- View all 2 R&D Systems CDH5 (VE-Cadherin) Proteins and Enzymes
- View all 25 R&D Systems CDH5 (VE-Cadherin) Primary Antibodies
- View all 3 R&D Systems CDH5 (VE-Cadherin) ELISAs
- View all 2 R&D Systems CDH5 (VE-Cadherin) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom CDH5 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for CDH5
- Custom Assay Services
- OriGene Purified Proteins for CDH5
- Search Origene for MassSpec and Protein Over-expression Lysates for CDH5
- Origene Custom Protein Services for CDH5
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDH5
- Browse OriGene Inhibitory RNA Products For CDH5
- OriGene qPCR primer pairs for CDH5
- OriGene CRISPR knockouts for CDH5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CDH5
- Sino Biological Human cDNA Clone for CDH5
- Sino Biological Recombinant Proteins for CDH5
- Sino Biological Cell Lysates for CDH5
- Sino Biological Antibodies for CDH5
- Sino Biological Assays for CDH5
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CDH5
- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for CDH5
- Abcam proteins for CDH5
- Abcam assays for CDH5
- Find your target
- Browse Primary Antibodies
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- Browse Matched Antibody Pairs
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- ApexBio compounds for CDH5
- VectorBuilder Custom and pre-made DNA vectors for CDH5 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CDH5 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CDH5 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CDH5 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CDH5
- Addgene plasmids for CDH5
- antibodies-online: Show 102 available Cadherin 5 Antibodies ranked by validation data
- Compare Top Cadherin 5 Antibodies
- Recommended
- 105 WB Antibodies (anti-mouse)
- 29 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 5 IHC (fro) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 32 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 158 WB Antibodies (anti-human)
- 51 FACS Antibodies (anti-human)
- 11 IF (p) Antibodies (anti-human)
- 10 IHC Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 3 EIA Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- antibodies-online: Show 79 available Cadherin 5 Elisa Kits ranked by validation data
- Compare Top Cadherin 5 Elisa Kits
- Quality Products:
- ABIN416976
- ABIN367068
- ABIN2859329
- ABIN1568912
- ABIN1117763
- ABIN5521996
- ABIN5668839
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- ABIN509901
- ABIN456772
- ABIN1113870
- ABIN812342
- ABIN424785
- ABIN2859330
- ABIN1568913
- ABIN5521997
- ABIN5596310
- ABIN5669939
- ABIN627657
- ABIN1381585
- ABIN1113868
- ABIN432081
- ABIN1568914
- ABIN5670597
- ABIN626836
- ABIN5652453
- ABIN2542308
- ABIN2952355
- ABIN6209603
- ABIN2043041
- ABIN989640
- ABIN1124630
- antibodies-online: Show 24 available Cadherin 5 Proteins ranked by validation data
- Compare Top Cadherin 5 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CDH5
- Search Santa Cruz Biotechnology (SCBT) for CDH5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CDH5
- Horizon Cell Lines for CDH5
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDH5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDH5
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CDH5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDH5
Sources for CDH5 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources