Aliases for CDH5 Gene
Aliases for CDH5 Gene
External Ids for CDH5 Gene
- HGNC: 1764
- Entrez Gene: 1003
- Ensembl: ENSG00000179776
- OMIM: 601120
- UniProtKB: P33151
Previous GeneCards Identifiers for CDH5 Gene
- GC16P056984
- GC16P066658
- GC16P066136
- GC16P066176
- GC16P064958
- GC16P066400
- GC16P052277
Summaries for CDH5 Gene
-
This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015]
GeneCards Summary for CDH5 Gene
CDH5 (Cadherin 5) is a Protein Coding gene. Diseases associated with CDH5 include Periapical Granuloma and Epithelioid Sarcoma. Among its related pathways are ERK Signaling and RET signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and ion channel binding.
UniProtKB/Swiss-Prot for CDH5 Gene
-
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.
Additional gene information for CDH5 Gene
- Monarch Initiative
- Search for CDH5 at DataMed
- Search for CDH5 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH5 Gene
Genomics for CDH5 Gene
GeneHancer (GH) Regulatory Elements for CDH5 Gene
Promoters and enhancers for CDH5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CDH5 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CDH5 gene promoter:
Regulatory Element Products
Genomic Locations for CDH5 Gene
Genomic Locations for CDH5 Gene
- chr16:66,366,622-66,404,786
- (GRCh38/hg38)
- Size:
- 38,165 bases
- Orientation:
- Plus strand
- chr16:66,400,525-66,438,689
- (GRCh37/hg19)
Genomic View for CDH5 Gene
Genes around CDH5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q21 by Ensembl
- 16q21 by Entrez Gene
- 16q21 by HGNC
CDH5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CDH5 Gene
Proteins for CDH5 Gene
-
Protein details for CDH5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P33151-CADH5_HUMAN
- Recommended name:
- Cadherin-5
- Protein Accession:
- P33151
- Q4VAI5
- Q4VAI6
Protein attributes for CDH5 Gene
- Size:
- 784 amino acids
- Molecular mass:
- 87528 Da
- Quaternary structure:
-
- Interacts (via cadherin 5 domain) with PTPRB (By similarity). Interacts with TRPC4. Interacts with KRIT1. Interacts with PARD3 (By similarity).
Protein Expression for CDH5 Gene
Post-translational modifications for CDH5 Gene
- O-glycosylated.
- Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB (By similarity).
- Glycosylation at Asn61, posLast=112112, posLast=157157, Asn362, Asn442, Asn523, and posLast=535535
Other Protein References for CDH5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CDH5 (VE-Cadherin)
- Cell Signaling Technology (CST) Antibodies for CDH5 (CDH5)
- Novus Biologicals Antibodies for CDH5
-
Abcam antibodies for CDH5
-
Cloud-Clone Corp. Antibodies for CDH5
- Invitrogen Antibodies for CDH5
- antibodies-online: Search results for 373 available Cadherin 5 Antibodies ranked by validation data
- Compare Top Cadherin 5 Antibodies
-
Recommended
- 1 IHC (fro) Antibody (anti-mouse)
- 1 IF Antibody (anti-human)
- 1 CC Antibody (anti-human)
- 2 IP Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 3 EIA Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 11 IF (p) Antibodies (anti-human)
- 59 FACS Antibodies (anti-human)
- 165 WB Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-rat)
- 1 IHC Antibody (anti-rat)
- 6 FACS Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 37 WB Antibodies (anti-rat)
- 1 IP Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 36 FACS Antibodies (anti-mouse)
- 97 WB Antibodies (anti-mouse)
- Search GeneTex for Antibodies for CDH5
-
Santa Cruz Biotechnology (SCBT) Antibodies for CDH5
- Sino Biological Antibodies for CDH5
Protein Products
- R&D Systems Proteins and Enzymes for CDH5 (VE-Cadherin)
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CDH5
- Origene Custom Protein Services for CDH5
- Novus Biologicals proteins for CDH5
- Sino Biological Cell Lysates for CDH5
- Sino Biological Recombinant Proteins for CDH5
- ProSpec Recombinant Proteins for CDH5
-
Cloud-Clone Corp. Proteins for CDH5
- Search GeneTex for Proteins for CDH5
-
Abcam proteins for CDH5
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, ELISAs, and other biochemical assays for CDH5 (VE-Cadherin)
-
Cloud-Clone Corp. Assay Kits for CDH5
-
Abcam assays for CDH5
- Sino Biological Assays for CDH5
No data available for DME Specific Peptides for CDH5 Gene
Domains & Families for CDH5 Gene
Gene Families for CDH5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for CDH5 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CDH5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P33151UniProtKB/Swiss-Prot:
CADH5_HUMAN :- Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
- Domain:
-
- Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Function for CDH5 Gene
Molecular function for CDH5 Gene
- GENATLAS Biochemistry:
- cadherin 5,VE-cadherin,transmembrane glycoprotein component of adherens junction,expressed in vascular endothelium,integrity and normal organ function required for vascular
- UniProtKB/Swiss-Prot Function:
- Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.
Phenotypes From GWAS Catalog for CDH5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | receptor binding | IPI | 12088286 |
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 17057644 |
| GO:0008013 | beta-catenin binding | IPI | 18287330 |
| GO:0019903 | protein phosphatase binding | IEA | -- |
Phenotypes for CDH5 Gene
- MGI mutant phenotypes for CDH5:
-
inferred from 13 alleles
- normal phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- growth/size/body region phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- integument phenotype
- embryo phenotype
- hematopoietic system phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for CDH5:
-
- Increased vaccinia virus (VACV) infection
- Synthetic lethal with Ras
- Increased shRNA abundance (Z-score > 2)
- Decreased viability ratio
- Dynamic nuclei (hole, folded or small irregular)
- Decreased shRNA abundance (Z-score < -2)
- Effect on mitosis
- Decreased IL-8 secretion
- Multipolar spindles
- Decreased viability with carboplatin
- Decreased viability with paclitaxel
- Inhibition of centrosomal clustering
Animal Models for CDH5 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CDH5
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CDH5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CDH5 gene
- Search ViGene Biosciences for CDH5
CRISPR Products
-
OriGene CRISPR knockouts for CDH5
- genomics-online: gRNA clones - Search results for 124 available Cadherin 5 gene related products
- Overview of 124 available Cadherin 5 gene related products
- Applied Biological Materials CRISPR for CDH5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDH5
- GenScript: Design CRISPR guide RNA sequences for CDH5
miRNA for CDH5 Gene
- miRTarBase miRNAs that target CDH5
-
- hsa-mir-211-5p (MIRT006257)
- hsa-mir-335-5p (MIRT017265)
- hsa-mir-128-3p (MIRT021947)
- hsa-mir-26b-5p (MIRT029178)
- hsa-mir-125b-5p (MIRT052977)
- hsa-mir-101-3p (MIRT053051)
- hsa-mir-544a (MIRT710468)
- hsa-mir-6721-5p (MIRT710469)
- hsa-mir-4763-3p (MIRT710470)
- hsa-mir-1207-5p (MIRT710471)
- hsa-mir-5581-5p (MIRT710472)
- hsa-mir-4297 (MIRT710473)
- hsa-mir-6836-5p (MIRT710474)
- hsa-mir-6132 (MIRT710475)
- hsa-mir-4708-3p (MIRT710476)
- hsa-mir-2276-3p (MIRT710477)
- hsa-mir-4772-3p (MIRT710478)
- hsa-mir-1915-5p (MIRT710479)
- hsa-mir-1237-3p (MIRT710480)
- hsa-mir-3918 (MIRT710481)
- hsa-mir-4761-5p (MIRT710482)
- hsa-mir-4512 (MIRT710483)
- hsa-mir-7843-5p (MIRT710484)
- hsa-mir-6879-5p (MIRT710485)
- hsa-mir-6735-5p (MIRT710486)
- hsa-mir-4632-5p (MIRT710487)
- hsa-mir-4436b-3p (MIRT710488)
- hsa-mir-27b-3p (MIRT734860)
miRNA Products
- Search ViGene Biosciences for CDH5
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDH5
- Browse OriGene Inhibitory RNA Products For CDH5
- genomics-online: shRNA clones - Search results for 124 available Cadherin 5 gene related products
- Overview of 124 available Cadherin 5 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CDH5 gene
Clone Products
- Sino Biological Human cDNA Clone for CDH5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CDH5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CDH5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CDH5
- Applied Biological Materials Clones for CDH5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CDH5
-
ViGene Biosciences adenoviral particle packaged cDNA for CDH5 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CDH5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CDH5 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDH5 Gene
Localization for CDH5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CDH5 Gene
- Cell junction. Cell membrane; Single-pass type I membrane protein. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions. {ECO:0000269 PubMed:20332120}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 3 |
| cytoskeleton | 3 |
| nucleus | 2 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| lysosome | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS,IDA | -- |
| GO:0005911 | cell-cell junction | IDA | 19996314 |
| GO:0005912 | adherens junction | IEA | -- |
| GO:0005913 | cell-cell adherens junction | IDA | 25978380 |
| GO:0005923 | bicellular tight junction | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CDH5 Gene
Pathways & Interactions for CDH5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways | ||
| 2 | Cell junction organization | ||
| 3 | Blood-Brain Barrier Pathway: Anatomy | ||
| 4 | ERK Signaling |
.49
|
|
| 5 | RET signaling | ||
Pathways by source for CDH5 Gene
1 Sino Biological pathway for CDH5 Gene
2 Cell Signaling Technology pathways for CDH5 Gene
2 BioSystems pathways for CDH5 Gene
8 Reactome pathways for CDH5 Gene
3 KEGG pathways for CDH5 Gene
2 GeneGo (Thomson Reuters) pathways for CDH5 Gene
7 R&D Systems pathways for CDH5 Gene
- Blood-Brain Barrier and Immune Cell Transmigration: CCL2/MCP-1 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview
- Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: VEGF Signaling Pathways
8 Qiagen pathways for CDH5 Gene
Interacting Proteins for CDH5 Gene
Selected Interacting proteins:
P33151-CADH5_HUMAN
ENSP00000344115
for CDH5 Gene via
MINT
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001955 | blood vessel maturation | IEA | -- |
| GO:0007043 | cell-cell junction assembly | IMP | 23288152 |
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | TAS,IEA | -- |
| GO:0007179 | transforming growth factor beta receptor signaling pathway | IDA | 21168935 |
Drugs & Compounds for CDH5 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for CDH5 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Cadherin Peptide, avian | Role in cell adhesion | 127650-08-2 |
Transcripts for CDH5 Gene
mRNA/cDNA for CDH5 Gene
- (3) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (101) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CDH5 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CDH5
- genomics-online: gRNA clones - Search results for 124 available Cadherin 5 gene related products
- Overview of 124 available Cadherin 5 gene related products
- Applied Biological Materials CRISPR for CDH5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDH5
- GenScript: Design CRISPR guide RNA sequences for CDH5
miRNA Products
- Search ViGene Biosciences for CDH5
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDH5
- Browse OriGene Inhibitory RNA Products For CDH5
- genomics-online: shRNA clones - Search results for 124 available Cadherin 5 gene related products
- Overview of 124 available Cadherin 5 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CDH5 gene
Clone Products
- Sino Biological Human cDNA Clone for CDH5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CDH5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CDH5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CDH5
- Applied Biological Materials Clones for CDH5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
Expression for CDH5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Endothelium (Cardiovascular System)
- Arterial Endothelial Cells Paired Dorsal Aorta
- Hemangioblasts Posterior Primitive Streak
- Angioblasts Embryonic Capillary Plexus
- Extraembryonic Angioblasts Extraembryonic Blood Islands
- Umbilical vein endothelial cells Umbilical Veins
- NULL (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- Hemangioblasts Posterior Primitive Streak
- Angiogenic cell precursors
- Hematopoietic progenitor cells(Takayama N et. al. 2012)
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Arterial Endothelial Cells Paired Dorsal Aorta
- Angioblasts Embryonic Capillary Plexus
- Angioblasts Embryonic Blood Islands
- Angioblasts Proepicardium
-
Skeletal Muscle (Muscoskeletal System)
- Myoblasts Mandibular Arch Muscles
- Muscle Progenitor Cells Mandibular Arch Muscles
- Myoblasts Hyoid Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
- Brain (Nervous System)
-
Adipose (Muscoskeletal System)
- Stromal Cells Subcutaneous White Adipose
- Body Subcutaneous White Adipose
- Visceral White Adipose
- Heart (Cardiovascular System)
- Kidney (Urinary System)
- Epithelial Cells (Uncategorized)
- Eye (Sensory Organs)
- Lung (Respiratory System)
- Dermis (Integumentary System)
- Lymph (Hematopoietic System)
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
-
Mesenchymal Stem Cells
- Bone Marrow Stromal Cells Pelvic Girdle
-
Primitive Streak (Early Embryonic Tissues)
- Hemangioblasts Posterior Primitive Streak
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Blood Islands
- Epiblast (Early Embryonic Tissues)
- Germ Cells (Reproductive System)
- Gonad
- Ovary (Reproductive System)
- Liver (Hepatobiliary System)
- Lower Urinary Tract (Urinary System)
- Intestine (Gastrointestinal Tract)
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for CDH5 Gene
This gene is overexpressed in Adipose - Visceral (Omentum) (x4.5) and Lung (x4.2).
This gene is overexpressed in Serum (53.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDH5 Gene
NURSA nuclear receptor signaling pathways regulating expression of CDH5 Gene:
CDH5SOURCE GeneReport for Unigene cluster for CDH5 Gene:
Hs.76206mRNA Expression by UniProt/SwissProt for CDH5 Gene:
P33151-CADH5_HUMAN
Tissue specificity:
Endothelial tissues and brain.
Evidence on tissue expression from TISSUES for CDH5 Gene
- Heart(4.8)
- Nervous system(4.7)
- Bone marrow(4.4)
- Muscle(3.1)
- Lung(3)
- Blood(2.8)
- Liver(2.2)
- Eye(2)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs for CDH5
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDH5 Gene
Orthologs for CDH5 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CDH5 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | CDH5 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CDH5 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cdh5 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Cdh5 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CDH5 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CDH5 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CDH5 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cdh5 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cdh5 33 34 |
|
- Species where no ortholog for CDH5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CDH5 Gene
(21) SIMAP similar genes for CDH5 Gene using alignment to 8 proteins:
No data available for Paralogs for CDH5 Gene
Variants for CDH5 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000009724 | -- | 66,401,799(+) | C/G | intron_variant | |
| rs1000052307 | -- | 66,390,433(+) | C/A | coding_sequence_variant, missense_variant | |
| rs1000110191 | -- | 66,397,240(+) | A/G | intron_variant | |
| rs1000140788 | -- | 66,384,600(+) | A/G | intron_variant | |
| rs1000278513 | -- | 66,384,317(+) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv958050 | CNV | deletion | 24416366 |
| nsv833264 | CNV | gain | 17160897 |
| nsv572902 | CNV | loss | 21841781 |
| esv4828 | CNV | loss | 18987735 |
| esv3448646 | CNV | duplication | 20981092 |
| esv2714643 | CNV | deletion | 23290073 |
| esv2714642 | CNV | deletion | 23290073 |
| esv2468646 | CNV | deletion | 19546169 |
Residual Variation Intolerance Score:
36.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.62;
56.58% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CDH5 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH5 Gene
Disorders for CDH5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| periapical granuloma |
|
|
| epithelioid sarcoma |
|
|
| ovarian hyperstimulation syndrome |
|
|
| melanoma, uveal |
|
|
| spastic paraplegia 3, autosomal dominant |
|
|
Search CDH5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CDH5
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CDH5 Gene
Publications for CDH5 Gene
- Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion. (PMID: 9219219) Ali J … Muller WA (Microcirculation (New York, N.Y. : 1994) 1997) 3 4 22 58
- Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin. (PMID: 7627717) Breviario F … Dejana E (Arteriosclerosis, thrombosis, and vascular biology 1995) 3 4 22 58
- Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. (PMID: 2059658) Suzuki S … Tanihara H (Cell regulation 1991) 2 3 4 58
- The role of VE-cadherin in osteosarcoma cells. (PMID: 19760520) Zhang LZ … Huang WD (Pathology oncology research : POR 2010) 3 22 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
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- Mammalian expression: PiggyBac
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Sources for CDH5 Gene
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