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Aliases for CDH4 Gene

Aliases for CDH4 Gene

  • Cadherin 4 2 3 5
  • R-Cadherin 2 3 4
  • Cadherin 4, Type 1, R-Cadherin (Retinal) 2 3
  • Retinal Cadherin 3 4
  • R-CAD 3 4
  • Cadherin 4, Type 1, Preproprotein 3
  • Cadherin-4 3
  • CAD4 3
  • RCAD 3

External Ids for CDH4 Gene

Previous GeneCards Identifiers for CDH4 Gene

  • GC20P060082
  • GC20P060466
  • GC20P060512
  • GC20P059260
  • GC20P059827
  • GC20P057100

Summaries for CDH4 Gene

Entrez Gene Summary for CDH4 Gene

  • This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for CDH4 Gene

CDH4 (Cadherin 4) is a Protein Coding gene. Diseases associated with CDH4 include Hepatocellular Carcinoma. Among its related pathways are ERK Signaling and Presenilin-Mediated Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH2.

UniProtKB/Swiss-Prot for CDH4 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.

Gene Wiki entry for CDH4 Gene

Additional gene information for CDH4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH4 Gene

Genomics for CDH4 Gene

GeneHancer (GH) Regulatory Elements for CDH4 Gene

Promoters and enhancers for CDH4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J061252 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE 668.6 +1.4 1436 3.7 CTCF MXI1 ZBTB6 SUZ12 SIN3A ZIC2 ZNF335 ZFHX2 GLIS2 POLR2A CDH4 GC20M061283
GH20J061956 Enhancer 0.9 ENCODE 8.9 +704.6 704613 1.2 PKNOX1 ATF1 FOXA2 ARNT INSM2 FEZF1 RARA ZNF614 ZNF366 ZSCAN5C CDH4 MIR1257 GC20P061972 GC20M061929 TAF4
GH20J062030 Enhancer 1 Ensembl ENCODE 7.9 +778.6 778645 1.5 ELF3 PKNOX1 MLX ARID4B DMAP1 RAD21 THRB ZNF48 PRPF4 MIXL1 CDH4 GC20M062040 LOC105372704 TAF4
GH20J062041 Enhancer 0.9 ENCODE 8.1 +790.5 790535 2.4 ARID4B DMAP1 YY1 GLIS2 ATF7 RXRA SP5 ZHX2 MXD4 PPARG TAF4 LSM14B SS18L1 PSMA7 CDH4 RPL17P48 MIR3195
GH20J061964 Enhancer 1 Ensembl ENCODE 6.9 +713.6 713642 2.5 BCOR IRF2 TFAP4 MXI1 USF1 SAP130 ARID4B ZMYM3 RAD21 THRB CDH4 GC20P061972 MIR1257 GC20M061929 TAF4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDH4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDH4 gene promoter:
  • NRSF form 1
  • NRSF form 2

Genomic Locations for CDH4 Gene

Genomic Locations for CDH4 Gene
688,192 bases
Plus strand
688,192 bases
Plus strand

Genomic View for CDH4 Gene

Genes around CDH4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH4 Gene

Proteins for CDH4 Gene

  • Protein details for CDH4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B3KWB8
    • G3V1P8
    • Q2M208
    • Q5VZ44
    • Q9BZ05

    Protein attributes for CDH4 Gene

    916 amino acids
    Molecular mass:
    100281 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDH4 Gene


neXtProt entry for CDH4 Gene

Post-translational modifications for CDH4 Gene

  • Glycosylation at posLast=702702, posLast=661661, Asn632, Asn557, posLast=412412, posLast=283283, Thr88, and posLast=8484
  • Modification sites at PhosphoSitePlus

Other Protein References for CDH4 Gene

No data available for DME Specific Peptides for CDH4 Gene

Domains & Families for CDH4 Gene

Gene Families for CDH4 Gene

Suggested Antigen Peptide Sequences for CDH4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
genes like me logo Genes that share domains with CDH4: view

Function for CDH4 Gene

Molecular function for CDH4 Gene

UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.
GENATLAS Biochemistry:
cadherin 4,R-cadherin,transmembrane glycoprotein component of adherens junction,expressed in retina,in brain,involved during brain segmentation and neuronal outgrowth and in kidney

Phenotypes From GWAS Catalog for CDH4 Gene

Gene Ontology (GO) - Molecular Function for CDH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0008092 cytoskeletal protein binding IBA --
GO:0042803 protein homodimerization activity IBA --
GO:0045296 cadherin binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CDH4: view
genes like me logo Genes that share phenotypes with CDH4: view

Animal Models for CDH4 Gene

MGI Knock Outs for CDH4:
  • Cdh4 Cdh4<tm1b(EUCOMM)Wtsi>
  • Cdh4 Cdh4<tm1Semb>

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDH4 Gene

Localization for CDH4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH4 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDH4 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0005913 cell-cell adherens junction IBA --
GO:0009986 cell surface IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CDH4: view

Pathways & Interactions for CDH4 Gene

genes like me logo Genes that share pathways with CDH4: view

Pathways by source for CDH4 Gene

1 Cell Signaling Technology pathway for CDH4 Gene

Interacting Proteins for CDH4 Gene

Gene Ontology (GO) - Biological Process for CDH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IBA --
GO:0007043 cell-cell junction assembly IBA --
GO:0007155 cell adhesion TAS 2059658
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA --
genes like me logo Genes that share ontologies with CDH4: view

No data available for SIGNOR curated interactions for CDH4 Gene

Drugs & Compounds for CDH4 Gene

(2) Drugs for CDH4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Cadherin Peptide, avian Pharma Role in cell adhesion 0
genes like me logo Genes that share compounds with CDH4: view

Transcripts for CDH4 Gene

mRNA/cDNA for CDH4 Gene

Unigene Clusters for CDH4 Gene

Cadherin 4, type 1, R-cadherin (retinal):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDH4 Gene

No ASD Table

Relevant External Links for CDH4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDH4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDH4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDH4 Gene

This gene is overexpressed in Brain - Amygdala (x5.6), Brain - Nucleus accumbens (basal ganglia) (x5.6), Brain - Caudate (basal ganglia) (x4.6), Brain - Cortex (x4.3), and Brain - Putamen (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for CDH4 Gene

This gene is overexpressed in Heart (27.3), Fetal Brain (23.9), and Retina (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDH4 Gene

Protein tissue co-expression partners for CDH4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDH4 Gene:


SOURCE GeneReport for Unigene cluster for CDH4 Gene:


mRNA Expression by UniProt/SwissProt for CDH4 Gene:

Tissue specificity: Expressed mainly in brain but also found in other tissues.

Evidence on tissue expression from TISSUES for CDH4 Gene

  • Nervous system(4.7)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with CDH4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CDH4 Gene

Orthologs for CDH4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDH4 34 33
  • 99.22 (n)
(Ornithorhynchus anatinus)
Mammalia CDH4 34
  • 95 (a)
(Monodelphis domestica)
Mammalia CDH4 34
  • 91 (a)
(Canis familiaris)
Mammalia CDH4 34 33
  • 89.17 (n)
(Bos Taurus)
Mammalia CDH4 34 33
  • 88.62 (n)
(Rattus norvegicus)
Mammalia Cdh4 33
  • 86.07 (n)
(Mus musculus)
Mammalia Cdh4 16 34 33
  • 84.8 (n)
(Gallus gallus)
Aves CDH4 34 33
  • 79.29 (n)
(Anolis carolinensis)
Reptilia CDH4 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh4 33
  • 70.83 (n)
(Danio rerio)
Actinopterygii cdh4 34 33
  • 67.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.8606 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8606 33
Species where no ortholog for CDH4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH4 Gene

Gene Tree for CDH4 (if available)
Gene Tree for CDH4 (if available)
Evolutionary constrained regions (ECRs) for CDH4: view image

Paralogs for CDH4 Gene

Paralogs for CDH4 Gene

(21) SIMAP similar genes for CDH4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDH4: view

Variants for CDH4 Gene

Sequence variations from dbSNP and Humsavar for CDH4 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs765815715 likely-pathogenic, Abnormality of brain morphology 61,928,394(+) G/A/C coding_sequence_variant, missense_variant
rs1000000578 -- 61,383,820(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000001216 -- 61,401,206(+) A/T genic_upstream_transcript_variant, intron_variant
rs1000003584 -- 61,643,429(+) G/T intron_variant
rs1000005634 -- 61,264,238(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CDH4 Gene

Variant ID Type Subtype PubMed ID
dgv2277n106 CNV deletion 24896259
dgv2278n106 CNV deletion 24896259
dgv2279n106 CNV deletion 24896259
dgv2452e59 CNV duplication 20981092
dgv4342n100 CNV loss 25217958
dgv516n27 CNV gain 19166990
dgv517n27 CNV loss 19166990
dgv662e201 CNV deletion 23290073
dgv663e201 CNV deletion 23290073
dgv7634n54 CNV gain 21841781
dgv7635n54 CNV loss 21841781
dgv7636n54 CNV gain 21841781
dgv7637n54 CNV gain 21841781
dgv7638n54 CNV gain 21841781
dgv7639n54 CNV gain+loss 21841781
dgv7640n54 CNV gain 21841781
dgv7641n54 CNV gain 21841781
dgv7642n54 CNV loss 21841781
esv1004654 CNV deletion 20482838
esv1006540 CNV deletion 20482838
esv1030240 CNV insertion 17803354
esv1051351 CNV deletion 17803354
esv1196998 CNV deletion 17803354
esv1217882 CNV deletion 17803354
esv1356276 CNV deletion 17803354
esv1375804 CNV insertion 17803354
esv1377539 CNV insertion 17803354
esv1403116 CNV insertion 17803354
esv1411893 CNV insertion 17803354
esv1524929 CNV deletion 17803354
esv1532419 CNV insertion 17803354
esv1590438 CNV deletion 17803354
esv1730838 CNV deletion 17803354
esv1730921 CNV insertion 17803354
esv1771538 CNV insertion 17803354
esv1919718 CNV deletion 18987734
esv1968864 CNV deletion 18987734
esv2035318 CNV deletion 18987734
esv2166723 CNV deletion 18987734
esv21842 CNV loss 19812545
esv2239488 CNV deletion 18987734
esv2249248 CNV deletion 18987734
esv2261889 CNV deletion 18987734
esv2345104 CNV deletion 18987734
esv23845 CNV loss 19812545
esv2384820 CNV deletion 18987734
esv2421637 CNV deletion 20811451
esv2464264 CNV insertion 19546169
esv2474289 CNV insertion 19546169
esv2490155 CNV insertion 19546169
esv2533474 CNV insertion 19546169
esv2554390 CNV insertion 19546169
esv2554517 CNV deletion 19546169
esv2574659 CNV insertion 19546169
esv26213 CNV gain 19812545
esv2657207 CNV deletion 23128226
esv2659757 CNV deletion 23128226
esv2661038 CNV deletion 23128226
esv2662705 CNV deletion 23128226
esv2664167 CNV deletion 23128226
esv2664194 CNV deletion 23128226
esv2667943 CNV deletion 23128226
esv2668257 CNV deletion 23128226
esv2669775 CNV deletion 23128226
esv2670163 CNV deletion 23128226
esv2670740 CNV deletion 23128226
esv2672261 CNV deletion 23128226
esv2673406 CNV deletion 23128226
esv2677512 CNV deletion 23128226
esv2677659 CNV deletion 23128226
esv2678442 CNV deletion 23128226
esv26919 CNV loss 19812545
esv26957 CNV loss 19812545
esv26994 CNV loss 19812545
esv2722685 CNV deletion 23290073
esv2722687 CNV deletion 23290073
esv2722688 CNV deletion 23290073
esv2722689 CNV deletion 23290073
esv2722691 CNV deletion 23290073
esv2722692 CNV deletion 23290073
esv2722693 CNV deletion 23290073
esv2722696 CNV deletion 23290073
esv2722697 CNV deletion 23290073
esv2722698 CNV deletion 23290073
esv2722699 CNV deletion 23290073
esv2722700 CNV deletion 23290073
esv2722701 CNV deletion 23290073
esv2722702 CNV deletion 23290073
esv2722703 CNV deletion 23290073
esv2722704 CNV deletion 23290073
esv2722705 CNV deletion 23290073
esv2722707 CNV deletion 23290073
esv2722708 CNV deletion 23290073
esv2722709 CNV deletion 23290073
esv2722710 CNV deletion 23290073
esv2722711 CNV deletion 23290073
esv2722712 CNV deletion 23290073
esv2722713 CNV deletion 23290073
esv2722714 CNV deletion 23290073
esv2722715 CNV deletion 23290073
esv2722716 CNV deletion 23290073
esv2722718 CNV deletion 23290073
esv2722719 CNV deletion 23290073
esv2722720 CNV deletion 23290073
esv2722721 CNV deletion 23290073
esv2722722 CNV deletion 23290073
esv2722723 CNV deletion 23290073
esv2722724 CNV deletion 23290073
esv2722725 CNV deletion 23290073
esv2722726 CNV deletion 23290073
esv2722727 CNV deletion 23290073
esv2722729 CNV deletion 23290073
esv2722730 CNV deletion 23290073
esv2722731 CNV deletion 23290073
esv2722732 CNV deletion 23290073
esv2722733 CNV deletion 23290073
esv2722734 CNV deletion 23290073
esv2722735 CNV deletion 23290073
esv2722736 CNV deletion 23290073
esv2722737 CNV deletion 23290073
esv2722738 CNV deletion 23290073
esv2722740 CNV deletion 23290073
esv2722741 CNV deletion 23290073
esv2722742 CNV deletion 23290073
esv2722743 CNV deletion 23290073
esv2722745 CNV deletion 23290073
esv2722747 CNV deletion 23290073
esv2722748 CNV deletion 23290073
esv2740723 CNV deletion 23290073
esv2758804 CNV gain+loss 17122850
esv27613 CNV loss 19812545
esv2854347 CNV duplication 24192839
esv28660 CNV gain 19812545
esv29173 CNV loss 19812545
esv29567 CNV gain 19812545
esv3229576 CNV deletion 24192839
esv3305366 CNV mobile element insertion 20981092
esv3330869 CNV duplication 20981092
esv3331750 CNV insertion 20981092
esv3343768 CNV duplication 20981092
esv3346844 CNV insertion 20981092
esv3376284 CNV duplication 20981092
esv3381322 CNV insertion 20981092
esv3381663 CNV duplication 20981092
esv3392915 CNV insertion 20981092
esv3393260 CNV duplication 20981092
esv3427 CNV loss 18987735
esv3432374 CNV duplication 20981092
esv3433289 CNV duplication 20981092
esv3557302 CNV deletion 23714750
esv3557305 CNV deletion 23714750
esv3557307 CNV deletion 23714750
esv3557311 CNV deletion 23714750
esv3557314 CNV deletion 23714750
esv3557318 CNV deletion 23714750
esv3646259 CNV loss 21293372
esv3646261 CNV loss 21293372
esv3646262 CNV loss 21293372
esv3646265 CNV loss 21293372
esv3646266 CNV loss 21293372
esv3646268 CNV loss 21293372
esv3646269 CNV loss 21293372
esv3646270 CNV gain 21293372
esv3646271 CNV gain 21293372
esv3646272 CNV gain 21293372
esv3646273 CNV gain 21293372
esv3646274 CNV gain 21293372
esv3646275 CNV gain 21293372
esv3646276 CNV loss 21293372
esv3646277 CNV gain 21293372
esv3646281 CNV loss 21293372
esv3646282 CNV loss 21293372
esv3823 CNV loss 18987735
esv3893356 CNV loss 25118596
esv4036 CNV loss 18987735
esv4512 CNV loss 18987735
esv6269 CNV gain 19470904
esv7139 CNV gain 19470904
esv8027 CNV loss 19470904
esv8975 CNV gain 19470904
esv991147 CNV deletion 20482838
esv994043 CNV deletion 20482838
nsv1056216 CNV gain 25217958
nsv1056669 CNV loss 25217958
nsv1059069 CNV loss 25217958
nsv1059192 CNV loss 25217958
nsv1061458 CNV loss 25217958
nsv1062903 CNV gain 25217958
nsv1071703 CNV deletion 25765185
nsv1071704 CNV deletion 25765185
nsv1071705 CNV deletion 25765185
nsv1073074 CNV deletion 25765185
nsv1073075 CNV deletion 25765185
nsv1076841 CNV insertion 25765185
nsv1077912 CNV duplication 25765185
nsv1078794 CNV insertion 25765185
nsv1112022 CNV deletion 24896259
nsv1112349 CNV deletion 24896259
nsv1115604 CNV duplication 24896259
nsv1116878 CNV deletion 24896259
nsv1116879 CNV deletion 24896259
nsv1117293 CNV tandem duplication 24896259
nsv1118921 CNV deletion 24896259
nsv1120396 CNV tandem duplication 24896259
nsv1120786 CNV deletion 24896259
nsv1123501 CNV deletion 24896259
nsv1125730 CNV tandem duplication 24896259
nsv1127850 CNV deletion 24896259
nsv1133300 CNV tandem duplication 24896259
nsv1140160 CNV insertion 24896259
nsv1145746 CNV deletion 26484159
nsv1148273 CNV insertion 26484159
nsv1148325 CNV deletion 26484159
nsv1151417 CNV insertion 26484159
nsv1152230 CNV insertion 26484159
nsv1153282 CNV deletion 26484159
nsv178561 CNV deletion 16902084
nsv178622 CNV insertion 16902084
nsv178924 CNV deletion 16902084
nsv179121 CNV deletion 16902084
nsv179156 CNV deletion 16902084
nsv179193 CNV deletion 16902084
nsv179279 CNV deletion 16902084
nsv179380 CNV deletion 16902084
nsv179441 CNV deletion 16902084
nsv179535 CNV deletion 16902084
nsv179872 CNV deletion 16902084
nsv180324 CNV insertion 16902084
nsv180477 CNV deletion 16902084
nsv3437 CNV insertion 18451855
nsv3438 CNV insertion 18451855
nsv3439 CNV deletion 18451855
nsv428377 CNV gain 18775914
nsv428378 CNV loss 18775914
nsv459050 CNV loss 19166990
nsv459051 CNV gain 19166990
nsv470554 CNV gain 18288195
nsv470555 CNV loss 18288195
nsv473028 CNV novel sequence insertion 20440878
nsv473569 CNV novel sequence insertion 20440878
nsv475025 CNV novel sequence insertion 20440878
nsv480220 CNV novel sequence insertion 20440878
nsv509780 CNV insertion 20534489
nsv509781 CNV insertion 20534489
nsv513554 CNV insertion 21212237
nsv520753 CNV loss 19592680
nsv586426 CNV loss 21841781
nsv586431 CNV loss 21841781
nsv586432 CNV gain+loss 21841781
nsv586433 CNV loss 21841781
nsv586434 CNV loss 21841781
nsv586435 CNV loss 21841781
nsv586436 CNV gain 21841781
nsv586437 CNV loss 21841781
nsv586443 CNV loss 21841781
nsv586444 CNV loss 21841781
nsv586445 CNV loss 21841781
nsv820509 CNV duplication 20802225
nsv820520 CNV deletion 20802225
nsv828767 CNV gain 20364138
nsv954262 CNV deletion 24416366
nsv954280 CNV deletion 24416366
nsv954281 CNV deletion 24416366
nsv955146 CNV deletion 24416366
nsv956216 CNV deletion 24416366
nsv965896 CNV duplication 23825009

Variation tolerance for CDH4 Gene

Residual Variation Intolerance Score: 38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.29; 53.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDH4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH4 Gene

Disorders for CDH4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDH4 Gene - From: LncRNADisease

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
Search CDH4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CDH4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CDH4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDH4 Gene

Publications for CDH4 Gene

  1. Assignment of cadherin-4 (R-cadherin, CDH4) to human chromosome band 20q13.3. (PMID: 10516427) Kools P … van Roy F (Cytogenetics and cell genetics 1999) 2 3 22 58
  2. Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin. (PMID: 7982033) Tanihara H … Suzuki S (Cell adhesion and communication 1994) 3 4 22 58
  3. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat BE … Tseng ZH (BMC cardiovascular disorders 2011) 3 44 58
  4. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 44 58
  5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 44 58

Products for CDH4 Gene

Sources for CDH4 Gene

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