This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuron... See more...

Aliases for CDH4 Gene

Aliases for CDH4 Gene

  • Cadherin 4 2 3 5
  • R-Cadherin 2 3 4
  • Cadherin 4, Type 1, R-Cadherin (Retinal) 2 3
  • Retinal Cadherin 3 4
  • Cadherin-4 3 4
  • R-CAD 3 4
  • Cadherin 4, Type 1, Preproprotein 3
  • CAD4 3
  • RCAD 3
  • CDH4 5

External Ids for CDH4 Gene

Previous GeneCards Identifiers for CDH4 Gene

  • GC20P060082
  • GC20P060466
  • GC20P060512
  • GC20P059260
  • GC20P059827
  • GC20P057100

Summaries for CDH4 Gene

Entrez Gene Summary for CDH4 Gene

  • This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for CDH4 Gene

CDH4 (Cadherin 4) is a Protein Coding gene. Diseases associated with CDH4 include Hepatocellular Carcinoma and Craniofacial-Deafness-Hand Syndrome. Among its related pathways are Presenilin-Mediated Signaling and Cell junction organization. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH2.

UniProtKB/Swiss-Prot Summary for CDH4 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.

Gene Wiki entry for CDH4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDH4 Gene

Genomics for CDH4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDH4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J061252 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 268.5 +1.4 1402 4.1 ZIC2 ZNF341 KLF9 CTCF ZNF189 POLR2A TAF1 GLIS1 ZNF398 ZNF561 CDH4 HSALNG0131440 ENSG00000286232 LOC105372704
GH20J062041 Enhancer 1.1 Ensembl ENCODE 8.1 +790.7 790700 2.4 ZNF600 ATF2 KLF9 CEBPA ZIC2 CHD4 YY1 MXD4 CEBPB HOMEZ TAF4 LSM14B PSMA7 SS18L1 CDH4 piR-35674-317 lnc-PSMA7-3 LOC105372704
GH20J062030 Enhancer 1 Ensembl ENCODE 8 +779.3 779340 4.4 MYC ZNF592 CEBPA ZIC2 MXD4 ZNF341 MNT KMT2B FOXA2 SMAD4 CDH4 lnc-PSMA7-4 lnc-PSMA7-5 LOC105372704 TAF4
GH20J061956 Enhancer 0.8 ENCODE 8.9 +704.8 704778 1.2 ZNF600 ATF2 CEBPA FEZF1 ZNF639 FOXA2 SAP130 MIER3 RARA ZNF316 CDH4 hsa-miR-5095-319 HSALNG0131465 lnc-TAF4-1 LOC105372704 TAF4
GH20J061981 Enhancer 0.9 Ensembl ENCODE 7.7 +729.5 729539 2 ZNF654 CTCF REST HOMEZ RAD21 SMC3 TEAD3 EBF1 SIN3A MYRF CDH4 lnc-PSMA7-7 MK280144-414 lnc-TAF4-1 LOC105372704 TAF4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDH4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDH4

Top Transcription factor binding sites by QIAGEN in the CDH4 gene promoter:
  • NRSF form 1
  • NRSF form 2

Genomic Locations for CDH4 Gene

Latest Assembly
688,357 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
688,357 bases
Plus strand

(GRCh37/hg19 by Ensembl)
688,192 bases
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr20(ALT_REF_LOCI_1):8,603-54,269 (+)

Genomic View for CDH4 Gene

Genes around CDH4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH4 Gene

Proteins for CDH4 Gene

  • Protein details for CDH4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B3KWB8
    • G3V1P8
    • Q2M208
    • Q5VZ44
    • Q9BZ05

    Protein attributes for CDH4 Gene

    916 amino acids
    Molecular mass:
    100281 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDH4 Gene


neXtProt entry for CDH4 Gene

Post-translational modifications for CDH4 Gene

  • Glycosylation at Thr84, Thr88, Asn283, Asn412, Asn557, Asn632, Asn661, and Asn702
  • Modification sites at PhosphoSitePlus

Other Protein References for CDH4 Gene

Antibodies for research

No data available for DME Specific Peptides for CDH4 Gene

Domains & Families for CDH4 Gene

Gene Families for CDH4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CDH4 Gene

  • Cadherin cytoplasmic region
  • Cadherin
  • Desmocollin signature

Suggested Antigen Peptide Sequences for CDH4 Gene

GenScript: Design optimal peptide antigens:
  • Retinal cadherin (CADH4_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
genes like me logo Genes that share domains with CDH4: view

Function for CDH4 Gene

Molecular function for CDH4 Gene

UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.
GENATLAS Biochemistry:
cadherin 4,R-cadherin,transmembrane glycoprotein component of adherens junction,expressed in retina,in brain,involved during brain segmentation and neuronal outgrowth and in kidney

Phenotypes From GWAS Catalog for CDH4 Gene

Gene Ontology (GO) - Molecular Function for CDH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA 21873635
GO:0045296 cadherin binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CDH4: view
genes like me logo Genes that share phenotypes with CDH4: view

Animal Models for CDH4 Gene

MGI Knock Outs for CDH4:
  • Cdh4 Cdh4<tm1b(EUCOMM)Wtsi>
  • Cdh4 Cdh4<tm1Semb>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDH4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDH4 Gene

Localization for CDH4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH4 Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDH4 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
mitochondrion 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016342 catenin complex IBA 21873635
genes like me logo Genes that share ontologies with CDH4: view

Pathways & Interactions for CDH4 Gene

genes like me logo Genes that share pathways with CDH4: view

Pathways by source for CDH4 Gene

7 Qiagen pathways for CDH4 Gene
  • G12-G13 in Cellular Signaling
  • GSK3 Signaling
  • ILK Signaling
  • Presenilin-Mediated Signaling
  • Rho Family GTPases
1 Cell Signaling Technology pathway for CDH4 Gene

SIGNOR curated interactions for CDH4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CDH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 2059658
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA 21873635
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA --
GO:0007411 axon guidance IEA --
GO:0034332 adherens junction organization TAS --
genes like me logo Genes that share ontologies with CDH4: view

Drugs & Compounds for CDH4 Gene

(2) Drugs for CDH4 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cadherin Peptide, avian Pharma Role in cell adhesion 0
Calcium Nutra 6959

(1) ApexBio Compounds for CDH4 Gene

Compound Action Cas Number
Cadherin Peptide, avian Role in cell adhesion 127650-08-2
genes like me logo Genes that share compounds with CDH4: view

Drug products for research

Transcripts for CDH4 Gene

mRNA/cDNA for CDH4 Gene

14 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDH4

Alternative Splicing Database (ASD) splice patterns (SP) for CDH4 Gene

No ASD Table

Relevant External Links for CDH4 Gene

GeneLoc Exon Structure for

Expression for CDH4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDH4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDH4 Gene

This gene is overexpressed in Brain - Amygdala (x5.6), Brain - Nucleus accumbens (basal ganglia) (x5.6), Brain - Caudate (basal ganglia) (x4.6), Brain - Cortex (x4.3), and Brain - Putamen (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for CDH4 Gene

This gene is overexpressed in Heart (27.3), Fetal Brain (23.9), and Retina (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDH4 Gene

Protein tissue co-expression partners for CDH4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDH4

SOURCE GeneReport for Unigene cluster for CDH4 Gene:


mRNA Expression by UniProt/SwissProt for CDH4 Gene:

Tissue specificity: Expressed mainly in brain but also found in other tissues.

Evidence on tissue expression from TISSUES for CDH4 Gene

  • Nervous system(4.7)
  • Eye(2.3)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with CDH4: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CDH4 Gene

Orthologs for CDH4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDH4 29 30
  • 99.22 (n)
(Ornithorhynchus anatinus)
Mammalia CDH4 30
  • 95 (a)
(Monodelphis domestica)
Mammalia CDH4 30
  • 91 (a)
(Canis familiaris)
Mammalia CDH4 29 30
  • 89.17 (n)
(Bos Taurus)
Mammalia CDH4 29 30
  • 88.62 (n)
(Rattus norvegicus)
Mammalia Cdh4 29
  • 86.07 (n)
(Mus musculus)
Mammalia Cdh4 29 16 30
  • 84.8 (n)
(Gallus gallus)
Aves CDH4 29 30
  • 79.29 (n)
(Anolis carolinensis)
Reptilia CDH4 30
  • 91 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cdh4 29
  • 70.83 (n)
(Danio rerio)
Actinopterygii cdh4 29 30
  • 67.88 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.8606 29
Species where no ortholog for CDH4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CDH4 Gene

Gene Tree for CDH4 (if available)
Gene Tree for CDH4 (if available)
Evolutionary constrained regions (ECRs) for CDH4: view image
Alliance of Genome Resources:
Additional Orthologs for CDH4

Paralogs for CDH4 Gene

(21) SIMAP similar genes for CDH4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDH4: view

Variants for CDH4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDH4 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs113364336 Benign: not provided 61,932,981(+) A/G
rs139577432 Uncertain Significance: Cortical gyral simplification 61,910,584(+) G/A
NM_001794.5(CDH4):c.1351G>A (p.Glu451Lys)
rs139703524 Benign: not provided 61,852,870(+) C/T
NM_001794.5(CDH4):c.849C>T (p.Asn283=)
rs144744391 Benign: not provided 61,254,865(+) G/A
NM_001794.5(CDH4):c.97G>A (p.Ala33Thr)
rs149390633 Likely Benign: not provided 61,254,848(+) C/T
NM_001794.5(CDH4):c.80C>T (p.Thr27Ile)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CDH4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CDH4 Gene

Variant ID Type Subtype PubMed ID
dgv2277n106 CNV deletion 24896259
dgv2278n106 CNV deletion 24896259
dgv2279n106 CNV deletion 24896259
dgv2452e59 CNV duplication 20981092
dgv4342n100 CNV loss 25217958
dgv516n27 CNV gain 19166990
dgv517n27 CNV loss 19166990
dgv662e201 CNV deletion 23290073
dgv663e201 CNV deletion 23290073
dgv7634n54 CNV gain 21841781
dgv7635n54 CNV loss 21841781
dgv7636n54 CNV gain 21841781
dgv7637n54 CNV gain 21841781
dgv7638n54 CNV gain 21841781
dgv7639n54 CNV gain+loss 21841781
dgv7640n54 CNV gain 21841781
dgv7641n54 CNV gain 21841781
dgv7642n54 CNV loss 21841781
esv1004654 CNV deletion 20482838
esv1006540 CNV deletion 20482838
esv1030240 CNV insertion 17803354
esv1051351 CNV deletion 17803354
esv1196998 CNV deletion 17803354
esv1217882 CNV deletion 17803354
esv1356276 CNV deletion 17803354
esv1375804 CNV insertion 17803354
esv1377539 CNV insertion 17803354
esv1403116 CNV insertion 17803354
esv1411893 CNV insertion 17803354
esv1524929 CNV deletion 17803354
esv1532419 CNV insertion 17803354
esv1590438 CNV deletion 17803354
esv1730838 CNV deletion 17803354
esv1730921 CNV insertion 17803354
esv1771538 CNV insertion 17803354
esv1919718 CNV deletion 18987734
esv1968864 CNV deletion 18987734
esv2035318 CNV deletion 18987734
esv2166723 CNV deletion 18987734
esv21842 CNV loss 19812545
esv2239488 CNV deletion 18987734
esv2249248 CNV deletion 18987734
esv2261889 CNV deletion 18987734
esv2345104 CNV deletion 18987734
esv23845 CNV loss 19812545
esv2384820 CNV deletion 18987734
esv2421637 CNV deletion 20811451
esv2464264 CNV insertion 19546169
esv2474289 CNV insertion 19546169
esv2490155 CNV insertion 19546169
esv2533474 CNV insertion 19546169
esv2554390 CNV insertion 19546169
esv2554517 CNV deletion 19546169
esv2574659 CNV insertion 19546169
esv26213 CNV gain 19812545
esv2657207 CNV deletion 23128226
esv2659757 CNV deletion 23128226
esv2661038 CNV deletion 23128226
esv2662705 CNV deletion 23128226
esv2664167 CNV deletion 23128226
esv2664194 CNV deletion 23128226
esv2667943 CNV deletion 23128226
esv2668257 CNV deletion 23128226
esv2669775 CNV deletion 23128226
esv2670163 CNV deletion 23128226
esv2670740 CNV deletion 23128226
esv2672261 CNV deletion 23128226
esv2673406 CNV deletion 23128226
esv2677512 CNV deletion 23128226
esv2677659 CNV deletion 23128226
esv2678442 CNV deletion 23128226
esv26919 CNV loss 19812545
esv26957 CNV loss 19812545
esv26994 CNV loss 19812545
esv2722685 CNV deletion 23290073
esv2722687 CNV deletion 23290073
esv2722688 CNV deletion 23290073
esv2722689 CNV deletion 23290073
esv2722691 CNV deletion 23290073
esv2722692 CNV deletion 23290073
esv2722693 CNV deletion 23290073
esv2722696 CNV deletion 23290073
esv2722697 CNV deletion 23290073
esv2722698 CNV deletion 23290073
esv2722699 CNV deletion 23290073
esv2722700 CNV deletion 23290073
esv2722701 CNV deletion 23290073
esv2722702 CNV deletion 23290073
esv2722703 CNV deletion 23290073
esv2722704 CNV deletion 23290073
esv2722705 CNV deletion 23290073
esv2722707 CNV deletion 23290073
esv2722708 CNV deletion 23290073
esv2722709 CNV deletion 23290073
esv2722710 CNV deletion 23290073
esv2722711 CNV deletion 23290073
esv2722712 CNV deletion 23290073
esv2722713 CNV deletion 23290073
esv2722714 CNV deletion 23290073
esv2722715 CNV deletion 23290073
esv2722716 CNV deletion 23290073
esv2722718 CNV deletion 23290073
esv2722719 CNV deletion 23290073
esv2722720 CNV deletion 23290073
esv2722721 CNV deletion 23290073
esv2722722 CNV deletion 23290073
esv2722723 CNV deletion 23290073
esv2722724 CNV deletion 23290073
esv2722725 CNV deletion 23290073
esv2722726 CNV deletion 23290073
esv2722727 CNV deletion 23290073
esv2722729 CNV deletion 23290073
esv2722730 CNV deletion 23290073
esv2722731 CNV deletion 23290073
esv2722732 CNV deletion 23290073
esv2722733 CNV deletion 23290073
esv2722734 CNV deletion 23290073
esv2722735 CNV deletion 23290073
esv2722736 CNV deletion 23290073
esv2722737 CNV deletion 23290073
esv2722738 CNV deletion 23290073
esv2722740 CNV deletion 23290073
esv2722741 CNV deletion 23290073
esv2722742 CNV deletion 23290073
esv2722743 CNV deletion 23290073
esv2722745 CNV deletion 23290073
esv2722747 CNV deletion 23290073
esv2722748 CNV deletion 23290073
esv2740723 CNV deletion 23290073
esv2758804 CNV gain+loss 17122850
esv27613 CNV loss 19812545
esv2854347 CNV duplication 24192839
esv28660 CNV gain 19812545
esv29173 CNV loss 19812545
esv29567 CNV gain 19812545
esv3229576 CNV deletion 24192839
esv3305366 CNV mobile element insertion 20981092
esv3330869 CNV duplication 20981092
esv3331750 CNV insertion 20981092
esv3343768 CNV duplication 20981092
esv3346844 CNV insertion 20981092
esv3376284 CNV duplication 20981092
esv3381322 CNV insertion 20981092
esv3381663 CNV duplication 20981092
esv3392915 CNV insertion 20981092
esv3393260 CNV duplication 20981092
esv3427 CNV loss 18987735
esv3432374 CNV duplication 20981092
esv3433289 CNV duplication 20981092
esv3557302 CNV deletion 23714750
esv3557305 CNV deletion 23714750
esv3557307 CNV deletion 23714750
esv3557311 CNV deletion 23714750
esv3557314 CNV deletion 23714750
esv3557318 CNV deletion 23714750
esv3646259 CNV loss 21293372
esv3646261 CNV loss 21293372
esv3646262 CNV loss 21293372
esv3646265 CNV loss 21293372
esv3646266 CNV loss 21293372
esv3646268 CNV loss 21293372
esv3646269 CNV loss 21293372
esv3646270 CNV gain 21293372
esv3646271 CNV gain 21293372
esv3646272 CNV gain 21293372
esv3646273 CNV gain 21293372
esv3646274 CNV gain 21293372
esv3646275 CNV gain 21293372
esv3646276 CNV loss 21293372
esv3646277 CNV gain 21293372
esv3646281 CNV loss 21293372
esv3646282 CNV loss 21293372
esv3823 CNV loss 18987735
esv3893356 CNV loss 25118596
esv4036 CNV loss 18987735
esv4512 CNV loss 18987735
esv6269 CNV gain 19470904
esv7139 CNV gain 19470904
esv8027 CNV loss 19470904
esv8975 CNV gain 19470904
esv991147 CNV deletion 20482838
esv994043 CNV deletion 20482838
nsv1056216 CNV gain 25217958
nsv1056669 CNV loss 25217958
nsv1059069 CNV loss 25217958
nsv1059192 CNV loss 25217958
nsv1061458 CNV loss 25217958
nsv1062903 CNV gain 25217958
nsv1071703 CNV deletion 25765185
nsv1071704 CNV deletion 25765185
nsv1071705 CNV deletion 25765185
nsv1073074 CNV deletion 25765185
nsv1073075 CNV deletion 25765185
nsv1076841 CNV insertion 25765185
nsv1077912 CNV duplication 25765185
nsv1078794 CNV insertion 25765185
nsv1112022 CNV deletion 24896259
nsv1112349 CNV deletion 24896259
nsv1115604 CNV duplication 24896259
nsv1116878 CNV deletion 24896259
nsv1116879 CNV deletion 24896259
nsv1117293 CNV tandem duplication 24896259
nsv1118921 CNV deletion 24896259
nsv1120396 CNV tandem duplication 24896259
nsv1120786 CNV deletion 24896259
nsv1123501 CNV deletion 24896259
nsv1125730 CNV tandem duplication 24896259
nsv1127850 CNV deletion 24896259
nsv1133300 CNV tandem duplication 24896259
nsv1140160 CNV insertion 24896259
nsv1145746 CNV deletion 26484159
nsv1148273 CNV insertion 26484159
nsv1148325 CNV deletion 26484159
nsv1151417 CNV insertion 26484159
nsv1152230 CNV insertion 26484159
nsv1153282 CNV deletion 26484159
nsv178561 CNV deletion 16902084
nsv178622 CNV insertion 16902084
nsv178924 CNV deletion 16902084
nsv179121 CNV deletion 16902084
nsv179156 CNV deletion 16902084
nsv179193 CNV deletion 16902084
nsv179279 CNV deletion 16902084
nsv179380 CNV deletion 16902084
nsv179441 CNV deletion 16902084
nsv179535 CNV deletion 16902084
nsv179872 CNV deletion 16902084
nsv180324 CNV insertion 16902084
nsv180477 CNV deletion 16902084
nsv3437 CNV insertion 18451855
nsv3438 CNV insertion 18451855
nsv3439 CNV deletion 18451855
nsv428377 CNV gain 18775914
nsv428378 CNV loss 18775914
nsv459050 CNV loss 19166990
nsv459051 CNV gain 19166990
nsv470554 CNV gain 18288195
nsv470555 CNV loss 18288195
nsv473028 CNV novel sequence insertion 20440878
nsv473569 CNV novel sequence insertion 20440878
nsv475025 CNV novel sequence insertion 20440878
nsv480220 CNV novel sequence insertion 20440878
nsv509780 CNV insertion 20534489
nsv509781 CNV insertion 20534489
nsv513554 CNV insertion 21212237
nsv520753 CNV loss 19592680
nsv586426 CNV loss 21841781
nsv586431 CNV loss 21841781
nsv586432 CNV gain+loss 21841781
nsv586433 CNV loss 21841781
nsv586434 CNV loss 21841781
nsv586435 CNV loss 21841781
nsv586436 CNV gain 21841781
nsv586437 CNV loss 21841781
nsv586443 CNV loss 21841781
nsv586444 CNV loss 21841781
nsv586445 CNV loss 21841781
nsv820509 CNV duplication 20802225
nsv820520 CNV deletion 20802225
nsv828767 CNV gain 20364138
nsv954262 CNV deletion 24416366
nsv954280 CNV deletion 24416366
nsv954281 CNV deletion 24416366
nsv955146 CNV deletion 24416366
nsv956216 CNV deletion 24416366
nsv965896 CNV duplication 23825009

Variation tolerance for CDH4 Gene

Residual Variation Intolerance Score: 38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.29; 53.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDH4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH4 Gene

Disorders for CDH4 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CDH4 Gene - From: LNC and COP

- elite association - COSMIC cancer census association via MalaCards
Search CDH4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CDH4

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CDH4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDH4 Gene

Publications for CDH4 Gene

  1. Assignment of cadherin-4 (R-cadherin, CDH4) to human chromosome band 20q13.3. (PMID: 10516427) Kools P … van Roy F (Cytogenetics and cell genetics 1999) 2 3 22
  2. Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin. (PMID: 7982033) Tanihara H … Suzuki S (Cell adhesion and communication 1994) 3 4 22
  3. Long non-coding RNA linc-cdh4-2 inhibits the migration and invasion of HCC cells by targeting R-cadherin pathway. (PMID: 27765630) Gao Y … Liu J (Biochemical and biophysical research communications 2016) 3 72
  4. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat BE … Tseng ZH (BMC cardiovascular disorders 2011) 3 40
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40

Products for CDH4 Gene

Sources for CDH4 Gene