This gene encodes a member of the cadherin protein family. Cadherins are a family of calcium-dependent adhesion molecules that mediate cell-cell adhesion in all solid tissues and modulate a wide variety of processes, including cell polarization, migration and differentiation. Cadherin domains occur as repeats in the extracellular region and are thought to contribute to the sort... See more...

Aliases for CDH26 Gene

Aliases for CDH26 Gene

  • Cadherin 26 2 3 5
  • Cadherin-Like Protein VR20 3 4
  • Cadherin-Like Protein 26 3 4
  • Cadherin-Like 26 2 3
  • VR20 2 3
  • CDH26 5

External Ids for CDH26 Gene

Previous GeneCards Identifiers for CDH26 Gene

  • GC20P058261
  • GC20P059171
  • GC20P059218
  • GC20P057966
  • GC20P058533
  • GC20P055323

Summaries for CDH26 Gene

Entrez Gene Summary for CDH26 Gene

  • This gene encodes a member of the cadherin protein family. Cadherins are a family of calcium-dependent adhesion molecules that mediate cell-cell adhesion in all solid tissues and modulate a wide variety of processes, including cell polarization, migration and differentiation. Cadherin domains occur as repeats in the extracellular region and are thought to contribute to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. This protein is expressed in gastrointestinal epithelial cells and may be upregulated during allergic inflammation. This protein interacts with alpha integrins and may also be involved in leukocyte migration and adhesion. [provided by RefSeq, Jan 2017]

GeneCards Summary for CDH26 Gene

CDH26 (Cadherin 26) is a Protein Coding gene. Diseases associated with CDH26 include Ross River Fever and Eosinophilic Gastritis. Among its related pathways are ERK Signaling and S-1P Stimulated Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH2.

UniProtKB/Swiss-Prot Summary for CDH26 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Ligand for integrins alpha-E/beta-7, ITGAE:ITGAB7, alpha-4/beta-7, ITGA4:ITGAB7 and alpha-4/beta-1, ITGA4:ITGAB1 through which modulates CD4(+) T cells activation (PubMed:28051089).

Additional gene information for CDH26 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDH26 Gene

Genomics for CDH26 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDH26 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J059996 Promoter/Enhancer 0.8 EPDnew ENCODE 611 +38.5 38517 0.2 FOXA1 RFX1 CUX1 GATA3 CDH26 C20orf197 LOC105372698
GH20J059958 Enhancer 0.3 Ensembl dbSUPER 600.7 +0.9 937 0.6 CDH26 C20orf197 LOC105372698
GH20J059993 Promoter/Enhancer 1 Ensembl ENCODE 11 +37.1 37138 2.2 CREB1 KDM1A FOXA1 PKNOX1 GTF2F1 ATF7 RFX1 SMARCA5 DDX20 CTBP1 C20orf197 CDH26 LOC105372698
GH20J059926 Enhancer 0.8 Ensembl ENCODE 11.2 -31.9 -31908 1.3 YBX1 ZHX2 FOXA1 RFX1 SMARCA5 CTBP1 ZNF266 KLF4 ZNF217 CUX1 CDH26 lnc-PPP1R3D-5 SYCP2 PHACTR3
GH20J060008 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 4.6 +51.6 51637 6 CREB1 CTCF PRDM10 SCRT2 HES1 ZKSCAN1 ZNF512B SCRT1 ZNF207 ZFHX2 C20orf197 CDH26 PPP1R3D LOC105372698
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDH26 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDH26

Top Transcription factor binding sites by QIAGEN in the CDH26 gene promoter:
  • AhR
  • AREB6
  • Arnt
  • E2F
  • E2F-1
  • FOXL1
  • NF-kappaB
  • NF-kappaB1
  • Olf-1
  • POU6F1 (c2)

Genomic Locations for CDH26 Gene

Genomic Locations for CDH26 Gene
chr20:59,957,764-60,037,971
(GRCh38/hg38)
Size:
80,208 bases
Orientation:
Plus strand
chr20:58,533,471-58,609,066
(GRCh37/hg19)
Size:
75,596 bases
Orientation:
Plus strand

Genomic View for CDH26 Gene

Genes around CDH26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH26 Gene

Proteins for CDH26 Gene

  • Protein details for CDH26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXH8-CAD26_HUMAN
    Recommended name:
    Cadherin-like protein 26
    Protein Accession:
    Q8IXH8
    Secondary Accessions:
    • A2A2M5
    • B3KNX3
    • Q6P5Y6
    • Q8TCH3
    • Q9BQN4
    • Q9NRU1

    Protein attributes for CDH26 Gene

    Size:
    832 amino acids
    Molecular mass:
    92416 Da
    Quaternary structure:
    • Homodimer (PubMed:28051089). Component of a cadherin:catenin adhesion complex composed of at least of CDH26, beta-catenin/CTNNB1, alpha-catenin/CTNNA1 and p120 catenin/CTNND1 (PubMed:28051089).

    Alternative splice isoforms for CDH26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDH26 Gene

Post-translational modifications for CDH26 Gene

No data available for DME Specific Peptides for CDH26 Gene

Domains & Families for CDH26 Gene

Gene Families for CDH26 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CDH26 Gene

InterPro:
Blocks:
  • Cadherin
ProtoNet:

Suggested Antigen Peptide Sequences for CDH26 Gene

GenScript: Design optimal peptide antigens:
  • CDH26 protein (B9EG96_HUMAN)
  • Cadherin-like protein VR20 (CAD26_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IXH8

UniProtKB/Swiss-Prot:

CAD26_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
genes like me logo Genes that share domains with CDH26: view

Function for CDH26 Gene

Molecular function for CDH26 Gene

UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Ligand for integrins alpha-E/beta-7, ITGAE:ITGAB7, alpha-4/beta-7, ITGA4:ITGAB7 and alpha-4/beta-1, ITGA4:ITGAB1 through which modulates CD4(+) T cells activation (PubMed:28051089).

Phenotypes From GWAS Catalog for CDH26 Gene

Gene Ontology (GO) - Molecular Function for CDH26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IDA 28051089
GO:0005509 calcium ion binding IBA 21873635
GO:0005515 protein binding IPI 28051089
GO:0008013 beta-catenin binding IDA 28051089
GO:0008092 cytoskeletal protein binding IBA --
genes like me logo Genes that share ontologies with CDH26: view
genes like me logo Genes that share phenotypes with CDH26: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDH26

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDH26 Gene

Localization for CDH26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH26 Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDH26 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 4
extracellular 2
nucleus 1
lysosome 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDH26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA,IDA 28051089
GO:0005912 adherens junction IBA --
GO:0009986 cell surface IBA --
GO:0015630 microtubule cytoskeleton IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CDH26: view

Pathways & Interactions for CDH26 Gene

PathCards logo

SuperPathways for CDH26 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
2 G12-G13 in Cellular Signaling
-
3 Nanog in Mammalian ESC Pluripotency
.62
4 ERK Signaling
.49
5 S-1P Stimulated Signaling
-
genes like me logo Genes that share pathways with CDH26: view

Pathways by source for CDH26 Gene

1 Sino Biological pathway for CDH26 Gene
5 Qiagen pathways for CDH26 Gene
  • G12-G13 in Cellular Signaling
  • GSK3 Signaling
  • ILK Signaling
  • S-1P Stimulated Signaling
  • WNT Signaling

Interacting Proteins for CDH26 Gene

Gene Ontology (GO) - Biological Process for CDH26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IBA --
GO:0007043 cell-cell junction assembly IBA --
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA --
GO:0007275 multicellular organism development IBA --
genes like me logo Genes that share ontologies with CDH26: view

No data available for SIGNOR curated interactions for CDH26 Gene

Drugs & Compounds for CDH26 Gene

(1) Drugs for CDH26 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6556
genes like me logo Genes that share compounds with CDH26: view

Transcripts for CDH26 Gene

mRNA/cDNA for CDH26 Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDH26

Alternative Splicing Database (ASD) splice patterns (SP) for CDH26 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^
SP1: - - - - - - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: -
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c · 22d ^ 23 ^ 24a · 24b
SP1:
SP2: - - - - - -
SP3: -
SP4: -
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11: - - - - - - - - -
SP12:

Relevant External Links for CDH26 Gene

GeneLoc Exon Structure for
CDH26

Expression for CDH26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDH26 Gene

mRNA differential expression in normal tissues according to GTEx for CDH26 Gene

This gene is overexpressed in Prostate (x6.7).

Protein differential expression in normal tissues from HIPED for CDH26 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDH26 Gene



Protein tissue co-expression partners for CDH26 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDH26

SOURCE GeneReport for Unigene cluster for CDH26 Gene:

Hs.729046

mRNA Expression by UniProt/SwissProt for CDH26 Gene:

Q8IXH8-CAD26_HUMAN
Tissue specificity: Expressed by epithelial cells of gastrointestinal tissue.

Evidence on tissue expression from TISSUES for CDH26 Gene

  • Lung(4.3)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with CDH26: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDH26 Gene

Orthologs for CDH26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH26 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDH26 30 31
  • 99.04 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cdh26 30 17 31
  • 76.09 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cdh26 30
  • 75.77 (n)
Dog
(Canis familiaris)
Mammalia CDH26 30 31
  • 74.76 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CDH26 30 31
  • 74.7 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CDH26 31
  • 54 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CDH26 31
  • 53 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CDH26 31
  • 43 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cdh26 30
  • 53.46 (n)
Zebrafish
(Danio rerio)
Actinopterygii si:ch73-96b22.2 30
  • 48.15 (n)
CDH26 31
  • 34 (a)
OneToOne
Species where no ortholog for CDH26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CDH26 Gene

ENSEMBL:
Gene Tree for CDH26 (if available)
TreeFam:
Gene Tree for CDH26 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDH26: view image

Paralogs for CDH26 Gene

(8) SIMAP similar genes for CDH26 Gene using alignment to 4 proteins:

  • CAD26_HUMAN
  • B9EG96_HUMAN
  • H7BY79_HUMAN
  • Q9NTY2_HUMAN
genes like me logo Genes that share paralogs with CDH26: view

Variants for CDH26 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDH26 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs11086690 - p.Arg301Gly
rs194998 - p.Val615Leu
rs34866303 - p.Val448Ala
rs6015609 - p.Ile144Thr
rs6071067 - p.Pro479Leu

Additional dbSNP identifiers (rs#s) for CDH26 Gene

Structural Variations from Database of Genomic Variants (DGV) for CDH26 Gene

Variant ID Type Subtype PubMed ID
esv1009769 CNV deletion 20482838
esv3646235 CNV loss 21293372
nsv817901 CNV loss 17921354

Variation tolerance for CDH26 Gene

Residual Variation Intolerance Score: 96.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.48; 64.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDH26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDH26

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH26 Gene

Disorders for CDH26 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CDH26 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ross river fever
  • ross river virus disease
eosinophilic gastritis
  • eosinophilic enteropathy
craniofacial-deafness-hand syndrome
  • cdhs
esophagitis, eosinophilic, 1
  • ee
- elite association - COSMIC cancer census association via MalaCards
Search CDH26 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CDH26

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CDH26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDH26 Gene

Publications for CDH26 Gene

  1. Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation. (PMID: 28051089) Caldwell JM … Rothenberg ME (Mucosal immunology 2017) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Association and interaction analyses of eight genes under asthma linkage peaks. (PMID: 19824886) Ferreira MA … Duffy DL (Allergy 2009) 3 41
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4

Products for CDH26 Gene

  • Signalway ELISA kits for CDH26

Sources for CDH26 Gene