Aliases for CDH24 Gene

Aliases for CDH24 Gene

  • Cadherin 24 2 3 5
  • CDH11L 2 3 4
  • Cadherin 24, Type 2 2 3
  • Cadherin-24 3 4
  • Cadherin-Like 24 2
  • CDH24 5

External Ids for CDH24 Gene

Previous GeneCards Identifiers for CDH24 Gene

  • GC14M020888
  • GC14M017303
  • GC14M021506
  • GC14M022586
  • GC14M023516
  • GC14M003633

Summaries for CDH24 Gene

GeneCards Summary for CDH24 Gene

CDH24 (Cadherin 24) is a Protein Coding gene. Diseases associated with CDH24 include Amelogenesis Imperfecta, Type Iiia and Craniofacial-Deafness-Hand Syndrome. Among its related pathways are ERK Signaling and Cell junction organization. Gene Ontology (GO) annotations related to this gene include calcium ion binding and alpha-catenin binding. An important paralog of this gene is CDH11.

UniProtKB/Swiss-Prot Summary for CDH24 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion.

Additional gene information for CDH24 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDH24 Gene

Genomics for CDH24 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDH24 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDH24 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDH24

Top Transcription factor binding sites by QIAGEN in the CDH24 gene promoter:
  • ATF
  • COMP1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • MAZR
  • Zic3

Genomic Locations for CDH24 Gene

Genomic Locations for CDH24 Gene
chr14:23,047,061-23,057,619
(GRCh38/hg38)
Size:
10,559 bases
Orientation:
Minus strand
chr14:23,516,270-23,526,747
(GRCh37/hg19)
Size:
10,478 bases
Orientation:
Minus strand

Genomic View for CDH24 Gene

Genes around CDH24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH24 Gene

Proteins for CDH24 Gene

  • Protein details for CDH24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UP0-CAD24_HUMAN
    Recommended name:
    Cadherin-24
    Protein Accession:
    Q86UP0
    Secondary Accessions:
    • D3DS44
    • Q86UP1
    • Q9NT84

    Protein attributes for CDH24 Gene

    Size:
    819 amino acids
    Molecular mass:
    87752 Da
    Quaternary structure:
    • Associates with alpha-, beta- and delta-catenins.

    Alternative splice isoforms for CDH24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDH24 Gene

Post-translational modifications for CDH24 Gene

  • Glycosylation at Asn548, Asn563, and Asn446
  • Modification sites at PhosphoSitePlus

Other Protein References for CDH24 Gene

No data available for DME Specific Peptides for CDH24 Gene

Domains & Families for CDH24 Gene

Gene Families for CDH24 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CDH24 Gene

InterPro:
Blocks:
  • Cadherin cytoplasmic region
  • Cadherin
  • Eubacterial/plasma membrane H+-transporting two-sector ATPase, C subunit
ProtoNet:

Suggested Antigen Peptide Sequences for CDH24 Gene

GenScript: Design optimal peptide antigens:
  • Cadherin-24 (CAD24_HUMAN)
  • CDH24 protein (Q2TAL1_HUMAN)
  • CDH24 protein (Q4VBZ5_HUMAN)
  • cDNA FLJ25193 fis, clone JTH00761 (Q96LQ7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86UP0

UniProtKB/Swiss-Prot:

CAD24_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
genes like me logo Genes that share domains with CDH24: view

Function for CDH24 Gene

Molecular function for CDH24 Gene

UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion.

Phenotypes From GWAS Catalog for CDH24 Gene

Gene Ontology (GO) - Molecular Function for CDH24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA,IDA 12734196
GO:0008092 cytoskeletal protein binding IBA --
GO:0045296 cadherin binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CDH24: view
genes like me logo Genes that share phenotypes with CDH24: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDH24

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDH24

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDH24 Gene

Localization for CDH24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH24 Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDH24 gene
Compartment Confidence
plasma membrane 4
nucleus 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Centriolar satellite (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDH24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005911 cell-cell junction IDA 12734196
GO:0005912 adherens junction IBA 21873635
GO:0009986 cell surface IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CDH24: view

Pathways & Interactions for CDH24 Gene

genes like me logo Genes that share pathways with CDH24: view

Pathways by source for CDH24 Gene

5 Qiagen pathways for CDH24 Gene
  • G12-G13 in Cellular Signaling
  • GSK3 Signaling
  • ILK Signaling
  • S-1P Stimulated Signaling
  • WNT Signaling

Gene Ontology (GO) - Biological Process for CDH24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IBA 21873635
GO:0007043 cell-cell junction assembly IBA 21873635
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007275 multicellular organism development IBA --
genes like me logo Genes that share ontologies with CDH24: view

No data available for SIGNOR curated interactions for CDH24 Gene

Drugs & Compounds for CDH24 Gene

(1) Drugs for CDH24 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6556
genes like me logo Genes that share compounds with CDH24: view

Transcripts for CDH24 Gene

mRNA/cDNA for CDH24 Gene

2 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDH24

Alternative Splicing Database (ASD) splice patterns (SP) for CDH24 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
SP1: -
SP2: - -
SP3: - -
SP4:

Relevant External Links for CDH24 Gene

GeneLoc Exon Structure for
CDH24

Expression for CDH24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDH24 Gene

Protein differential expression in normal tissues from HIPED for CDH24 Gene

This gene is overexpressed in Pancreatic juice (54.3) and Adipocyte (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDH24 Gene



Protein tissue co-expression partners for CDH24 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDH24

SOURCE GeneReport for Unigene cluster for CDH24 Gene:

Hs.155912
genes like me logo Genes that share expression patterns with CDH24: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDH24 Gene

Orthologs for CDH24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH24 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDH24 30 31
  • 99.23 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CDH24 30 31
  • 90.27 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CDH24 31
  • 90 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia CDH24 30 31
  • 89.63 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cdh24 30 17 31
  • 88.69 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cdh24 30
  • 87.92 (n)
Lizard
(Anolis carolinensis)
Reptilia CDH24 31
  • 70 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii LOC100007192 30
  • 62.79 (n)
CDH24 (2 of 2) 31
  • 27 (a)
OneToMany
CDH24 (1 of 2) 31
  • 21 (a)
OneToMany
Species where no ortholog for CDH24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CDH24 Gene

ENSEMBL:
Gene Tree for CDH24 (if available)
TreeFam:
Gene Tree for CDH24 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDH24: view image

Paralogs for CDH24 Gene

(19) SIMAP similar genes for CDH24 Gene using alignment to 4 proteins:

  • CAD24_HUMAN
  • Q2TAL1_HUMAN
  • Q4VBZ5_HUMAN
  • Q96LQ7_HUMAN
genes like me logo Genes that share paralogs with CDH24: view

Variants for CDH24 Gene

Additional dbSNP identifiers (rs#s) for CDH24 Gene

Variation tolerance for CDH24 Gene

Residual Variation Intolerance Score: 50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.27; 62.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDH24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDH24

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for CDH24 Gene

Disorders for CDH24 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CDH24 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search CDH24 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with CDH24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDH24 Gene

Publications for CDH24 Gene

  1. Characterization of cadherin-24, a novel alternatively spliced type II cadherin. (PMID: 12734196) Katafiasz BJ … Johnson KR (The Journal of biological chemistry 2003) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. Frameshift mutations of cadherin genes DCHS2, CDH10 and CDH24 genes in gastric and colorectal cancers with high microsatellite instability. (PMID: 24898286) An CH … Lee SH (Pathology oncology research : POR 2015) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3

Products for CDH24 Gene

Sources for CDH24 Gene