Aliases for CDH2 Gene
External Ids for CDH2 Gene
Previous HGNC Symbols for CDH2 Gene
Previous GeneCards Identifiers for CDH2 Gene
This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015]
GeneCards Summary for CDH2 Gene
CDH2 (Cadherin 2) is a Protein Coding gene. Diseases associated with CDH2 include Corpus Callosum, Agenesis Of and Arrhythmogenic Right Ventricular Cardiomyopathy. Among its related pathways are Neural Crest Differentiation and Mesenchymal Stem Cells and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein phosphatase binding. An important paralog of this gene is CDH4.
UniProtKB/Swiss-Prot Summary for CDH2 Gene
Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.