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Aliases for CDH18 Gene

Aliases for CDH18 Gene

  • Cadherin 18 2 3 5
  • Cadherin 18, Type 2 2 3
  • Cadherin-14 3 4
  • CDH14 3 4
  • Cadherin-Like 24 3
  • Cadherin-18 3
  • Ey-Cadherin 3
  • CDH14L 3
  • CDH24 3

External Ids for CDH18 Gene

Previous GeneCards Identifiers for CDH18 Gene

  • GC05M019421
  • GC05M019706
  • GC05M019518

Summaries for CDH18 Gene

Entrez Gene Summary for CDH18 Gene

  • This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

GeneCards Summary for CDH18 Gene

CDH18 (Cadherin 18) is a Protein Coding gene. Among its related pathways are ERK Signaling and Presenilin-Mediated Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH7.

UniProtKB/Swiss-Prot for CDH18 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Additional gene information for CDH18 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH18 Gene

Genomics for CDH18 Gene

GeneHancer (GH) Regulatory Elements for CDH18 Gene

Promoters and enhancers for CDH18 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J019987 Promoter 1.3 EPDnew Ensembl 650 +587.8 587772 0.6 CTBP1 PKNOX1 ZNF512B RCOR1 CDH18 GC05P020115 GC05P020116 GC05P019822
GH05J020447 Enhancer 0.2 FANTOM5 20.5 +128.6 128563 0.2 CDH18 GC05M020468 GC05M020403
GH05J020604 Enhancer 0.2 ENCODE 11.3 -29.4 -29362 0.9 CDH18 LINC02146 LINC02241 GC05M020572
GH05J020606 Enhancer 0.2 ENCODE 11.3 -30.2 -30228 0.1 CDH18 LINC02241 GC05M020572
GH05J020572 Enhancer 0.6 ENCODE 0.7 +3.1 3086 0.2 CTCF CEBPB EP300 RAD21 FOXA1 SP1 ZNF217 CTBP1 POLR2A FOS CDH18 GC05M020551 GC05M020572
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDH18 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDH18 gene promoter:
  • STAT5A
  • HNF-3beta
  • IRF-7A
  • AML1a
  • AREB6
  • POU2F1a
  • POU2F1
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for CDH18 Gene

Genomic Locations for CDH18 Gene
1,102,944 bases
Minus strand
1,102,923 bases
Minus strand

Genomic View for CDH18 Gene

Genes around CDH18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH18 Gene

Proteins for CDH18 Gene

  • Protein details for CDH18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K0I2
    • B4DHG6
    • Q8N5Z2

    Protein attributes for CDH18 Gene

    790 amino acids
    Molecular mass:
    88073 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDH18 Gene


neXtProt entry for CDH18 Gene

Post-translational modifications for CDH18 Gene

  • Glycosylation at Asn536, Asn455, Asn255, and posLast=3636
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDH18 Gene

Domains & Families for CDH18 Gene

Gene Families for CDH18 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CDH18 Gene

Graphical View of Domain Structure for InterPro Entry



  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
genes like me logo Genes that share domains with CDH18: view

Function for CDH18 Gene

Molecular function for CDH18 Gene

UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
GENATLAS Biochemistry:
cadherin 18,R-cadherin,transmembrane glycoprotein cell adhesion molecule,expressed specifically in the central nervous system also in small cell lung carcinoma,putatively involved in synaptic adhesion,axon outgrowth and guidance

Phenotypes From GWAS Catalog for CDH18 Gene

Gene Ontology (GO) - Molecular Function for CDH18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0008092 cytoskeletal protein binding IBA --
GO:0042803 protein homodimerization activity IBA --
GO:0045296 cadherin binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CDH18: view
genes like me logo Genes that share phenotypes with CDH18: view

Animal Model Products

miRNA for CDH18 Gene

miRTarBase miRNAs that target CDH18

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDH18 Gene

Localization for CDH18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH18 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDH18 gene
Compartment Confidence
plasma membrane 5
extracellular 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CDH18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005913 cell-cell adherens junction IBA --
GO:0009986 cell surface IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDH18: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CDH18 Gene

Pathways & Interactions for CDH18 Gene

genes like me logo Genes that share pathways with CDH18: view

Gene Ontology (GO) - Biological Process for CDH18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IBA --
GO:0007043 cell-cell junction assembly IBA --
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007275 multicellular organism development IBA --
genes like me logo Genes that share ontologies with CDH18: view

No data available for SIGNOR curated interactions for CDH18 Gene

Drugs & Compounds for CDH18 Gene

(1) Drugs for CDH18 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with CDH18: view

Transcripts for CDH18 Gene

mRNA/cDNA for CDH18 Gene

(22) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDH18 Gene

Cadherin 18, type 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDH18 Gene

No ASD Table

Relevant External Links for CDH18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDH18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDH18 Gene

mRNA differential expression in normal tissues according to GTEx for CDH18 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x9.8), Brain - Cerebellum (x8.0), Brain - Frontal Cortex (BA9) (x6.6), Brain - Cortex (x5.4), Brain - Hypothalamus (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.6).

Protein differential expression in normal tissues from HIPED for CDH18 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDH18 Gene

Protein tissue co-expression partners for CDH18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDH18 Gene:


SOURCE GeneReport for Unigene cluster for CDH18 Gene:


Evidence on tissue expression from TISSUES for CDH18 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with CDH18: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDH18 Gene

Orthologs for CDH18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDH18 34 33
  • 99.37 (n)
(Monodelphis domestica)
Mammalia CDH18 34
  • 94 (a)
(Bos Taurus)
Mammalia CDH18 34 33
  • 92.45 (n)
(Canis familiaris)
Mammalia CDH18 34 33
  • 92.32 (n)
(Rattus norvegicus)
Mammalia Cdh18 33
  • 90.21 (n)
(Ornithorhynchus anatinus)
Mammalia CDH18 34
  • 90 (a)
(Mus musculus)
Mammalia Cdh18 16 34 33
  • 89.28 (n)
(Gallus gallus)
Aves CDH18 34 33
  • 82.78 (n)
(Anolis carolinensis)
Reptilia CDH18 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488093 33
  • 77.34 (n)
(Danio rerio)
Actinopterygii CDH18 (2 of 2) 34
  • 70 (a)
LOC100534833 33
  • 68.24 (n)
cdh18 34
  • 67 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7870 33
Species where no ortholog for CDH18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH18 Gene

Gene Tree for CDH18 (if available)
Gene Tree for CDH18 (if available)
Evolutionary constrained regions (ECRs) for CDH18: view image

Paralogs for CDH18 Gene

Paralogs for CDH18 Gene

(20) SIMAP similar genes for CDH18 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CDH18: view

Variants for CDH18 Gene

Sequence variations from dbSNP and Humsavar for CDH18 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000003094 -- 20,318,340(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000006536 -- 20,219,544(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000012778 -- 20,442,904(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000015203 -- 20,134,381(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000017440 -- 20,155,933(-) A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CDH18 Gene

Variant ID Type Subtype PubMed ID
dgv1081e214 CNV gain 21293372
esv1002274 CNV deletion 20482838
esv1394798 CNV insertion 17803354
esv1636230 CNV deletion 17803354
esv1661144 CNV deletion 17803354
esv2217776 CNV deletion 18987734
esv2422102 CNV deletion 20811451
esv2442104 CNV deletion 19546169
esv2468276 CNV deletion 19546169
esv2515726 CNV deletion 19546169
esv2553113 CNV insertion 19546169
esv26518 CNV loss 19812545
esv2657852 CNV deletion 23128226
esv2661167 CNV deletion 23128226
esv2667744 CNV deletion 23128226
esv2669398 CNV deletion 23128226
esv2674377 CNV deletion 23128226
esv26956 CNV loss 19812545
esv27108 CNV loss 19812545
esv2729889 CNV deletion 23290073
esv2729890 CNV deletion 23290073
esv2729891 CNV deletion 23290073
esv2729892 CNV deletion 23290073
esv2729893 CNV deletion 23290073
esv2729894 CNV deletion 23290073
esv2729896 CNV deletion 23290073
esv2759330 CNV loss 17122850
esv2760930 CNV loss 21179565
esv2762503 CNV loss 21179565
esv2762504 CNV loss 21179565
esv2763445 CNV loss 21179565
esv3303355 CNV mobile element insertion 20981092
esv3306256 CNV mobile element insertion 20981092
esv3325043 CNV insertion 20981092
esv3358875 CNV insertion 20981092
esv3446982 CNV insertion 20981092
esv3565634 CNV deletion 23714750
esv3604274 CNV gain 21293372
esv3604276 CNV loss 21293372
esv3604278 CNV loss 21293372
esv3604279 CNV loss 21293372
esv3604280 CNV loss 21293372
esv3604284 CNV loss 21293372
esv3604286 CNV loss 21293372
esv3604287 CNV loss 21293372
esv3604288 CNV loss 21293372
esv3604289 CNV loss 21293372
esv6505 CNV gain 19470904
esv8380 CNV loss 19470904
esv8395 CNV gain 19470904
esv988327 CNV deletion 20482838
esv991722 CNV deletion 20482838
esv993326 CNV deletion 20482838
nsv1017619 CNV loss 25217958
nsv1019058 CNV loss 25217958
nsv1025083 CNV loss 25217958
nsv1025466 CNV gain 25217958
nsv1026262 CNV gain 25217958
nsv1031377 CNV loss 25217958
nsv1031810 CNV loss 25217958
nsv1033072 CNV loss 25217958
nsv1033073 CNV loss 25217958
nsv10676 CNV loss 18304495
nsv1073868 CNV deletion 25765185
nsv1074820 CNV deletion 25765185
nsv1074821 CNV deletion 25765185
nsv1109681 CNV deletion 24896259
nsv1117543 CNV deletion 24896259
nsv1121643 CNV deletion 24896259
nsv1123922 CNV deletion 24896259
nsv1130835 CNV deletion 24896259
nsv1136974 CNV deletion 24896259
nsv1136975 CNV deletion 24896259
nsv1140518 CNV deletion 24896259
nsv1143310 CNV deletion 24896259
nsv1161218 CNV deletion 26073780
nsv1161219 CNV duplication 26073780
nsv327301 CNV deletion 16902084
nsv328739 CNV deletion 16902084
nsv329335 CNV deletion 16902084
nsv441944 CNV loss 18776908
nsv462002 CNV loss 19166990
nsv470997 CNV loss 18288195
nsv471628 CNV loss 15918152
nsv4752 CNV insertion 18451855
nsv4753 CNV insertion 18451855
nsv4754 CNV insertion 18451855
nsv509962 OTHER sequence alteration 20534489
nsv514296 CNV loss 21397061
nsv516609 CNV loss 19592680
nsv517689 CNV loss 19592680
nsv518092 CNV loss 19592680
nsv518192 CNV loss 19592680
nsv520215 CNV loss 19592680
nsv525360 CNV gain 19592680
nsv597424 CNV gain 21841781
nsv597426 CNV loss 21841781
nsv597427 CNV loss 21841781
nsv597428 CNV loss 21841781
nsv7369 OTHER inversion 18451855
nsv818327 CNV loss 17921354
nsv830224 CNV loss 17160897
nsv830225 CNV gain+loss 17160897
nsv955833 CNV deletion 24416366
nsv958309 CNV deletion 24416366
nsv968884 CNV duplication 23825009

Variation tolerance for CDH18 Gene

Residual Variation Intolerance Score: 3.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDH18 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH18 Gene

Disorders for CDH18 Gene

Additional Disease Information for CDH18

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CDH18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDH18 Gene

Publications for CDH18 Gene

  1. Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning. (PMID: 9030594) Shibata T … Hirohashi S (The Journal of biological chemistry 1997) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma. (PMID: 10191097) Chalmers IJ … Atkinson MJ (Genomics 1999) 2 3 58
  4. Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy. (PMID: 25642632) Liu H … Zhang F (Nature genetics 2015) 3 58
  5. A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels. (PMID: 25240745) López S … Soria JM (Mitochondrion 2014) 3 58

Products for CDH18 Gene

Sources for CDH18 Gene

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