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This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]
CDH13 (Cadherin 13) is a Protein Coding gene. Diseases associated with CDH13 include Familial Adenomatous Polyposis and Seminoma. Among its related pathways are ERK Signaling and Cell junction organization. Gene Ontology (GO) annotations related to this gene include calcium ion binding and cadherin binding. An important paralog of this gene is CDH2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH16J082626 | Promoter/Enhancer | 2.4 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 607.3 | +4.7 | 4743 | 10.3 | CTCF FOXA1 RAD21 EZH2 YY1 RUNX3 BRCA1 CEBPB RAD51 JUN | CDH13 HSALNG0113054 5MWI_A-063 | |
GH16J082698 | Enhancer | 1 | FANTOM5 Ensembl ENCODE | 17.8 | +73.8 | 73778 | 4.8 | JUND CEBPB FOXA2 JUN FOS FOSL1 MAX EP300 CEBPG ZNF335 | CDH13 MIR8058 ENSG00000280044 | |
GH16J082651 | Enhancer | 1.3 | FANTOM5 ENCODE dbSUPER | 12.1 | +27.8 | 27835 | 6.9 | SP1 POLR2A BACH1 JUND ZNF143 RELA TCF12 IKZF2 RCOR1 TRIM22 | CDH13 5MWI_A-063 MIR8058 | |
GH16J082659 | Enhancer | 0.8 | FANTOM5 ENCODE dbSUPER | 11.2 | +34.1 | 34086 | 2.5 | PKNOX1 RUNX3 | CDH13 PLCG2 5MWI_A-063 MIR8058 | |
GH16J082715 | Enhancer | 0.3 | Ensembl | 27.8 | +89.1 | 89078 | 1.4 | TEAD4 | CDH13 ENSG00000280044 MIR8058 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005509 | calcium ion binding | IBA | 21873635 |
GO:0008092 | cytoskeletal protein binding | IBA | -- |
GO:0030169 | low-density lipoprotein particle binding | IDA | 16013438 |
GO:0042803 | protein homodimerization activity | IEA | -- |
GO:0045296 | cadherin binding | IBA,IDA | 10601632 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | HDA | 27068509 |
GO:0005615 | extracellular space | IDA | 16873731 |
GO:0005737 | cytoplasm | IDA | 10737605 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005901 | caveola | IDA | 9650591 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cell junction organization | ||
2 | ERK Signaling |
Rho Family GTPases
.61
|
ILK Signaling
.49
|
3 | Regulation of activated PAK-2p34 by proteasome mediated degradation | ||
4 | G12-G13 in Cellular Signaling |
G12-G13 in Cellular Signaling
-
|
|
5 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.62
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000278 | mitotic cell cycle | IEA | -- |
GO:0000902 | cell morphogenesis | IBA | -- |
GO:0001938 | positive regulation of endothelial cell proliferation | IMP | 15364621 |
GO:0001954 | positive regulation of cell-matrix adhesion | IMP | 17573778 |
GO:0002040 | sprouting angiogenesis | IBA,IDA | 16873731 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
Cadherin Peptide, avian | Role in cell adhesion | 127650-08-2 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CDH13 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CDH13 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CDH13 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cdh13 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cdh13 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CDH13 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CDH13 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CDH13 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cdh13 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cdh13 30 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
714137 | Likely Benign: not provided | 83,032,186(+) | G/A | MISSENSE_VARIANT,INTRON_VARIANT | |
715243 | Likely Benign: not provided | 83,602,531(+) | G/A | SYNONYMOUS_VARIANT | |
715939 | Likely Benign: not provided | 83,783,266(+) | T/G | MISSENSE_VARIANT | |
721508 | Benign: not provided | 83,602,444(+) | T/C | INTRON_VARIANT | |
722550 | Likely Benign: not provided | 83,670,900(+) | C/T | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
familial adenomatous polyposis |
|
|
seminoma |
|
|
attention deficit-hyperactivity disorder |
|
|
lung cancer |
|
|
endometrial cancer |
|