CDH13 Gene (Protein Coding)

Cadherin 13

GC16P082626
GIFtS:
44
This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of... See more...

Aliases for CDH13 Gene

Aliases for CDH13 Gene

  • Cadherin 13 2 3 5
  • T-Cadherin 2 3 4
  • CDHH 2 3 4
  • H-Cadherin (Heart) 2 3
  • Heart Cadherin 3 4
  • Cadherin-13 3 4
  • T-Cad 3 4
  • P105 3 4
  • Cadherin 13, H-Cadherin (Heart) 3
  • Truncated Cadherin 4
  • H-Cadherin 4
  • CDH13 5

External Ids for CDH13 Gene

Previous GeneCards Identifiers for CDH13 Gene

  • GC16P073743
  • GC16P083625
  • GC16P082399
  • GC16P082440
  • GC16P081218
  • GC16P082660
  • GC16P068413

Summaries for CDH13 Gene

Entrez Gene Summary for CDH13 Gene

  • This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]

GeneCards Summary for CDH13 Gene

CDH13 (Cadherin 13) is a Protein Coding gene. Diseases associated with CDH13 include Vater/Vacterl Association and Vacterl Association. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and S-1P Stimulated Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and cadherin binding. An important paralog of this gene is CDH2.

UniProtKB/Swiss-Prot Summary for CDH13 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.

Gene Wiki entry for CDH13 Gene

Additional gene information for CDH13 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDH13 Gene

Genomics for CDH13 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CDH13 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH16J082626 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 257.3 +4.7 4743 10.3 DEK CTCF BRCA1 CEBPB RAD51 SIN3A EP300 GABPB1 RAD21 YY1 CDH13 HSALNG0113054 5MWI_A-062
GH16J082698 Enhancer 1 FANTOM5 Ensembl ENCODE 17.8 +73.6 73578 4.4 CEBPB ZNF395 MAX VEZF1 EP300 FOXA2 STAT3 JUND TBP FOSL1 CDH13 MIR8058 ENSG00000280044 lnc-HSD17B2-6
GH16J082651 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 12.1 +27.8 27835 6.9 SP1 BCL11A CEBPA POLR2A CEBPB FOXA2 IRF4 TRIM22 EP300 GABPA CDH13 5MWI_A-062 MIR8058
GH16J082990 Enhancer 1 FANTOM5 Ensembl ENCODE 8.2 +367.1 367112 6.1 ZNF513 MAFF JUND ZNF316 SPI1 YBX1 MAFK MAFG LARP7 CREB1 ENSG00000259914 CDH13 LOC101928417 piR-50444-157 HSBP1
GH16J082659 Enhancer 0.7 FANTOM5 ENCODE dbSUPER 11.2 +34.1 34086 2.5 RUNX3 CDH13 PLCG2 5MWI_A-062 MIR8058
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDH13 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDH13

Top Transcription factor binding sites by QIAGEN in the CDH13 gene promoter:
  • AP-1
  • ATF
  • ATF-2
  • c-Jun
  • GR
  • GR-alpha
  • GR-beta
  • IRF-7A
  • p53

Genomic Locations for CDH13 Gene

Latest Assembly
chr16:82,626,823-83,800,640
(GRCh38/hg38)
Size:
1,173,818 bases
Orientation:
Plus strand

Previous Assembly
chr16:82,660,574-83,834,245
(GRCh37/hg19 by Entrez Gene)
Size:
1,173,672 bases
Orientation:
Plus strand

chr16:82,660,408-83,830,204
(GRCh37/hg19 by Ensembl)
Size:
1,169,797 bases
Orientation:
Plus strand

Genomic View for CDH13 Gene

Genes around CDH13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH13 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CDH13 Gene

Proteins for CDH13 Gene

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  • Protein details for CDH13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55290-CAD13_HUMAN
    Recommended name:
    Cadherin-13
    Protein Accession:
    P55290
    Secondary Accessions:
    • A8W476
    • A8W477
    • B7Z590
    • C9JRI6
    • J3KN62
    • Q6GTW4
    • Q8TBX3

    Protein attributes for CDH13 Gene

    Size:
    713 amino acids
    Molecular mass:
    78287 Da
    Quaternary structure:
    • By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape.

    Three dimensional structures from OCA and Proteopedia for CDH13 Gene

    Alternative splice isoforms for CDH13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDH13 Gene

Protein Expression for CDH13 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CDH13 Gene

  • Glycosylation at Asn52, Asn86, Thr200, Asn382, Asn500, Asn530, Asn598, Asn638, and Asn671
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • CAD13_HUMAN (1921)

Other Protein References for CDH13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDH13 Gene

Domains & Families for CDH13 Gene

Gene Families for CDH13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CDH13 Gene

InterPro:
Blocks:
  • Cadherin
ProtoNet:

Suggested Antigen Peptide Sequences for CDH13 Gene

GenScript: Design optimal peptide antigens:
  • Truncated cadherin (CAD13_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P55290

UniProtKB/Swiss-Prot:

CAD13_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
genes like me logo Genes that share domains with CDH13: view

Function for CDH13 Gene

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  6. Cell Lines for research

Molecular function for CDH13 Gene

UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
GENATLAS Biochemistry:
cadherin 13,H-cadherin,transmembrane glycoprotein component of adherens junction,expressed in the heart,deleted in lung carcinoma (see TSG16H),hypermethylated or deleted in ovarian tumors (see TSG16A)

Phenotypes From GWAS Catalog for CDH13 Gene

Gene Ontology (GO) - Molecular Function for CDH13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA 21873635
GO:0005515 protein binding IPI 32814053
GO:0030169 low-density lipoprotein particle binding IDA 16013438
GO:0042803 protein homodimerization activity IEA --
GO:0045296 cadherin binding IBA,IDA 10601632
genes like me logo Genes that share ontologies with CDH13: view
genes like me logo Genes that share phenotypes with CDH13: view

Animal Models for CDH13 Gene

MGI Knock Outs for CDH13:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDH13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDH13 Gene

Localization for CDH13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH13 Gene

Cell membrane. Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDH13 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 3
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDH13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region HDA 27068509
GO:0005615 extracellular space IDA 16873731
GO:0005737 cytoplasm IDA 10737605
GO:0005886 plasma membrane TAS --
GO:0005901 caveola IDA 9650591
genes like me logo Genes that share ontologies with CDH13: view

Pathways & Interactions for CDH13 Gene

PathCards logo

SuperPathways for CDH13 Gene

genes like me logo Genes that share pathways with CDH13: view

Pathways by source for CDH13 Gene

1 Sino Biological pathway for CDH13 Gene
7 Qiagen pathways for CDH13 Gene
  • G12-G13 in Cellular Signaling
  • GSK3 Signaling
  • ILK Signaling
  • Presenilin-Mediated Signaling
  • Rho Family GTPases

SIGNOR curated interactions for CDH13 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CDH13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IEA --
GO:0001938 positive regulation of endothelial cell proliferation IMP 15364621
GO:0001954 positive regulation of cell-matrix adhesion IMP 17573778
GO:0002040 sprouting angiogenesis IBA,IDA 16873731
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with CDH13: view

Drugs & Compounds for CDH13 Gene

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(4) Drugs for CDH13 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6876
Cadherin Peptide, avian Pharma Role in cell adhesion 0

(5) Additional Compounds for CDH13 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CDH13 Gene

Compound Action Cas Number
Cadherin Peptide, avian Role in cell adhesion 127650-08-2
genes like me logo Genes that share compounds with CDH13: view

Drug products for research

Transcripts for CDH13 Gene

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mRNA/cDNA for CDH13 Gene

6 REFSEQ mRNAs :
30 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDH13

Alternative Splicing Database (ASD) splice patterns (SP) for CDH13 Gene

No ASD Table

Relevant External Links for CDH13 Gene

GeneLoc Exon Structure for
CDH13

Expression for CDH13 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDH13 Gene

mRNA expression in normal human tissues for CDH13 Gene
mRNA expression by GTEx for CDH13 GenemRNA expression by BioGPS for CDH13 Gene

mRNA differential expression in normal tissues according to GTEx for CDH13 Gene

This gene is overexpressed in Artery - Aorta (x8.6) and Artery - Coronary (x4.9).

Protein differential expression in normal tissues from HIPED for CDH13 Gene

This gene is overexpressed in Urine (11.9), Uterus (10.1), Heart (8.9), and Cerebrospinal fluid (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDH13 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDH13

SOURCE GeneReport for Unigene cluster for CDH13 Gene:

Hs.654386

mRNA Expression by UniProt/SwissProt for CDH13 Gene:

P55290-CAD13_HUMAN
Tissue specificity: Highly expressed in heart. In the CNS, expressed in cerebral cortex, medulla, hippocampus, amygdala, thalamus and substantia nigra. No expression detected in cerebellum or spinal cord.

Evidence on tissue expression from TISSUES for CDH13 Gene

  • Nervous system(5)
  • Liver(4.4)
  • Bone marrow(4.3)
  • Heart(3.1)
  • Muscle(3.1)
  • Skin(2.7)
  • Lung(2.5)
  • Kidney(2.5)
  • Blood(2.3)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with CDH13: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDH13 Gene

Orthologs for CDH13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH13 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia CDH13 30 31
  • 98.73 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia CDH13 30 31
  • 91.72 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia CDH13 30 31
  • 91.61 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Cdh13 30
  • 88.24 (n)
Mouse
(Mus musculus)
 Mammalia Cdh13 30 17 31
  • 87.99 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia CDH13 31
  • 84 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia CDH13 31
  • 83 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves CDH13 30 31
  • 73.79 (n)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia cdh13 30
  • 69.85 (n)
Zebrafish
(Danio rerio)
 Actinopterygii cdh13 30 31
  • 64.34 (n)
 OneToOne
Species where no ortholog for CDH13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CDH13 Gene

ENSEMBL:
Gene Tree for CDH13 (if available)
TreeFam:
Gene Tree for CDH13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDH13: view image

Paralogs for CDH13 Gene

Paralogs for CDH13 Gene

(12) SIMAP similar genes for CDH13 Gene using alignment to 6 proteins:

  • CAD13_HUMAN
  • F5H7W7_HUMAN
  • H3BQH4_HUMAN
  • H3BRL7_HUMAN
  • H3BTF2_HUMAN
  • H3BV21_HUMAN
genes like me logo Genes that share paralogs with CDH13: view

Variants for CDH13 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDH13 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs1048612 Benign: not specified 83,783,414(+) A/G
NM_001257.5(CDH13):c.2076A>G (p.Ala692=) 		SYNONYMOUS
rs112122090 Likely Benign: not provided 83,678,312(+) C/T
NM_001257.5(CDH13):c.1389C>T (p.Thr463=) 		SYNONYMOUS
rs117780495 Benign: not provided 83,783,282(+) A/G
NM_001257.5(CDH13):c.1944A>G (p.Gln648=) 		SYNONYMOUS
rs137974484 Benign: not provided 83,602,444(+) T/C
NM_001257.5(CDH13):c.961-10T>C 		INTRON
rs141537452 Benign: not provided 83,783,267(+) G/A
NM_001257.5(CDH13):c.1929G>A (p.Leu643=) 		SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CDH13 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CDH13 Gene

Variant ID Type Subtype PubMed ID
dgv168n21 CNV loss 19592680
dgv3051n100 CNV gain 25217958
dgv3052n100 CNV loss 25217958
dgv3053n100 CNV loss 25217958
dgv3054n100 CNV gain 25217958
dgv3055n100 CNV gain 25217958
dgv495n67 CNV loss 20364138
dgv511e199 CNV deletion 23128226
dgv5253n54 CNV gain 21841781
dgv5255n54 CNV loss 21841781
dgv5256n54 CNV loss 21841781
dgv5257n54 CNV loss 21841781
dgv5258n54 CNV loss 21841781
dgv545e214 CNV loss 21293372
dgv866e212 CNV loss 25503493
dgv867e212 CNV loss 25503493
dgv868e212 CNV loss 25503493
dgv869e212 CNV loss 25503493
esv1001951 CNV loss 20482838
esv1003403 CNV deletion 20482838
esv1010099 CNV insertion 20482838
esv1369956 CNV insertion 17803354
esv1557614 CNV insertion 17803354
esv1572586 CNV deletion 17803354
esv1768316 CNV deletion 17803354
esv2112702 CNV deletion 18987734
esv22422 CNV loss 19812545
esv2286188 CNV deletion 18987734
esv2430420 CNV deletion 19546169
esv2523201 CNV deletion 19546169
esv2660028 CNV deletion 23128226
esv2664269 CNV deletion 23128226
esv2668528 CNV deletion 23128226
esv2670466 CNV deletion 23128226
esv2671591 CNV deletion 23128226
esv2675891 CNV deletion 23128226
esv2677002 CNV deletion 23128226
esv2714801 CNV deletion 23290073
esv2714802 CNV deletion 23290073
esv2714803 CNV deletion 23290073
esv2714804 CNV deletion 23290073
esv2714805 CNV deletion 23290073
esv2714808 CNV deletion 23290073
esv2714809 CNV deletion 23290073
esv2714810 CNV deletion 23290073
esv2714811 CNV deletion 23290073
esv2714812 CNV deletion 23290073
esv275004 CNV loss 21479260
esv275089 CNV loss 21479260
esv2751616 CNV gain 17911159
esv275233 CNV gain+loss 21479260
esv275268 CNV gain+loss 21479260
esv275275 CNV gain+loss 21479260
esv2758664 CNV loss 17122850
esv2760405 CNV loss 21179565
esv2760442 CNV loss 21179565
esv2761928 CNV loss 21179565
esv2761929 CNV loss 21179565
esv2762287 CNV loss 21179565
esv28755 CNV loss 19812545
esv29576 CNV loss 19812545
esv3135 CNV loss 18987735
esv32756 CNV loss 17666407
esv3303052 CNV tandem duplication 20981092
esv3303381 CNV mobile element insertion 20981092
esv3305093 CNV mobile element insertion 20981092
esv3306176 CNV mobile element insertion 20981092
esv3307245 CNV mobile element insertion 20981092
esv3308310 CNV mobile element insertion 20981092
esv3310555 CNV novel sequence insertion 20981092
esv3325357 CNV insertion 20981092
esv3334036 CNV insertion 20981092
esv33495 CNV loss 17666407
esv3404617 CNV insertion 20981092
esv3405118 CNV insertion 20981092
esv3405695 CNV insertion 20981092
esv3429289 CNV insertion 20981092
esv3443683 CNV insertion 20981092
esv3553773 CNV deletion 23714750
esv3553776 CNV deletion 23714750
esv3553778 CNV deletion 23714750
esv3553779 CNV deletion 23714750
esv3553783 CNV deletion 23714750
esv3553786 CNV deletion 23714750
esv3553791 CNV deletion 23714750
esv3582391 CNV loss 25503493
esv3582392 CNV loss 25503493
esv3582395 CNV loss 25503493
esv3582400 CNV loss 25503493
esv3582401 CNV loss 25503493
esv3582407 CNV loss 25503493
esv3582408 CNV loss 25503493
esv3582409 CNV loss 25503493
esv3582412 CNV loss 25503493
esv3582413 CNV loss 25503493
esv3639368 CNV loss 21293372
esv3639369 CNV loss 21293372
esv3639372 CNV loss 21293372
esv3639379 CNV loss 21293372
esv3639380 CNV loss 21293372
esv3639382 CNV gain 21293372
esv3639384 CNV loss 21293372
esv3639385 CNV loss 21293372
esv3639386 CNV loss 21293372
esv3639387 CNV loss 21293372
esv3639390 CNV loss 21293372
esv3639391 CNV loss 21293372
esv3639392 CNV loss 21293372
esv3639393 CNV loss 21293372
esv3639394 CNV loss 21293372
esv3639395 CNV loss 21293372
esv3892916 CNV loss 25118596
esv3892917 CNV loss 25118596
esv3892918 CNV loss 25118596
esv3892919 CNV loss 25118596
esv3892920 CNV loss 25118596
esv3892921 CNV loss 25118596
esv3892922 CNV loss 25118596
esv3892923 CNV loss 25118596
esv9464 CNV loss 19470904
esv993231 CNV loss 20482838
nsv103273 CNV deletion 16902084
nsv1055277 CNV gain 25217958
nsv1055454 CNV loss 25217958
nsv1055547 CNV loss 25217958
nsv1056158 CNV loss 25217958
nsv1057720 CNV gain 25217958
nsv1059219 CNV loss 25217958
nsv1059489 CNV gain 25217958
nsv1059718 CNV loss 25217958
nsv1060011 CNV gain 25217958
nsv1060245 CNV loss 25217958
nsv1061195 CNV gain 25217958
nsv1061288 CNV gain+loss 25217958
nsv1062520 CNV loss 25217958
nsv1063276 CNV loss 25217958
nsv1063412 CNV gain 25217958
nsv1064158 CNV loss 25217958
nsv1064438 CNV gain 25217958
nsv1064630 CNV gain 25217958
nsv1064977 CNV loss 25217958
nsv1065896 CNV gain 25217958
nsv1065912 CNV loss 25217958
nsv1066140 CNV loss 25217958
nsv1066832 CNV loss 25217958
nsv1070360 CNV deletion 25765185
nsv1109026 CNV deletion 24896259
nsv1127520 CNV deletion 24896259
nsv1142886 CNV tandem duplication 24896259
nsv1903 CNV deletion 18451855
nsv1904 CNV insertion 18451855
nsv1905 CNV insertion 18451855
nsv1906 CNV deletion 18451855
nsv457583 CNV loss 19166990
nsv457586 CNV loss 19166990
nsv471102 CNV gain 18288195
nsv478536 CNV novel sequence insertion 20440878
nsv510428 OTHER sequence alteration 20534489
nsv515680 CNV loss 19592680
nsv515825 CNV loss 19592680
nsv517665 CNV loss 19592680
nsv518084 CNV loss 19592680
nsv518143 CNV loss 19592680
nsv521310 CNV loss 19592680
nsv522570 CNV loss 19592680
nsv522936 CNV loss 19592680
nsv523157 CNV loss 19592680
nsv524580 CNV loss 19592680
nsv526366 CNV loss 19592680
nsv527342 CNV loss 19592680
nsv527828 CNV loss 19592680
nsv573367 CNV gain 21841781
nsv573371 CNV loss 21841781
nsv573379 CNV gain 21841781
nsv573380 CNV loss 21841781
nsv573381 CNV loss 21841781
nsv573382 CNV loss 21841781
nsv573385 CNV loss 21841781
nsv573386 CNV loss 21841781
nsv573387 CNV loss 21841781
nsv573388 CNV loss 21841781
nsv573395 CNV loss 21841781
nsv573396 CNV loss 21841781
nsv573397 CNV loss 21841781
nsv573398 CNV gain 21841781
nsv573399 CNV loss 21841781
nsv573400 CNV loss 21841781
nsv573401 CNV gain 21841781
nsv573404 CNV loss 21841781
nsv573405 CNV gain 21841781
nsv827777 CNV loss 20364138
nsv833305 CNV gain 17160897
nsv833306 CNV loss 17160897
nsv833307 CNV gain+loss 17160897
nsv833308 CNV loss 17160897

Variation tolerance for CDH13 Gene

Residual Variation Intolerance Score: 47.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDH13 Gene

Human Gene Mutation Database (HGMD)
CDH13
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDH13

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH13 Gene

Disorders for CDH13 Gene

MalaCards: The human disease database

(16) MalaCards diseases for CDH13 Gene - From: CVR, COP, and GCD

Disorder Aliases PubMed IDs
vater/vacterl association
  • vacterl/vater association
vacterl association
  • vater syndrome
familial adenomatous polyposis
  • adenomatous polyposis of the colon
seminoma
  • seminoma, pure
lung cancer
  • lung cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search CDH13 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CDH13

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CDH13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDH13 Gene

Publications for CDH13 Gene

  1. Identification of an atypical lipoprotein-binding protein from human aortic smooth muscle as T-cadherin. (PMID: 9468307) Tkachuk VA … Resink TJ (FEBS letters 1998) 2 3 4 23
  2. H-cadherin, a novel cadherin with growth inhibitory functions and diminished expression in human breast cancer. (PMID: 8673923) Lee SW (Nature medicine 1996) 2 3 4 23
  3. Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations. (PMID: 19304780) Org E … Laan M (Human molecular genetics 2009) 3 23 41
  4. Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study. (PMID: 19165155) Ling H … Mitchell BD (Obesity (Silver Spring, Md.) 2009) 3 23 41
  5. The glycosyl phosphatidylinositol anchor of human T-cadherin binds lipoproteins. (PMID: 11027617) Niermann T … Resink T (Biochemical and biophysical research communications 2000) 3 4 23

ExternalLinks

View latest publications for CDH13 gene in Mastermind

Products for CDH13 Gene

Sources for CDH13 Gene