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This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]
CDH13 (Cadherin 13) is a Protein Coding gene. Diseases associated with CDH13 include Vater/Vacterl Association and Vacterl Association. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and S-1P Stimulated Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and cadherin binding. An important paralog of this gene is CDH2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH16J082626 | Promoter/Enhancer | 2.3 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 257.3 | +4.7 | 4743 | 10.3 | DEK CTCF BRCA1 CEBPB RAD51 SIN3A EP300 GABPB1 RAD21 YY1 | CDH13 HSALNG0113054 5MWI_A-062 | |
GH16J082698 | Enhancer | 1 | FANTOM5 Ensembl ENCODE | 17.8 | +73.6 | 73578 | 4.4 | CEBPB ZNF395 MAX VEZF1 EP300 FOXA2 STAT3 JUND TBP FOSL1 | CDH13 MIR8058 ENSG00000280044 lnc-HSD17B2-6 | |
GH16J082651 | Enhancer | 1.3 | FANTOM5 ENCODE dbSUPER | 12.1 | +27.8 | 27835 | 6.9 | SP1 BCL11A CEBPA POLR2A CEBPB FOXA2 IRF4 TRIM22 EP300 GABPA | CDH13 5MWI_A-062 MIR8058 | |
GH16J082990 | Enhancer | 1 | FANTOM5 Ensembl ENCODE | 8.2 | +367.1 | 367112 | 6.1 | ZNF513 MAFF JUND ZNF316 SPI1 YBX1 MAFK MAFG LARP7 CREB1 | ENSG00000259914 CDH13 LOC101928417 piR-50444-157 HSBP1 | |
GH16J082659 | Enhancer | 0.7 | FANTOM5 ENCODE dbSUPER | 11.2 | +34.1 | 34086 | 2.5 | RUNX3 | CDH13 PLCG2 5MWI_A-062 MIR8058 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005509 | calcium ion binding | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 32814053 |
GO:0030169 | low-density lipoprotein particle binding | IDA | 16013438 |
GO:0042803 | protein homodimerization activity | IEA | -- |
GO:0045296 | cadherin binding | IBA,IDA | 10601632 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | HDA | 27068509 |
GO:0005615 | extracellular space | IDA | 16873731 |
GO:0005737 | cytoplasm | IDA | 10737605 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005901 | caveola | IDA | 9650591 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cell junction organization | ||
2 | ERK Signaling |
Rho Family GTPases
.61
|
ILK Signaling
.49
|
3 | CDK-mediated phosphorylation and removal of Cdc6 | ||
4 | G12-G13 in Cellular Signaling |
G12-G13 in Cellular Signaling
-
|
|
5 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000278 | mitotic cell cycle | IEA | -- |
GO:0001938 | positive regulation of endothelial cell proliferation | IMP | 15364621 |
GO:0001954 | positive regulation of cell-matrix adhesion | IMP | 17573778 |
GO:0002040 | sprouting angiogenesis | IBA,IDA | 16873731 |
GO:0007155 | cell adhesion | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
Cadherin Peptide, avian | Role in cell adhesion | 127650-08-2 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CDH13 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CDH13 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CDH13 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cdh13 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cdh13 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CDH13 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CDH13 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CDH13 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cdh13 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cdh13 30 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1048612 | Benign: not specified | 83,783,414(+) |
A/G NM_001257.5(CDH13):c.2076A>G (p.Ala692=) |
SYNONYMOUS | |
rs112122090 | Likely Benign: not provided | 83,678,312(+) |
C/T NM_001257.5(CDH13):c.1389C>T (p.Thr463=) |
SYNONYMOUS | |
rs117780495 | Benign: not provided | 83,783,282(+) |
A/G NM_001257.5(CDH13):c.1944A>G (p.Gln648=) |
SYNONYMOUS | |
rs137974484 | Benign: not provided | 83,602,444(+) |
T/C NM_001257.5(CDH13):c.961-10T>C |
INTRON | |
rs141537452 | Benign: not provided | 83,783,267(+) |
G/A NM_001257.5(CDH13):c.1929G>A (p.Leu643=) |
SYNONYMOUS |
Disorder | Aliases | PubMed IDs |
---|---|---|
vater/vacterl association |
|
|
vacterl association |
|
|
familial adenomatous polyposis |
|
|
seminoma |
|
|
lung cancer |
|
|