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Aliases for CDH11 Gene

Aliases for CDH11 Gene

  • Cadherin 11 2 3 5
  • Cadherin 11, Type 2, OB-Cadherin (Osteoblast) 2 3
  • OB-Cadherin 2 4
  • OSF-4 3 4
  • Osteoblast Cadherin 4
  • Cadherin-11 3
  • CAD11 3
  • CDHOB 3
  • ESWS 3
  • OB 3

External Ids for CDH11 Gene

Previous GeneCards Identifiers for CDH11 Gene

  • GC16M055361
  • GC16M065268
  • GC16M064715
  • GC16M064755
  • GC16M063538
  • GC16M064977
  • GC16M050850

Summaries for CDH11 Gene

Entrez Gene Summary for CDH11 Gene

  • This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDH11 Gene

CDH11 (Cadherin 11) is a Protein Coding gene. Diseases associated with CDH11 include Elsahy-Waters Syndrome and Aneurysmal Bone Cysts. Among its related pathways are ERK Signaling and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH8.

UniProtKB/Swiss-Prot for CDH11 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Gene Wiki entry for CDH11 Gene

Additional gene information for CDH11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH11 Gene

Genomics for CDH11 Gene

GeneHancer (GH) Regulatory Elements for CDH11 Gene

Promoters and enhancers for CDH11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J065118 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 663 +4.3 4295 5.9 CTCF SUZ12 NR2F1 ZNF335 CBX8 POLR2A SCRT2 RCOR1 CDH11 LOC105371314 LINC02126 ENSG00000278893
GH16J065125 Promoter/Enhancer 0.9 EPDnew ENCODE dbSUPER 650.7 +0.0 27 0.6 CDH11 LOC105371314
GH16J065094 Promoter 0.5 EPDnew 661.7 +31.5 31465 0.1 CDH11 LOC105371314 ENSG00000278893
GH16J065067 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 4.9 +55.9 55906 5 JUN YBX1 ZNF384 ZNF366 POLR2A ATF7 FOSL2 FOS RXRA NFYC CDH11 LOC105371314 ENSG00000278893
GH16J065176 Enhancer 0.5 Ensembl ENCODE 10.9 -50.8 -50775 1.1 NR2F2 LINC02126 CDH11 GC16P065181
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDH11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDH11 gene promoter:
  • FOXD3
  • Sox9
  • IRF-1
  • Bach1
  • C/EBPbeta
  • aMEF-2
  • MEF-2A
  • CUTL1
  • Nkx2-2
  • Ik-2

Genomic Locations for CDH11 Gene

Genomic Locations for CDH11 Gene
chr16:64,943,753-65,126,112
(GRCh38/hg38)
Size:
182,360 bases
Orientation:
Minus strand
chr16:64,977,656-65,160,015
(GRCh37/hg19)
Size:
182,360 bases
Orientation:
Minus strand

Genomic View for CDH11 Gene

Genes around CDH11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH11 Gene

Proteins for CDH11 Gene

  • Protein details for CDH11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55287-CAD11_HUMAN
    Recommended name:
    Cadherin-11
    Protein Accession:
    P55287
    Secondary Accessions:
    • A8K5D6
    • A8MZC8
    • B7WP28
    • Q15065
    • Q15066
    • Q9UQ93
    • Q9UQ94

    Protein attributes for CDH11 Gene

    Size:
    796 amino acids
    Molecular mass:
    87965 Da
    Quaternary structure:
    • Interacts with PCDH8.

    Alternative splice isoforms for CDH11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDH11 Gene

Post-translational modifications for CDH11 Gene

  • Glycosylation at posLast=540540 and posLast=455455
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDH11 Gene

Domains & Families for CDH11 Gene

Gene Families for CDH11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CDH11 Gene

Graphical View of Domain Structure for InterPro Entry

P55287

UniProtKB/Swiss-Prot:

CAD11_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
genes like me logo Genes that share domains with CDH11: view

Function for CDH11 Gene

Molecular function for CDH11 Gene

UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
GENATLAS Biochemistry:
cadherin 11,OB-cadherin,transmembrane glycoprotein component of adherens junction,expressed in osteoblast

Phenotypes From GWAS Catalog for CDH11 Gene

Gene Ontology (GO) - Molecular Function for CDH11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0008092 cytoskeletal protein binding IBA --
GO:0042803 protein homodimerization activity IBA --
GO:0045296 cadherin binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CDH11: view
genes like me logo Genes that share phenotypes with CDH11: view

Human Phenotype Ontology for CDH11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CDH11 Gene

MGI Knock Outs for CDH11:

Animal Model Products

CRISPR Products

miRNA for CDH11 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDH11

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CDH11 Gene

Localization for CDH11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH11 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDH11 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 2
endoplasmic reticulum 2
nucleus 1

Gene Ontology (GO) - Cellular Components for CDH11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0005913 cell-cell adherens junction IBA --
GO:0009986 cell surface IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CDH11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CDH11 Gene

Pathways & Interactions for CDH11 Gene

genes like me logo Genes that share pathways with CDH11: view

Pathways by source for CDH11 Gene

Gene Ontology (GO) - Biological Process for CDH11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IBA --
GO:0001501 skeletal system development TAS 8163513
GO:0001503 ossification NAS 8163513
GO:0007043 cell-cell junction assembly IBA --
GO:0007155 cell adhesion IEA,TAS 8163513
genes like me logo Genes that share ontologies with CDH11: view

No data available for SIGNOR curated interactions for CDH11 Gene

Drugs & Compounds for CDH11 Gene

(2) Drugs for CDH11 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with CDH11: view

Transcripts for CDH11 Gene

Unigene Clusters for CDH11 Gene

Cadherin 11, type 2, OB-cadherin (osteoblast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDH11

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDH11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g · 11h · 11i ^ 12a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - - - - -
SP8: - - - - -
SP9: - - - - -
SP10: - - - -
SP11: - - -
SP12: - -
SP13: - - - - - - - - - - - - -
SP14: - - - - - - -
SP15:

ExUns: 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for CDH11 Gene

GeneLoc Exon Structure for
CDH11
ECgene alternative splicing isoforms for
CDH11

Expression for CDH11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDH11 Gene

mRNA differential expression in normal tissues according to GTEx for CDH11 Gene

This gene is overexpressed in Ovary (x6.2).

Protein differential expression in normal tissues from HIPED for CDH11 Gene

This gene is overexpressed in Ovary (9.2), Amniocyte (9.0), and Urine (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDH11 Gene



Protein tissue co-expression partners for CDH11 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDH11 Gene:

CDH11

SOURCE GeneReport for Unigene cluster for CDH11 Gene:

Hs.116471

mRNA Expression by UniProt/SwissProt for CDH11 Gene:

P55287-CAD11_HUMAN
Tissue specificity: Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.

Evidence on tissue expression from TISSUES for CDH11 Gene

  • Nervous system(4.9)
  • Bone(2.2)
  • Lung(2.2)
  • Skin(2.2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with CDH11: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CDH11 Gene

Orthologs for CDH11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDH11 34 33
  • 99.62 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDH11 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDH11 34 33
  • 92.88 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CDH11 34 33
  • 91.88 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdh11 33
  • 90.24 (n)
mouse
(Mus musculus)
Mammalia Cdh11 16 34 33
  • 89.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDH11 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDH11 34 33
  • 80.05 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDH11 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh11 33
  • 75.13 (n)
Str.15472 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.16169 33
zebrafish
(Danio rerio)
Actinopterygii cdh11 34 33 33
  • 69.82 (n)
OneToOne
Species where no ortholog for CDH11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH11 Gene

ENSEMBL:
Gene Tree for CDH11 (if available)
TreeFam:
Gene Tree for CDH11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDH11: view image

Paralogs for CDH11 Gene

Paralogs for CDH11 Gene

(23) SIMAP similar genes for CDH11 Gene using alignment to 9 proteins:

  • CAD11_HUMAN
  • H3BP26_HUMAN
  • H3BPQ2_HUMAN
  • H3BQB5_HUMAN
  • H3BQH2_HUMAN
  • H3BR78_HUMAN
  • H3BSM4_HUMAN
  • H3BUU9_HUMAN
  • Q96CZ9_HUMAN
genes like me logo Genes that share paralogs with CDH11: view

Variants for CDH11 Gene

Sequence variations from dbSNP and Humsavar for CDH11 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs200234049 likely-benign, Oromandibular-limb hypogenesis spectrum 64,982,054(-) G/A coding_sequence_variant, missense_variant
rs757142171 likely-benign, Oromandibular-limb hypogenesis spectrum 65,004,775(-) C/A/T coding_sequence_variant, intron_variant, missense_variant
rs1000000861 -- 65,014,386(-) T/C intron_variant
rs1000012180 -- 65,095,336(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000047729 -- 65,055,254(-) G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CDH11 Gene

Variant ID Type Subtype PubMed ID
esv34131 CNV loss 18971310
esv3638844 CNV loss 21293372
nsv1831 CNV deletion 18451855
nsv572901 CNV loss 21841781
nsv833260 CNV loss 17160897

Variation tolerance for CDH11 Gene

Residual Variation Intolerance Score: 22.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.47; 96.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDH11 Gene

Human Gene Mutation Database (HGMD)
CDH11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDH11

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH11 Gene

Disorders for CDH11 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CDH11 Gene - From: HGMD, OMIM, ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
elsahy-waters syndrome
  • esws
aneurysmal bone cysts
  • aneurysmal bone cyst
deafness, autosomal recessive 89
  • dfnb89
- elite association - COSMIC cancer census association via MalaCards
Search CDH11 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CAD11_HUMAN
  • Note=A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.

Additional Disease Information for CDH11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CDH11: view

No data available for Genatlas for CDH11 Gene

Publications for CDH11 Gene

  1. Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts. (PMID: 8163513) Okazaki M … Amann E (The Journal of biological chemistry 1994) 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1. (PMID: 19996288) Sachdeva M … Mo YY (Cancer research 2010) 3 22 58
  4. Post-transcriptional regulation of cadherin-11 expression by GSK-3 and beta-catenin in prostate and breast cancer cells. (PMID: 19274078) Farina AK … Byers SW (PloS one 2009) 3 22 58
  5. Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PMID: 19339270) Canova C … Brennan P (Cancer research 2009) 3 44 58

Products for CDH11 Gene

Sources for CDH11 Gene

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