This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a... See more...

Aliases for CDH10 Gene

Aliases for CDH10 Gene

  • Cadherin 10 2 3 5
  • Cadherin-10 3 4
  • T2-Cadherin 3 4
  • Cadherin 10, Type 2 (T2-Cadherin) 2
  • Cadherin 10 Type 2 3

External Ids for CDH10 Gene

Previous GeneCards Identifiers for CDH10 Gene

  • GC05M024168
  • GC05M024923
  • GC05M024486
  • GC05M024532

Summaries for CDH10 Gene

Entrez Gene Summary for CDH10 Gene

  • This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal cancer in human patients. [provided by RefSeq, Nov 2015]

GeneCards Summary for CDH10 Gene

CDH10 (Cadherin 10) is a Protein Coding gene. Diseases associated with CDH10 include Lung Squamous Cell Carcinoma and Obsessive-Compulsive Disorder. Among its related pathways are Presenilin-Mediated Signaling and Cell junction organization. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH6.

UniProtKB/Swiss-Prot Summary for CDH10 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Gene Wiki entry for CDH10 Gene

Additional gene information for CDH10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDH10 Gene

Genomics for CDH10 Gene

GeneHancer (GH) Regulatory Elements for CDH10 Gene

Promoters and enhancers for CDH10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J024644 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 511.2 +0.6 577 2.3 EP300 TEAD4 CTCF SMC3 NANOG POLR2A TCF12 ETS1 GATA3 FOXP2 CDH10 HSALNG0040646 piR-35002-007
GH05J024621 Enhancer 0.5 Ensembl 23.9 +22.2 22223 2.4 NFIC CEBPG FOXP2 NFIB TAF1 ATF4 POLR2A CDH10 piR-35002-007 HSALNG0040646
GH05J024614 Enhancer 0.2 FANTOM5 12.2 +30.3 30267 0.4 CDH10 piR-35002-007 HSALNG0040646
GH05J024567 Enhancer 0.2 FANTOM5 10.9 +78.0 78010 0 CDH10 ENSG00000249562 ENSG00000251294 lnc-CDH12-7
GH05J023950 Promoter 0.3 Ensembl 6.2 +693.4 693423 1.2 C5orf17 HSALNG0040620 piR-39099-205 CDH10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDH10 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDH10

Top Transcription factor binding sites by QIAGEN in the CDH10 gene promoter:
  • AML1a
  • Evi-1
  • FOXD1
  • FOXO4
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU6F1 (c2)
  • TBP

Genomic Locations for CDH10 Gene

Genomic Locations for CDH10 Gene
chr5:24,487,100-24,645,024
(GRCh38/hg38)
Size:
157,925 bases
Orientation:
Minus strand
chr5:24,487,209-24,645,087
(GRCh37/hg19)
Size:
157,879 bases
Orientation:
Minus strand

Genomic View for CDH10 Gene

Genes around CDH10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH10 Gene

Proteins for CDH10 Gene

  • Protein details for CDH10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6N8-CAD10_HUMAN
    Recommended name:
    Cadherin-10
    Protein Accession:
    Q9Y6N8
    Secondary Accessions:
    • Q9ULB3

    Protein attributes for CDH10 Gene

    Size:
    788 amino acids
    Molecular mass:
    88451 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CDH10 Gene

Post-translational modifications for CDH10 Gene

  • Glycosylation at Asn256, Asn438, Asn456, and Asn534
  • Modification sites at PhosphoSitePlus

Other Protein References for CDH10 Gene

No data available for DME Specific Peptides for CDH10 Gene

Domains & Families for CDH10 Gene

Gene Families for CDH10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CDH10 Gene

Blocks:
  • Cadherin
  • Cadherin cytoplasmic region
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDH10 Gene

GenScript: Design optimal peptide antigens:
  • T2-cadherin (CAD10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y6N8

UniProtKB/Swiss-Prot:

CAD10_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
genes like me logo Genes that share domains with CDH10: view

Function for CDH10 Gene

Molecular function for CDH10 Gene

UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
GENATLAS Biochemistry:
cadherin 10,T2 cadherin,transmembrane glycoprotein,component of adherens junction,predominantly expressed in brain,putatively involved in synaptic adhesions,axon outgrowth and guidance,also expressed in kidney,prostate,fetal lung

Phenotypes From GWAS Catalog for CDH10 Gene

Gene Ontology (GO) - Molecular Function for CDH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA,IEA 21873635
GO:0008092 cytoskeletal protein binding IBA 21873635
GO:0042803 protein homodimerization activity IBA 21873635
GO:0045296 cadherin binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CDH10: view
genes like me logo Genes that share phenotypes with CDH10: view

Animal Models for CDH10 Gene

MGI Knock Outs for CDH10:
  • Cdh10 Cdh10<tm2b(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for CDH10

miRNA for CDH10 Gene

miRTarBase miRNAs that target CDH10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDH10 Gene

Localization for CDH10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH10 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDH10 gene
Compartment Confidence
plasma membrane 4
extracellular 2
endoplasmic reticulum 2
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for CDH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005913 cell-cell adherens junction IBA 21873635
GO:0009986 cell surface IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDH10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CDH10 Gene

Pathways & Interactions for CDH10 Gene

PathCards logo

SuperPathways for CDH10 Gene

SuperPathway Contained pathways
1 Cell junction organization
2 ERK Signaling
.61
.49
3 G12-G13 in Cellular Signaling
-
4 Nanog in Mammalian ESC Pluripotency
.61
5 Presenilin-Mediated Signaling
-
genes like me logo Genes that share pathways with CDH10: view

Pathways by source for CDH10 Gene

7 Qiagen pathways for CDH10 Gene
  • G12-G13 in Cellular Signaling
  • GSK3 Signaling
  • ILK Signaling
  • Presenilin-Mediated Signaling
  • Rho Family GTPases

Gene Ontology (GO) - Biological Process for CDH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IBA 21873635
GO:0007043 cell-cell junction assembly IBA 21873635
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA,IBA 21873635
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA 21873635
genes like me logo Genes that share ontologies with CDH10: view

No data available for SIGNOR curated interactions for CDH10 Gene

Drugs & Compounds for CDH10 Gene

(1) Drugs for CDH10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7884
genes like me logo Genes that share compounds with CDH10: view

Transcripts for CDH10 Gene

mRNA/cDNA for CDH10 Gene

5 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDH10 Gene

No ASD Table

Relevant External Links for CDH10 Gene

GeneLoc Exon Structure for
CDH10

Expression for CDH10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDH10 Gene

mRNA differential expression in normal tissues according to GTEx for CDH10 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.5), Brain - Frontal Cortex (BA9) (x7.4), Brain - Anterior cingulate cortex (BA24) (x6.9), Brain - Cerebellum (x6.7), and Brain - Cortex (x5.4).

Protein differential expression in normal tissues from HIPED for CDH10 Gene

This gene is overexpressed in Frontal cortex (39.2) and Fetal Brain (25.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDH10 Gene



Protein tissue co-expression partners for CDH10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDH10

SOURCE GeneReport for Unigene cluster for CDH10 Gene:

Hs.92489

mRNA Expression by UniProt/SwissProt for CDH10 Gene:

Q9Y6N8-CAD10_HUMAN
Tissue specificity: Predominantly expressed in brain. Also found in adult and fetal kidney. Very low levels detected in prostate and fetal lung.

Evidence on tissue expression from TISSUES for CDH10 Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with CDH10: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CDH10 Gene

Orthologs for CDH10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDH10 31 30
  • 99.87 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDH10 31
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDH10 31
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDH10 31 30
  • 91.62 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CDH10 31 30
  • 90.36 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cdh10 17 31 30
  • 88.11 (n)
rat
(Rattus norvegicus)
Mammalia Cdh10 30
  • 87.48 (n)
chicken
(Gallus gallus)
Aves CDH10 31 30
  • 83.29 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDH10 31
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh10 30
  • 75.1 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01067945.1 31
  • 67 (a)
ManyToMany
cdh10 31 30
  • 65.09 (n)
ManyToMany
cdh6 31
  • 61 (a)
ManyToMany
Species where no ortholog for CDH10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH10 Gene

ENSEMBL:
Gene Tree for CDH10 (if available)
TreeFam:
Gene Tree for CDH10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDH10: view image

Paralogs for CDH10 Gene

(20) SIMAP similar genes for CDH10 Gene using alignment to 3 proteins:

  • CAD10_HUMAN
  • D6RJG0_HUMAN
  • L8ECD4_HUMAN
genes like me logo Genes that share paralogs with CDH10: view

Variants for CDH10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDH10 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
727797 Benign: not provided 24,537,396(-) G/A SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
772871 Benign: not provided 24,488,011(-) G/A SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
790016 Benign: not provided 24,498,506(-) C/T SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
VAR_036102 A breast cancer sample p.Val371Leu
rs1395027 - p.Ser413Phe

Additional dbSNP identifiers (rs#s) for CDH10 Gene

Structural Variations from Database of Genomic Variants (DGV) for CDH10 Gene

Variant ID Type Subtype PubMed ID
esv1416666 CNV insertion 17803354
esv25919 CNV loss 19812545
esv2657466 CNV deletion 23128226
esv2670513 CNV deletion 23128226
esv2759334 CNV loss 17122850
esv3380329 OTHER inversion 20981092
esv3444242 CNV insertion 20981092
esv3604397 CNV loss 21293372
esv3604398 CNV loss 21293372
nsv1022665 CNV loss 25217958
nsv1131878 CNV deletion 24896259
nsv4765 CNV insertion 18451855
nsv476676 CNV novel sequence insertion 20440878
nsv512848 CNV insertion 21212237
nsv597607 CNV loss 21841781
nsv597608 CNV loss 21841781
nsv7369 OTHER inversion 18451855
nsv830236 CNV loss 17160897

Variation tolerance for CDH10 Gene

Residual Variation Intolerance Score: 3.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDH10 Gene

Human Gene Mutation Database (HGMD)
CDH10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDH10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH10 Gene

Disorders for CDH10 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CDH10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
obsessive-compulsive disorder
  • ocd
childhood disintegrative disease
  • disintegrative psychosis
autism
  • autistic disorder
pervasive developmental disorder
  • pervasive development disorder
- elite association - COSMIC cancer census association via MalaCards
Search CDH10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CDH10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CDH10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDH10 Gene

Publications for CDH10 Gene

  1. Common genetic variants on 5p14.1 associate with autism spectrum disorders. (PMID: 19404256) Wang K … Hakonarson H (Nature 2009) 3 23 41 54
  2. The human cadherin-10 gene: complete coding sequence, predominant expression in the brain, and mapping on chromosome 5p13-14. (PMID: 10386616) Kools P … van Roy F (FEBS letters 1999) 3 4 23 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. A genome-wide association study of autism reveals a common novel risk locus at 5p14.1. (PMID: 19456320) Ma D … Pericak-Vance MA (Annals of human genetics 2009) 3 41 54
  5. Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. (PMID: 10861224) Shimoyama Y … Natori M (The Biochemical journal 2000) 3 4 54

Products for CDH10 Gene

Sources for CDH10 Gene