Aliases for CDCP2 Gene

Aliases for CDCP2 Gene

  • CUB Domain Containing Protein 2 2 3 5
  • CUB Domain-Containing Protein 2 3 4
  • CDCP2 5

External Ids for CDCP2 Gene

Previous GeneCards Identifiers for CDCP2 Gene

  • GC01M054322
  • GC01M054605
  • GC01M052721

Summaries for CDCP2 Gene

GeneCards Summary for CDCP2 Gene

CDCP2 (CUB Domain Containing Protein 2) is a Protein Coding gene. Diseases associated with CDCP2 include Brachial Plexus Neuritis and Osteosclerotic Myeloma. An important paralog of this gene is CUBN.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDCP2 Gene

Genomics for CDCP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDCP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDCP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDCP2

Top Transcription factor binding sites by QIAGEN in the CDCP2 gene promoter:
  • AML1a
  • C/EBPalpha
  • Pax-2
  • Pax-2a
  • Pax-6
  • PPAR-gamma1
  • PPAR-gamma2
  • RFX1
  • Roaz
  • SRF

Genomic Locations for CDCP2 Gene

Latest Assembly
chr1:54,132,687-54,153,770
(GRCh38/hg38)
Size:
21,084 bases
Orientation:
Minus strand

Previous Assembly
chr1:54,598,360-54,618,854
(GRCh37/hg19 by Entrez Gene)
Size:
20,495 bases
Orientation:
Minus strand

chr1:54,598,747-54,619,443
(GRCh37/hg19 by Ensembl)
Size:
20,697 bases
Orientation:
Minus strand

Genomic View for CDCP2 Gene

Genes around CDCP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDCP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDCP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDCP2 Gene

Proteins for CDCP2 Gene

  • Protein details for CDCP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VXM1-CDCP2_HUMAN
    Recommended name:
    CUB domain-containing protein 2
    Protein Accession:
    Q5VXM1
    Secondary Accessions:
    • Q6ZWJ3

    Protein attributes for CDCP2 Gene

    Size:
    449 amino acids
    Molecular mass:
    48752 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDCP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDCP2 Gene

Post-translational modifications for CDCP2 Gene

  • Glycosylation at Asn40 and Asn267

Other Protein References for CDCP2 Gene

No data available for DME Specific Peptides for CDCP2 Gene

Domains & Families for CDCP2 Gene

Gene Families for CDCP2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CDCP2 Gene

InterPro:
Blocks:
  • CUB domain

Suggested Antigen Peptide Sequences for CDCP2 Gene

GenScript: Design optimal peptide antigens:
  • CUB domain-containing protein 2 (CDCP2_HUMAN)
genes like me logo Genes that share domains with CDCP2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CDCP2 Gene

Function for CDCP2 Gene

Phenotypes From GWAS Catalog for CDCP2 Gene

genes like me logo Genes that share phenotypes with CDCP2: view

Animal Models for research

  • Taconic Biosciences Mouse Models for CDCP2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDCP2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDCP2 Gene

Localization for CDCP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDCP2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDCP2 gene
Compartment Confidence
extracellular 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for CDCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDCP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CDCP2 Gene

Pathways & Interactions for CDCP2 Gene

PathCards logo

SuperPathways for CDCP2 Gene

No Data Available

Interacting Proteins for CDCP2 Gene

Selected Interacting proteins: Q5VXM1-CDCP2_HUMAN for CDCP2 Gene via IID

Symbol External ID(s) Details
C1S
MASP2

Gene Ontology (GO) - Biological Process for CDCP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CDCP2 Gene

Drugs & Compounds for CDCP2 Gene

No Compound Related Data Available

Transcripts for CDCP2 Gene

mRNA/cDNA for CDCP2 Gene

2 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDCP2

Alternative Splicing Database (ASD) splice patterns (SP) for CDCP2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14
SP1: - - - - - - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: - -
SP6: -
SP7: - - - - -
SP8: - - - -
SP9:

Relevant External Links for CDCP2 Gene

GeneLoc Exon Structure for
CDCP2

Expression for CDCP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDCP2 Gene

mRNA differential expression in normal tissues according to GTEx for CDCP2 Gene

This gene is overexpressed in Spleen (x7.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDCP2

SOURCE GeneReport for Unigene cluster for CDCP2 Gene:

Hs.568555

Evidence on tissue expression from TISSUES for CDCP2 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with CDCP2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDCP2 Gene

Orthologs for CDCP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDCP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDCP2 29 30
  • 99.03 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CDCP2 30
  • 87 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Cdcp2 29 16 30
  • 86.88 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CDCP2 30
  • 64 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia CDCP2 30
  • 64 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CDCP2 30
  • 61 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CDCP2 30
  • 45 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CDCP2 30
  • 70 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii cdcp2 30
  • 42 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG42255 30
  • 3 (a)
ManyToMany
CG32702 30
  • 3 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea ZC116.3 30
  • 2 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 22 (a)
OneToOne
Species where no ortholog for CDCP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for CDCP2 Gene

ENSEMBL:
Gene Tree for CDCP2 (if available)
TreeFam:
Gene Tree for CDCP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDCP2: view image
Alliance of Genome Resources:
Additional Orthologs for CDCP2

Paralogs for CDCP2 Gene

(2) SIMAP similar genes for CDCP2 Gene using alignment to 1 proteins:

  • CDCP2_HUMAN
genes like me logo Genes that share paralogs with CDCP2: view

Variants for CDCP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDCP2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs3766465 -- p.Gly244Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CDCP2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CDCP2 Gene

Variant ID Type Subtype PubMed ID
dgv44e199 CNV deletion 23128226
dgv5n21 CNV loss 19592680
esv24487 CNV loss 19812545
esv3586084 CNV loss 21293372
esv3586085 CNV loss 21293372

Variation tolerance for CDCP2 Gene

Residual Variation Intolerance Score: 85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.26; 94.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDCP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDCP2
Leiden Open Variation Database (LOVD)
CDCP2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDCP2 Gene

Disorders for CDCP2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CDCP2 Gene - From: COP

Disorder Aliases PubMed IDs
brachial plexus neuritis
  • brachial neuritis
osteosclerotic myeloma
bartter syndrome, type 3
  • barts3
wolff-parkinson-white syndrome
  • wpw syndrome
bartter disease
  • aldosteronism with hyperplasia of the adrenal cortex
- elite association - COSMIC cancer census association via MalaCards
Search CDCP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CDCP2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CDCP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDCP2 Gene

Publications for CDCP2 Gene

  1. Investigation of the PARK10 gene in Parkinson disease. (PMID: 17388942) Li YJ … Vance JM (Annals of human genetics 2007) 3 40
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4
  4. High-resolution whole-genome association study of Parkinson disease. (PMID: 16252231) Maraganore DM … Ballinger DG (American journal of human genetics 2005) 40
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4

Products for CDCP2 Gene

Sources for CDCP2 Gene