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Aliases for CDCP2 Gene

Aliases for CDCP2 Gene

  • CUB Domain Containing Protein 2 2 3 5

External Ids for CDCP2 Gene

Previous GeneCards Identifiers for CDCP2 Gene

  • GC01M054322
  • GC01M054605
  • GC01M052721

Summaries for CDCP2 Gene

GeneCards Summary for CDCP2 Gene

CDCP2 (CUB Domain Containing Protein 2) is a Protein Coding gene. An important paralog of this gene is CUBN.

Additional gene information for CDCP2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDCP2 Gene

Genomics for CDCP2 Gene

GeneHancer (GH) Regulatory Elements for CDCP2 Gene

Promoters and enhancers for CDCP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I054153 Enhancer 0.9 Ensembl ENCODE 550.8 -0.1 -111 0.9 ZNF792 SAP130 ZNF449 ETV1 MAX PYGO2 CEBPG RAD21 YY1 ZNF335 CDCP2 MRPL37 ENSG00000256407
GH01I054309 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -158.8 -158763 5.9 SIN3A RAD21 RARA GLIS2 ARID2 ZNF143 THAP11 EGR2 ZNF654 RXRA HSPB11 ENSG00000225632 SSBP3 SSBP3-AS1 CDCP2 TCEANC2 TMEM59 ENSG00000256407 TTC22 ENSG00000237453
GH01I054081 Enhancer 1.1 Ensembl ENCODE 11.2 +72.0 72021 0.3 FOXA2 RB1 ARID4B SIN3A IRF4 RAD21 RARA ZNF121 ZNF143 THAP11 TCEANC2 TMEM59 CDCP2 LDLRAD1 HSPB11 LRRC42 SSBP3-AS1 GC01P054077 LOC100507586
GH01I054297 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -145.2 -145153 3.6 OSR2 KLF1 KLF17 KLF4 ZIC2 CHD2 EZH2 SSBP3 SSBP3-AS1 CDCP2 ENSG00000237453 TTC22 MROH7 ENSG00000225632 GC01M054384
GH01I054218 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.3 -66.4 -66365 3.1 KLF1 MAX ZIC2 ZFHX2 POLR2B ZNF316 POLR2A EGR1 SCRT2 MAFK PIR40840 MRPL37 CDCP2 SSBP3-AS1 PIR51493
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CDCP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDCP2 gene promoter:

Genomic Locations for CDCP2 Gene

Genomic Locations for CDCP2 Gene
chr1:54,132,968-54,153,770
(GRCh38/hg38)
Size:
20,803 bases
Orientation:
Minus strand
chr1:54,598,747-54,619,443
(GRCh37/hg19)

Genomic View for CDCP2 Gene

Genes around CDCP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDCP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDCP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDCP2 Gene

Proteins for CDCP2 Gene

  • Protein details for CDCP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VXM1-CDCP2_HUMAN
    Recommended name:
    CUB domain-containing protein 2
    Protein Accession:
    Q5VXM1
    Secondary Accessions:
    • Q6ZWJ3

    Protein attributes for CDCP2 Gene

    Size:
    449 amino acids
    Molecular mass:
    48752 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDCP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDCP2 Gene

Post-translational modifications for CDCP2 Gene

  • Glycosylation at posLast=4040 and Asn267

Other Protein References for CDCP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDCP2 Gene

Domains & Families for CDCP2 Gene

Gene Families for CDCP2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CDCP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CDCP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDCP2: view

No data available for UniProtKB/Swiss-Prot for CDCP2 Gene

Function for CDCP2 Gene

Phenotypes From GWAS Catalog for CDCP2 Gene

genes like me logo Genes that share phenotypes with CDCP2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDCP2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDCP2 Gene

Localization for CDCP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDCP2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDCP2 gene
Compartment Confidence
extracellular 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for CDCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDCP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CDCP2 Gene

Pathways & Interactions for CDCP2 Gene

SuperPathways for CDCP2 Gene

No Data Available

Interacting Proteins for CDCP2 Gene

Selected Interacting proteins: Q5VXM1-CDCP2_HUMAN for CDCP2 Gene via IID

Symbol External ID(s) Details
C1S
MASP2

Gene Ontology (GO) - Biological Process for CDCP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CDCP2 Gene

Drugs & Compounds for CDCP2 Gene

No Compound Related Data Available

Transcripts for CDCP2 Gene

mRNA/cDNA for CDCP2 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(79) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDCP2 Gene

CUB domain containing protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDCP2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14
SP1: - - - - - - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: - -
SP6: -
SP7: - - - - -
SP8: - - - -
SP9:

Relevant External Links for CDCP2 Gene

GeneLoc Exon Structure for
CDCP2
ECgene alternative splicing isoforms for
CDCP2

Expression for CDCP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDCP2 Gene

mRNA differential expression in normal tissues according to GTEx for CDCP2 Gene

This gene is overexpressed in Spleen (x7.4).

NURSA nuclear receptor signaling pathways regulating expression of CDCP2 Gene:

CDCP2

SOURCE GeneReport for Unigene cluster for CDCP2 Gene:

Hs.568555

Evidence on tissue expression from TISSUES for CDCP2 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with CDCP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDCP2 Gene

Orthologs for CDCP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDCP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDCP2 33 34
  • 99.03 (n)
dog
(Canis familiaris)
Mammalia CDCP2 34
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdcp2 33 16 34
  • 86.88 (n)
cow
(Bos Taurus)
Mammalia CDCP2 34
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDCP2 34
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDCP2 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDCP2 34
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDCP2 34
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cdcp2 34
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG32702 34
  • 3 (a)
ManyToMany
CG42255 34
  • 3 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ZC116.3 34
  • 2 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
OneToOne
Species where no ortholog for CDCP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CDCP2 Gene

ENSEMBL:
Gene Tree for CDCP2 (if available)
TreeFam:
Gene Tree for CDCP2 (if available)

Paralogs for CDCP2 Gene

Paralogs for CDCP2 Gene

(2) SIMAP similar genes for CDCP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDCP2: view

Variants for CDCP2 Gene

Sequence variations from dbSNP and Humsavar for CDCP2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000249456 -- 54,144,019(-) G/T intron_variant
rs1000294561 -- 54,144,267(-) C/T intron_variant
rs1000526750 -- 54,152,154(-) GGAGGAG/GGAG intron_variant
rs1000628871 -- 54,142,891(-) T/C intron_variant
rs1000934805 -- 54,154,457(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CDCP2 Gene

Variant ID Type Subtype PubMed ID
dgv44e199 CNV deletion 23128226
dgv5n21 CNV loss 19592680
esv24487 CNV loss 19812545
esv3586084 CNV loss 21293372
esv3586085 CNV loss 21293372

Variation tolerance for CDCP2 Gene

Residual Variation Intolerance Score: 85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.26; 94.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDCP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDCP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDCP2 Gene

Disorders for CDCP2 Gene

Additional Disease Information for CDCP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CDCP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDCP2 Gene

Publications for CDCP2 Gene

  1. Investigation of the PARK10 gene in Parkinson disease. (PMID: 17388942) Li YJ … Vance JM (Annals of human genetics 2007) 3 44 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  4. High-resolution whole-genome association study of Parkinson disease. (PMID: 16252231) Maraganore DM … Ballinger DG (American journal of human genetics 2005) 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for CDCP2 Gene

Sources for CDCP2 Gene

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