Aliases for CDCA8 Gene
External Ids for CDCA8 Gene
Previous GeneCards Identifiers for CDCA8 Gene
This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]
GeneCards Summary for CDCA8 Gene
CDCA8 (Cell Division Cycle Associated 8) is a Protein Coding gene. Diseases associated with CDCA8 include Cholestasis, Intrahepatic, Of Pregnancy, 1 and Polyposis Syndrome, Hereditary Mixed, 1. Among its related pathways are Signaling by GPCR and Metabolism of proteins.
UniProtKB/Swiss-Prot Summary for CDCA8 Gene
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.