This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 1... See more...

Aliases for CDCA8 Gene

Aliases for CDCA8 Gene

  • Cell Division Cycle Associated 8 2 3 5
  • Borealin 2 3 4
  • Pluripotent Embryonic Stem Cell-Related Gene 3 Protein 3 4
  • Cell Division Cycle-Associated Protein 8 3 4
  • HDasra-B 3 4
  • Dasra-B 3 4
  • DasraB 2 3
  • MESRGP 2 3
  • BOR 2 3
  • BOREALIN 3
  • FLJ12042 2
  • Dasra B 3
  • PESCRG3 4
  • CDCA8 5

External Ids for CDCA8 Gene

Previous GeneCards Identifiers for CDCA8 Gene

  • GC01U990479
  • GC01P037584
  • GC01P037585
  • GC01P037827
  • GC01P037931
  • GC01P038158
  • GC01P036275

Summaries for CDCA8 Gene

Entrez Gene Summary for CDCA8 Gene

  • This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]

GeneCards Summary for CDCA8 Gene

CDCA8 (Cell Division Cycle Associated 8) is a Protein Coding gene. Diseases associated with CDCA8 include Cholestasis, Intrahepatic, Of Pregnancy, 1 and Polyposis Syndrome, Hereditary Mixed, 1. Among its related pathways are Signaling by GPCR and Mitotic Prometaphase.

UniProtKB/Swiss-Prot Summary for CDCA8 Gene

  • Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.

Gene Wiki entry for CDCA8 Gene

Additional gene information for CDCA8 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDCA8 Gene

Genomics for CDCA8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDCA8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDCA8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDCA8

Top Transcription factor binding sites by QIAGEN in the CDCA8 gene promoter:
  • AML1a
  • AREB6
  • FOXD3
  • FOXF2
  • FOXL1
  • Ik-2
  • Nkx2-2
  • TBP
  • YY1

Genomic Locations for CDCA8 Gene

Genomic Locations for CDCA8 Gene
chr1:37,692,481-37,709,719
(GRCh38/hg38)
Size:
17,239 bases
Orientation:
Plus strand
chr1:38,158,090-38,175,391
(GRCh37/hg19)
Size:
17,302 bases
Orientation:
Plus strand

Genomic View for CDCA8 Gene

Genes around CDCA8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDCA8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDCA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDCA8 Gene

Proteins for CDCA8 Gene

  • Protein details for CDCA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53HL2-BOREA_HUMAN
    Recommended name:
    Borealin
    Protein Accession:
    Q53HL2
    Secondary Accessions:
    • D3DPT4
    • Q53HN1
    • Q96AM3
    • Q9NVW5

    Protein attributes for CDCA8 Gene

    Size:
    280 amino acids
    Molecular mass:
    31323 Da
    Quaternary structure:
    • May form homooligomers and homodimers. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex forms a triple-helix bundle-based subcomplex with INCENP and BIRC5 (PubMed:17956729). Interacts with SENP3, UBE2I and RANBP2. Interacts (phosphorylated) with SGO1 and SGO2; the association is dependent on CDK1.
    SequenceCaution:
    • Sequence=BG354581; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • Cells lacking CDCA8 display a slight decrease in histone H3 'Ser-10' phosphorylation, suggesting that the CPC complex mediates phosphorylation of 'Ser-10' of histone H3.

    Three dimensional structures from OCA and Proteopedia for CDCA8 Gene

neXtProt entry for CDCA8 Gene

Post-translational modifications for CDCA8 Gene

  • Phosphorylated by TTK, essentially at Thr-88, Thr94, Thr-169 and Thr-230. Phosphorylation (probably by CDK1) promotes targeting of the CPC to centromeric DNA.
  • Sumoylated by UBE2I and RANBP2. Desumoylated by SENP3 through the removal of SUMO2 and SUMO3.
  • Ubiquitination at Lys37 and Lys183
  • Modification sites at PhosphoSitePlus

Other Protein References for CDCA8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDCA8 Gene

Domains & Families for CDCA8 Gene

Gene Families for CDCA8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CDCA8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDCA8 Gene

GenScript: Design optimal peptide antigens:
  • Pluripotent embryonic stem cell-related gene 3 protein (BOREA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q53HL2

UniProtKB/Swiss-Prot:

BOREA_HUMAN :
  • The C-terminal region (aa 207-280) represents the dimerization motif.
  • Belongs to the borealin family.
Domain:
  • The C-terminal region (aa 207-280) represents the dimerization motif.
Family:
  • Belongs to the borealin family.
genes like me logo Genes that share domains with CDCA8: view

Function for CDCA8 Gene

Molecular function for CDCA8 Gene

UniProtKB/Swiss-Prot Function:
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.

Phenotypes From GWAS Catalog for CDCA8 Gene

Gene Ontology (GO) - Molecular Function for CDCA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239925
genes like me logo Genes that share ontologies with CDCA8: view
genes like me logo Genes that share phenotypes with CDCA8: view

Animal Models for CDCA8 Gene

MGI Knock Outs for CDCA8:
  • Cdca8 Cdca8<tm1Tatn>
  • Cdca8 Cdca8<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDCA8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDCA8 Gene

Localization for CDCA8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDCA8 Gene

Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in interphase cells. {ECO:0000269 PubMed:18946085}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDCA8 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 4
plasma membrane 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
peroxisome 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (4)
  • Nucleoli (4)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDCA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IBA,IDA 15260989
GO:0005623 cell IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with CDCA8: view

Pathways & Interactions for CDCA8 Gene

genes like me logo Genes that share pathways with CDCA8: view

Pathways by source for CDCA8 Gene

1 BioSystems pathway for CDCA8 Gene

SIGNOR curated interactions for CDCA8 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CDCA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IBA 21873635
GO:0007049 cell cycle IEA --
GO:0007080 mitotic metaphase plate congression IMP 15260989
GO:0051276 chromosome organization IMP 15260989
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CDCA8: view

Drugs & Compounds for CDCA8 Gene

No Compound Related Data Available

Transcripts for CDCA8 Gene

mRNA/cDNA for CDCA8 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDCA8

Alternative Splicing Database (ASD) splice patterns (SP) for CDCA8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: -
SP3:
SP4: -

Relevant External Links for CDCA8 Gene

GeneLoc Exon Structure for
CDCA8

Expression for CDCA8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDCA8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDCA8 Gene

This gene is overexpressed in Testis (x7.8).

Protein differential expression in normal tissues from HIPED for CDCA8 Gene

This gene is overexpressed in Lung (54.5) and Testis (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDCA8 Gene



Protein tissue co-expression partners for CDCA8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDCA8

SOURCE GeneReport for Unigene cluster for CDCA8 Gene:

Hs.524571

Evidence on tissue expression from TISSUES for CDCA8 Gene

  • Intestine(4.5)
  • Kidney(4.4)
  • Lung(4.2)
  • Heart(4.2)
  • Nervous system(3.2)
  • Skin(2.6)
genes like me logo Genes that share expression patterns with CDCA8: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDCA8 Gene

Orthologs for CDCA8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDCA8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDCA8 30 31
  • 99.29 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CDCA8 30 31
  • 87.93 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CDCA8 30 31
  • 87.48 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cdca8 30 17 31
  • 81.71 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cdca8 30
  • 81.12 (n)
Oppossum
(Monodelphis domestica)
Mammalia CDCA8 31
  • 74 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CDCA8 31
  • 57 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CDCA8 31
  • 44 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CDCA8 31
  • 39 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cdca8 30
  • 52.56 (n)
Zebrafish
(Danio rerio)
Actinopterygii cdca8 30 31
  • 48.62 (n)
OneToOne
Species where no ortholog for CDCA8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CDCA8 Gene

ENSEMBL:
Gene Tree for CDCA8 (if available)
TreeFam:
Gene Tree for CDCA8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDCA8: view image

Paralogs for CDCA8 Gene

Pseudogenes.org Pseudogenes for CDCA8 Gene

genes like me logo Genes that share paralogs with CDCA8: view

No data available for Paralogs for CDCA8 Gene

Variants for CDCA8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDCA8 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
782079 Likely Benign: not provided 37,707,064(+) C/T SYNONYMOUS_VARIANT
rs17851453 - p.Lys12Asn

Additional dbSNP identifiers (rs#s) for CDCA8 Gene

Structural Variations from Database of Genomic Variants (DGV) for CDCA8 Gene

Variant ID Type Subtype PubMed ID
nsv472046 CNV novel sequence insertion 20440878
nsv834746 CNV loss 17160897

Variation tolerance for CDCA8 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDCA8 Gene

Human Gene Mutation Database (HGMD)
CDCA8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDCA8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDCA8 Gene

Disorders for CDCA8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CDCA8 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search CDCA8 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with CDCA8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDCA8 Gene

Publications for CDCA8 Gene

  1. Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation. (PMID: 19530738) Bourhis E … Cochran AG (Biochemistry 2009) 3 4 23
  2. RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin. (PMID: 18946085) Klein UR … Muller S (Molecular biology of the cell 2009) 3 4 23
  3. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. (PMID: 18243099) Jelluma N … Kops GJ (Cell 2008) 3 4 23
  4. Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. (PMID: 17956729) Jeyaprakash AA … Conti E (Cell 2007) 3 4 23
  5. Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer. (PMID: 16427043) Chang JL … Chen CM (Experimental cell research 2006) 3 4 23

Products for CDCA8 Gene

  • Signalway Proteins for CDCA8

Sources for CDCA8 Gene