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Aliases for CDCA7L Gene

Aliases for CDCA7L Gene

  • Cell Division Cycle Associated 7 Like 2 3 5
  • Transcription Factor RAM2 3 4
  • JPO2 3 4
  • R1 3 4
  • Cell Division Cycle-Associated 7-Like Protein 3
  • Cell Division Cycle Associated 7-Like 2
  • Protein JPO2 4
  • RAM2 3
  • HR1 4

External Ids for CDCA7L Gene

Previous GeneCards Identifiers for CDCA7L Gene

  • GC07M021714
  • GC07M021907

Summaries for CDCA7L Gene

GeneCards Summary for CDCA7L Gene

CDCA7L (Cell Division Cycle Associated 7 Like) is a Protein Coding gene. Diseases associated with CDCA7L include Medulloblastoma. Among its related pathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. An important paralog of this gene is CDCA7.

UniProtKB/Swiss-Prot for CDCA7L Gene

  • Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.

Gene Wiki entry for CDCA7L Gene

Additional gene information for CDCA7L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDCA7L Gene

Genomics for CDCA7L Gene

GeneHancer (GH) Regulatory Elements for CDCA7L Gene

Promoters and enhancers for CDCA7L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J021941 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 662.1 +1.9 1866 5.9 FOXA2 CLOCK SIN3A FEZF1 ZNF2 YY1 ZNF213 E2F8 ZNF416 ZNF207 CDCA7L ASS1P11 EEF1A1P6 IL6 PIR47500
GH07J021947 Enhancer 0.7 ENCODE dbSUPER 650.7 -1.2 -1154 0.2 EED ETV6 PRDM1 SPI1 CDCA7L GC07P021987
GH07J021938 Enhancer 1.2 Ensembl ENCODE dbSUPER 23.6 +6.6 6614 2.2 PKNOX1 MZF1 STAT5A BMI1 FEZF1 BATF KLF5 IRF4 ZNF366 ATF7 CDCA7L IL6 PIR47500
GH07J021771 Enhancer 1.5 VISTA UCNEbase ENCODE 10.3 +173.7 173720 1.2 MEIS2 PKNOX1 ATF1 TEAD4 TAL1 ETS1 FOSL1 TCF12 POLR2A NCOR1 CDCA7L LOC100506178 PIR48952 GC07P021597 DNAH11
GH07J021426 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 5.6 +518.4 518356 3.3 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 SP4 CDCA7L ENSG00000229949
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDCA7L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDCA7L gene promoter:
  • AML1a
  • Sp1
  • FAC1
  • MZF-1

Genomic Locations for CDCA7L Gene

Genomic Locations for CDCA7L Gene
chr7:21,900,899-21,946,084
(GRCh38/hg38)
Size:
45,186 bases
Orientation:
Minus strand
chr7:21,940,517-21,985,702
(GRCh37/hg19)
Size:
45,186 bases
Orientation:
Minus strand

Genomic View for CDCA7L Gene

Genes around CDCA7L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDCA7L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDCA7L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDCA7L Gene

Proteins for CDCA7L Gene

  • Protein details for CDCA7L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GN5-CDA7L_HUMAN
    Recommended name:
    Cell division cycle-associated 7-like protein
    Protein Accession:
    Q96GN5
    Secondary Accessions:
    • A4D141
    • A6NF50
    • B3KTR5
    • B4DUT3
    • C9K0Y1
    • Q6PIL4
    • Q86YT0
    • Q8IXN5
    • Q96C70
    • Q9H9A2
    • Q9NPV2

    Protein attributes for CDCA7L Gene

    Size:
    454 amino acids
    Molecular mass:
    52206 Da
    Quaternary structure:
    • Interacts with MYC and PSIP1.
    Miscellaneous:
    • Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation.
    SequenceCaution:
    • Sequence=BAB14330.1; Type=Frameshift; Positions=260; Evidence={ECO:0000305};

    Alternative splice isoforms for CDCA7L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDCA7L Gene

Post-translational modifications for CDCA7L Gene

  • Ubiquitination at posLast=440440, posLast=347347, posLast=280280, and posLast=6363
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDCA7L Gene

Domains & Families for CDCA7L Gene

Gene Families for CDCA7L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CDCA7L Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDCA7L: view

No data available for UniProtKB/Swiss-Prot for CDCA7L Gene

Function for CDCA7L Gene

Molecular function for CDCA7L Gene

UniProtKB/Swiss-Prot Function:
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
UniProtKB/Swiss-Prot Induction:
By MYC overexpression in a concentration dependent manner in neuroblastoma cell line.

Phenotypes From GWAS Catalog for CDCA7L Gene

Gene Ontology (GO) - Molecular Function for CDCA7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CDCA7L: view
genes like me logo Genes that share phenotypes with CDCA7L: view

Animal Model Products

CRISPR Products

miRNA for CDCA7L Gene

miRTarBase miRNAs that target CDCA7L

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDCA7L

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDCA7L Gene

Localization for CDCA7L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDCA7L Gene

Cytoplasm. Nucleus. Note=Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDCA7L gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDCA7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA 15994933
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CDCA7L: view

Pathways & Interactions for CDCA7L Gene

genes like me logo Genes that share pathways with CDCA7L: view

Pathways by source for CDCA7L Gene

Gene Ontology (GO) - Biological Process for CDCA7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008284 positive regulation of cell proliferation IEA,IDA 15994933
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CDCA7L: view

No data available for SIGNOR curated interactions for CDCA7L Gene

Drugs & Compounds for CDCA7L Gene

No Compound Related Data Available

Transcripts for CDCA7L Gene

mRNA/cDNA for CDCA7L Gene

Unigene Clusters for CDCA7L Gene

Cell division cycle associated 7-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDCA7L

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDCA7L Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6: -
SP7:

Relevant External Links for CDCA7L Gene

GeneLoc Exon Structure for
CDCA7L
ECgene alternative splicing isoforms for
CDCA7L

Expression for CDCA7L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDCA7L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDCA7L Gene

This gene is overexpressed in Fetal ovary (57.5) and Blymphocyte (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDCA7L Gene



Protein tissue co-expression partners for CDCA7L Gene

NURSA nuclear receptor signaling pathways regulating expression of CDCA7L Gene:

CDCA7L

SOURCE GeneReport for Unigene cluster for CDCA7L Gene:

Hs.744069

mRNA Expression by UniProt/SwissProt for CDCA7L Gene:

Q96GN5-CDA7L_HUMAN
Tissue specificity: Ubiquitous. Overexpressed in medulloblastoma.

Evidence on tissue expression from TISSUES for CDCA7L Gene

  • Lung(4.2)
  • Muscle(4.2)
  • Eye(4.1)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with CDCA7L: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDCA7L Gene

Orthologs for CDCA7L Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDCA7L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDCA7L 34 33
  • 99.34 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CDCA7L 34 33
  • 87.2 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CDCA7L 34 33
  • 86.41 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdca7l 33
  • 80.92 (n)
mouse
(Mus musculus)
Mammalia Cdca7l 16 34 33
  • 80.2 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDCA7L 34
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDCA7L 34
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDCA7L 34 33
  • 66.96 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDCA7L 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdca7l 33
  • 64.29 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4910 33
zebrafish
(Danio rerio)
Actinopterygii cdca7b 34 33
  • 52.44 (n)
OneToOne
Species where no ortholog for CDCA7L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDCA7L Gene

ENSEMBL:
Gene Tree for CDCA7L (if available)
TreeFam:
Gene Tree for CDCA7L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDCA7L: view image

Paralogs for CDCA7L Gene

Paralogs for CDCA7L Gene

(1) SIMAP similar genes for CDCA7L Gene using alignment to 5 proteins:

  • CDA7L_HUMAN
  • C9IZR6_HUMAN
  • C9J8L0_HUMAN
  • C9JFL7_HUMAN
  • H7C1J6_HUMAN

Pseudogenes.org Pseudogenes for CDCA7L Gene

genes like me logo Genes that share paralogs with CDCA7L: view

Variants for CDCA7L Gene

Sequence variations from dbSNP and Humsavar for CDCA7L Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs12700325 likely-benign, Primary ciliary dyskinesia 21,901,821(-) A/G 3_prime_UTR_variant
rs143362381 conflicting-interpretations-of-pathogenicity, benign, not specified, Primary ciliary dyskinesia 21,901,198(-) G/A 3_prime_UTR_variant
rs150682314 likely-benign, conflicting-interpretations-of-pathogenicity, not specified, Primary ciliary dyskinesia 21,901,008(-) C/T 3_prime_UTR_variant
rs183031009 likely-benign, Primary ciliary dyskinesia 21,901,109(-) G/A 3_prime_UTR_variant
rs192395057 uncertain-significance, Primary ciliary dyskinesia 21,901,380(-) G/A/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for CDCA7L Gene

Variant ID Type Subtype PubMed ID
esv275068 CNV loss 21479260
esv3343555 CNV insertion 20981092
esv3571696 CNV loss 25503493
nsv1027453 CNV gain 25217958
nsv7393 OTHER inversion 18451855
nsv830922 CNV loss 17160897

Variation tolerance for CDCA7L Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDCA7L Gene

Human Gene Mutation Database (HGMD)
CDCA7L
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDCA7L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDCA7L Gene

Disorders for CDCA7L Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDCA7L Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
medulloblastoma
  • mdb
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CDCA7L

genes like me logo Genes that share disorders with CDCA7L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDCA7L Gene

Publications for CDCA7L Gene

  1. Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway. (PMID: 16829576) Ou XM … Shih JC (Proceedings of the National Academy of Sciences of the United States of America 2006) 2 3 4 58
  2. R1, a novel repressor of the human monoamine oxidase A. (PMID: 15654081) Chen K … Shih JC (The Journal of biological chemistry 2005) 3 4 22 58
  3. A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PMID: 20189936) Okada Y … Kamatani N (Human molecular genetics 2010) 3 44 58
  4. Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1. (PMID: 16728402) Ou XM … Shih JC (The Journal of biological chemistry 2006) 3 4 58
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58

Products for CDCA7L Gene

Sources for CDCA7L Gene

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