Aliases for CDCA7 Gene
External Ids for CDCA7 Gene
Previous GeneCards Identifiers for CDCA7 Gene
This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDCA7 Gene
CDCA7 (Cell Division Cycle Associated 7) is a Protein Coding gene. Diseases associated with CDCA7 include Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 3 and Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome. Among its related pathways are Validated targets of C-MYC transcriptional activation. An important paralog of this gene is CDCA7L.
UniProtKB/Swiss-Prot Summary for CDCA7 Gene
Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator.