Aliases for CDCA5 Gene

Aliases for CDCA5 Gene

  • Cell Division Cycle Associated 5 2 3 5
  • Sororin 2 3 4
  • Cell Division Cycle-Associated Protein 5 3 4
  • P35 3 4
  • SORORIN 3
  • CDCA5 5

External Ids for CDCA5 Gene

Previous GeneCards Identifiers for CDCA5 Gene

  • GC11U990624
  • GC11M065095
  • GC11M064620
  • GC11M064601
  • GC11M064844
  • GC11M061171
  • GC11M064833

Summaries for CDCA5 Gene

GeneCards Summary for CDCA5 Gene

CDCA5 (Cell Division Cycle Associated 5) is a Protein Coding gene. Diseases associated with CDCA5 include Cornelia De Lange Syndrome and Warsaw Breakage Syndrome. Among its related pathways are Mitotic Prometaphase and Regulation of activated PAK-2p34 by proteasome mediated degradation. Gene Ontology (GO) annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot Summary for CDCA5 Gene

  • Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair.

Gene Wiki entry for CDCA5 Gene

Additional gene information for CDCA5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDCA5 Gene

Genomics for CDCA5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDCA5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDCA5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDCA5

Top Transcription factor binding sites by QIAGEN in the CDCA5 gene promoter:
  • C/EBPalpha
  • FOXO1
  • FOXO1a
  • ISGF-3
  • p53
  • Pax-4a
  • SRF
  • SRF (504 AA)

Genomic Locations for CDCA5 Gene

Genomic Locations for CDCA5 Gene
chr11:65,061,009-65,084,164
(GRCh38/hg38)
Size:
23,156 bases
Orientation:
Minus strand
chr11:64,833,772-64,851,636
(GRCh37/hg19)
Size:
17,865 bases
Orientation:
Minus strand

Genomic View for CDCA5 Gene

Genes around CDCA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDCA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDCA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDCA5 Gene

Proteins for CDCA5 Gene

  • Protein details for CDCA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FF9-CDCA5_HUMAN
    Recommended name:
    Sororin
    Protein Accession:
    Q96FF9
    Secondary Accessions:
    • A8K625

    Protein attributes for CDCA5 Gene

    Size:
    252 amino acids
    Molecular mass:
    27601 Da
    Quaternary structure:
    • Interacts with the APC/C complex (By similarity). Interacts with the chromatin-bound cohesin complex; the interaction is indirect, occurs after DNA replication and requires acetylation of the cohesin component SMC3. Interacts (via the FGF motif) with PDS5A and PDS5B; the interaction is direct and prevents the interaction of PDS5A with WAPL.
    Miscellaneous:
    • Named sororin after the Latin word 'soror', which means 'sister', because of its critical role in sister chromatid cohesion.

neXtProt entry for CDCA5 Gene

Post-translational modifications for CDCA5 Gene

  • Phosphorylated. Phosphorylation, as cells enter mitosis, disrupts the interaction with PDS5A and relieves the inhibition of WAPL by CDCA5.
  • Ubiquitinated by the APC/C complex in G1, leading to its degradation.
  • Ubiquitination at Lys99
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDCA5 Gene

Domains & Families for CDCA5 Gene

Gene Families for CDCA5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CDCA5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDCA5 Gene

GenScript: Design optimal peptide antigens:
  • p35 (CDCA5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96FF9

UniProtKB/Swiss-Prot:

CDCA5_HUMAN :
  • The KEN box is required for the association with the APC/C complex.
  • Belongs to the sororin family.
Domain:
  • The KEN box is required for the association with the APC/C complex.
Family:
  • Belongs to the sororin family.
genes like me logo Genes that share domains with CDCA5: view

Function for CDCA5 Gene

Molecular function for CDCA5 Gene

UniProtKB/Swiss-Prot Function:
Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair.

Phenotypes From GWAS Catalog for CDCA5 Gene

Gene Ontology (GO) - Molecular Function for CDCA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding TAS 15837422
GO:0005515 protein binding IPI 21111234
GO:0044877 protein-containing complex binding IDA 15837422
genes like me logo Genes that share ontologies with CDCA5: view
genes like me logo Genes that share phenotypes with CDCA5: view

Animal Models for CDCA5 Gene

MGI Knock Outs for CDCA5:
  • Cdca5 Cdca5<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for CDCA5 Gene

miRTarBase miRNAs that target CDCA5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDCA5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDCA5 Gene

Localization for CDCA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDCA5 Gene

Nucleus. Chromosome. Cytoplasm. Note=Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDCA5 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 2
cytoskeleton 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CDCA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region TAS --
GO:0000785 chromatin IEA --
GO:0000790 nuclear chromatin IEA,ISS --
GO:0005623 cell IEA --
GO:0005634 nucleus IBA,ISS --
genes like me logo Genes that share ontologies with CDCA5: view

Pathways & Interactions for CDCA5 Gene

genes like me logo Genes that share pathways with CDCA5: view

Pathways by source for CDCA5 Gene

Gene Ontology (GO) - Biological Process for CDCA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IDA 15837422
GO:0006302 double-strand break repair IBA,IMP 17349791
GO:0007049 cell cycle IEA --
GO:0007064 mitotic sister chromatid cohesion IBA,IPI 21111234
GO:0007076 mitotic chromosome condensation IBA,IMP 15837422
genes like me logo Genes that share ontologies with CDCA5: view

No data available for SIGNOR curated interactions for CDCA5 Gene

Drugs & Compounds for CDCA5 Gene

No Compound Related Data Available

Transcripts for CDCA5 Gene

mRNA/cDNA for CDCA5 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDCA5

Alternative Splicing Database (ASD) splice patterns (SP) for CDCA5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: - -
SP2: - -
SP3:
SP4:

Relevant External Links for CDCA5 Gene

GeneLoc Exon Structure for
CDCA5

Expression for CDCA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDCA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDCA5 Gene

This gene is overexpressed in Testis (x9.5).

Protein differential expression in normal tissues from HIPED for CDCA5 Gene

This gene is overexpressed in Fetal ovary (55.8) and Fetal Liver (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDCA5 Gene



Protein tissue co-expression partners for CDCA5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDCA5

SOURCE GeneReport for Unigene cluster for CDCA5 Gene:

Hs.434886

Evidence on tissue expression from TISSUES for CDCA5 Gene

  • Lung(4.2)
  • Nervous system(3.1)
  • Skin(2.6)
  • Intestine(2.4)
genes like me logo Genes that share expression patterns with CDCA5: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDCA5 Gene

Orthologs for CDCA5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDCA5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDCA5 30 31
  • 99.47 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC612071 30
  • 84.13 (n)
CDCA5 31
  • 77 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia CDCA5 30 31
  • 80.97 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC100910252 30
  • 75.21 (n)
Mouse
(Mus musculus)
Mammalia Cdca5 30 17 31
  • 74.9 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CDCA5 31
  • 45 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cdca5 30
  • 48.61 (n)
Str.11789 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.12922 30
Species where no ortholog for CDCA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CDCA5 Gene

ENSEMBL:
Gene Tree for CDCA5 (if available)
TreeFam:
Gene Tree for CDCA5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDCA5: view image

Paralogs for CDCA5 Gene

No data available for Paralogs for CDCA5 Gene

Variants for CDCA5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDCA5 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
709975 Likely Benign: not provided 65,079,377(-) C/T SYNONYMOUS_VARIANT
714410 Likely Benign: not provided 65,083,354(-) G/A INTRON_VARIANT
716423 Benign: not provided 65,079,716(-) T/C SYNONYMOUS_VARIANT
720322 Benign: not provided 65,079,664(-) C/T MISSENSE_VARIANT
729058 Benign: not provided 65,079,671(-) A/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for CDCA5 Gene

Structural Variations from Database of Genomic Variants (DGV) for CDCA5 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV gain 19592680

Variation tolerance for CDCA5 Gene

Residual Variation Intolerance Score: 80.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDCA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDCA5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDCA5 Gene

Disorders for CDCA5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CDCA5 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CDCA5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CDCA5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CDCA5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDCA5 Gene

Publications for CDCA5 Gene

  1. Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. (PMID: 15837422) Rankin S … Kirschner MW (Molecular cell 2005) 2 3 4 23
  2. Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase. (PMID: 17349791) Schmitz J … Peters JM (Current biology : CB 2007) 3 4 23
  3. Drug target discovery by gene expression analysis: cell cycle genes. (PMID: 12188893) Walker MG (Current cancer drug targets 2001) 2 3 4
  4. Sororin mediates sister chromatid cohesion by antagonizing Wapl. (PMID: 21111234) Nishiyama T … Peters JM (Cell 2010) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41

Products for CDCA5 Gene

Sources for CDCA5 Gene