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CDCA5 (Cell Division Cycle Associated 5) is a Protein Coding gene. Diseases associated with CDCA5 include Cornelia De Lange Syndrome and Warsaw Breakage Syndrome. Among its related pathways are Mitotic Prometaphase and Regulation of activated PAK-2p34 by proteasome mediated degradation. Gene Ontology (GO) annotations related to this gene include chromatin binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003682 | chromatin binding | TAS | 15837422 |
GO:0005515 | protein binding | IPI | 21111234 |
GO:0044877 | protein-containing complex binding | IDA | 15837422 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000775 | chromosome, centromeric region | TAS | -- |
GO:0000785 | chromatin | IEA | -- |
GO:0000790 | nuclear chromatin | IEA,ISS | -- |
GO:0005623 | cell | IEA | -- |
GO:0005634 | nucleus | IBA,ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cell Cycle, Mitotic |
.83
|
.60
|
2 | Mitotic Metaphase and Anaphase |
.94
|
|
3 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.78
|
|
4 | Mitotic Prometaphase | ||
5 | MicroRNAs in cancer |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000278 | mitotic cell cycle | IDA | 15837422 |
GO:0006302 | double-strand break repair | IBA,IMP | 17349791 |
GO:0007049 | cell cycle | IEA | -- |
GO:0007064 | mitotic sister chromatid cohesion | IBA,IPI | 21111234 |
GO:0007076 | mitotic chromosome condensation | IBA,IMP | 15837422 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||
SP2: | - | - | |||||||||||||||||||
SP3: | |||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CDCA5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LOC612071 30 |
|
||
CDCA5 31 |
|
OneToOne | |||
Cow (Bos Taurus) |
Mammalia | CDCA5 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | LOC100910252 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cdca5 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CDCA5 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cdca5 30 |
|
||
Str.11789 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.12922 30 |
|
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
709975 | Likely Benign: not provided | 65,079,377(-) | C/T | SYNONYMOUS_VARIANT | |
714410 | Likely Benign: not provided | 65,083,354(-) | G/A | INTRON_VARIANT | |
716423 | Benign: not provided | 65,079,716(-) | T/C | SYNONYMOUS_VARIANT | |
720322 | Benign: not provided | 65,079,664(-) | C/T | MISSENSE_VARIANT | |
729058 | Benign: not provided | 65,079,671(-) | A/T | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
cornelia de lange syndrome |
|
|
warsaw breakage syndrome |
|
|
roberts syndrome |
|
|
fanconi anemia, complementation group a |
|
|