Aliases for CDCA4 Gene
External Ids for CDCA4 Gene
Previous GeneCards Identifiers for CDCA4 Gene
This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulation of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1. [provided by RefSeq, May 2014]
GeneCards Summary for CDCA4 Gene
CDCA4 (Cell Division Cycle Associated 4) is a Protein Coding gene. Diseases associated with CDCA4 include Gillespie Syndrome and Short-Rib Thoracic Dysplasia 4 With Or Without Polydactyly. An important paralog of this gene is SERTAD2.
UniProtKB/Swiss-Prot Summary for CDCA4 Gene
May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity).