Aliases for CDCA3 Gene
Aliases for CDCA3 Gene
External Ids for CDCA3 Gene
- HGNC: 14624
- Entrez Gene: 83461
- Ensembl: ENSG00000111665
- OMIM: 607749
- UniProtKB: Q99618
Previous GeneCards Identifiers for CDCA3 Gene
- GC12U990228
- GC12M006833
- GC12M006828
- GC12M006959
- GC12M006960
Summaries for CDCA3 Gene
GeneCards Summary for CDCA3 Gene
CDCA3 (Cell Division Cycle Associated 3) is a Protein Coding gene. Diseases associated with CDCA3 include Night Blindness, Congenital Stationary, Type 1H. Among its related pathways are Cell cycle_Role of APC in cell cycle regulation.
UniProtKB/Swiss-Prot for CDCA3 Gene
-
F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity).
Additional gene information for CDCA3 Gene
- Monarch Initiative
- Search for CDCA3 at DataMed
- Search for CDCA3 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDCA3 Gene
Genomics for CDCA3 Gene
GeneHancer (GH) Regulatory Elements for CDCA3 Gene
Promoters and enhancers for CDCA3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CDCA3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CDCA3 gene promoter:
-
- ATF-2
- c-Jun
- PPAR-gamma2
- PPAR-gamma1
- AP-1
- c-Fos
- c-Ets-1
- GATA-2
Regulatory Element Products
Genomic Locations for CDCA3 Gene
Genomic Locations for CDCA3 Gene
- chr12:6,844,793-6,852,066
- (GRCh38/hg38)
- Size:
- 7,274 bases
- Orientation:
- Minus strand
- chr12:6,953,957-6,961,230
- (GRCh37/hg19)
- Size:
- 7,274 bases
- Orientation:
- Minus strand
Genomic View for CDCA3 Gene
Genes around CDCA3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.31 by Entrez Gene
- 12p13.31 by HGNC
- 12p13.31 by Ensembl
CDCA3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CDCA3 Gene
Proteins for CDCA3 Gene
-
Protein details for CDCA3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99618-CDCA3_HUMAN
- Recommended name:
- Cell division cycle-associated protein 3
- Protein Accession:
- Q99618
- A8K5V6
- D3DUS6
Protein attributes for CDCA3 Gene
- Size:
- 268 amino acids
- Molecular mass:
- 28998 Da
- Quaternary structure:
-
- Interacts with SKP1. Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity).
Protein Expression for CDCA3 Gene
Post-translational modifications for CDCA3 Gene
- Ubiquitinated and degraded by the APC/C-Cdh1 complex.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CDCA3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CDCA3
- Novus Biologicals Antibodies for CDCA3
-
Abcam antibodies for CDCA3
- Invitrogen Antibodies for CDCA3 (AFLGC-CDCA3)
- GeneTex CDCA3 Antibody for CDCA3
- Sino Biological Antibodies for CDCA3
Protein Products
-
OriGene Purified Proteins for CDCA3
- Search Origene for MassSpec and Protein Over-expression Lysates for CDCA3
- Origene Custom Protein Services for CDCA3
- antibodies-online: Search results for 5 available CDCA3 Proteins ranked by validation data
- Compare Top CDCA3 Proteins
-
Quality Products:
- Search GeneTex for Proteins for CDCA3
-
Abcam proteins for CDCA3
Assay Products
No data available for DME Specific Peptides for CDCA3 Gene
Domains & Families for CDCA3 Gene
Gene Families for CDCA3 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CDCA3 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for CDCA3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q99618UniProtKB/Swiss-Prot:
CDCA3_HUMAN :- The KEN box is required for the association with the APC/C-Cdh1 complex.
- Domain:
-
- The KEN box is required for the association with the APC/C-Cdh1 complex.
Function for CDCA3 Gene
Molecular function for CDCA3 Gene
- UniProtKB/Swiss-Prot Function:
- F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity).
Phenotypes From GWAS Catalog for CDCA3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
Phenotypes for CDCA3 Gene
- GenomeRNAi human phenotypes for CDCA3:
-
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased viability
- no effect
- Synthetic lethal with Ras
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Increased cell number in S
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CDCA3
-
CRISPR Products
-
OriGene CRISPR knockouts for CDCA3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDCA3
- genomics-online: gRNA clones - Search results for 110 available CDCA3 gene related products
- Overview of 110 available CDCA3 gene related products
- Applied Biological Materials CRISPR for CDCA3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDCA3
- GenScript: Design CRISPR guide RNA sequences for CDCA3
miRNA for CDCA3 Gene
- miRTarBase miRNAs that target CDCA3
-
- hsa-mir-26b-5p (MIRT029492)
- hsa-mir-320a (MIRT044752)
- hsa-let-7e-5p (MIRT051450)
- hsa-mir-6739-5p (MIRT451801)
- hsa-mir-6733-5p (MIRT451802)
- hsa-mir-3153 (MIRT451803)
- hsa-mir-4668-5p (MIRT451804)
- hsa-mir-144-5p (MIRT451805)
- hsa-mir-5004-5p (MIRT451806)
- hsa-mir-3179 (MIRT451807)
- hsa-mir-4646-5p (MIRT451808)
- hsa-mir-204-3p (MIRT451809)
- hsa-mir-6791-5p (MIRT451810)
- hsa-mir-4292 (MIRT451811)
- hsa-mir-4308 (MIRT451812)
- hsa-mir-4733-3p (MIRT451813)
- hsa-mir-1226-3p (MIRT451814)
- hsa-mir-6866-3p (MIRT451815)
- hsa-mir-188-5p (MIRT451816)
- hsa-mir-6782-5p (MIRT451817)
- hsa-mir-3154 (MIRT451818)
- hsa-mir-3936 (MIRT451819)
- hsa-mir-1197 (MIRT508360)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDCA3
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- genomics-online: shRNA clones - Search results for 110 available CDCA3 gene related products
- Overview of 110 available CDCA3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CDCA3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDCA3
- Applied Biological Materials Clones for CDCA3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CDCA3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDCA3 Gene
Localization for CDCA3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CDCA3 Gene
- Cytoplasm, cytosol.
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| mitochondrion | 2 |
| extracellular | 1 |
| nucleus | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IEA | -- |
| GO:0005913 | cell-cell adherens junction | IDA | 25468996 |
Pathways & Interactions for CDCA3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell cycle_Role of APC in cell cycle regulation | ||
Pathways by source for CDCA3 Gene
1 GeneGo (Thomson Reuters) pathway for CDCA3 Gene
UniProtKB/Swiss-Prot Q99618-CDCA3_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for CDCA3 Gene
Selected Interacting proteins:
Q99618-CDCA3_HUMAN
ENSP00000442068
for CDCA3 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CDCA3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007049 | cell cycle | IEA | -- |
| GO:0008150 | biological_process | ND | -- |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0051301 | cell division | IEA | -- |
Transcripts for CDCA3 Gene
mRNA/cDNA for CDCA3 Gene
- (5) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (164) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000422785 2760 bps (uc001qre.3)
- ENST00000604599 2917 bps (uc058klx.1)
- ENST00000603043 1995 bps (uc001qrf.2)
- ENST00000538862 1943 bps (uc001qrg.3)
- ENST00000229265 1047 bps (uc058klz.1)
Unigene Clusters for CDCA3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CDCA3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDCA3
- genomics-online: gRNA clones - Search results for 110 available CDCA3 gene related products
- Overview of 110 available CDCA3 gene related products
- Applied Biological Materials CRISPR for CDCA3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDCA3
- GenScript: Design CRISPR guide RNA sequences for CDCA3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDCA3
- Browse OriGene Inhibitory RNA Products For CDCA3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDCA3
- genomics-online: shRNA clones - Search results for 110 available CDCA3 gene related products
- Overview of 110 available CDCA3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CDCA3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDCA3
- Applied Biological Materials Clones for CDCA3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||
| SP10: |
Expression for CDCA3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
-
Thymus (Hematopoietic System)
- Double Negative 2 Thymocytes Thymus
-
Blood (Cardiovascular System)
- Double Negative 2 Thymocytes Thymus
- Brain (Nervous System)
mRNA differential expression in normal tissues according to GTEx for CDCA3 Gene
This gene is overexpressed in Testis (x9.3).
This gene is overexpressed in Bone (62.7) and Fetal Liver (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDCA3 Gene
NURSA nuclear receptor signaling pathways regulating expression of CDCA3 Gene:
CDCA3SOURCE GeneReport for Unigene cluster for CDCA3 Gene:
Hs.524216Evidence on tissue expression from TISSUES for CDCA3 Gene
- Nervous system(4.4)
Primer Products
-
OriGene qPCR primer pairs for CDCA3
-
OriGene qPCR primer pairs and template standards for CDCA3
- genomics-online: primer clones - Search results for 110 available CDCA3 gene related products
- Overview of 110 available CDCA3 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDCA3 Gene
Orthologs for CDCA3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CDCA3 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CDCA3 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CDCA3 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Cdca3 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cdca3 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CDCA3 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CDCA3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CDCA3 33 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cdca3 33 |
|
- Species where no ortholog for CDCA3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for CDCA3 Gene
- ENSEMBL:
- Gene Tree for CDCA3 (if available)
- TreeFam:
- Gene Tree for CDCA3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CDCA3: view image
Paralogs for CDCA3 Gene
Pseudogenes.org Pseudogenes for CDCA3 Gene
No data available for Paralogs for CDCA3 Gene
Variants for CDCA3 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs5443 | drug-response, sildenafil response - Efficacy | 6,845,711(-) | C/T | genic_downstream_transcript_variant, non_coding_transcript_variant | |
| rs879253773 | pathogenic, Night blindness, congenital stationary, type 1h | 6,846,892(-) | G/A | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
| rs1001237782 | -- | 6,847,183(-) | C/A | genic_downstream_transcript_variant, intron_variant | |
| rs1001404924 | -- | 6,853,305(-) | G/A/C | upstream_transcript_variant | |
| rs1003545766 | -- | 6,848,991(-) | A/G | 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant |
Residual Variation Intolerance Score:
56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.31;
26.01% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CDCA3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CDCA3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDCA3 Gene
Disorders for CDCA3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| night blindness, congenital stationary, type 1h |
|
|
Search CDCA3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CDCA3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CDCA3 Gene
Publications for CDCA3 Gene
- Drug target discovery by gene expression analysis: cell cycle genes. (PMID: 12188893) Walker MG (Current cancer drug targets 2001) 2 3 4 58
- Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. (PMID: 9074930) Ansari-Lari MA … Gibbs RA (Genome research 1997) 2 3 4 58
- Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PMID: 20416077) Ban HJ … Park KJ (BMC genetics 2010) 3 44 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for CDCA3 Gene
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- Quality Products:
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Sources for CDCA3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
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