Aliases for CDCA2 Gene
External Ids for CDCA2 Gene
Previous GeneCards Identifiers for CDCA2 Gene
This gene encodes a targeting subunit of the cell-cycle associated protein, protein phosphatase 1, with a role in targeting this protein to chromatin during anaphase. These two proteins comprise a phosphatase complex that is involved in nuclear envelope reformation and regulation of the DNA damage response. The encoded protein may also play a role in cancer progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for CDCA2 Gene
CDCA2 (Cell Division Cycle Associated 2) is a Protein Coding gene. Diseases associated with CDCA2 include Uterine Adnexa Cancer and Retinitis Pigmentosa 75. Among its related pathways are DNA Damage. An important paralog of this gene is MKI67.
UniProtKB/Swiss-Prot Summary for CDCA2 Gene
Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.