This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same ... See more...

Aliases for CDC7 Gene

Aliases for CDC7 Gene

  • Cell Division Cycle 7 2 3 5
  • CDC7 (Cell Division Cycle 7, S. Cerevisiae, Homolog)-Like 1 2 3
  • Cell Division Cycle 7-Related Protein Kinase 3 4
  • CDC7-Related Kinase 3 4
  • CDC7L1 3 4
  • Cell Division Cycle 7 Homolog (S. Cerevisiae) 2
  • Epididymis Secretory Sperm Binding Protein 3
  • CDC7 Cell Division Cycle 7 (S. Cerevisiae) 2
  • Cell Division Cycle 7 (S. Cerevisiae) 2
  • Cell Division Cycle 7-Like Protein 1 3
  • Cell Division Cycle 7 Homolog 3
  • EC 2.7.11.1 4
  • HsCDC7 3
  • HuCDC7 3
  • HsCdc7 4
  • HuCdc7 4
  • Hsk1 3

External Ids for CDC7 Gene

Previous HGNC Symbols for CDC7 Gene

  • CDC7L1

Previous GeneCards Identifiers for CDC7 Gene

  • GC01P091303
  • GC01P091438
  • GC01P091678
  • GC01P091739
  • GC01P091966
  • GC01P090085

Summaries for CDC7 Gene

Entrez Gene Summary for CDC7 Gene

  • This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]

GeneCards Summary for CDC7 Gene

CDC7 (Cell Division Cycle 7) is a Protein Coding gene. Among its related pathways are E2F mediated regulation of DNA replication and Mitotic Roles of Polo Like Kinases. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TTBK1.

UniProtKB/Swiss-Prot Summary for CDC7 Gene

  • Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.

Tocris Summary for CDC7 Gene

  • Checkpoint control kinases is a term used to describe a group of enzymes that regulate progression of a cell through the cell cycle. Catastrophic genetic damage can occur if cells progress to the next phase of the cell cycle before the previous phase is properly completed.

Gene Wiki entry for CDC7 Gene

Additional gene information for CDC7 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDC7 Gene

Genomics for CDC7 Gene

GeneHancer (GH) Regulatory Elements for CDC7 Gene

Promoters and enhancers for CDC7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J091499 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 787.9 +0.8 760 3.4 ZBTB40 CTCF SMARCE1 POLR2A ZNF362 MYC ELF1 HLF L3MBTL2 CEBPB CDC7 HFM1 SNORD3G ZNF644 ACTBP12 ENSG00000229201 ENSG00000273487 SETSIP EPHX4 GLMN
GH01J091500 Enhancer 0.5 ENCODE 760.3 -1.0 -992 0.1 SOX6 HDAC1 ZNF24 SOX13 HDGF NCOR1 ZFHX2 ZNF366 ZNF395 CDC7 LOC105378856 lnc-HFM1-1
GH01J091545 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 24.8 +53.0 53004 16.8 SMARCE1 L3MBTL2 RAD21 DACH1 TEAD4 CBFA2T2 BACH1 SMARCA4 CREM TRIM24 CDC7 ZNF644 GLMN WDR82P2 PHKA1P1 LOC102723436 lnc-HFM1-4
GH01J091530 Enhancer 0.8 Ensembl dbSUPER 24.3 +29.4 29387 0.8 CTCF CC2D1A RAD21 ARID2 REST MAFG SMC3 MAFK SKIL ZNF366 CDC7 HFM1 WDR82P2 piR-38134-001 lnc-HFM1-4 LOC102723436
GH01J091523 Enhancer 0.6 Ensembl dbSUPER 22.3 +22.9 22887 1 BATF EBF1 ATF7 CDC7 piR-38134-001 lnc-HFM1-4 LOC102723436
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDC7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDC7 gene promoter:
  • AML1a
  • Evi-1
  • GR
  • GR-alpha
  • Pax-6

Genomic Locations for CDC7 Gene

Genomic Locations for CDC7 Gene
chr1:91,500,814-91,525,764
(GRCh38/hg38)
Size:
24,951 bases
Orientation:
Plus strand
chr1:91,966,404-91,991,321
(GRCh37/hg19)
Size:
24,918 bases
Orientation:
Plus strand

Genomic View for CDC7 Gene

Genes around CDC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC7 Gene

Proteins for CDC7 Gene

  • Protein details for CDC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00311-CDC7_HUMAN
    Recommended name:
    Cell division cycle 7-related protein kinase
    Protein Accession:
    O00311
    Secondary Accessions:
    • D3DT31
    • O00558
    • Q5T5U5

    Protein attributes for CDC7 Gene

    Size:
    574 amino acids
    Molecular mass:
    63888 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Forms a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity.

    Three dimensional structures from OCA and Proteopedia for CDC7 Gene

    Alternative splice isoforms for CDC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC7 Gene

Post-translational modifications for CDC7 Gene

  • Ubiquitination at Lys212
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDC7 Gene

Domains & Families for CDC7 Gene

Gene Families for CDC7 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CDC7 Gene

Suggested Antigen Peptide Sequences for CDC7 Gene

GenScript: Design optimal peptide antigens:
  • Cell division cycle 7-related protein kinase (CDC7_HUMAN)
  • Cell division cycle 7-like protein 1 (Q6JSD6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00311

UniProtKB/Swiss-Prot:

CDC7_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.
genes like me logo Genes that share domains with CDC7: view

Function for CDC7 Gene

Molecular function for CDC7 Gene

UniProtKB/Swiss-Prot Function:
Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.

Enzyme Numbers (IUBMB) for CDC7 Gene

Phenotypes From GWAS Catalog for CDC7 Gene

Gene Ontology (GO) - Molecular Function for CDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IMP 12065429
GO:0004674 protein serine/threonine kinase activity IBA 21873635
GO:0005515 protein binding IPI 12065429
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDC7: view
genes like me logo Genes that share phenotypes with CDC7: view

Animal Models for CDC7 Gene

MGI Knock Outs for CDC7:
  • Cdc7 Cdc7<tm1Hmas>
  • Cdc7 Cdc7<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC7

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDC7 Gene

Localization for CDC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC7 gene
Compartment Confidence
nucleus 5
extracellular 4
cytoskeleton 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (3)
  • Mitotic spindle (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9250678
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 9250678
GO:0045171 intercellular bridge IDA --
GO:0072686 mitotic spindle IDA --
genes like me logo Genes that share ontologies with CDC7: view

Pathways & Interactions for CDC7 Gene

genes like me logo Genes that share pathways with CDC7: view

Pathways by source for CDC7 Gene

1 GeneGo (Thomson Reuters) pathway for CDC7 Gene
2 Qiagen pathways for CDC7 Gene
  • Cell Cycle Control of Chromosomal Replication
  • Mitotic Roles of Polo Like Kinases
1 Cell Signaling Technology pathway for CDC7 Gene

SIGNOR curated interactions for CDC7 Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000727 double-strand break repair via break-induced replication IBA 21873635
GO:0006260 DNA replication TAS --
GO:0006468 protein phosphorylation IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with CDC7: view

Drugs & Compounds for CDC7 Gene

(12) Drugs for CDC7 Gene - From: ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
BMS-863233 Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
DMNB Pharma DNA-PK inhibitor 0
PHA-767491 Pharma Cdc7/cdk9 inhibitor, potent, ATP-competitive 0
XL413 Pharma Cdc7 inhibitor 0

(5) Additional Compounds for CDC7 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
MRT 68601 hydrochloride
MRT 68921 dihydrochloride
TNP
519178-28-0
XL 413 hydrochloride
1169562-71-3

(5) Tocris Compounds for CDC7 Gene

Compound Action Cas Number
MRT 68601 hydrochloride Potent TBK1 inhibitor
MRT 68921 dihydrochloride Potent ULK inhibitor; inhibits autophagy
Necrostatin-1 RIPK1 inhibitor; inhibits necroptosis 4311-88-0
TNP Inhibitor of IP6K; also inhibits IP3K 519178-28-0
XL 413 hydrochloride Potent and selective Cdc7 inhibitor 1169562-71-3

(4) ApexBio Compounds for CDC7 Gene

Compound Action Cas Number
DMNB 20357-25-9
PHA-767491 Cdc7/cdk9 inhibitor, potent, ATP-competitive 845714-00-3
XL413 Cdc7 inhibitor 1169558-38-6
XL413 hydrochloride Cdc7 inhibitor 1169562-71-3
genes like me logo Genes that share compounds with CDC7: view

Drug Products

Transcripts for CDC7 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC7

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d
SP1: - -
SP2: - - -
SP3: - - -
SP4: -
SP5:

Relevant External Links for CDC7 Gene

GeneLoc Exon Structure for
CDC7
ECgene alternative splicing isoforms for
CDC7

Expression for CDC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC7 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for CDC7 Gene

This gene is overexpressed in Heart (30.4), Testis (15.5), Prostate (11.7), and Urinary Bladder (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDC7 Gene



Protein tissue co-expression partners for CDC7 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDC7 Gene:

CDC7

SOURCE GeneReport for Unigene cluster for CDC7 Gene:

Hs.533573

Evidence on tissue expression from TISSUES for CDC7 Gene

  • Liver(4.1)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with CDC7: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC7 Gene

Orthologs for CDC7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC7 32
  • 98.56 (n)
dog
(Canis familiaris)
Mammalia CDC7 33 32
  • 92.92 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CDC7 32
  • 90.82 (n)
CDC7L1 33
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC7 33
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc7 17 33 32
  • 83.21 (n)
rat
(Rattus norvegicus)
Mammalia Cdc7 32
  • 81.94 (n)
oppossum
(Monodelphis domestica)
Mammalia CDC7 33
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC7 33 32
  • 74.05 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC7 33
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc7 32
  • 68.3 (n)
Str.6524 32
African clawed frog
(Xenopus laevis)
Amphibia Cdc7 32
zebrafish
(Danio rerio)
Actinopterygii cdc7 33 32
  • 60.65 (n)
OneToOne
Dr.20362 32
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002110 32
  • 43.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(1)G0148 33
  • 27 (a)
OneToMany
CG5790 33
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC7 35 33
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 34 (a)
OneToOne
Species where no ortholog for CDC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDC7 Gene

ENSEMBL:
Gene Tree for CDC7 (if available)
TreeFam:
Gene Tree for CDC7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDC7: view image

Paralogs for CDC7 Gene

genes like me logo Genes that share paralogs with CDC7: view

Variants for CDC7 Gene

Sequence variations from dbSNP and Humsavar for CDC7 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1298398066 uncertain-significance, Inborn genetic diseases 91,513,246(+) C/G/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs780309556 uncertain-significance, Premature ovarian insufficiency 91,513,166(+) ATCCCACAT/AT coding_sequence_variant, non_coding_transcript_variant, stop_gained
rs1000114537 -- 91,522,884(+) CAGTCAG/CAG intron_variant
rs1000187232 -- 91,523,172(+) A/C intron_variant
rs1000326672 -- 91,520,929(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CDC7 Gene

Variant ID Type Subtype PubMed ID
esv2452061 CNV deletion 19546169
esv2714684 CNV deletion 23290073

Variation tolerance for CDC7 Gene

Residual Variation Intolerance Score: 40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC7 Gene

Disorders for CDC7 Gene

Additional Disease Information for CDC7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CDC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC7 Gene

Publications for CDC7 Gene

  1. Identification and characterization of a human protein kinase related to budding yeast Cdc7p. (PMID: 9405610) Jiang W … Hunter T (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 23 56
  2. Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. (PMID: 9250678) Sato N … Masai H (The EMBO journal 1997) 2 3 4 23 56
  3. Cdc7 is an active kinase in human cancer cells undergoing replication stress. (PMID: 17062569) Tenca P … Santocanale C (The Journal of biological chemistry 2007) 3 4 23 56
  4. A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases. (PMID: 15668232) Yoshizawa-Sugata N … Masai H (The Journal of biological chemistry 2005) 3 4 23 56
  5. A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells. (PMID: 10373557) Kumagai H … Masai H (Molecular and cellular biology 1999) 3 4 23 56

Products for CDC7 Gene

Sources for CDC7 Gene