Aliases for CDC7 Gene
External Ids for CDC7 Gene
Previous HGNC Symbols for CDC7 Gene
Previous GeneCards Identifiers for CDC7 Gene
This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]
GeneCards Summary for CDC7 Gene
CDC7 (Cell Division Cycle 7) is a Protein Coding gene. Diseases associated with CDC7 include Open-Angle Glaucoma and Masa Syndrome. Among its related pathways are Cell cycle and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1G3.
UniProtKB/Swiss-Prot Summary for CDC7 Gene
Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylate MCM2 and MCM3.
Checkpoint control kinases is a term used to describe a group of enzymes that regulate progression of a cell through the cell cycle. Catastrophic genetic damage can occur if cells progress to the next phase of the cell cycle before the previous phase is properly completed.