The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein duri... See more...

Aliases for CDC6 Gene

Aliases for CDC6 Gene

  • Cell Division Cycle 6 2 3 5
  • Cell Division Control Protein 6 Homolog 3 4
  • Cdc18-Related Protein 3 4
  • CDC6-Related Protein 3 4
  • P62(Cdc6) 3 4
  • CDC18L 3 4
  • HsCDC6 3 4
  • CDC6 (Cell Division Cycle 6, S. Cerevisiae) Homolog 2
  • CDC6 Cell Division Cycle 6 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle 6 Homolog (S. Cerevisiae) 2
  • CDC6 Cell Division Cycle 6 Homolog 3
  • Cell Division Cycle 6 Homolog 3
  • HsCDC18 3
  • HsCdc18 4
  • MGORS5 3

External Ids for CDC6 Gene

Previous HGNC Symbols for CDC6 Gene

  • CDC18L

Previous GeneCards Identifiers for CDC6 Gene

  • GC17P037939
  • GC17P040619
  • GC17P038352
  • GC17P038817
  • GC17P035697
  • GC17P038443
  • GC17P034237

Summaries for CDC6 Gene

Entrez Gene Summary for CDC6 Gene

  • The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC6 Gene

CDC6 (Cell Division Cycle 6) is a Protein Coding gene. Diseases associated with CDC6 include Meier-Gorlin Syndrome 5 and Meier-Gorlin Syndrome 1. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and E2F mediated regulation of DNA replication. Gene Ontology (GO) annotations related to this gene include nucleotide binding and kinase binding. An important paralog of this gene is ORC1.

UniProtKB/Swiss-Prot Summary for CDC6 Gene

  • Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.

Gene Wiki entry for CDC6 Gene

Additional gene information for CDC6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDC6 Gene

Genomics for CDC6 Gene

GeneHancer (GH) Regulatory Elements for CDC6 Gene

Promoters and enhancers for CDC6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J040285 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +0.1 82 3.7 FOXK2 ZBTB40 ZNF217 SIN3A NRF1 POLR2G SP1 PHF8 SIX5 FOS CDC6 RF00017-2378 RARA ENSG00000266208 WIPF2
GH17J040306 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.4 +30.0 29977 23.1 RXRA ZBTB40 ZNF217 CTCF TCF12 SIN3A NRF1 POLR2G ZNF300 USF1 RARA ENSG00000287644 MED1 SNORD124 SMARCE1 CDK12 MED24 MSL1 TMEM99 CDC6
GH17J040088 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 -192.3 -192342 14.4 EP300 FOXK2 ZNF217 TCF12 SIN3A MYC NRF1 POLR2G USF1 SP1 NR1D1 MSL1 MED24 CDK12 GSDMA CCR7 THRA RPL19 CDC6 TOP2A
GH17J040102 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.6 -178.2 -178247 13.4 EP300 FOXK2 ZNF217 CTCF TCF12 SIN3A MYC NRF1 POLR2G USF1 NR1D1 MED1 SMARCE1 CDK12 MSL1 MED24 CASC3 THRA IGFBP4 RPL19
GH17J040217 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 10.5 -68.2 -68230 3.5 HNRNPK ZBTB40 ZNF217 EP300 CTCF ZSCAN5C TCF12 SIN3A NRF1 USF1 WIPF2 SMARCE1 MED1 CDK12 RAPGEFL1 IGFBP4 ENSG00000266208 PGAP3 MSL1 RARA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDC6 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDC6

Top Transcription factor binding sites by QIAGEN in the CDC6 gene promoter:
  • AP-1
  • ATF
  • c-Fos
  • c-Jun
  • HNF-4alpha1
  • Nkx2-5
  • NRSF form 1
  • NRSF form 2
  • SRF
  • SRF (504 AA)

Genomic Locations for CDC6 Gene

Genomic Locations for CDC6 Gene
chr17:40,287,689-40,304,657
(GRCh38/hg38)
Size:
16,969 bases
Orientation:
Plus strand
chr17:38,443,885-38,459,413
(GRCh37/hg19)
Size:
15,529 bases
Orientation:
Plus strand

Genomic View for CDC6 Gene

Genes around CDC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC6 Gene

Proteins for CDC6 Gene

  • Protein details for CDC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99741-CDC6_HUMAN
    Recommended name:
    Cell division control protein 6 homolog
    Protein Accession:
    Q99741
    Secondary Accessions:
    • Q8TB30

    Protein attributes for CDC6 Gene

    Size:
    560 amino acids
    Molecular mass:
    62720 Da
    Quaternary structure:
    • Interacts with PCNA, ORC1, cyclin-CDK (PubMed:9566895). Interacts with HUWE1 (PubMed:17567951). Interacts with ANKRD17 (PubMed:23711367). Interacts with GRWD1; origin binding of GRWD1 is dependent on CDC6 (PubMed:25990725). Interacts with CDT1; are mutually dependent on one another for loading MCM complexes onto chromatin (PubMed:14672932). Interacts with TTC4 (PubMed:18320024).

    Three dimensional structures from OCA and Proteopedia for CDC6 Gene

neXtProt entry for CDC6 Gene

Post-translational modifications for CDC6 Gene

  • Ubiquitination at Lys208
  • Modification sites at PhosphoSitePlus

Other Protein References for CDC6 Gene

Antibody Products

  • Abcam antibodies for CDC6

No data available for DME Specific Peptides for CDC6 Gene

Domains & Families for CDC6 Gene

Gene Families for CDC6 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CDC6 Gene

Suggested Antigen Peptide Sequences for CDC6 Gene

GenScript: Design optimal peptide antigens:
  • p62(cdc6) (CDC6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99741

UniProtKB/Swiss-Prot:

CDC6_HUMAN :
  • Belongs to the CDC6/cdc18 family.
Family:
  • Belongs to the CDC6/cdc18 family.
genes like me logo Genes that share domains with CDC6: view

Function for CDC6 Gene

Molecular function for CDC6 Gene

UniProtKB/Swiss-Prot Function:
Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
GENATLAS Biochemistry:
cell division cycle 6,S cerevisiae homolog,selectively expressed in proliferating but not quiescent cell,regulated by E2F proteins,required for the initiation of DNA replication ,ORC1 homolog

Phenotypes From GWAS Catalog for CDC6 Gene

Gene Ontology (GO) - Molecular Function for CDC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding TAS 8990175
GO:0003688 DNA replication origin binding IBA 21873635
GO:0005515 protein binding IPI 14672932
GO:0005524 ATP binding IEA --
GO:0019900 kinase binding IPI 21041660
genes like me logo Genes that share ontologies with CDC6: view
genes like me logo Genes that share phenotypes with CDC6: view

Human Phenotype Ontology for CDC6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for CDC6

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC6 Gene

Localization for CDC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC6 Gene

Nucleus. Cytoplasm. Note=The protein is nuclear in G1 and cytoplasmic in S-phase cells (PubMed:9566895). {ECO:0000269 PubMed:9566895}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC6 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4
plasma membrane 2
extracellular 2
mitochondrion 2
golgi apparatus 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (3)
  • Cytosol (3)
  • Mitotic spindle (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 21041660
GO:0005634 nucleus IDA,TAS 21041660
GO:0005654 nucleoplasm TAS --
GO:0005730 NOT nucleolus IDA 21383955
GO:0005737 cytoplasm TAS 9566895
genes like me logo Genes that share ontologies with CDC6: view

Pathways & Interactions for CDC6 Gene

genes like me logo Genes that share pathways with CDC6: view

Pathways by source for CDC6 Gene

2 GeneGo (Thomson Reuters) pathways for CDC6 Gene
  • Cell cycle Start of DNA replication in early S phase
  • Cell cycle_Role of APC in cell cycle regulation
2 Qiagen pathways for CDC6 Gene
  • Cell Cycle Control of Chromosomal Replication
  • Factors Promoting Cardiogenesis in Vertebrates
1 Cell Signaling Technology pathway for CDC6 Gene

SIGNOR curated interactions for CDC6 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CDC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000076 DNA replication checkpoint TAS 9566895
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 9566895
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle IMP 22581055
genes like me logo Genes that share ontologies with CDC6: view

Drugs & Compounds for CDC6 Gene

(3) Drugs for CDC6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for CDC6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CDC6: view

Transcripts for CDC6 Gene

mRNA/cDNA for CDC6 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for CDC6

Alternative Splicing Database (ASD) splice patterns (SP) for CDC6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for CDC6 Gene

GeneLoc Exon Structure for
CDC6

Expression for CDC6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC6 Gene

This gene is overexpressed in Testis (x4.2).

Protein differential expression in normal tissues from HIPED for CDC6 Gene

This gene is overexpressed in Monocytes (38.4) and Tlymphocyte (29.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDC6 Gene



Protein tissue co-expression partners for CDC6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDC6

SOURCE GeneReport for Unigene cluster for CDC6 Gene:

Hs.405958

Evidence on tissue expression from TISSUES for CDC6 Gene

  • Nervous system(4.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC6 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • inner ear
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • middle ear
  • mouth
  • neck
  • nose
  • outer ear
  • skull
  • tongue
  • tooth
  • vocal cord
Thorax:
  • breast
  • bronchus
  • chest wall
  • clavicle
  • esophagus
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • trachea
Abdomen:
  • stomach
Pelvis:
  • pelvis
  • penis
  • testicle
  • uterus
  • vagina
  • vulva
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • hair
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with CDC6: view

Primer Products