Aliases for CDC6 Gene
External Ids for CDC6 Gene
Previous HGNC Symbols for CDC6 Gene
Previous GeneCards Identifiers for CDC6 Gene
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDC6 Gene
CDC6 (Cell Division Cycle 6) is a Protein Coding gene. Diseases associated with CDC6 include Meier-Gorlin Syndrome 5 and Meier-Gorlin Syndrome 1. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and E2F mediated regulation of DNA replication. Gene Ontology (GO) annotations related to this gene include nucleotide binding and kinase binding. An important paralog of this gene is ORC1.
UniProtKB/Swiss-Prot Summary for CDC6 Gene
Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.