Aliases for CDC42EP4 Gene
External Ids for CDC42EP4 Gene
Previous GeneCards Identifiers for CDC42EP4 Gene
The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDC42EP4 Gene
CDC42EP4 (CDC42 Effector Protein 4) is a Protein Coding gene. Diseases associated with CDC42EP4 include Opitz-Gbbb Syndrome. Among its related pathways are Actin Nucleation by ARP-WASP Complex and ERK Signaling. Gene Ontology (GO) annotations related to this gene include GTP-Rho binding. An important paralog of this gene is CDC42EP1.
UniProtKB/Swiss-Prot Summary for CDC42EP4 Gene
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts.