Aliases for CDC42EP2 Gene
External Ids for CDC42EP2 Gene
Previous GeneCards Identifiers for CDC42EP2 Gene
CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011]
GeneCards Summary for CDC42EP2 Gene
CDC42EP2 (CDC42 Effector Protein 2) is a Protein Coding gene. Among its related pathways are Actin Nucleation by ARP-WASP Complex and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and opioid peptide activity. An important paralog of this gene is CDC42EP3.
UniProtKB/Swiss-Prot for CDC42EP2 Gene
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner.