Aliases for CDC42BPG Gene

Aliases for CDC42BPG Gene

  • CDC42 Binding Protein Kinase Gamma 2 3 5
  • Myotonic Dystrophy Kinase-Related CDC42-Binding Kinase Gamma 3 4
  • CDC42 Binding Protein Kinase Gamma (DMPK-Like) 2 3
  • Myotonic Dystrophy Protein Kinase-Like Alpha 3 4
  • Myotonic Dystrophy Protein Kinase-Like Gamma 3 4
  • Serine/Threonine-Protein Kinase MRCK Gamma 3 4
  • DMPK-Like Gamma 3 4
  • EC 2.7.11.1 4 54
  • MRCK Gamma 3 4
  • DMPK2 3 4
  • MRCKG 3 4
  • Myotonic Dystrophy Protein Kinase Like Protein 3
  • CDC42-Binding Protein Kinase Gamma 4
  • KAPPA-200 3
  • MRCKgamma 3
  • EC 2.7.11 54
  • HSMDPKIN 3

External Ids for CDC42BPG Gene

Previous GeneCards Identifiers for CDC42BPG Gene

  • GC11M064348
  • GC11M064591
  • GC11M060918

Summaries for CDC42BPG Gene

GeneCards Summary for CDC42BPG Gene

CDC42BPG (CDC42 Binding Protein Kinase Gamma) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDC42BPA.

UniProtKB/Swiss-Prot Summary for CDC42BPG Gene

  • May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity).

Additional gene information for CDC42BPG Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDC42BPG Gene

Genomics for CDC42BPG Gene

GeneHancer (GH) Regulatory Elements for CDC42BPG Gene

Promoters and enhancers for CDC42BPG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDC42BPG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDC42BPG gene promoter:
  • AP-2gamma
  • AREB6
  • c-Myb
  • LCR-F1
  • Lmo2
  • RREB-1
  • Sp1
  • ZIC2
  • ZID

Genomic Locations for CDC42BPG Gene

Genomic Locations for CDC42BPG Gene
chr11:64,823,052-64,844,673
(GRCh38/hg38)
Size:
21,622 bases
Orientation:
Minus strand
chr11:64,590,859-64,612,041
(GRCh37/hg19)
Size:
21,183 bases
Orientation:
Minus strand

Genomic View for CDC42BPG Gene

Genes around CDC42BPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC42BPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC42BPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC42BPG Gene

Proteins for CDC42BPG Gene

  • Protein details for CDC42BPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6DT37-MRCKG_HUMAN
    Recommended name:
    Serine/threonine-protein kinase MRCK gamma
    Protein Accession:
    Q6DT37
    Secondary Accessions:
    • O00565

    Protein attributes for CDC42BPG Gene

    Size:
    1551 amino acids
    Molecular mass:
    172459 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42 (By similarity).

neXtProt entry for CDC42BPG Gene

Selected DME Specific Peptides for CDC42BPG Gene

Q6DT37:
  • DTSNFDVDD
  • KVIGRGAF
  • CDWWSLG
  • RLADFGSCL
  • PLKKVRPLN
  • GTPDYISPE
  • GETPFYAESLVETYGKIMNH
  • VAVGTPDYISPEIL
  • CFREERDVLV
  • AFSGHHLPFVGFTYTS
  • LHYAFQD
  • GGDLLTLLS
  • RGYLQALA
  • LYLVMDY

Post-translational modifications for CDC42BPG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CDC42BPG Gene

Gene Families for CDC42BPG Gene

Suggested Antigen Peptide Sequences for CDC42BPG Gene

GenScript: Design optimal peptide antigens:
  • Myotonic dystrophy protein kinase-like alpha (MRCKG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6DT37

UniProtKB/Swiss-Prot:

MRCKG_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
genes like me logo Genes that share domains with CDC42BPG: view

Function for CDC42BPG Gene

Molecular function for CDC42BPG Gene

UniProtKB/Swiss-Prot Function:
May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation (By similarity).

Enzyme Numbers (IUBMB) for CDC42BPG Gene

Phenotypes From GWAS Catalog for CDC42BPG Gene

Gene Ontology (GO) - Molecular Function for CDC42BPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 15194684
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity NAS,IBA 9341881
GO:0005515 protein binding IPI 21903422
GO:0005524 ATP binding NAS 9341881
genes like me logo Genes that share ontologies with CDC42BPG: view
genes like me logo Genes that share phenotypes with CDC42BPG: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDC42BPG

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC42BPG

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC42BPG Gene

Localization for CDC42BPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC42BPG Gene

Cytoplasm. Note=Concentrates at the leading edge of cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC42BPG gene
Compartment Confidence
cytosol 5
cytoskeleton 4
extracellular 1
nucleus 1
mitochondrion 0
peroxisome 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CDC42BPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005815 microtubule organizing center IBA,IDA --
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IBA 21873635
GO:0031252 cell leading edge IDA 15194684
genes like me logo Genes that share ontologies with CDC42BPG: view

Pathways & Interactions for CDC42BPG Gene

PathCards logo

SuperPathways for CDC42BPG Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDC42BPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation NAS 9341881
GO:0016310 phosphorylation IEA --
GO:0018107 peptidyl-threonine phosphorylation IBA 21873635
GO:0031032 actomyosin structure organization IBA 21873635
GO:0031532 actin cytoskeleton reorganization ISS --
genes like me logo Genes that share ontologies with CDC42BPG: view

No data available for Pathways by source and SIGNOR curated interactions for CDC42BPG Gene

Drugs & Compounds for CDC42BPG Gene

(4) Drugs for CDC42BPG Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
Guanosine triphosphate Experimental Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(5) Additional Compounds for CDC42BPG Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
Diglycerides Group A
  • 1-arachidonyl-3-behenoyl-sn-glycerol
  • DAG(42:0)
  • Diacylglycerol(20:0/0:0/22:0)
  • DG(42:0)
  • Diglyceride
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-Stearoyl-2-palmitoyl-sn-glycerol
  • DAG(18:0/16:0)
  • DAG(34:0)
  • DG(18:0/16:0)
  • DG(34:0)
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)
genes like me logo Genes that share compounds with CDC42BPG: view

Transcripts for CDC42BPG Gene

mRNA/cDNA for CDC42BPG Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(25) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC42BPG

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC42BPG Gene

No ASD Table

Relevant External Links for CDC42BPG Gene

GeneLoc Exon Structure for
CDC42BPG
ECgene alternative splicing isoforms for
CDC42BPG

Expression for CDC42BPG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDC42BPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC42BPG Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x5.6), Skin - Sun Exposed (Lower leg) (x5.1), Brain - Cerebellar Hemisphere (x4.8), Brain - Cerebellum (x4.7), and Esophagus - Mucosa (x4.7).

Protein differential expression in normal tissues from HIPED for CDC42BPG Gene

This gene is overexpressed in Fetal Brain (35.3) and Platelet (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDC42BPG Gene



NURSA nuclear receptor signaling pathways regulating expression of CDC42BPG Gene:

CDC42BPG

SOURCE GeneReport for Unigene cluster for CDC42BPG Gene:

Hs.293590

mRNA Expression by UniProt/SwissProt for CDC42BPG Gene:

Q6DT37-MRCKG_HUMAN
Tissue specificity: Expressed in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with CDC42BPG: view

No data available for Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC42BPG Gene

Orthologs for CDC42BPG Gene

This gene was present in the common ancestor of animals.

Orthologs for CDC42BPG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC42BPG 33 32
  • 99.36 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CDC42BPG 33 32
  • 87.75 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CDC42BPG 33 32
  • 87.15 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc42bpg 17 33 32
  • 83.98 (n)
rat
(Rattus norvegicus)
Mammalia Cdc42bpg 32
  • 83.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDC42BPG 33
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDC42BPG 33
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC42BPG 33
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta gek 33
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mrck-1 33
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2297 33
  • 38 (a)
OneToMany
Species where no ortholog for CDC42BPG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CDC42BPG Gene

ENSEMBL:
Gene Tree for CDC42BPG (if available)
TreeFam:
Gene Tree for CDC42BPG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDC42BPG: view image

Paralogs for CDC42BPG Gene

Paralogs for CDC42BPG Gene

(20) SIMAP similar genes for CDC42BPG Gene using alignment to 1 proteins:

  • MRCKG_HUMAN
genes like me logo Genes that share paralogs with CDC42BPG: view

Variants for CDC42BPG Gene

Sequence variations from dbSNP and Humsavar for CDC42BPG Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs770462360 A glioblastoma multiforme sample 64,839,070(-) G/A coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs1000462747 -- 64,834,940(-) C/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000480085 -- 64,823,604(-) CT/ 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000504371 -- 64,831,341(-) G/C downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000523292 -- 64,823,276(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CDC42BPG Gene

Variant ID Type Subtype PubMed ID
nsv469962 CNV loss 18288195
nsv528506 CNV loss 19592680
nsv555207 CNV loss 21841781
nsv832189 CNV loss 17160897
nsv951013 CNV deletion 24416366

Variation tolerance for CDC42BPG Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.26; 88.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDC42BPG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC42BPG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC42BPG Gene

Disorders for CDC42BPG Gene

Additional Disease Information for CDC42BPG

No disorders were found for CDC42BPG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC42BPG Gene

Publications for CDC42BPG Gene

  1. Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding. (PMID: 15194684) Ng Y … Leung T (The Journal of biological chemistry 2004) 2 3 4 23 56
  2. The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13. (PMID: 9341881) Kedra D … Dumanski J (Human genetics 1997) 2 3 4 56
  3. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 56
  4. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3 56
  5. MRCKα is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion. (PMID: 29162624) Gagliardi PA … Primo L (The Journal of cell biology 2018) 3 56

Products for CDC42BPG Gene

Sources for CDC42BPG Gene