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Aliases for CDC42BPB Gene

Aliases for CDC42BPB Gene

  • CDC42 Binding Protein Kinase Beta 2 3 5
  • Myotonic Dystrophy Kinase-Related CDC42-Binding Kinase Beta 3 4
  • Myotonic Dystrophy Protein Kinase-Like Beta 3 4
  • DMPK-Like Beta 3 4
  • CDC42BP-Beta 3 4
  • MRCK Beta 3 4
  • CDC42 Binding Protein Kinase Beta (DMPK-Like) 3
  • CDC42-Binding Protein Kinase Beta (DMPK-Like) 2
  • Serine/Threonine-Protein Kinase MRCK Beta 3
  • CDC42-Binding Protein Kinase Beta 4
  • EC 2.7.11.1 4
  • KIAA1124 4
  • MRCKB 3

External Ids for CDC42BPB Gene

Previous GeneCards Identifiers for CDC42BPB Gene

  • GC14M100789
  • GC14M097214
  • GC14M101388
  • GC14M102468
  • GC14M103398
  • GC14M083573

Summaries for CDC42BPB Gene

Entrez Gene Summary for CDC42BPB Gene

  • This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC42BPB Gene

CDC42BPB (CDC42 Binding Protein Kinase Beta) is a Protein Coding gene. Diseases associated with CDC42BPB include Myotonic Dystrophy. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDC42BPA.

UniProtKB/Swiss-Prot for CDC42BPB Gene

  • Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity).

Additional gene information for CDC42BPB Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC42BPB Gene

Genomics for CDC42BPB Gene

GeneHancer (GH) Regulatory Elements for CDC42BPB Gene

Promoters and enhancers for CDC42BPB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J103054 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.7 691 3.9 FOXA2 ARID4B SIN3A DMAP1 ZBTB7B ZNF48 GLIS2 ELK1 ZNF143 SP3 CDC42BPB GC14P103459 RPL13P6
GH14J103204 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 22.1 -149.9 -149891 6 PKNOX1 ARNT ZNF133 GLI4 BRCA1 ZNF280A TCF12 CBX5 GATA2 ZNF416 ENSG00000278071 ENSG00000270705 XRCC3 CDC42BPB RCOR1 BAG5 PPP1R13B MOK TNFAIP2 LINC00605
GH14J102588 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 21.8 +465.5 465496 6.8 PKNOX1 CLOCK FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B RCOR1 CDC42BPB MOK WDR20 ENSG00000271780 KLC1 DYNC1H1 BAG5 ENSG00000272444 CKB
GH14J103103 Enhancer 1.5 Ensembl ENCODE dbSUPER 23.1 -47.4 -47365 3 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 YBX1 XRCC3 WDR20 RCOR1 BAG5 CDC42BPB ZNF839 ENSG00000259444 ENSG00000269940 RPL23AP11 KLC1
GH14J103517 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 13.5 -463.2 -463206 6.4 HDGF ARNT ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF213 CKB GC14M103376 XRCC3 MARK3 BAG5 RPL23AP11 CDC42BPB RNU7-160P ENSG00000269940 ENSG00000260285
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDC42BPB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDC42BPB gene promoter:
  • Arnt
  • AhR
  • CREB
  • C/EBPbeta
  • AREB6
  • Nkx5-1
  • GATA-1
  • E2F-1

Genomic Locations for CDC42BPB Gene

Genomic Locations for CDC42BPB Gene
chr14:102,932,379-103,057,462
(GRCh38/hg38)
Size:
125,084 bases
Orientation:
Minus strand
chr14:103,398,716-103,523,799
(GRCh37/hg19)
Size:
125,084 bases
Orientation:
Minus strand

Genomic View for CDC42BPB Gene

Genes around CDC42BPB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC42BPB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC42BPB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC42BPB Gene

Proteins for CDC42BPB Gene

  • Protein details for CDC42BPB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5S2-MRCKB_HUMAN
    Recommended name:
    Serine/threonine-protein kinase MRCK beta
    Protein Accession:
    Q9Y5S2
    Secondary Accessions:
    • A9JR72
    • Q2L7A5
    • Q86TJ1
    • Q9ULU5

    Protein attributes for CDC42BPB Gene

    Size:
    1711 amino acids
    Molecular mass:
    194315 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer and homotetramer via the coiled coil regions (PubMed:21949762). Interacts tightly with GTP-bound but not GDP-bound CDC42. Interacts with TJP1, when in the presence of catalytically active CDC42 (By similarity). Forms a tripartite complex with MYO18A and LURAP1 with the latter acting as an adapter connecting CDC42BPB and MYO18A. LURAP1 binding results in activation of CDC42BPB by abolition of its negative autoregulation (PubMed:18854160). Interacts with STRIP1, STRN3 and SIKE1 (PubMed:25743393). Interacts with CPNE4 (via VWFA domain). Interacts with LURAP1. Interacts (via AGC-kinase C-terminal domain) with FAM89B/LRAP25 (via LRR repeat). Forms a tripartite complex with FAM89B/LRAP25 and LIMK1 (By similarity).
    SequenceCaution:
    • Sequence=AAH47871.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA86438.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDC42BPB Gene

neXtProt entry for CDC42BPB Gene

Post-translational modifications for CDC42BPB Gene

  • Ubiquitination at posLast=864864
  • Modification sites at PhosphoSitePlus

Other Protein References for CDC42BPB Gene

No data available for DME Specific Peptides for CDC42BPB Gene

Domains & Families for CDC42BPB Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5S2

UniProtKB/Swiss-Prot:

MRCKB_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
genes like me logo Genes that share domains with CDC42BPB: view

Function for CDC42BPB Gene

Molecular function for CDC42BPB Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation (By similarity). Inhibited by chelerythrine chloride.
GENATLAS Biochemistry:
CDC42-binding protein kinase beta,rat myotonic dystrophy protein kinase related (DMPK-like),beta (MRCKB),widely expressed,phosphorylating non muscle myosin like chain (see MYLK),a prerequisite for the activation of actin-myosin contractility,downstream effector of CDC42 in cytoskeletal reorganization

Enzyme Numbers (IUBMB) for CDC42BPB Gene

Phenotypes From GWAS Catalog for CDC42BPB Gene

Gene Ontology (GO) - Molecular Function for CDC42BPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0004672 protein kinase activity IDA,IEA 21949762
GO:0004674 protein serine/threonine kinase activity IEA,ISS --
GO:0005515 protein binding IEA --
GO:0005524 ATP binding ISS,IEA --
genes like me logo Genes that share ontologies with CDC42BPB: view
genes like me logo Genes that share phenotypes with CDC42BPB: view

Animal Model Products

miRNA for CDC42BPB Gene

miRTarBase miRNAs that target CDC42BPB

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC42BPB Gene

Localization for CDC42BPB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC42BPB Gene

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Cell projection, lamellipodium. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). Detected at the leading edge of migrating cells. Localization at the leading edge of migrating cells requires interaction with catalytically active CDC42 (PubMed:21240187). Localizes in the lamellipodium in a FAM89B/LRAP25-dependent manner (By similarity). {ECO:0000250 UniProtKB:O54874, ECO:0000250 UniProtKB:Q3UU96, ECO:0000269 PubMed:21240187}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC42BPB gene
Compartment Confidence
extracellular 5
cytoskeleton 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for CDC42BPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton TAS 9418861
GO:0005886 plasma membrane IEA --
GO:0005911 cell-cell junction ISS --
genes like me logo Genes that share ontologies with CDC42BPB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CDC42BPB Gene

Pathways & Interactions for CDC42BPB Gene

SuperPathways for CDC42BPB Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDC42BPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,ISS --
GO:0007010 cytoskeleton organization TAS 9418861
GO:0007163 establishment or maintenance of cell polarity TAS 9418861
GO:0007165 signal transduction TAS 9418861
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with CDC42BPB: view

No data available for Pathways by source and SIGNOR curated interactions for CDC42BPB Gene

Drugs & Compounds for CDC42BPB Gene

(2) Drugs for CDC42BPB Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved Nutra 0
Guanosine triphosphate Experimental Pharma 0

(4) Additional Compounds for CDC42BPB Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group B
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group C
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (11Z,14Z)-icosa-11,14-dienoic acid
  • DAG(15:0/0:0/20:2w6)
  • Diacylglycerol(15:0/0:0/20:2w6)
  • Diacylglycerol(15:0/0:0/20:2)
  • DAG(15:0/0:0/20:2n6)
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)
genes like me logo Genes that share compounds with CDC42BPB: view

Transcripts for CDC42BPB Gene

Unigene Clusters for CDC42BPB Gene

CDC42 binding protein kinase beta (DMPK-like):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC42BPB Gene

No ASD Table

Relevant External Links for CDC42BPB Gene

GeneLoc Exon Structure for
CDC42BPB
ECgene alternative splicing isoforms for
CDC42BPB

Expression for CDC42BPB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDC42BPB Gene

Protein differential expression in normal tissues from HIPED for CDC42BPB Gene

This gene is overexpressed in Heart (15.1) and Peripheral blood mononuclear cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDC42BPB Gene



Protein tissue co-expression partners for CDC42BPB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDC42BPB Gene:

CDC42BPB

SOURCE GeneReport for Unigene cluster for CDC42BPB Gene:

Hs.654634

mRNA Expression by UniProt/SwissProt for CDC42BPB Gene:

Q9Y5S2-MRCKB_HUMAN
Tissue specificity: Expressed in all tissues examined, with high levels in heart, brain, placenta and lung.

Evidence on tissue expression from TISSUES for CDC42BPB Gene

  • Liver(4.3)
  • Nervous system(3.9)
  • Eye(3.1)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with CDC42BPB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC42BPB Gene

Orthologs for CDC42BPB Gene

This gene was present in the common ancestor of animals.

Orthologs for CDC42BPB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC42BPB 34 33
  • 99.78 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CDC42BPB 34 33
  • 88.35 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDC42BPB 34
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc42bpb 33
  • 86.56 (n)
mouse
(Mus musculus)
Mammalia Cdc42bpb 16 34 33
  • 85.86 (n)
cow
(Bos Taurus)
Mammalia CDC42BPB 34 33
  • 85.56 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC42BPB 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC42BPB 34 33
  • 77.88 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC42BPB 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc42bpb 33
  • 73.95 (n)
Str.7145 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23572 33
zebrafish
(Danio rerio)
Actinopterygii cdc42bpb 34 33
  • 71.1 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8420 33
fruit fly
(Drosophila melanogaster)
Insecta gek 34 35
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mrck-1 34
  • 40 (a)
OneToMany
K08B12.5 35
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2297 34
  • 49 (a)
OneToMany
Species where no ortholog for CDC42BPB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC42BPB Gene

ENSEMBL:
Gene Tree for CDC42BPB (if available)
TreeFam:
Gene Tree for CDC42BPB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDC42BPB: view image

Paralogs for CDC42BPB Gene

Paralogs for CDC42BPB Gene

(41) SIMAP similar genes for CDC42BPB Gene using alignment to 5 proteins:

  • MRCKB_HUMAN
  • A9JR72_HUMAN
  • H0YLR5_HUMAN
  • H0YLY0_HUMAN
  • Q86XZ8_HUMAN

Pseudogenes.org Pseudogenes for CDC42BPB Gene

genes like me logo Genes that share paralogs with CDC42BPB: view

Variants for CDC42BPB Gene

Sequence variations from dbSNP and Humsavar for CDC42BPB Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
VAR_040834 A breast infiltrating ductal carcinoma sample p.Lys500Glu
VAR_040837 A colorectal adenocarcinoma sample p.Arg876Trp
VAR_040838 A lung large cell carcinoma sample p.Glu1315Lys
rs1000018391 -- 103,013,735(-) C/G intron_variant
rs1000049597 -- 103,013,901(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CDC42BPB Gene

Variant ID Type Subtype PubMed ID
dgv1139n106 CNV deletion 24896259
esv2671530 CNV deletion 23128226
esv2749154 CNV deletion 23290073
esv2749155 CNV deletion 23290073
esv2749156 CNV deletion 23290073
esv2749157 CNV deletion 23290073
esv2760337 CNV loss 21179565
esv3305477 CNV mobile element insertion 20981092
esv3332114 CNV insertion 20981092
esv3635574 CNV gain 21293372
esv3635575 CNV loss 21293372
nsv1070240 CNV deletion 25765185
nsv1071173 CNV deletion 25765185
nsv1118297 CNV deletion 24896259
nsv1431 CNV insertion 18451855
nsv474283 CNV novel sequence insertion 20440878
nsv509552 CNV insertion 20534489
nsv832882 CNV loss 17160897
nsv85067 CNV deletion 16902084
nsv9167 CNV gain 18304495
nsv952256 CNV deletion 24416366

Variation tolerance for CDC42BPB Gene

Residual Variation Intolerance Score: 0.964% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 46.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDC42BPB Gene

Human Gene Mutation Database (HGMD)
CDC42BPB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC42BPB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC42BPB Gene

Disorders for CDC42BPB Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDC42BPB Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
myotonic dystrophy
  • myotonic dystrophy 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CDC42BPB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CDC42BPB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDC42BPB Gene

Publications for CDC42BPB Gene

  1. Cloning and chromosomal localization of human Cdc42-binding protein kinase beta. (PMID: 10198171) Moncrieff CL … Johnson KJ (Genomics 1999) 2 3 4 22 58
  2. CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling. (PMID: 25743393) Lant B … Derry WB (Nature communications 2015) 3 4 58
  3. Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration. (PMID: 21240187) Huo L … Zhang M (The EMBO journal 2011) 3 4 58
  4. Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility. (PMID: 21471979) Kumar V … Matsuda K (Journal of human genetics 2011) 3 44 58
  5. Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion. (PMID: 21949762) Heikkila T … Olson MF (PloS one 2011) 3 4 58

Products for CDC42BPB Gene

Sources for CDC42BPB Gene