CDC37L1 is a cytoplasmic phosphoprotein that exists in complex with HSP90 (HSPCA; MIM 140571) as well as several other proteins involved in HSP90-mediated protein folding (Scholz et al., 2001 [PubMed 11413142]).[supplied by OMIM, Mar 2008] See more...

Aliases for CDC37L1 Gene

Aliases for CDC37L1 Gene

  • Cell Division Cycle 37 Like 1 2 3 5
  • Hsp90-Associating Relative Of Cdc37 3 4
  • Hsp90 Co-Chaperone Cdc37-Like 1 3 4
  • CDC37B 3 4
  • HARC 3 4
  • CDC37 Cell Division Cycle 37 Homolog (S. Cerevisiae)-Like 1 2
  • Cell Division Cycle 37 Homolog (S. Cerevisiae)-Like 1 2
  • CDC37 Cell Division Cycle 37 Homolog-Like 1 3
  • Cell Division Cycle 37 Homolog-Like 1 3
  • Cell Division Cycle 37-Like 1 2

External Ids for CDC37L1 Gene

Previous GeneCards Identifiers for CDC37L1 Gene

  • GC09P004670

Summaries for CDC37L1 Gene

Entrez Gene Summary for CDC37L1 Gene

  • CDC37L1 is a cytoplasmic phosphoprotein that exists in complex with HSP90 (HSPCA; MIM 140571) as well as several other proteins involved in HSP90-mediated protein folding (Scholz et al., 2001 [PubMed 11413142]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CDC37L1 Gene

CDC37L1 (Cell Division Cycle 37 Like 1) is a Protein Coding gene. Diseases associated with CDC37L1 include Delusional Disorder. Among its related pathways are Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and heat shock protein binding. An important paralog of this gene is CDC37.

UniProtKB/Swiss-Prot Summary for CDC37L1 Gene

  • Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90.

Additional gene information for CDC37L1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDC37L1 Gene

Genomics for CDC37L1 Gene

GeneHancer (GH) Regulatory Elements for CDC37L1 Gene

Promoters and enhancers for CDC37L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J004677 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 0.0 -35 4.4 EP300 ZBTB40 ZNF217 CTCF TCF12 POLR2G SP1 NCOR1 GTF2E2 TEAD4 CDC37L1-DT CDC37L1 SPATA6L RIC1 PDSS1P1 lnc-SPATA6L-2-002
GH09J004738 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.4 +61.9 61871 5.1 HNRNPK ZBTB40 SIN3A NRF1 POLR2G NCOR1 PHF8 ZFX CTCF ZIC2 AK3 ENSG00000287759 RIC1 PDSS1P1 CDC37L1 JAK2 PLPP6 MTND5P14 piR-57460-657
GH09J004595 Enhancer 0.8 Ensembl ENCODE 10.8 -83.1 -83052 3 FOXA2 NR2F2 ZNF316 MAFF ZBTB33 MAFK JUND ZFHX2 EBF1 MAFG SPATA6L PLPP6 CDC37L1 piR-32287-157 piR-57176-629
GH09J004619 Enhancer 0.7 Ensembl ENCODE 11.2 -58.7 -58653 3.8 ATF2 CREB1 JUN POLR2A EZH2 MYC MAX SPI1 RNF2 ZNF83 SPATA6L PLPP6 CDC37L1 piR-32214-662 piR-41525-660
GH09J004713 Enhancer 0.7 Ensembl ENCODE 11.6 +34.8 34798 0.9 MAFF ZFHX2 MAFK PAX8 ZNF18 KDM1A MXI1 EGR2 ZEB2 AK3 CDC37L1 AB372793 piR-30853-076
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDC37L1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDC37L1

Top Transcription factor binding sites by QIAGEN in the CDC37L1 gene promoter:
  • AhR
  • AML1a
  • AREB6
  • Arnt
  • COMP1
  • CUTL1
  • Egr-3
  • FOXO1a
  • p53
  • STAT3

Genomic Locations for CDC37L1 Gene

Genomic Locations for CDC37L1 Gene
chr9:4,679,553-4,708,399
(GRCh38/hg38)
Size:
28,847 bases
Orientation:
Plus strand
chr9:4,679,559-4,708,398
(GRCh37/hg19)
Size:
28,840 bases
Orientation:
Plus strand

Genomic View for CDC37L1 Gene

Genes around CDC37L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC37L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC37L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC37L1 Gene

Proteins for CDC37L1 Gene

  • Protein details for CDC37L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L3B6-CD37L_HUMAN
    Recommended name:
    Hsp90 co-chaperone Cdc37-like 1
    Protein Accession:
    Q7L3B6
    Secondary Accessions:
    • B1AL70
    • Q9NWS3
    • Q9NX16

    Protein attributes for CDC37L1 Gene

    Size:
    337 amino acids
    Molecular mass:
    38835 Da
    Quaternary structure:
    • Self-associates. Forms complexes with Hsp70 and Hsp90. Interacts with CDC37, FKBP4, PPID and STIP1.
    SequenceCaution:
    • Sequence=BAA91206.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};

neXtProt entry for CDC37L1 Gene

Post-translational modifications for CDC37L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDC37L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDC37L1 Gene

Domains & Families for CDC37L1 Gene

Gene Families for CDC37L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CDC37L1 Gene

Suggested Antigen Peptide Sequences for CDC37L1 Gene

GenScript: Design optimal peptide antigens:
  • Hsp90-associating relative of Cdc37 (CD37L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7L3B6

UniProtKB/Swiss-Prot:

CD37L_HUMAN :
  • Belongs to the CDC37 family.
Family:
  • Belongs to the CDC37 family.
genes like me logo Genes that share domains with CDC37L1: view

Function for CDC37L1 Gene

Molecular function for CDC37L1 Gene

UniProtKB/Swiss-Prot Function:
Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90.

Phenotypes From GWAS Catalog for CDC37L1 Gene

Gene Ontology (GO) - Molecular Function for CDC37L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
GO:0031072 heat shock protein binding IBA 21873635
GO:0051082 unfolded protein binding IBA 21873635
GO:0051087 chaperone binding IBA 21873635
genes like me logo Genes that share ontologies with CDC37L1: view
genes like me logo Genes that share phenotypes with CDC37L1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC37L1 Gene

Localization for CDC37L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC37L1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC37L1 gene
Compartment Confidence
extracellular 4
cytosol 4
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CDC37L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IDA --
GO:0031089 platelet dense granule lumen TAS --
genes like me logo Genes that share ontologies with CDC37L1: view

Pathways & Interactions for CDC37L1 Gene

genes like me logo Genes that share pathways with CDC37L1: view

Gene Ontology (GO) - Biological Process for CDC37L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0006457 protein folding IBA 21873635
GO:0050821 protein stabilization IBA 21873635
genes like me logo Genes that share ontologies with CDC37L1: view

No data available for SIGNOR curated interactions for CDC37L1 Gene

Drugs & Compounds for CDC37L1 Gene

No Compound Related Data Available

Transcripts for CDC37L1 Gene

mRNA/cDNA for CDC37L1 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC37L1 Gene

No ASD Table

Relevant External Links for CDC37L1 Gene

GeneLoc Exon Structure for
CDC37L1

Expression for CDC37L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDC37L1 Gene

mRNA differential expression in normal tissues according to GTEx for CDC37L1 Gene

This gene is overexpressed in Muscle - Skeletal (x5.0).

Protein differential expression in normal tissues from HIPED for CDC37L1 Gene

This gene is overexpressed in Bone (32.3), Plasma (13.1), and Testis (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDC37L1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDC37L1

SOURCE GeneReport for Unigene cluster for CDC37L1 Gene:

Hs.666439

mRNA Expression by UniProt/SwissProt for CDC37L1 Gene:

Q7L3B6-CD37L_HUMAN
Tissue specificity: Expressed in brain, heart, kidney, liver, placenta and skeletal muscle.

Evidence on tissue expression from TISSUES for CDC37L1 Gene

  • Lung(4.6)
  • Liver(4.4)
  • Nervous system(4.2)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with CDC37L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC37L1 Gene

Orthologs for CDC37L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDC37L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC37L1 31 30
  • 99.8 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CDC37L1 31 30
  • 94.36 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CDC37L1 31 30
  • 94.08 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDC37L1 31
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc37l1 17 31 30
  • 88.96 (n)
rat
(Rattus norvegicus)
Mammalia Cdc37l1 30
  • 88.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDC37L1 31
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC37L1 31 30
  • 77.69 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC37L1 31
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc37l1 30
  • 70.88 (n)
Str.4272 30
zebrafish
(Danio rerio)
Actinopterygii cdc37l1 31 30
  • 58.88 (n)
OneToOne
Dr.17699 30
fruit fly
(Drosophila melanogaster)
Insecta Cdc37 31
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdc-37 31
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 27 (a)
OneToMany
Species where no ortholog for CDC37L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC37L1 Gene

ENSEMBL:
Gene Tree for CDC37L1 (if available)
TreeFam:
Gene Tree for CDC37L1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDC37L1: view image

Paralogs for CDC37L1 Gene

Paralogs for CDC37L1 Gene

(1) SIMAP similar genes for CDC37L1 Gene using alignment to 2 proteins:

  • CD37L_HUMAN
  • B1AL69_HUMAN
genes like me logo Genes that share paralogs with CDC37L1: view

Variants for CDC37L1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDC37L1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs7036014 - p.Ser291Phe

Additional dbSNP identifiers (rs#s) for CDC37L1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CDC37L1 Gene

Variant ID Type Subtype PubMed ID
nsv1015376 CNV gain 25217958
nsv1018499 CNV loss 25217958
nsv819262 CNV loss 19587683
nsv819702 CNV gain 19587683

Variation tolerance for CDC37L1 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDC37L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC37L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC37L1 Gene

Disorders for CDC37L1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDC37L1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
delusional disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CDC37L1

genes like me logo Genes that share disorders with CDC37L1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDC37L1 Gene

Publications for CDC37L1 Gene

  1. Domain-mediated dimerization of the Hsp90 cochaperones Harc and Cdc37. (PMID: 15850399) Roiniotis J … Scholz GM (Biochemistry 2005) 3 4 23 54
  2. Identification and characterization of Harc, a novel Hsp90-associating relative of Cdc37. (PMID: 11413142) Scholz GM … Hall NE (The Journal of biological chemistry 2001) 3 4 23 54
  3. Importance of the C-terminal domain of Harc for binding to Hsp70 and Hop as well as its response to heat shock. (PMID: 18052042) Cartledge K … Scholz GM (Biochemistry 2007) 3 4 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54

Products for CDC37L1 Gene

Sources for CDC37L1 Gene