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The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought ... See more...
Aliases for CDC37 Gene
Aliases for CDC37 Gene
External Ids for CDC37 Gene
- HGNC: 1735
- Entrez Gene: 11140
- Ensembl: ENSG00000105401
- OMIM: 605065
- UniProtKB: Q16543
Previous GeneCards Identifiers for CDC37 Gene
- GC19M010623
- GC19M010724
- GC19M010348
- GC19M010362
- GC19M010501
- GC19M010081
Summaries for CDC37 Gene
-
The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDC37 Gene
CDC37 (Cell Division Cycle 37, HSP90 Cochaperone) is a Protein Coding gene. Among its related pathways are Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein kinase binding and kinase binding. An important paralog of this gene is CDC37L1.
UniProtKB/Swiss-Prot Summary for CDC37 Gene
-
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206).
Additional gene information for CDC37 Gene
- HGNC(1735)
- Entrez Gene(11140)
- Ensembl(ENSG00000105401)
- OMIM(605065)
- UniProtKB(Q16543)
- Open Targets Platform(ENSG00000105401)
- Monarch Initiative
- Search for CDC37 at DataMed
- Search for CDC37 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDC37 Gene
Genomics for CDC37 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CDC37 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CDC37 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDC37
- Top Transcription factor binding sites by QIAGEN in the CDC37 gene promoter:
-
- AREB6
- C/EBPalpha
- CREB
- deltaCREB
- LCR-F1
- Nkx2-5
- Pbx1a
- STAT3
- XBP-1
- ZID
Genomic Locations for CDC37 Gene
Genomic Locations for CDC37 Gene
- chr19:10,391,128-10,420,121
- (GRCh38/hg38)
- Size:
- 28,994 bases
- Orientation:
- Minus strand
- chr19:10,501,809-10,530,797
- (GRCh37/hg19)
- Size:
- 28,989 bases
- Orientation:
- Minus strand
Genomic View for CDC37 Gene
Genes around CDC37 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by HGNC
- 19p13.2 by Entrez Gene
- 19p13.2 by Ensembl
CDC37 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CDC37 Gene
Proteins for CDC37 Gene
-
Protein details for CDC37 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16543-CDC37_HUMAN
- Recommended name:
- Hsp90 co-chaperone Cdc37
- Protein Accession:
- Q16543
- Q53YA2
Protein attributes for CDC37 Gene
- Size:
- 378 amino acids
- Molecular mass:
- 44468 Da
- Quaternary structure:
-
- Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (PubMed:29127155). Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23 (PubMed:29127155). Forms a complex with Hsp90/HSP90AB1 and CDK6 (PubMed:9482106). Interacts with HSP90AA1 (PubMed:23569206, PubMed:27353360). Interacts with AR, CDK4, CDK6 and EIF2AK1 (PubMed:11036079, PubMed:11085988, PubMed:9150368, PubMed:9482106). Interacts with RB1 (By similarity). Interacts with KSR1 (PubMed:10409742). Interacts with FLCN, FNIP1 and FNIP2 (PubMed:27353360).
Protein Expression for CDC37 Gene
Post-translational modifications for CDC37 Gene
- Constitutively sumoylated by UBE2I.
-
Ubiquitination at Lys110, Lys121, and Lys330
- NX_Q16543 (NX_Q16543-1)
- Modification sites at PhosphoSitePlus
Other Protein References for CDC37 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences CDC37 Antibody
- G Biosciences Immunotag™ Phospho-CDC37 (Ser13) Antibody and Immunotag™ CDC37 Antibody
- GeneTex Anti-CDC37 antibody and Anti-CDC37 antibody [JJ087-06]
-
Custom Antibody ServicesOriGene Antibodies for CDC37
- Novus Biologicals Antibodies for CDC37
-
Abcam antibodies for CDC37
- Invitrogen Antibodies for CDC37 (AFLGC-CDC37)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CDC37
- Sino Biological Antibodies for CDC37
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CDC37
- Origene Custom Protein Services for CDC37
- Sino Biological Recombinant Proteins for CDC37
- Sino Biological Cell Lysates for CDC37
- ProSpec Recombinant Proteins for CDC37
-
Abcam proteins for CDC37
Assay Products
- RayBiotech Custom Human CDC37 ELISA
- antibodies-online: Show 4 available CDC37 Elisa Kits ranked by validation data
- Compare Top CDC37 Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for CDC37
No data available for DME Specific Peptides for CDC37 Gene
Domains & Families for CDC37 Gene
Gene Families for CDC37 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for CDC37 Gene
- InterPro:
- Blocks:
-
- Cdc37 family
- ProtoNet:
Suggested Antigen Peptide Sequences for CDC37 Gene
- GenScript: Design optimal peptide antigens:
-
- p50Cdc37 (CDC37_HUMAN)
- CDC37 protein (Q6FG59_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q16543- Family:
-
- Belongs to the CDC37 family.
Function for CDC37 Gene
Molecular function for CDC37 Gene
- UniProtKB/Swiss-Prot Function:
- Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206).
- GENATLAS Biochemistry:
- cell division cycle 37,S cerevisiae homolog,protein kinase targetting subunit of HSP90 that binds and stabilizes CDK4 (HSPC*),potential regulator of cell cycle
Phenotypes From GWAS Catalog for CDC37 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 9150368 |
| GO:0019887 | protein kinase regulator activity | IEA | -- |
| GO:0019900 | kinase binding | IPI | 21855797 |
| GO:0019901 | protein kinase binding | IEA | -- |
| GO:0031072 | heat shock protein binding | IBA,IPI | 9660753 |
Phenotypes for CDC37 Gene
- GenomeRNAi human phenotypes for CDC37:
-
- Decreased hepcidin::fluc mRNA expression
- no effect
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability ratio
- Decreased viability
- Increased gamma-H2AX phosphorylation
- Strongly decreased CFP-tsO45G cell surface transport
- Reduced mammosphere formation
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CDC37 - Select products 50% OFF >
- * CDC37 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CDC37
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDC37
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDC37
miRNA for CDC37 Gene
- miRTarBase miRNAs that target CDC37
-
- hsa-miR-615-3p (MIRT016144)
- hsa-miR-193b-3p (MIRT016565)
- hsa-miR-7-5p (MIRT025907)
- hsa-miR-16-5p (MIRT031991)
- hsa-miR-421 (MIRT039401)
- hsa-miR-92a-3p (MIRT049255)
- hsa-miR-3200-3p (MIRT052815)
- hsa-miR-155-5p (MIRT440973)
- mmu-miR-329-3p (MIRT579159)
- mmu-miR-362-3p (MIRT579160)
- mmu-miR-466i-3p (MIRT579161)
- mmu-miR-465b-5p (MIRT579162)
- mmu-miR-465a-5p (MIRT579163)
- mmu-miR-465c-5p (MIRT579164)
- mmu-miR-1199-5p (MIRT587689)
- mmu-miR-5135 (MIRT587690)
- hsa-miR-1228-5p (MIRT736181)
- hsa-miR-1321 (MIRT737320)
- hsa-miR-139-3p (MIRT737543)
- hsa-miR-149-3p (MIRT737709)
- hsa-miR-185-5p (MIRT738235)
- hsa-miR-3135b (MIRT740123)
- hsa-miR-3178 (MIRT740712)
- hsa-miR-4270 (MIRT743554)
- hsa-miR-4306 (MIRT743888)
- hsa-miR-4441 (MIRT744521)
- hsa-miR-4446-3p (MIRT744608)
- hsa-miR-4486 (MIRT745178)
- hsa-miR-4492 (MIRT745276)
- hsa-miR-4498 (MIRT745357)
- hsa-miR-4505 (MIRT745510)
- hsa-miR-4524a-3p (MIRT745838)
- hsa-miR-4644 (MIRT746361)
- hsa-miR-4693-3p (MIRT747142)
- hsa-miR-4721 (MIRT747548)
- hsa-miR-4728-5p (MIRT747805)
- hsa-miR-4739 (MIRT748038)
- hsa-miR-4756-5p (MIRT748410)
- hsa-miR-4790-3p (MIRT748901)
- hsa-miR-5001-5p (MIRT749350)
- hsa-miR-5192 (MIRT749934)
- hsa-miR-5787 (MIRT751460)
- hsa-miR-6754-5p (MIRT754696)
- hsa-miR-6785-5p (MIRT755800)
- hsa-miR-6883-5p (MIRT758385)
- hsa-miR-7113-5p (MIRT759098)
- hsa-miR-762 (MIRT759492)
- hsa-miR-330-3p (MIRT765630)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDC37
- Browse OriGene Inhibitory RNA Products For CDC37
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC37
Clone Products
- Applied Biological Materials (abm): Clones for CDC37 - Select products 50% OFF >
- * CDC37 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CDC37
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDC37
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC37 Gene
Localization for CDC37 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CDC37 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 4 |
| nucleus | 3 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | -- |
| GO:0005829 | cytosol | IDA,TAS | -- |
| GO:0070062 | extracellular exosome | HDA | 20458337 |
| GO:0101031 | chaperone complex | IDA | 29127155 |
| GO:1990565 | HSP90-CDC37 chaperone complex | IDA | 21855797 |
Pathways & Interactions for CDC37 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by Ligand-Responsive EGFR Variants in Cancer | ||
| 2 | HIV Life Cycle |
.45
|
|
| 3 | Signaling by ERBB2 | ||
| 4 | Cytoskeletal Signaling | ||
| 5 | DNA Damage | ||
Pathways by source for CDC37 Gene
1 Sino Biological pathway for CDC37 Gene
5 BioSystems pathways for CDC37 Gene
1 KEGG pathway for CDC37 Gene
1 Qiagen pathway for CDC37 Gene
- Akt Signaling
2 Cell Signaling Technology pathways for CDC37 Gene
Interacting Proteins for CDC37 Gene
Selected Interacting proteins:
Q16543-CDC37_HUMAN
ENSP00000222005
for CDC37 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CDC37
SIGNOR curated interactions for CDC37 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | TAS | 8666233 |
| GO:0006457 | protein folding | IBA | 21873635 |
| GO:0006605 | protein targeting | TAS | 8666233 |
| GO:0010608 | posttranscriptional regulation of gene expression | IEA | -- |
| GO:0038128 | ERBB2 signaling pathway | TAS | -- |
Drugs & Compounds for CDC37 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| heme | Pharma | Agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CDC37 Gene
mRNA/cDNA for CDC37 Gene
- 1 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000222005 1618 nts (view in UCSC)
- ENST00000591248 1377 nts (view in UCSC)
- ENST00000589625 587 nts (view in UCSC)
- ENST00000589331 537 nts (view in UCSC)
- ENST00000590632 601 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CDC37 - Select products 50% OFF >
- * CDC37 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CDC37
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDC37
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDC37
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDC37
- Browse OriGene Inhibitory RNA Products For CDC37
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC37
Clone Products
- Applied Biological Materials (abm): Clones for CDC37 - Select products 50% OFF >
- * CDC37 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CDC37
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDC37
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - |
Relevant External Links for CDC37 Gene
- GeneLoc Exon Structure for
- CDC37
Expression for CDC37 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (6.4) and Bone marrow stromal cell (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDC37 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDC37
SOURCE GeneReport for Unigene cluster for CDC37 Gene:
Hs.160958Evidence on tissue expression from TISSUES for CDC37 Gene
- Liver(4.5)
- Skin(4.5)
- Nervous system(4.3)
- Lung(3.7)
- Muscle(2.8)
- Kidney(2.7)
- Intestine(2.6)
- Heart(2.6)
- Spleen(2.5)
- Thyroid gland(2.2)
- Bone marrow(2.2)
- Lymph node(2.2)
Primer Products
-
OriGene qPCR primer pairs for CDC37
-
OriGene qPCR primer pairs and template standards for CDC37
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC37 Gene
Orthologs for CDC37 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CDC37 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CDC37 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CDC37 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Cdc37 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cdc37 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | CDC37 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CDC37 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CDC37 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cdc37 30 |
|
||
| Str.7392 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | cdc37-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | cdc37 30 |
|
||
| CABZ01043370.1 31 |
|
OneToOne | |||
| zgc56210 30 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001914 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Cdc37 30 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | cdc-37 30 31 |
|
OneToMany | |
| W08F4.8 32 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.3576 30 |
|
- Species where no ortholog for CDC37 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CDC37 Gene
- ENSEMBL:
- Gene Tree for CDC37 (if available)
- TreeFam:
- Gene Tree for CDC37 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CDC37: view image
Paralogs for CDC37 Gene
(2) SIMAP similar genes for CDC37 Gene using alignment to 7 proteins:
- CDC37_HUMAN
- K7EIU0_HUMAN
- K7EJ06_HUMAN
- K7EKQ2_HUMAN
- K7EL68_HUMAN
- K7EQA9_HUMAN
- Q6FG59_HUMAN
Pseudogenes.org Pseudogenes for CDC37 Gene
Variants for CDC37 Gene
Residual Variation Intolerance Score:
47.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.15;
39.05% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CDC37 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CDC37
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC37 Gene
Disorders for CDC37 Gene
Additional Disease Information for CDC37
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for CDC37 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC37 Gene
Publications for CDC37 Gene
- Functional interaction of human Cdc37 with the androgen receptor but not with the glucocorticoid receptor. (PMID: 11085988) Rao J … Caplan AJ (The Journal of biological chemistry 2001) 3 4 23
- Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase. (PMID: 11036079) Shao J … Matts RL (The Journal of biological chemistry 2001) 3 4 23
- Interaction between Cdc37 and Cdk4 in human cells. (PMID: 9150368) Lamphere L … Gyuris J (Oncogene 1997) 3 4 23
- Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4. (PMID: 8666233) Stepanova L … Harper JW (Genes & development 1996) 2 3 4
- Physical interaction of mammalian CDC37 with CDK4. (PMID: 8703009) Dai K … Beach D (The Journal of biological chemistry 1996) 2 3 4
ExternalLinks
Products for CDC37 Gene
- Custom Antibody ServicesOriGene Antibodies for CDC37
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CDC37
- Origene Custom Protein Services for CDC37
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDC37
- Browse OriGene Inhibitory RNA Products For CDC37
- OriGene qPCR primer pairs for CDC37
- OriGene qPCR primer pairs and template standards for CDC37
- OriGene CRISPR knockouts for CDC37
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CDC37
- Sino Biological Human cDNA Clone for CDC37
- Sino Biological Recombinant Proteins for CDC37
- Sino Biological Cell Lysates for CDC37
- Sino Biological Antibodies for CDC37
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
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- Novus Biologicals Antibodies for CDC37
- Novus Biologicals proteins and lysates for CDC37
- Browse Antibodies
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- Abcam antibodies for CDC37
- Abcam proteins for CDC37
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- Browse Primary Antibodies
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- VectorBuilder Custom and pre-made DNA vectors for CDC37 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CDC37 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CDC37 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CDC37 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CDC37
- antibodies-online: Show 70 available CDC37 Antibodies ranked by validation data
- Compare Top CDC37 Antibodies
- antibodies-online: Show 4 available CDC37 Elisa Kits ranked by validation data
- Compare Top CDC37 Elisa Kits
- Quality Products:
- antibodies-online: Show 19 available CDC37 Proteins ranked by validation data
- Compare Top CDC37 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CDC37
- Search Santa Cruz Biotechnology (SCBT) for CDC37 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CDC37
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDC37
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDC37
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CDC37
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC37
Sources for CDC37 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131)