Aliases for CDC37 Gene
External Ids for CDC37 Gene
Previous GeneCards Identifiers for CDC37 Gene
The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDC37 Gene
CDC37 (Cell Division Cycle 37) is a Protein Coding gene. Among its related pathways are Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants and Aryl Hydrocarbon Receptor. Gene Ontology (GO) annotations related to this gene include protein kinase binding and kinase binding. An important paralog of this gene is CDC37L1.
UniProtKB/Swiss-Prot for CDC37 Gene
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206).