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Aliases for CDC37 Gene

Aliases for CDC37 Gene

  • Cell Division Cycle 37 2 3 5
  • CDC37 (Cell Division Cycle 37, S. Cerevisiae, Homolog) 2 2 3
  • Hsp90 Chaperone Protein Kinase-Targeting Subunit 3 4
  • CDC37 Cell Division Cycle 37 Homolog 2 3
  • Hsp90 Co-Chaperone Cdc37 2 3
  • CDC37 Cell Division Cycle 37 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle 37 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle 37 Homolog 3
  • P50CDC37 3
  • P50Cdc37 4
  • CDC37A 4

External Ids for CDC37 Gene

Previous GeneCards Identifiers for CDC37 Gene

  • GC19M010623
  • GC19M010724
  • GC19M010348
  • GC19M010501
  • GC19M010081

Summaries for CDC37 Gene

Entrez Gene Summary for CDC37 Gene

  • The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC37 Gene

CDC37 (Cell Division Cycle 37) is a Protein Coding gene. Among its related pathways are Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway and Akt Signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and kinase binding. An important paralog of this gene is CDC37L1.

UniProtKB/Swiss-Prot for CDC37 Gene

  • Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206).

Gene Wiki entry for CDC37 Gene

Additional gene information for CDC37 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC37 Gene

Genomics for CDC37 Gene

GeneHancer (GH) Regulatory Elements for CDC37 Gene

Promoters and enhancers for CDC37 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J010400 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 650.4 +15.9 15904 6.5 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 ZNF207 PDE4A MIR1181 CDC37 ICAM1 MRPL4 ICAM5 ICAM4 RAVER1 TYK2 C19orf38
GH19J010419 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 661.9 -0.1 -79 2 HDGF PKNOX1 CLOCK ARNT SIN3A YBX1 ZNF2 YY1 POLR2B CBX5 CDC37 PDE4A ILF3 DNMT1 KRI1 ZNF266 PPAN LOC100419831 FBXL12 RAVER1
GH19J010421 Enhancer 1 FANTOM5 ENCODE 650.7 -1.9 -1948 0.5 HDAC1 SOX13 ZNF146 SUZ12 CEBPG E4F1 IRF9 RBAK FOXK2 ZBTB48 CDC37 ILF3 LOC100419831 ZNF562 ZNF121 QTRT1 DNMT1 C19orf38 ICAM1 PDE4A
GH19J010418 Enhancer 0.9 ENCODE 650.7 +1.7 1694 0.9 HDGF HDAC1 ZSCAN4 INSM2 KLF17 MZF1 ZBTB40 EGR1 ZNF366 KLF7 PDE4A CDC37 ZNF266 RAVER1 KRI1 FBXL12 ZNF561 ILF3 EIF3G LOC100419831
GH19J010420 Enhancer 0.6 ENCODE 650.7 +1.1 1061 0.2 CTCF MTA2 ZNF740 ZBTB2 ZNF148 FOSL1 EGR1 VEZF1 RLF PRDM10 CDC37 PDE4A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDC37 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDC37 gene promoter:
  • C/EBPalpha
  • STAT3
  • AREB6
  • LCR-F1
  • Nkx2-5
  • ZID
  • XBP-1
  • Pbx1a
  • deltaCREB
  • CREB

Genomic Locations for CDC37 Gene

Genomic Locations for CDC37 Gene
chr19:10,391,131-10,420,121
(GRCh38/hg38)
Size:
28,991 bases
Orientation:
Minus strand
chr19:10,501,809-10,530,797
(GRCh37/hg19)
Size:
28,989 bases
Orientation:
Minus strand

Genomic View for CDC37 Gene

Genes around CDC37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC37 Gene

Proteins for CDC37 Gene

  • Protein details for CDC37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16543-CDC37_HUMAN
    Recommended name:
    Hsp90 co-chaperone Cdc37
    Protein Accession:
    Q16543
    Secondary Accessions:
    • Q53YA2

    Protein attributes for CDC37 Gene

    Size:
    378 amino acids
    Molecular mass:
    44468 Da
    Quaternary structure:
    • Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (PubMed:29127155). Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23 (PubMed:29127155). Forms a complex with Hsp90/HSP90AB1 and CDK6 (PubMed:9482106). Interacts with HSP90AA1 (PubMed:23569206, PubMed:27353360). Interacts with AR, CDK4, CDK6 and EIF2AK1 (PubMed:11036079, PubMed:11085988, PubMed:9150368, PubMed:9482106). Interacts with RB1 (By similarity). Interacts with KSR1 (PubMed:10409742). Interacts with FLCN, FNIP1 and FNIP2 (PubMed:27353360).

    Three dimensional structures from OCA and Proteopedia for CDC37 Gene

neXtProt entry for CDC37 Gene

Post-translational modifications for CDC37 Gene

  • Constitutively sumoylated by UBE2I.
  • Ubiquitination at posLast=330330, Lys121, and posLast=110110
  • Modification sites at PhosphoSitePlus

Other Protein References for CDC37 Gene

No data available for DME Specific Peptides for CDC37 Gene

Domains & Families for CDC37 Gene

Gene Families for CDC37 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for CDC37 Gene

Suggested Antigen Peptide Sequences for CDC37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16543

UniProtKB/Swiss-Prot:

CDC37_HUMAN :
  • Belongs to the CDC37 family.
Family:
  • Belongs to the CDC37 family.
genes like me logo Genes that share domains with CDC37: view

Function for CDC37 Gene

Molecular function for CDC37 Gene

UniProtKB/Swiss-Prot Function:
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206).
GENATLAS Biochemistry:
cell division cycle 37,S cerevisiae homolog,protein kinase targetting subunit of HSP90 that binds and stabilizes CDK4 (HSPC*),potential regulator of cell cycle

Phenotypes From GWAS Catalog for CDC37 Gene

Gene Ontology (GO) - Molecular Function for CDC37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity EXP 17349580
GO:0005515 protein binding IPI 9150368
GO:0019887 protein kinase regulator activity IEA --
GO:0019900 kinase binding IPI 21855797
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CDC37: view
genes like me logo Genes that share phenotypes with CDC37: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC37 Gene

Localization for CDC37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC37 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC37 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CDC37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS,IDA --
GO:0070062 extracellular exosome HDA 20458337
GO:0101031 chaperone complex IDA 29127155
GO:1990565 HSP90-CDC37 chaperone complex IEA --
genes like me logo Genes that share ontologies with CDC37: view

Pathways & Interactions for CDC37 Gene

genes like me logo Genes that share pathways with CDC37: view

Gene Ontology (GO) - Biological Process for CDC37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 8666233
GO:0006457 protein folding IBA --
GO:0006605 protein targeting TAS 8666233
GO:0010608 posttranscriptional regulation of gene expression IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
genes like me logo Genes that share ontologies with CDC37: view

No data available for SIGNOR curated interactions for CDC37 Gene

Drugs & Compounds for CDC37 Gene

(7) Drugs for CDC37 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0

(4) Additional Compounds for CDC37 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CDC37: view

Transcripts for CDC37 Gene

mRNA/cDNA for CDC37 Gene

Unigene Clusters for CDC37 Gene

Cell division cycle 37:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC37 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - -
SP2:
SP3:
SP4: -
SP5: - -
SP6: - - - - -
SP7:
SP8:
SP9:
SP10: -
SP11: -

Relevant External Links for CDC37 Gene

GeneLoc Exon Structure for
CDC37
ECgene alternative splicing isoforms for
CDC37

Expression for CDC37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDC37 Gene

Protein differential expression in normal tissues from HIPED for CDC37 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.4) and Bone marrow stromal cell (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDC37 Gene



Protein tissue co-expression partners for CDC37 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDC37 Gene:

CDC37

SOURCE GeneReport for Unigene cluster for CDC37 Gene:

Hs.160958

Evidence on tissue expression from TISSUES for CDC37 Gene

  • Liver(4.4)
  • Skin(4.4)
  • Nervous system(4.1)
  • Lung(3.4)
  • Muscle(2.3)
  • Heart(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with CDC37: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC37 Gene

Orthologs for CDC37 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDC37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC37 34 33
  • 94 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CDC37 34 33
  • 91.71 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CDC37 34 33
  • 91.62 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc37 16 34 33
  • 88.27 (n)
rat
(Rattus norvegicus)
Mammalia Cdc37 33
  • 85.98 (n)
oppossum
(Monodelphis domestica)
Mammalia CDC37 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC37 34
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC37 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc37 33
  • 72.73 (n)
Str.7392 33
African clawed frog
(Xenopus laevis)
Amphibia cdc37-prov 33
zebrafish
(Danio rerio)
Actinopterygii cdc37 33
  • 75.99 (n)
CABZ01043370.1 34
  • 63 (a)
OneToOne
zgc56210 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001914 33
  • 64.03 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cdc37 34 35 33
  • 63.18 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdc-37 34 33
  • 53.95 (n)
OneToMany
W08F4.8 35
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
OneToMany
Cin.3576 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3576 33
Species where no ortholog for CDC37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC37 Gene

ENSEMBL:
Gene Tree for CDC37 (if available)
TreeFam:
Gene Tree for CDC37 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDC37: view image

Paralogs for CDC37 Gene

Paralogs for CDC37 Gene

(2) SIMAP similar genes for CDC37 Gene using alignment to 7 proteins:

  • CDC37_HUMAN
  • K7EIU0_HUMAN
  • K7EJ06_HUMAN
  • K7EKQ2_HUMAN
  • K7EL68_HUMAN
  • K7EQA9_HUMAN
  • Q6FG59_HUMAN

Pseudogenes.org Pseudogenes for CDC37 Gene

genes like me logo Genes that share paralogs with CDC37: view

Variants for CDC37 Gene

Sequence variations from dbSNP and Humsavar for CDC37 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000169834 -- 10,402,298(-) C/T intron_variant
rs1000430938 -- 10,399,568(-) G/A intron_variant
rs1000888151 -- 10,401,998(-) T/C intron_variant
rs1001004712 -- 10,395,831(-) G/A intron_variant
rs1001005806 -- 10,401,637(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CDC37 Gene

Variant ID Type Subtype PubMed ID
esv24860 CNV gain 19812545
nsv518008 CNV gain 19592680

Variation tolerance for CDC37 Gene

Residual Variation Intolerance Score: 47.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.15; 39.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDC37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC37

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC37 Gene

Disorders for CDC37 Gene

Additional Disease Information for CDC37

No disorders were found for CDC37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC37 Gene

Publications for CDC37 Gene

  1. Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase. (PMID: 11036079) Shao J … Matts RL (The Journal of biological chemistry 2001) 3 4 22 58
  2. Functional interaction of human Cdc37 with the androgen receptor but not with the glucocorticoid receptor. (PMID: 11085988) Rao J … Caplan AJ (The Journal of biological chemistry 2001) 3 4 22 58
  3. Interaction between Cdc37 and Cdk4 in human cells. (PMID: 9150368) Lamphere L … Gyuris J (Oncogene 1997) 3 4 22 58
  4. Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4. (PMID: 8666233) Stepanova L … Harper JW (Genes & development 1996) 2 3 4 58
  5. Physical interaction of mammalian CDC37 with CDK4. (PMID: 8703009) Dai K … Beach D (The Journal of biological chemistry 1996) 2 3 4 58

Products for CDC37 Gene

Sources for CDC37 Gene

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