The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by ... See more...

Aliases for CDC34 Gene

Aliases for CDC34 Gene

  • Cell Division Cycle 34 2 3 5
  • (E3-Independent) E2 Ubiquitin-Conjugating Enzyme R1 3 4
  • Ubiquitin-Conjugating Enzyme E2-CDC34 3 4
  • Ubiquitin-Conjugating Enzyme E2 R1 3 4
  • E2 Ubiquitin-Conjugating Enzyme R1 3 4
  • Ubiquitin-Protein Ligase R1 3 4
  • UBE2R1 3 4
  • UBCH3 3 4
  • Ubiquitin-Conjugating Enzyme E2-32 KDA Complementing 3
  • Ubiquitin-Conjugating Enzyme E2-32 KDa Complementing 4
  • Ubiquitin Conjugating Enzyme E2 R1 2
  • Cell Division Cycle 34 Homolog 3
  • Ubiquitin Carrier Protein 3
  • EC 6.3.2.19 52
  • EC 2.3.2.23 4
  • EC 2.3.2.24 4
  • E2-CDC34 3
  • UBC3 3

External Ids for CDC34 Gene

Previous GeneCards Identifiers for CDC34 Gene

  • GC19P000542
  • GC19P000566
  • GC19P000471
  • GC19P000482
  • GC19P000302

Summaries for CDC34 Gene

Entrez Gene Summary for CDC34 Gene

  • The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC34 Gene

CDC34 (Cell Division Cycle 34) is a Protein Coding gene. Diseases associated with CDC34 include Ceroid Lipofuscinosis, Neuronal, 2 and Ceroid Lipofuscinosis, Neuronal, 1. Among its related pathways are Metabolism of proteins and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is UBE2R2.

UniProtKB/Swiss-Prot Summary for CDC34 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:22496338). Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation. Also involved in the degradation of beta-catenin. Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes (PubMed:10329681, PubMed:10373550, PubMed:10871850, PubMed:11675391, PubMed:12037680, PubMed:15652359, PubMed:17461777, PubMed:17698585, PubMed:19112177, PubMed:19126550, PubMed:19945379, PubMed:20061386, PubMed:20347421).

Gene Wiki entry for CDC34 Gene

Additional gene information for CDC34 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDC34 Gene

Genomics for CDC34 Gene

GeneHancer (GH) Regulatory Elements for CDC34 Gene

Promoters and enhancers for CDC34 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J000530 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 511.2 +0.7 725 4.1 HNRNPK EP300 CTCF NRF1 POLR2G PHF8 SIX5 POLR2A KDM6A ZBTB10 CDC34 GZMM ENSG00000267751 MIER2 TMEM259 ARID3A R3HDM4 HSALNG0122886
GH19J000543 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 10.7 +12.5 12528 2.2 POLR2G DNMT1 KLF7 MYC MCM3 ZNF148 SP2 ZBTB17 ZNF263 TBP GZMM DAZAP1 PTBP1 ENSG00000267317 TMEM259 CDC34 MIER2 CNN2 FSTL3 ENSG00000267751
GH19J000588 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 6.3 +56.9 56882 0.8 CTCF ZNF639 ZIC2 ZBTB10 ZBTB26 REST ZBTB7A SKI MXI1 ZNF341 HCN2 NONHSAG024297.2 BSG CDC34 HSALNG0122896
GH19J000906 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 3.2 +378.6 378574 8.2 FOXK2 ZBTB40 ZNF217 NRF1 TCF12 POLR2G USF1 SP1 PHF8 PHB2 R3HDM4 piR-56497-072 DAZAP1 ARHGAP45 MIER2 TMEM259 MIDN CIRBP LOC100288123 GRIN3B
GH19J000589 Promoter/Enhancer 1.5 EPDnew Ensembl dbSUPER 5.2 +58.7 58682 2.4 NRF1 ZFX REST AFF1 ZBTB26 ZBTB25 TGIF2 RUNX1 EZH2 ZSCAN9 ENSG00000267036 HCN2 LOC100420586 NONHSAG024297.2 lnc-POLRMT-8 BSG CDC34
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDC34 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDC34

Top Transcription factor binding sites by QIAGEN in the CDC34 gene promoter:
  • ER-alpha
  • MyoD
  • Pax-5

Genomic Locations for CDC34 Gene

Genomic Locations for CDC34 Gene
chr19:531,719-542,092
(GRCh38/hg38)
Size:
10,374 bases
Orientation:
Plus strand
chr19:531,714-542,097
(GRCh37/hg19)
Size:
10,384 bases
Orientation:
Plus strand

Genomic View for CDC34 Gene

Genes around CDC34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC34 Gene

Proteins for CDC34 Gene

  • Protein details for CDC34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49427-UB2R1_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 R1
    Protein Accession:
    P49427
    Secondary Accessions:
    • A8K689

    Protein attributes for CDC34 Gene

    Size:
    236 amino acids
    Molecular mass:
    26737 Da
    Quaternary structure:
    • Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. Identified in a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex together with HINT1 and RBX1. When cullin is neddylated, the interaction between the E2 and the SCF complex is strengthened (PubMed:10918611, PubMed:11675391, PubMed:18851830, PubMed:19945379, PubMed:19112177, PubMed:24316736). When phosphorylated, interacts with beta-TrCP (BTRC) (PubMed:12037680). Interacts with human herpes virus 1 protein ICP0 and associates with the proteasome for degradation (PubMed:11447293, PubMed:11805320, PubMed:12060736). Interacts with casein kinase subunit CSNK2B (PubMed:11546811).
    SequenceCaution:
    • Sequence=AAC37534.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDC34 Gene

neXtProt entry for CDC34 Gene

Selected DME Specific Peptides for CDC34 Gene

P49427:
  • LQEEPVEGFR
  • LLSVISLLNEPN
  • KFPIDYPYSPP
  • DLYNWEVAIFGPPNT
  • DGVKVPTTLAEYC
  • VCISILH
  • FRFLTKMWHPNIYE

Post-translational modifications for CDC34 Gene

  • Autoubiquitinated (PubMed:22496338, PubMed:11805320, PubMed:12060736). Autoubiquitination is promoted by the human herpes virus 1 protein ICP0 and leads to degradation by the Ubiquitin-proteasomal pathway (PubMed:11805320, PubMed:12060736).
  • Phosphorylated by CK2. Phosphorylation of the C-terminal tail by CK2 controles the nuclear localization.
  • Ubiquitination at Lys11, Lys18, and Lys63
  • Modification sites at PhosphoSitePlus

Other Protein References for CDC34 Gene

Antibody Products

  • Abcam antibodies for CDC34
  • Boster Bio Antibodies for CDC34

Domains & Families for CDC34 Gene

Gene Families for CDC34 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CDC34 Gene

Blocks:
  • Ubiquitin-conjugating enzymes
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDC34 Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin-protein ligase R1 (UB2R1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49427

UniProtKB/Swiss-Prot:

UB2R1_HUMAN :
  • The C-terminal acidic tail is required for nuclear localization and is involved in the binding to SCF E3 ligase complexes, and more specifically with the CUL1 subunit.
  • Belongs to the ubiquitin-conjugating enzyme family.
Domain:
  • The C-terminal acidic tail is required for nuclear localization and is involved in the binding to SCF E3 ligase complexes, and more specifically with the CUL1 subunit.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with CDC34: view

Function for CDC34 Gene

Molecular function for CDC34 Gene

UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:22496338). Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation. Also involved in the degradation of beta-catenin. Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes (PubMed:10329681, PubMed:10373550, PubMed:10871850, PubMed:11675391, PubMed:12037680, PubMed:15652359, PubMed:17461777, PubMed:17698585, PubMed:19112177, PubMed:19126550, PubMed:19945379, PubMed:20061386, PubMed:20347421).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence={ECO:0000255 PROSITE-ProRule:PRU00388, ECO:0000255 PROSITE-ProRule:PRU10133, ECO:0000269 PubMed:12037680, ECO:0000269 PubMed:17698585, ECO:0000269 PubMed:20061386, ECO:0000269 PubMed:20347421};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.24; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
CDC34-catalyzed polyubiquitin chain assembly activity is stimulated by the conjugation of NEDD8 to the CUL1 SCF E3 ligase complex subunit.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.11 uM for beta-catenin-monoubiquin {ECO:0000269 PubMed:19945379};
UniProtKB/Swiss-Prot Induction:
Negatively regulated by the let-7 microRNA.
GENATLAS Biochemistry:
yeast (S cerevisiae) Cdc34 homolog,involved in late G1 to S transition regulator of the cell cycle,ubiquitin conjugating enzyme E2,component of the complex SCF (SKP1/CDC53-CUL*) /F-boxprotein,involved in the ubiquitin-proteasome degradation system

Enzyme Numbers (IUBMB) for CDC34 Gene

Phenotypes From GWAS Catalog for CDC34 Gene

Gene Ontology (GO) - Molecular Function for CDC34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004842 ubiquitin-protein transferase activity NAS 8248134
GO:0005515 protein binding IPI 10373550
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with CDC34: view
genes like me logo Genes that share phenotypes with CDC34: view

Animal Models for CDC34 Gene

MGI Knock Outs for CDC34:
  • Cdc34 Cdc34<tm1.1(KOMP)Mbp>

Animal Model Products

  • Taconic Biosciences Mouse Models for CDC34

CRISPR Products

Clone Products

  • Addgene plasmids for CDC34

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDC34 Gene

Localization for CDC34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC34 Gene

Cytoplasm. Nucleus. Note=The phosphorylation of the C-terminal tail plays an important role in mediating nuclear localization. Colocalizes with beta-tubulin on mitotic spindles in anaphase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC34 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
plasma membrane 1
extracellular 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDC34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 8248134
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with CDC34: view

Pathways & Interactions for CDC34 Gene

genes like me logo Genes that share pathways with CDC34: view

Pathways by source for CDC34 Gene

1 GeneGo (Thomson Reuters) pathway for CDC34 Gene
  • Cell cycle Role of SCF complex in cell cycle regulation
1 R&D Systems pathway for CDC34 Gene

UniProtKB/Swiss-Prot P49427-UB2R1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for CDC34 Gene

Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDC34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle NAS 8248134
GO:0000209 protein polyubiquitination IDA 20347421
GO:0006270 DNA replication initiation NAS 8248134
GO:0006464 cellular protein modification process NAS 8248134
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with CDC34: view

Drugs & Compounds for CDC34 Gene

(4) Drugs for CDC34 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for CDC34 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with CDC34: view

Transcripts for CDC34 Gene

mRNA/cDNA for CDC34 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for CDC34

Alternative Splicing Database (ASD) splice patterns (SP) for CDC34 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2: -
SP3: -
SP4:

Relevant External Links for CDC34 Gene

GeneLoc Exon Structure for
CDC34

Expression for CDC34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDC34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC34 Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for CDC34 Gene

This gene is overexpressed in Cervix (17.2), Fetal Brain (7.6), and Heart (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDC34 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDC34

SOURCE GeneReport for Unigene cluster for CDC34 Gene:

Hs.514997

mRNA Expression by UniProt/SwissProt for CDC34 Gene:

P49427-UB2R1_HUMAN
Tissue specificity: Expressed in testes during spermatogenesis to regulate repression of cAMP-induced transcription.

Evidence on tissue expression from TISSUES for CDC34 Gene

  • Nervous system(4.5)
  • Lung(4.2)
  • Eye(2.3)
genes like me logo Genes that share expression patterns with CDC34: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC34 Gene

Orthologs for CDC34 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDC34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC34 31
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDC34 31
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc34 30
  • 92.34 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDC34 31
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC34 31 30
  • 91.53 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc34 17 31 30
  • 91.21 (n)
cow
(Bos Taurus)
Mammalia CDC34 31 30
  • 91.03 (n)
OneToOne
chicken
(Gallus gallus)
Aves CDC34 31 30
  • 84.11 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC34 31
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc34 30
  • 77.45 (n)
zebrafish
(Danio rerio)
Actinopterygii cdc34a 31 30
  • 75.4 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10464 30
fruit fly
(Drosophila melanogaster)
Insecta CG7656 31 32
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ubc-3 31
  • 58 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC7 31
  • 44 (a)
OneToMany
CDC34 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 59 (a)
OneToMany
Cin.13305 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13305 30
Species where no ortholog for CDC34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC34 Gene

ENSEMBL:
Gene Tree for CDC34 (if available)
TreeFam:
Gene Tree for CDC34 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDC34: view image

Paralogs for CDC34 Gene

(18) SIMAP similar genes for CDC34 Gene using alignment to 7 proteins:

  • UB2R1_HUMAN
  • U3KPV8_HUMAN
  • U3KQ74_HUMAN
  • U3KQ77_HUMAN
  • U3KQB6_HUMAN
  • U3KQP9_HUMAN
  • U3KQQ6_HUMAN
genes like me logo Genes that share paralogs with CDC34: view

Variants for CDC34 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDC34 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs16990650 - p.Asp227His

Additional dbSNP identifiers (rs#s) for CDC34 Gene

Structural Variations from Database of Genomic Variants (DGV) for CDC34 Gene

Variant ID Type Subtype PubMed ID
dgv478e201 CNV deletion 23290073
dgv6168n54 CNV gain 21841781
esv1634833 CNV insertion 17803354
esv21617 CNV loss 19812545
esv2717721 CNV deletion 23290073
esv2717724 CNV deletion 23290073
esv2717725 CNV deletion 23290073
esv2717726 CNV deletion 23290073
esv2717727 CNV deletion 23290073
esv2717728 CNV deletion 23290073
esv2717730 CNV deletion 23290073
esv2717731 CNV deletion 23290073
esv3103790 CNV deletion 24192839
esv3555818 CNV deletion 23714750
nsv1113952 CNV deletion 24896259
nsv1149447 CNV deletion 26484159
nsv428360 CNV gain 18775914
nsv470101 CNV loss 18288195
nsv509712 CNV insertion 20534489
nsv577978 CNV gain 21841781
nsv578128 CNV gain 21841781
nsv578129 CNV loss 21841781
nsv578133 CNV loss 21841781
nsv828349 CNV loss 20364138
nsv953938 CNV deletion 24416366

Variation tolerance for CDC34 Gene

Residual Variation Intolerance Score: 26.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDC34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC34

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC34 Gene

Disorders for CDC34 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CDC34 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search CDC34 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CDC34

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CDC34: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDC34 Gene

Publications for CDC34 Gene

  1. Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate. (PMID: 20347421) Wu K … Pan ZQ (Molecular cell 2010) 3 4 23 54
  2. let-7 Overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts. (PMID: 19126550) Legesse-Miller A … Coller HA (The Journal of biological chemistry 2009) 3 4 23 54
  3. Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation. (PMID: 18851830) Saha A … Deshaies RJ (Molecular cell 2008) 3 4 23 54
  4. Cdc34 C-terminal tail phosphorylation regulates Skp1/cullin/F-box (SCF)-mediated ubiquitination and cell cycle progression. (PMID: 17461777) Sadowski M … Sarcevic B (The Biochemical journal 2007) 3 4 23 54
  5. Association of human ubiquitin-conjugating enzyme CDC34 with the mitotic spindle in anaphase. (PMID: 10769200) Reymond F … Krek W (Journal of cell science 2000) 3 4 23 54

Products for CDC34 Gene

Sources for CDC34 Gene