The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin con... See more...

Aliases for CDC27 Gene

Aliases for CDC27 Gene

  • Cell Division Cycle 27 2 3 5
  • Cell Division Cycle Protein 27 Homolog 3 4
  • Anaphase Promoting Complex Subunit 3 2 3
  • D0S1430E, D17S978E 2 3
  • D0S1430E 3 4
  • D17S978E 3 4
  • CDC27Hs 3 4
  • ANAPC3 3 4
  • H-NUC 3 4
  • APC3 3 4
  • Anaphase-Promoting Complex, Protein 3 3
  • Anaphase-Promoting Complex Subunit 3 4
  • Cell Division Cycle 27 Homolog 3
  • CDC27 Homolog 4
  • Nuc2 Homolog 3
  • HNUC 3
  • NUC2 3

External Ids for CDC27 Gene

Previous HGNC Symbols for CDC27 Gene

  • D0S1430E
  • D17S978E

Previous GeneCards Identifiers for CDC27 Gene

  • GC17M044695
  • GC17M047596
  • GC17M045539
  • GC17M045672
  • GC17M042552
  • GC17M045195
  • GC17M040572

Summaries for CDC27 Gene

Entrez Gene Summary for CDC27 Gene

  • The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]

GeneCards Summary for CDC27 Gene

CDC27 (Cell Division Cycle 27) is a Protein Coding gene. Diseases associated with CDC27 include Cervix Carcinoma and Glandular Tularemia. Among its related pathways are Oocyte meiosis and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include protein phosphatase binding. An important paralog of this gene is CDC23.

UniProtKB/Swiss-Prot Summary for CDC27 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Gene Wiki entry for CDC27 Gene

Additional gene information for CDC27 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDC27 Gene

Genomics for CDC27 Gene

GeneHancer (GH) Regulatory Elements for CDC27 Gene

Promoters and enhancers for CDC27 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDC27 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDC27

Top Transcription factor binding sites by QIAGEN in the CDC27 gene promoter:
  • c-Rel
  • E47
  • GATA-3
  • Hand1
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • RelA
  • Zic1
  • Zic3

Genomic Locations for CDC27 Gene

Genomic Locations for CDC27 Gene
chr17:47,117,697-47,189,422
(GRCh38/hg38)
Size:
71,726 bases
Orientation:
Minus strand
chr17:45,195,069-45,266,788
(GRCh37/hg19)
Size:
71,720 bases
Orientation:
Minus strand

Genomic View for CDC27 Gene

Genes around CDC27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC27 Gene

Proteins for CDC27 Gene

  • Protein details for CDC27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30260-CDC27_HUMAN
    Recommended name:
    Cell division cycle protein 27 homolog
    Protein Accession:
    P30260
    Secondary Accessions:
    • G3V1C4
    • Q16349
    • Q96F35

    Protein attributes for CDC27 Gene

    Size:
    824 amino acids
    Molecular mass:
    91867 Da
    Quaternary structure:
    • Homodimer. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5 (PubMed:26083744, PubMed:25043029). Interacts with RB. Interacts with FAM168B/MANI (By similarity). Interacts with MCPH1 (PubMed:22139841).
    Miscellaneous:
    • [Isoform 2]: May be due to competing acceptor splice site.

    Three dimensional structures from OCA and Proteopedia for CDC27 Gene

    Alternative splice isoforms for CDC27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC27 Gene

Post-translational modifications for CDC27 Gene

  • Phosphorylated. Phosphorylation on Ser-426 and Thr-446 occurs specifically during mitosis.
  • Ubiquitination at Lys99, Lys588, Lys694, and Lys735
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDC27 Gene

Domains & Families for CDC27 Gene

Gene Families for CDC27 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CDC27 Gene

Suggested Antigen Peptide Sequences for CDC27 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57525, highly similar to Cell division cycle protein 27 homolog (B4DL80_HUMAN)
  • H-NUC (CDC27_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P30260

UniProtKB/Swiss-Prot:

CDC27_HUMAN :
  • Belongs to the APC3/CDC27 family.
Family:
  • Belongs to the APC3/CDC27 family.
genes like me logo Genes that share domains with CDC27: view

Function for CDC27 Gene

Molecular function for CDC27 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
GENATLAS Biochemistry:
cell division cycle 27,human homolog of S cerevisiae,yeast cdc27,component of the anaphase promoting complex that control anaphase initiation and late mitotic events

Phenotypes From GWAS Catalog for CDC27 Gene

Gene Ontology (GO) - Molecular Function for CDC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10548110
GO:0019903 protein phosphatase binding IPI 21241890
genes like me logo Genes that share ontologies with CDC27: view
genes like me logo Genes that share phenotypes with CDC27: view

Animal Model Products

CRISPR Products

miRNA for CDC27 Gene

miRTarBase miRNAs that target CDC27

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC27

Clone Products

  • Addgene plasmids for CDC27

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC27 Gene

Localization for CDC27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC27 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC27 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CDC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 21241890
GO:0005654 nucleoplasm IDA,TAS --
GO:0005680 anaphase-promoting complex IDA 16364912
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 7736578
genes like me logo Genes that share ontologies with CDC27: view

Pathways & Interactions for CDC27 Gene

PathCards logo

SuperPathways for CDC27 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.60
5 Cellular Senescence (REACTOME)
genes like me logo Genes that share pathways with CDC27: view

Pathways by source for CDC27 Gene

7 GeneGo (Thomson Reuters) pathways for CDC27 Gene
  • Cell cycle Regulation of G1/S transition (part 1)
  • Cell cycle Role of SCF complex in cell cycle regulation
  • Cell cycle_Role of APC in cell cycle regulation
  • Cell cycle_Spindle assembly and chromosome separation
  • Development_TGF-beta receptor signaling
6 Qiagen pathways for CDC27 Gene
  • Activation of PKA through GPCR
  • cAMP Pathway
  • CDC42 Pathway
  • Epithelial Adherens Junctions
  • Mitotic Roles of Polo Like Kinases
1 Cell Signaling Technology pathway for CDC27 Gene

UniProtKB/Swiss-Prot P30260-CDC27_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for CDC27 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process TAS --
GO:0007091 metaphase/anaphase transition of mitotic cell cycle IMP 7736578
GO:0016567 protein ubiquitination IEA --
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CDC27: view

Drugs & Compounds for CDC27 Gene

No Compound Related Data Available

Transcripts for CDC27 Gene

mRNA/cDNA for CDC27 Gene

9 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC27

Clone Products

  • Addgene plasmids for CDC27

Alternative Splicing Database (ASD) splice patterns (SP) for CDC27 Gene

No ASD Table

Relevant External Links for CDC27 Gene

GeneLoc Exon Structure for
CDC27

Expression for CDC27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDC27 Gene

Protein differential expression in normal tissues from HIPED for CDC27 Gene

This gene is overexpressed in Lung (24.5), Placenta (14.9), and Breast (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDC27 Gene



Protein tissue co-expression partners for CDC27 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDC27

SOURCE GeneReport for Unigene cluster for CDC27 Gene:

Hs.463295

Evidence on tissue expression from TISSUES for CDC27 Gene

  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with CDC27: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC27 Gene

Orthologs for CDC27 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC27 31 30
  • 99.88 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CDC27 31 30
  • 97.17 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CDC27 31 30
  • 96.52 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDC27 31
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc27 17 31 30
  • 92.92 (n)
rat
(Rattus norvegicus)
Mammalia Cdc27 30
  • 92.79 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDC27 31
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC27 31 30
  • 86.27 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC27 31
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc27 30
  • 78.43 (n)
Str.17164 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.14864 30
zebrafish
(Danio rerio)
Actinopterygii cdc27 31 30
  • 72.19 (n)
OneToOne
wufb54g06 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5705 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007690 30
  • 51.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cdc27 31 32 30
  • 49.35 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mat-1 31
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC27 33 31
  • 29 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons HBT 30
  • 51.56 (n)
rice
(Oryza sativa)
Liliopsida Os06g0622500 30
  • 47.95 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.74 31
  • 43 (a)
OneToOne
Cin.4019 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4019 30
Species where no ortholog for CDC27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC27 Gene

ENSEMBL:
Gene Tree for CDC27 (if available)
TreeFam:
Gene Tree for CDC27 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDC27: view image

Paralogs for CDC27 Gene

Variants for CDC27 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDC27 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
691419 Uncertain Significance: Pyloric stenosis; Esophageal atresia 47,189,169(-) T/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT
782550 Benign: not provided 47,154,771(-) T/C NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
VAR_035861 A breast cancer sample p.Gly270Ala
rs13666 - p.Tyr496His

Additional dbSNP identifiers (rs#s) for CDC27 Gene

Structural Variations from Database of Genomic Variants (DGV) for CDC27 Gene

Variant ID Type Subtype PubMed ID
dgv417e201 CNV deletion 23290073
dgv418e201 CNV deletion 23290073
dgv419e201 CNV deletion 23290073
dgv41n68 CNV loss 17160897
dgv420e201 CNV deletion 23290073
dgv421e201 CNV deletion 23290073
dgv422e201 CNV deletion 23290073
dgv423e201 CNV deletion 23290073
dgv532n67 CNV gain 20364138
dgv65e19 CNV loss 19470904
esv1725912 CNV insertion 17803354
esv22671 CNV gain 19812545
esv2543466 CNV insertion 19546169
esv2655194 CNV gain 19546169
esv2715978 CNV deletion 23290073
esv2715987 CNV deletion 23290073
esv2715988 CNV deletion 23290073
esv2715992 CNV deletion 23290073
esv2715993 CNV deletion 23290073
esv2716009 CNV deletion 23290073
esv2742082 CNV deletion 23290073
esv2758692 CNV gain+loss 17122850
esv2760450 CNV gain 21179565
esv2990 CNV loss 18987735
esv3411051 CNV duplication 20981092
esv3426884 CNV insertion 20981092
esv3435421 CNV duplication 20981092
esv3584 OTHER complex 18987735
esv3790 CNV loss 18987735
esv4309 OTHER complex 18987735
esv4323 CNV loss 18987735
esv4562 CNV loss 18987735
esv4785 OTHER complex 18987735
esv4896 CNV loss 18987735
esv5454 CNV loss 19470904
esv5729 CNV loss 19470904
esv6177 CNV loss 19470904
esv6495 CNV loss 19470904
esv6742 CNV loss 19470904
esv7557 CNV loss 19470904
esv7866 CNV loss 19470904
esv8272 CNV loss 19470904
esv8768 CNV loss 19470904
nsv1059766 CNV gain 25217958
nsv1127577 CNV deletion 24896259
nsv1138548 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv513476 CNV insertion 21212237
nsv521632 CNV gain 19592680
nsv955389 CNV deletion 24416366
nsv955402 CNV deletion 24416366
nsv955412 CNV deletion 24416366
nsv955428 CNV deletion 24416366
nsv960117 CNV duplication 23825009
nsv960498 CNV duplication 23825009
nsv962332 CNV duplication 23825009
nsv962333 CNV duplication 23825009
nsv978432 CNV duplication 23825009

Variation tolerance for CDC27 Gene

Residual Variation Intolerance Score: 99.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDC27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC27

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC27 Gene

Disorders for CDC27 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CDC27 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cervix carcinoma
  • cancer of cervix
glandular tularemia
typhoidal tularemia
breast cancer
  • breast cancer, familial
joubert syndrome 1
  • jbts1
- elite association - COSMIC cancer census association via MalaCards
Search CDC27 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CDC27

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CDC27: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDC27 Gene

Publications for CDC27 Gene

  1. Identification of a human homologue of yeast nuc2 which interacts with the retinoblastoma protein in a specific manner. (PMID: 7756179) Chen PL … Lee WH (Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995) 3 4 23 54
  2. Linking yeast genetics to mammalian genomes: identification and mapping of the human homolog of CDC27 via the expressed sequence tag (EST) data base. (PMID: 8234252) Tugendreich S … Hieter P (Proceedings of the National Academy of Sciences of the United States of America 1993) 2 3 4 54
  3. Atomic structure of the APC/C and its mechanism of protein ubiquitination. (PMID: 26083744) Chang L … Barford D (Nature 2015) 3 4 54
  4. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang LF … Barford D (Nature 2014) 3 4 54
  5. Molecular basis for the association of microcephalin (MCPH1) protein with the cell division cycle protein 27 (Cdc27) subunit of the anaphase-promoting complex. (PMID: 22139841) Singh N … Couch FJ (The Journal of biological chemistry 2012) 3 4 54

Products for CDC27 Gene