Aliases for CDC26 Gene
External Ids for CDC26 Gene
Previous HGNC Symbols for CDC26 Gene
Previous GeneCards Identifiers for CDC26 Gene
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDC26 Gene
CDC26 (Cell Division Cycle 26) is a Protein Coding gene. Diseases associated with CDC26 include Cornea Cancer. Among its related pathways are Cellular Senescence (REACTOME) and Class I MHC mediated antigen processing and presentation.
UniProtKB/Swiss-Prot Summary for CDC26 Gene
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.