The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2... See more...

Aliases for CDC26 Gene

Aliases for CDC26 Gene

  • Cell Division Cycle 26 2 3 5
  • C9orf17 2 3 4
  • ANAPC12 2 3 4
  • APC12 2 3 4
  • CDC26 Subunit Of Anaphase Promoting Complex 2 3
  • Anaphase-Promoting Complex Subunit CDC26 3 4
  • Cell Division Cycle Protein 26 Homolog 3 4
  • Anaphase-Promoting Complex Subunit 12 3 4
  • Anaphase Promoting Complex Subunit 12 2
  • Cell Division Cycle 26 Homolog 3
  • CDC26 5

External Ids for CDC26 Gene

Previous HGNC Symbols for CDC26 Gene

  • C9orf17

Previous GeneCards Identifiers for CDC26 Gene

  • GC09M106827
  • GC09M107761
  • GC09M109471
  • GC09M111405
  • GC09M113108
  • GC09M115069
  • GC09M116018
  • GC09M085636

Summaries for CDC26 Gene

Entrez Gene Summary for CDC26 Gene

  • The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC26 Gene

CDC26 (Cell Division Cycle 26) is a Protein Coding gene. Diseases associated with CDC26 include Cornea Cancer. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Signal transduction_PKA signaling.

UniProtKB/Swiss-Prot Summary for CDC26 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

Additional gene information for CDC26 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDC26 Gene

Genomics for CDC26 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDC26 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDC26 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDC26

Top Transcription factor binding sites by QIAGEN in the CDC26 gene promoter:
  • E47
  • Elk-1
  • Hand1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • NF-E2 p45
  • RP58

Genomic Locations for CDC26 Gene

Genomic Locations for CDC26 Gene
chr9:113,255,835-113,275,579
(GRCh38/hg38)
Size:
19,745 bases
Orientation:
Minus strand
chr9:116,018,115-116,037,869
(GRCh37/hg19)
Size:
19,755 bases
Orientation:
Minus strand

Genomic View for CDC26 Gene

Genes around CDC26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC26 Gene

Proteins for CDC26 Gene

  • Protein details for CDC26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHZ8-CDC26_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit CDC26
    Protein Accession:
    Q8NHZ8

    Protein attributes for CDC26 Gene

    Size:
    85 amino acids
    Molecular mass:
    9777 Da
    Quaternary structure:
    • V-shaped homodimer. Interacts with CDC16. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5.

    Three dimensional structures from OCA and Proteopedia for CDC26 Gene

neXtProt entry for CDC26 Gene

Post-translational modifications for CDC26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDC26 Gene

No data available for DME Specific Peptides for CDC26 Gene

Domains & Families for CDC26 Gene

Gene Families for CDC26 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CDC26 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDC26 Gene

GenScript: Design optimal peptide antigens:
  • Cell division cycle protein 26 homolog (CDC26_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NHZ8

UniProtKB/Swiss-Prot:

CDC26_HUMAN :
  • Belongs to the CDC26 family.
Family:
  • Belongs to the CDC26 family.
genes like me logo Genes that share domains with CDC26: view

Function for CDC26 Gene

Molecular function for CDC26 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

Phenotypes From GWAS Catalog for CDC26 Gene

Gene Ontology (GO) - Molecular Function for CDC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19668213
genes like me logo Genes that share ontologies with CDC26: view
genes like me logo Genes that share phenotypes with CDC26: view

Animal Models for CDC26 Gene

MGI Knock Outs for CDC26:
  • Cdc26 Cdc26<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC26

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CDC26 Gene

Localization for CDC26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC26 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC26 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CDC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IBA,IDA 10922056
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CDC26: view

Pathways & Interactions for CDC26 Gene

PathCards logo

SuperPathways for CDC26 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
2 APC-Cdc20 mediated degradation of Nek2A
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.60
5 Cellular Senescence (REACTOME)
genes like me logo Genes that share pathways with CDC26: view

Pathways by source for CDC26 Gene

7 GeneGo (Thomson Reuters) pathways for CDC26 Gene
  • Cell cycle Regulation of G1/S transition (part 1)
  • Cell cycle Role of SCF complex in cell cycle regulation
  • Cell cycle_Role of APC in cell cycle regulation
  • Cell cycle_Spindle assembly and chromosome separation
  • Development_TGF-beta receptor signaling

UniProtKB/Swiss-Prot Q8NHZ8-CDC26_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for CDC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process TAS --
GO:0007049 cell cycle IEA --
GO:0007346 regulation of mitotic cell cycle IBA 21873635
GO:0016567 protein ubiquitination IEA --
GO:0030071 regulation of mitotic metaphase/anaphase transition IEA --
genes like me logo Genes that share ontologies with CDC26: view

No data available for SIGNOR curated interactions for CDC26 Gene

Drugs & Compounds for CDC26 Gene

No Compound Related Data Available

Transcripts for CDC26 Gene

mRNA/cDNA for CDC26 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC26

Alternative Splicing Database (ASD) splice patterns (SP) for CDC26 Gene

No ASD Table

Relevant External Links for CDC26 Gene

GeneLoc Exon Structure for
CDC26

Expression for CDC26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDC26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDC26 Gene

This gene is overexpressed in Lung (29.3), Peripheral blood mononuclear cells (9.1), and Breast (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDC26 Gene



Protein tissue co-expression partners for CDC26 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDC26

SOURCE GeneReport for Unigene cluster for CDC26 Gene:

Hs.727648

Evidence on tissue expression from TISSUES for CDC26 Gene

  • Nervous system(4.5)
  • Skin(4.3)
  • Liver(2.3)
  • Intestine(2.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with CDC26: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC26 Gene

Orthologs for CDC26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDC26 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDC26 30 31
  • 100 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CDC26 30 31
  • 91.76 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CDC26 30 31
  • 91.37 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CDC26 31
  • 89 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cdc26 30
  • 87.45 (n)
Mouse
(Mus musculus)
Mammalia Cdc26 30 17 31
  • 86.27 (n)
OneToOne
Chicken
(Gallus gallus)
Aves CDC26 31
  • 63 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CDC26 31
  • 81 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.15762 30
Zebrafish
(Danio rerio)
Actinopterygii cdc26 30 31
  • 66.67 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9059 30
Species where no ortholog for CDC26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CDC26 Gene

ENSEMBL:
Gene Tree for CDC26 (if available)
TreeFam:
Gene Tree for CDC26 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDC26: view image

Paralogs for CDC26 Gene

No data available for Paralogs for CDC26 Gene

Variants for CDC26 Gene

Additional dbSNP identifiers (rs#s) for CDC26 Gene

Variation tolerance for CDC26 Gene

Residual Variation Intolerance Score: 63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDC26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC26

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for CDC26 Gene

Disorders for CDC26 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDC26 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cornea cancer
  • corneal tumor
- elite association - COSMIC cancer census association via MalaCards
Search CDC26 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with CDC26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDC26 Gene

Publications for CDC26 Gene

  1. The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. (PMID: 10922056) Gmachl M … Peters JM (Proceedings of the National Academy of Sciences of the United States of America 2000) 2 3 4
  2. Atomic structure of the APC/C and its mechanism of protein ubiquitination. (PMID: 26083744) Chang L … Barford D (Nature 2015) 3 4
  3. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang LF … Barford D (Nature 2014) 3 4
  4. Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure. (PMID: 19668213) Wang J … Schulman BA (Nature structural & molecular biology 2009) 3 4
  5. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PMID: 18485873) Jin L … Rape M (Cell 2008) 3 4

Products for CDC26 Gene

Sources for CDC26 Gene