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Aliases for CDC25C Gene

Aliases for CDC25C Gene

  • Cell Division Cycle 25C 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 60 2 3
  • EC 4 56
  • CDC25 2 3
  • Dual Specificity Phosphatase CDC25C 3
  • Dual Specificity Phosphatase Cdc25C 4
  • M-Phase Inducer Phosphatase 3 3
  • Phosphotyrosine Phosphatase 3
  • Mitosis Inducer CDC25 3
  • PPP1R60 3

External Ids for CDC25C Gene

Previous HGNC Symbols for CDC25C Gene

  • CDC25

Previous GeneCards Identifiers for CDC25C Gene

  • GC05M137495
  • GC05M137651
  • GC05M137697
  • GC05M137648
  • GC05M132811
  • GC05M137620

Summaries for CDC25C Gene

Entrez Gene Summary for CDC25C Gene

  • This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015]

GeneCards Summary for CDC25C Gene

CDC25C (Cell Division Cycle 25C) is a Protein Coding gene. Diseases associated with CDC25C include Plague and Prostate Cancer. Among its related pathways are Gene Expression and Akt Signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and WW domain binding. An important paralog of this gene is CDC25B.

UniProtKB/Swiss-Prot for CDC25C Gene

  • Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.

Tocris Summary for CDC25C Gene

  • Cdc25 is a dual specificity phosphatase with three isoforms in mammalian cells - Cdc25A, B and C. Cdc25 activates cdk complexes that drive the cell cycle. Cdc25 is involved in the DNA damage checkpoints and is known as a key mediator of cell cycle progression.

Gene Wiki entry for CDC25C Gene

Additional gene information for CDC25C Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC25C Gene

Genomics for CDC25C Gene

GeneHancer (GH) Regulatory Elements for CDC25C Gene

Promoters and enhancers for CDC25C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I138335 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 556.7 +0.8 815 5 CLOCK ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 CDC25C FAM53C HNRNPA0 KDM3B RPL7P19 CDC23 REEP2 MATR3 NME5 SPOCK1
GH05I138330 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.4 +6.8 6795 2.1 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 FAM53C LOC100128966 CDC25C HNRNPA0 KDM3B GFRA3 LOC105379194 GC05P138279 GC05M138244
GH05I138368 Enhancer 1 Ensembl ENCODE dbSUPER 12.7 -31.5 -31546 3.8 FOXA2 CBFA2T3 ATF2 ZNF121 ZNF316 EGR1 MAFK WT1 EMSY FAM53C CDC25C ENSG00000249971 BRD8 KIF20A HSPA9 GFRA3 KDM3B REEP2 GC05P138377
GH05I138463 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.6 -126.9 -126894 4.1 CLOCK IRF4 YY1 E2F8 ZNF143 SP3 SSRP1 ZNF610 ZNF585B GLIS1 EGR1 HNRNPA0 CDC23 KDM3B BRD8 RPL7P19 ETF1 FAM13B FAM53C REEP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CDC25C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDC25C gene promoter:

Genomic Locations for CDC25C Gene

Genomic Locations for CDC25C Gene
53,091 bases
Minus strand

Genomic View for CDC25C Gene

Genes around CDC25C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC25C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC25C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC25C Gene

Proteins for CDC25C Gene

  • Protein details for CDC25C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    M-phase inducer phosphatase 3
    Protein Accession:
    Secondary Accessions:
    • D3DQB8
    • Q96PL3
    • Q9H168
    • Q9H2E8
    • Q9H2E9
    • Q9H2F1

    Protein attributes for CDC25C Gene

    473 amino acids
    Molecular mass:
    53365 Da
    Quaternary structure:
    • Interacts with HIV-1 Vpr, thereby inactivating CDC25C phosphatase activity. Interacts with MAPK14 and 14-3-3 proteins. When phosphorylated on Ser-129 and/or Thr-130, interacts with PLK1.

    Three dimensional structures from OCA and Proteopedia for CDC25C Gene

    Alternative splice isoforms for CDC25C Gene


neXtProt entry for CDC25C Gene

Selected DME Specific Peptides for CDC25C Gene


Post-translational modifications for CDC25C Gene

  • Phosphorylated by CHEK1 and MAPK14 at Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase. Phosphorylated by PLK4. Phosphorylated by PLK1, leading to activate the phosphatase activity. Phosphorylation by PLK3 at Ser-191 promotes nuclear translocation. Ser-198 is a minor phosphorylation site. Was initially reported to be phosphorylated by PLK3 at Ser-216 (PubMed:10557092). However, such phosphorylation by PLK3 was not confirmed by other groups. Phosphorylation at Thr-48, Thr-67, Ser-122, Thr-130, Ser-168 and Ser-214 occurs at G2 and G2-M transition and is probably catalyzed by CDK1. Ser-168 phosphorylation levels are lower than those at the other 5 CDK1 sites. Phosphorylation by CDK1 leads to increased activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for CDC25C

Domains & Families for CDC25C Gene

Gene Families for CDC25C Gene

Suggested Antigen Peptide Sequences for CDC25C Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MPI phosphatase family.
  • Belongs to the MPI phosphatase family.
genes like me logo Genes that share domains with CDC25C: view

Function for CDC25C Gene

Molecular function for CDC25C Gene

GENATLAS Biochemistry:
cdc25 protein phosphatase,non receptor type,form C,complexing with CDC2 (M phase promoting factor (MPF) component),regulator of the cell cycle entry into mitosis by dephosphorylating the protein kinase CDC2
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.

Enzyme Numbers (IUBMB) for CDC25C Gene

Phenotypes From GWAS Catalog for CDC25C Gene

Gene Ontology (GO) - Molecular Function for CDC25C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity TAS --
GO:0004725 protein tyrosine phosphatase activity NAS 11078813
GO:0005515 protein binding IPI 11836499
GO:0016787 hydrolase activity IEA --
GO:0019901 protein kinase binding IPI 14968113
genes like me logo Genes that share ontologies with CDC25C: view
genes like me logo Genes that share phenotypes with CDC25C: view

Animal Models for CDC25C Gene

MGI Knock Outs for CDC25C:

Animal Model Products

  • Taconic Biosciences Mouse Models for CDC25C

miRNA for CDC25C Gene

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDC25C Gene

Localization for CDC25C Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC25C Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC25C gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDC25C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 14968113
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CDC25C: view

Pathways & Interactions for CDC25C Gene

genes like me logo Genes that share pathways with CDC25C: view

SIGNOR curated interactions for CDC25C Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CDC25C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 11139144
GO:0000086 G2/M transition of mitotic cell cycle TAS,IGI --
GO:0006260 DNA replication TAS --
GO:0006470 protein dephosphorylation IEA --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
genes like me logo Genes that share ontologies with CDC25C: view

Drugs & Compounds for CDC25C Gene

(55) Drugs for CDC25C Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Temozolomide Approved, Investigational Pharma 758
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
NSC 95397 Pharma Selective Cdc25 dual specificity phosphatase inhibitor 0
NSC 663284 Pharma 0

(31) Additional Compounds for CDC25C Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)

(2) Tocris Compounds for CDC25C Gene

Compound Action Cas Number
NSC 663284 Potent, selective Cdc25 phosphatase inhibitor 383907-43-5
NSC 95397 Selective Cdc25 dual specificity phosphatase inhibitor 93718-83-3

(3) ApexBio Compounds for CDC25C Gene

Compound Action Cas Number
NSC 663284 383907-43-5
NSC 95397 93718-83-3
Temozolomide 85622-93-1
genes like me logo Genes that share compounds with CDC25C: view

Drug Products

Transcripts for CDC25C Gene

Unigene Clusters for CDC25C Gene

Cell division cycle 25C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC25C Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP3: - - -
SP4: - - -

Relevant External Links for CDC25C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDC25C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDC25C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC25C Gene

This gene is overexpressed in Testis (x18.2).

Protein differential expression in normal tissues from HIPED for CDC25C Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDC25C Gene

Protein tissue co-expression partners for CDC25C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDC25C Gene:


SOURCE GeneReport for Unigene cluster for CDC25C Gene:


Evidence on tissue expression from TISSUES for CDC25C Gene

  • Skin(4.4)
  • Intestine(2.5)
genes like me logo Genes that share expression patterns with CDC25C: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC25C Gene

Orthologs for CDC25C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDC25C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDC25C 33 34
  • 99.44 (n)
(Canis familiaris)
Mammalia CDC25C 33 34
  • 86.86 (n)
(Bos Taurus)
Mammalia CDC25C 33 34
  • 86.61 (n)
(Rattus norvegicus)
Mammalia Cdc25c 33
  • 83.46 (n)
(Mus musculus)
Mammalia Cdc25c 33 16 34
  • 79.65 (n)
(Monodelphis domestica)
Mammalia CDC25C 34
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 28 (a)
(Anolis carolinensis)
Reptilia CDC25C 34
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc25c 33
  • 57.86 (n)
African clawed frog
(Xenopus laevis)
Amphibia xcdc25-3 33
(Danio rerio)
Actinopterygii cdc25d 34
  • 25 (a)
fruit fly
(Drosophila melanogaster)
Insecta stg 35 34
  • 46 (a)
twe 35 34
  • 45 (a)
(Caenorhabditis elegans)
Secernentea cdc-25.3 34
  • 26 (a)
cdc-25.4 34
  • 25 (a)
cdc-25.2 34
  • 17 (a)
cdc-25.1 34
  • 14 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIH1 34
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1787 34
  • 31 (a)
Species where no ortholog for CDC25C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC25C Gene

Gene Tree for CDC25C (if available)
Gene Tree for CDC25C (if available)

Paralogs for CDC25C Gene

Paralogs for CDC25C Gene

(3) SIMAP similar genes for CDC25C Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CDC25C: view

Variants for CDC25C Gene

Sequence variations from dbSNP and Humsavar for CDC25C Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000105508 -- 138,303,572(-) C/T intron_variant
rs1000142993 -- 138,291,107(-) A/G intron_variant
rs1000162414 -- 138,320,030(-) G/A intron_variant
rs1000169474 -- 138,289,888(-) G/A intron_variant
rs1000173148 -- 138,321,107(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CDC25C Gene

Variant ID Type Subtype PubMed ID
nsv1033604 CNV gain 25217958
nsv1142451 CNV tandem duplication 24896259
nsv472931 CNV novel sequence insertion 20440878

Variation tolerance for CDC25C Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.79; 93.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDC25C Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC25C Gene

Disorders for CDC25C Gene

MalaCards: The human disease database

(3) MalaCards diseases for CDC25C Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • yersiniosis
prostate cancer
  • prostate cancer, susceptibility to
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CDC25C

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CDC25C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDC25C Gene

Publications for CDC25C Gene

  1. Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation. (PMID: 14968113) Bahassi el M … Stambrook PJ (Oncogene 2004) 3 4 22 58
  2. The human immunodeficiency virus Vpr protein binds Cdc25C: implications for G2 arrest. (PMID: 14972559) Goh WC … Emerman M (Virology 2004) 3 4 22 58
  3. The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase. (PMID: 11202906) Roshak AK … Marshall LA (Cellular signalling 2000) 3 4 22 58
  4. An additional transcript of the cdc25C gene from A431 cells encodes a functional protein. (PMID: 11078813) Bureik M … Wagner P (International journal of oncology 2000) 3 4 22 58
  5. Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C. (PMID: 11139144) Wegener S … Schaller HC (European journal of cell biology 2000) 3 4 22 58

Products for CDC25C Gene

Sources for CDC25C Gene

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