This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015] See more...

Aliases for CDC25C Gene

Aliases for CDC25C Gene

  • Cell Division Cycle 25C 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 60 2 3
  • M-Phase Inducer Phosphatase 3 3 4
  • EC 3.1.3.48 4 51
  • PPP1R60 2 3
  • CDC25 2 3
  • Dual Specificity Phosphatase CDC25C 3
  • Dual Specificity Phosphatase Cdc25C 4
  • Phosphotyrosine Phosphatase 3
  • Mitosis Inducer CDC25 3
  • CDC25C 5

External Ids for CDC25C Gene

Previous HGNC Symbols for CDC25C Gene

  • CDC25

Previous GeneCards Identifiers for CDC25C Gene

  • GC05M137495
  • GC05M138296
  • GC05M137651
  • GC05M137697
  • GC05M137648
  • GC05M132811
  • GC05M137620

Summaries for CDC25C Gene

Entrez Gene Summary for CDC25C Gene

  • This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015]

GeneCards Summary for CDC25C Gene

CDC25C (Cell Division Cycle 25C) is a Protein Coding gene. Diseases associated with CDC25C include Ataxia-Telangiectasia and Breast Adenocarcinoma. Among its related pathways are ATM Pathway and Monoamine Transport. Gene Ontology (GO) annotations related to this gene include protein kinase binding and WW domain binding. An important paralog of this gene is CDC25B.

UniProtKB/Swiss-Prot Summary for CDC25C Gene

  • Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.

Tocris Summary for CDC25C Gene

  • Cdc25 is a dual specificity phosphatase with three isoforms in mammalian cells - Cdc25A, B and C. Cdc25 activates cdk complexes that drive the cell cycle. Cdc25 is involved in the DNA damage checkpoints and is known as a key mediator of cell cycle progression.

Gene Wiki entry for CDC25C Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDC25C Gene

Genomics for CDC25C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDC25C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDC25C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDC25C

Top Transcription factor binding sites by QIAGEN in the CDC25C gene promoter:
  • ATF-2
  • NF-kappaB
  • NF-kappaB1
  • STAT3

Genomic Locations for CDC25C Gene

Genomic Locations for CDC25C Gene
chr5:138,285,265-138,338,355
(GRCh38/hg38)
Size:
53,091 bases
Orientation:
Minus strand
chr5:137,620,954-137,674,044
(GRCh37/hg19)
Size:
53,091 bases
Orientation:
Minus strand

Genomic View for CDC25C Gene

Genes around CDC25C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC25C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC25C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC25C Gene

Proteins for CDC25C Gene

  • Protein details for CDC25C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30307-MPIP3_HUMAN
    Recommended name:
    M-phase inducer phosphatase 3
    Protein Accession:
    P30307
    Secondary Accessions:
    • D3DQB8
    • Q96PL3
    • Q9H168
    • Q9H2E8
    • Q9H2E9
    • Q9H2F1

    Protein attributes for CDC25C Gene

    Size:
    473 amino acids
    Molecular mass:
    53365 Da
    Quaternary structure:
    • Interacts with MAPK14 and 14-3-3 proteins. When phosphorylated on Ser-129 and/or Thr-130, interacts with PLK1.
    • (Microbial infection) Interacts with HIV-1 Vpr; this interaction inactivates CDC25C phosphatase activity.

    Three dimensional structures from OCA and Proteopedia for CDC25C Gene

    Alternative splice isoforms for CDC25C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC25C Gene

Selected DME Specific Peptides for CDC25C Gene

P30307:
  • PQSYCPM
  • CEFSSERGPRMCR
  • QIALLVK
  • FHCEFSS
  • YCPMHHQD
  • GKHQDLKY
  • LYRSPSMPE
  • CLDLSNL
  • YPELYIL

Post-translational modifications for CDC25C Gene

  • Phosphorylated by CHEK1 and MAPK14 at Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase. Phosphorylated by PLK4. Phosphorylated by PLK1, leading to activate the phosphatase activity. Phosphorylation by PLK3 at Ser-191 promotes nuclear translocation. Ser-198 is a minor phosphorylation site. Was initially reported to be phosphorylated by PLK3 at Ser-216 (PubMed:10557092). However, such phosphorylation by PLK3 was not confirmed by other groups. Phosphorylation at Thr-48, Thr-67, Ser-122, Thr-130, Ser-168 and Ser-214 occurs at G2 and G2-M transition and is probably catalyzed by CDK1. Ser-168 phosphorylation levels are lower than those at the other 5 CDK1 sites. Phosphorylation by CDK1 leads to increased activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for CDC25C

Domains & Families for CDC25C Gene

Gene Families for CDC25C Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CDC25C Gene

InterPro:
Blocks:
  • M-phase inducer phosphatase signature
  • Rhodanese-like
ProtoNet:

Suggested Antigen Peptide Sequences for CDC25C Gene

GenScript: Design optimal peptide antigens:
  • Dual specificity phosphatase Cdc25C (MPIP3_HUMAN)
  • Cell division cycle 25C splice variant 3 (Q9H2F0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P30307

UniProtKB/Swiss-Prot:

MPIP3_HUMAN :
  • Belongs to the MPI phosphatase family.
Family:
  • Belongs to the MPI phosphatase family.
genes like me logo Genes that share domains with CDC25C: view

Function for CDC25C Gene

Molecular function for CDC25C Gene

UniProtKB/Swiss-Prot Function:
Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48;.
GENATLAS Biochemistry:
cdc25 protein phosphatase,non receptor type,form C,complexing with CDC2 (M phase promoting factor (MPF) component),regulator of the cell cycle entry into mitosis by dephosphorylating the protein kinase CDC2

Enzyme Numbers (IUBMB) for CDC25C Gene

Phenotypes From GWAS Catalog for CDC25C Gene

Gene Ontology (GO) - Molecular Function for CDC25C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IBA,NAS 11078813
GO:0005515 protein binding IPI 9543386
GO:0016787 hydrolase activity IEA --
GO:0019901 protein kinase binding IPI 9543386
genes like me logo Genes that share ontologies with CDC25C: view
genes like me logo Genes that share phenotypes with CDC25C: view

Animal Models for CDC25C Gene

MGI Knock Outs for CDC25C:

Animal Model Products

  • Taconic Biosciences Mouse Models for CDC25C

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC25C

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDC25C Gene

Localization for CDC25C Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC25C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC25C gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDC25C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 14968113
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with CDC25C: view

Pathways & Interactions for CDC25C Gene

genes like me logo Genes that share pathways with CDC25C: view

Pathways by source for CDC25C Gene

2 GeneGo (Thomson Reuters) pathways for CDC25C Gene
  • Cell cycle Cell cycle (generic schema)
  • Cell cycle Role of 14-3-3 proteins in cell cycle regulation
7 Qiagen pathways for CDC25C Gene
  • 14-3-3 and Cell Cycle Regulation
  • ATM Pathway
  • Chks in Checkpoint Regulation
  • G2-M Phase Transition
  • Mitotic Roles of Polo Like Kinases
1 Cell Signaling Technology pathway for CDC25C Gene
2 GeneTex pathways for CDC25C Gene

SIGNOR curated interactions for CDC25C Gene

Activates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDC25C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 11139144
GO:0000086 G2/M transition of mitotic cell cycle IGI,TAS --
GO:0006470 protein dephosphorylation IEA --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with CDC25C: view

Drugs & Compounds for CDC25C Gene

(53) Drugs for CDC25C Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Temozolomide Approved, Investigational Pharma Alkylating Agents 892
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
NSC 663284 Pharma Potent, selective Cdc25 phosphatase inhibitor 0
NSC 95397 Pharma Selective Cdc25 dual specificity phosphatase inhibitor 0

(33) Additional Compounds for CDC25C Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2

(2) Tocris Compounds for CDC25C Gene

Compound Action Cas Number
NSC 663284 Potent, selective Cdc25 phosphatase inhibitor 383907-43-5
NSC 95397 Selective Cdc25 dual specificity phosphatase inhibitor 93718-83-3

(3) ApexBio Compounds for CDC25C Gene

Compound Action Cas Number
NSC 663284 383907-43-5
NSC 95397 93718-83-3
Temozolomide 85622-93-1
genes like me logo Genes that share compounds with CDC25C: view

Drug Products

Transcripts for CDC25C Gene

mRNA/cDNA for CDC25C Gene

8 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC25C

Alternative Splicing Database (ASD) splice patterns (SP) for CDC25C Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1:
SP2:
SP3: - - -
SP4: - - -

Relevant External Links for CDC25C Gene

GeneLoc Exon Structure for
CDC25C

Expression for CDC25C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDC25C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC25C Gene

This gene is overexpressed in Testis (x18.2).

Protein differential expression in normal tissues from HIPED for CDC25C Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDC25C Gene



Protein tissue co-expression partners for CDC25C Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDC25C

SOURCE GeneReport for Unigene cluster for CDC25C Gene:

Hs.656

Evidence on tissue expression from TISSUES for CDC25C Gene

  • Skin(4.5)
  • Intestine(2.9)
  • Nervous system(2.5)
  • Pancreas(2.4)
  • Lung(2.4)
  • Kidney(2.2)
  • Blood(2.1)
  • Stomach(2.1)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with CDC25C: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC25C Gene

Orthologs for CDC25C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDC25C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDC25C 30 31
  • 99.44 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CDC25C 30 31
  • 86.86 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CDC25C 30 31
  • 86.61 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cdc25c 30
  • 83.46 (n)
Mouse
(Mus musculus)
Mammalia Cdc25c 30 17 31
  • 79.65 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CDC25C 31
  • 54 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 28 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia CDC25C 31
  • 39 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cdc25c 30
  • 57.86 (n)
African clawed frog
(Xenopus laevis)
Amphibia xcdc25-3 30
Zebrafish
(Danio rerio)
Actinopterygii cdc25d 31
  • 25 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta stg 31 32
  • 28 (a)
ManyToMany
twe 31 32
  • 26 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea cdc-25.3 31
  • 26 (a)
ManyToMany
cdc-25.4 31
  • 25 (a)
ManyToMany
cdc-25.2 31
  • 17 (a)
ManyToMany
cdc-25.1 31
  • 14 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIH1 31
  • 16 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.1787 31
  • 31 (a)
OneToMany
Species where no ortholog for CDC25C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CDC25C Gene

ENSEMBL:
Gene Tree for CDC25C (if available)
TreeFam:
Gene Tree for CDC25C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDC25C: view image

Paralogs for CDC25C Gene

Paralogs for CDC25C Gene

(3) SIMAP similar genes for CDC25C Gene using alignment to 5 proteins:

  • MPIP3_HUMAN
  • D6RD20_HUMAN
  • D6RJC2_HUMAN
  • H0Y999_HUMAN
  • Q9H2F0_HUMAN
genes like me logo Genes that share paralogs with CDC25C: view

Variants for CDC25C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDC25C Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
755565 Likely Benign: not provided 138,289,546(-) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT
rs11567959 - p.Ser14Asn
rs11567962 - p.Ser78Asn
rs11567997 - p.Gly297Arg
rs3734166 - p.Arg70Cys

Additional dbSNP identifiers (rs#s) for CDC25C Gene

Structural Variations from Database of Genomic Variants (DGV) for CDC25C Gene

Variant ID Type Subtype PubMed ID
nsv1033604 CNV gain 25217958
nsv1142451 CNV tandem duplication 24896259
nsv472931 CNV novel sequence insertion 20440878

Variation tolerance for CDC25C Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.79; 93.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDC25C Gene

Human Gene Mutation Database (HGMD)
CDC25C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC25C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC25C Gene

Disorders for CDC25C Gene

MalaCards: The human disease database

(8) MalaCards diseases for CDC25C Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ataxia-telangiectasia
  • at
breast adenocarcinoma
  • adenocarcinoma of breast
vulva squamous cell carcinoma
  • squamous cell carcinoma of vulva
prostate cancer
  • prostate cancer, somatic
plague
  • yersiniosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CDC25C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CDC25C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDC25C Gene

Publications for CDC25C Gene

  1. The human immunodeficiency virus Vpr protein binds Cdc25C: implications for G2 arrest. (PMID: 14972559) Goh WC … Emerman M (Virology 2004) 3 4 23
  2. Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation. (PMID: 14968113) Bahassi el M … Stambrook PJ (Oncogene 2004) 3 4 23
  3. Differential expression of cdc25 cell-cycle-activating phosphatases in human colorectal carcinoma. (PMID: 11304565) Hernández S … Campo E (Laboratory investigation; a journal of technical methods and pathology 2001) 3 4 23
  4. Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C. (PMID: 11139144) Wegener S … Schaller HC (European journal of cell biology 2000) 3 4 23
  5. The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase. (PMID: 11202906) Roshak AK … Marshall LA (Cellular signalling 2000) 3 4 23

Products for CDC25C Gene

  • Signalway Proteins for CDC25C

Sources for CDC25C Gene