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Aliases for CDC25A Gene

Aliases for CDC25A Gene

  • Cell Division Cycle 25A 2 3 5
  • Dual Specificity Phosphatase CDC25A 3
  • Dual Specificity Phosphatase Cdc25A 4
  • M-Phase Inducer Phosphatase 1 3
  • CDC25 Isoform A1-CAG 3
  • CDC25A2-CAG Isoform 3
  • EC 3.1.3.48 4
  • CDC25A2 3

External Ids for CDC25A Gene

Previous GeneCards Identifiers for CDC25A Gene

  • GC03P048003
  • GC03M047482
  • GC03M048019
  • GC03M048160
  • GC03M048159

Summaries for CDC25A Gene

Entrez Gene Summary for CDC25A Gene

  • CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC25A Gene

CDC25A (Cell Division Cycle 25A) is a Protein Coding gene. Diseases associated with CDC25A include Breast Cancer. Among its related pathways are Integrated Breast Cancer Pathway and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is CDC25B.

UniProtKB/Swiss-Prot for CDC25A Gene

  • Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.

Tocris Summary for CDC25A Gene

  • Cdc25 is a dual specificity phosphatase with three isoforms in mammalian cells - Cdc25A, B and C. Cdc25 activates cdk complexes that drive the cell cycle. Cdc25 is involved in the DNA damage checkpoints and is known as a key mediator of cell cycle progression.

Gene Wiki entry for CDC25A Gene

Additional gene information for CDC25A Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC25A Gene

Genomics for CDC25A Gene

GeneHancer (GH) Regulatory Elements for CDC25A Gene

Promoters and enhancers for CDC25A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J048186 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.7 743 2.6 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 E2F8 ZNF143 FOS CDC25A ZNF589 QRICH1 ATRIP USP19 TMEM89 CCDC71 PTPN23 NME6 MRPS18AP1
GH03J048190 Enhancer 0.2 ENCODE 650.7 -1.8 -1816 0.6 CDC25A QRICH1 MIR4443
GH03J048551 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 -370.6 -370612 15.4 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B PFKFB4 UCN2 TMA7 NME6 QRICH1 ATRIP USP19 ZNF589 WDR6 TMEM89
GH03J048424 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.2 -242.0 -241969 12.1 HDGF FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 PLXNB1 LOC105377077 TMA7 SHISA5 DHX30 ATRIP FBXW12 NME6 SPINK8 RNU7-128P
GH03J048239 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.3 -52.3 -52266 2.8 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF589 GC03M048234 QRICH1 PTPN23 NME6 ATRIP IP6K2 CCDC71 USP19 MRPS18AP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDC25A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDC25A gene promoter:
  • STAT3
  • CREB
  • deltaCREB
  • Sp1

Genomic Locations for CDC25A Gene

Genomic Locations for CDC25A Gene
chr3:48,157,146-48,188,658
(GRCh38/hg38)
Size:
31,513 bases
Orientation:
Minus strand
chr3:48,198,636-48,229,892
(GRCh37/hg19)
Size:
31,257 bases
Orientation:
Minus strand

Genomic View for CDC25A Gene

Genes around CDC25A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC25A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC25A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC25A Gene

Proteins for CDC25A Gene

  • Protein details for CDC25A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30304-MPIP1_HUMAN
    Recommended name:
    M-phase inducer phosphatase 1
    Protein Accession:
    P30304
    Secondary Accessions:
    • Q8IZH5
    • Q96IL3
    • Q9H2F2

    Protein attributes for CDC25A Gene

    Size:
    524 amino acids
    Molecular mass:
    59087 Da
    Quaternary structure:
    • Interacts with CCNB1/cyclin B1. Interacts with YWHAE/14-3-3 epsilon when phosphorylated. Interacts with CUL1 specifically when CUL1 is neddylated and active. Interacts with BTRC/BTRCP1 and FBXW11/BTRCP2. Interactions with CUL1, BTRC and FBXW11 are enhanced upon DNA damage. Interacts with PIM1. Interacts with CHEK2; mediates CDC25A phosphorylation and degradation in response to infrared-induced DNA damages. Interacts with HSP90AB1; prevents heat shock-mediated CDC25A degradation and contributes to cell cycle progression (PubMed:22843495).

    Three dimensional structures from OCA and Proteopedia for CDC25A Gene

    Alternative splice isoforms for CDC25A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC25A Gene

Post-translational modifications for CDC25A Gene

  • Phosphorylated by CHEK1 on Ser-76, Ser-124, Ser-178, Ser-279, Ser-293 and Thr-507 during checkpoint mediated cell cycle arrest. Also phosphorylated by CHEK2 on Ser-124, Ser-279, and Ser-293 during checkpoint mediated cell cycle arrest. Phosphorylation on Ser-178 and Thr-507 creates binding sites for YWHAE/14-3-3 epsilon which inhibits CDC25A. Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A by the SCF complex. Phosphorylation of CDC25A at Ser-76 by CHEK1 primes it for subsequent phosphorylation at Ser-79, Ser-82 and Ser-88 by NEK11. Phosphorylation by NEK11 is required for BTRC-mediated polyubiquitination and degradation. Phosphorylation by PIM1 leads to an increase in phosphatase activity. Phosphorylated by PLK3 following DNA damage, leading to promote its ubiquitination and degradation.
  • Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex that contains FZR1/CDH1 during G1 phase leading to its degradation by the proteasome. Ubiquitinated by a SCF complex containing BTRC and FBXW11 during S phase leading to its degradation by the proteasome. Deubiquitination by USP17L2/DUB3 leads to its stabilization.
  • Ubiquitination at Lys372, Lys343, and posLast=169169
  • Modification sites at PhosphoSitePlus

Other Protein References for CDC25A Gene

Antibody Products

  • Abcam antibodies for CDC25A

No data available for DME Specific Peptides for CDC25A Gene

Domains & Families for CDC25A Gene

Gene Families for CDC25A Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CDC25A Gene

Graphical View of Domain Structure for InterPro Entry

P30304

UniProtKB/Swiss-Prot:

MPIP1_HUMAN :
  • The phosphodegron motif mediates interaction with specific F-box proteins when phosphorylated. Putative phosphorylation sites at Ser-79 and Ser-82 appear to be essential for this interaction.
  • Belongs to the MPI phosphatase family.
Domain:
  • The phosphodegron motif mediates interaction with specific F-box proteins when phosphorylated. Putative phosphorylation sites at Ser-79 and Ser-82 appear to be essential for this interaction.
Family:
  • Belongs to the MPI phosphatase family.
genes like me logo Genes that share domains with CDC25A: view

Function for CDC25A Gene

Molecular function for CDC25A Gene

UniProtKB/Swiss-Prot Function:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by B-type cyclins. Stimulated by PIM1-mediated phosphorylation.
GENATLAS Biochemistry:
cdc25 protein phosphatase,non receptor type,complexing with CDC2 (M phase promoting factor (MPF) component),form A,regulator of the cell cycle,putative up-regulated c-Myc target gene,

Enzyme Numbers (IUBMB) for CDC25A Gene

Phenotypes From GWAS Catalog for CDC25A Gene

Gene Ontology (GO) - Molecular Function for CDC25A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity TAS --
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 7644510
GO:0016787 hydrolase activity IEA --
GO:0019901 protein kinase binding IPI 21376736
genes like me logo Genes that share ontologies with CDC25A: view
genes like me logo Genes that share phenotypes with CDC25A: view

Animal Models for CDC25A Gene

MGI Knock Outs for CDC25A:

Animal Model Products

  • Taconic Biosciences Mouse Models for CDC25A

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDC25A Gene

Localization for CDC25A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC25A gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2
golgi apparatus 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDC25A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CDC25A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDC25A Gene

Pathways & Interactions for CDC25A Gene

genes like me logo Genes that share pathways with CDC25A: view

SIGNOR curated interactions for CDC25A Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CDC25A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 11139144
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0006260 DNA replication TAS --
GO:0006470 protein dephosphorylation IEA --
genes like me logo Genes that share ontologies with CDC25A: view

Drugs & Compounds for CDC25A Gene

(25) Drugs for CDC25A Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
NSC 663284 Pharma Potent, selective Cdc25 phosphatase inhibitor 0
NSC 95397 Pharma Selective Cdc25 dual specificity phosphatase inhibitor 0

(9) Additional Compounds for CDC25A Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14265-44-2

(2) Tocris Compounds for CDC25A Gene

Compound Action Cas Number
NSC 663284 Potent, selective Cdc25 phosphatase inhibitor 383907-43-5
NSC 95397 Selective Cdc25 dual specificity phosphatase inhibitor 93718-83-3
genes like me logo Genes that share compounds with CDC25A: view

Transcripts for CDC25A Gene

mRNA/cDNA for CDC25A Gene

Unigene Clusters for CDC25A Gene

Cell division cycle 25A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC25A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP1:
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for CDC25A Gene

GeneLoc Exon Structure for
CDC25A
ECgene alternative splicing isoforms for
CDC25A

Expression for CDC25A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDC25A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC25A Gene

This gene is overexpressed in Testis (x9.5).

Protein differential expression in normal tissues from HIPED for CDC25A Gene

This gene is overexpressed in NK cells (67.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDC25A Gene



Protein tissue co-expression partners for CDC25A Gene

NURSA nuclear receptor signaling pathways regulating expression of CDC25A Gene:

CDC25A

SOURCE GeneReport for Unigene cluster for CDC25A Gene:

Hs.437705

Evidence on tissue expression from TISSUES for CDC25A Gene

  • Liver(2.2)
genes like me logo Genes that share expression patterns with CDC25A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC25A Gene

Orthologs for CDC25A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDC25A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC25A 34 33
  • 99.55 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CDC25A 34 33
  • 90.23 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CDC25A 34 33
  • 90.18 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc25a 33
  • 86.09 (n)
mouse
(Mus musculus)
Mammalia Cdc25a 16 34 33
  • 85.83 (n)
oppossum
(Monodelphis domestica)
Mammalia CDC25A 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC25A 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC25A 34 33
  • 67.65 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 72 (a)
OneToMany
-- 34
  • 40 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc25a 33
  • 60.26 (n)
Str.6078 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398141 33
zebrafish
(Danio rerio)
Actinopterygii cdc25 34 33 33
  • 56.84 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta stg 34 35
  • 28 (a)
ManyToMany
twe 34 35
  • 26 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cdc-25.4 34
  • 26 (a)
ManyToMany
cdc-25.3 34
  • 24 (a)
ManyToMany
cdc-25.2 34
  • 20 (a)
ManyToMany
cdc-25.1 34
  • 18 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIH1 34
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1787 34
  • 37 (a)
OneToMany
Species where no ortholog for CDC25A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC25A Gene

ENSEMBL:
Gene Tree for CDC25A (if available)
TreeFam:
Gene Tree for CDC25A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDC25A: view image

Paralogs for CDC25A Gene

Paralogs for CDC25A Gene

(3) SIMAP similar genes for CDC25A Gene using alignment to 4 proteins:

  • MPIP1_HUMAN
  • C9JFR5_HUMAN
  • C9JH94_HUMAN
  • D8KXX0_HUMAN
genes like me logo Genes that share paralogs with CDC25A: view

Variants for CDC25A Gene

Sequence variations from dbSNP and Humsavar for CDC25A Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000072837 -- 48,157,712(-) AAAA/AAA 3_prime_UTR_variant, non_coding_transcript_variant
rs1000190056 -- 48,185,230(-) T/C intron_variant
rs1000252284 -- 48,164,882(-) C/T intron_variant
rs1000392875 -- 48,171,113(-) T/G intron_variant
rs1000428241 -- 48,172,471(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CDC25A Gene

Variant ID Type Subtype PubMed ID
nsv1001056 CNV gain 25217958
nsv1012024 CNV gain 25217958
nsv1127957 CNV deletion 24896259
nsv834682 CNV gain 17160897

Variation tolerance for CDC25A Gene

Residual Variation Intolerance Score: 24.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDC25A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC25A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC25A Gene

Disorders for CDC25A Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDC25A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CDC25A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CDC25A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDC25A Gene

Publications for CDC25A Gene

  1. Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. (PMID: 1836978) Galaktionov K … Beach D (Cell 1991) 2 3 4 22 58
  2. NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling. (PMID: 20090422) Sørensen CS … Helin K (Cell cycle (Georgetown, Tex.) 2010) 3 4 22 58
  3. Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A. (PMID: 20228808) Pereg Y … Dixit VM (Nature cell biology 2010) 3 4 22 58
  4. Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents. (PMID: 12676925) Xiao Z … Zhang H (The Journal of biological chemistry 2003) 3 4 22 58
  5. Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint. (PMID: 12759351) Hassepass I … Hoffmann I (The Journal of biological chemistry 2003) 3 4 22 58

Products for CDC25A Gene

Sources for CDC25A Gene