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The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]
CDC23 (Cell Division Cycle 23) is a Protein Coding gene. Diseases associated with CDC23 include Neurotic Excoriation. Among its related pathways are Activation of cAMP-Dependent PKA and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is CDC27.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004842 | ubiquitin-protein transferase activity | TAS | 12629511 |
GO:0005515 | protein binding | IEA,IPI | 16189514 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005680 | anaphase-promoting complex | IBA,IDA | 14657031 |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | CDK-mediated phosphorylation and removal of Cdc6 | ||
2 | APC-Cdc20 mediated degradation of Nek2A | ||
3 | Class I MHC mediated antigen processing and presentation | ||
4 | Cell Cycle, Mitotic |
.83
|
.60
|
5 | Cellular Senescence (REACTOME) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000278 | mitotic cell cycle | TAS,IDA | 14657031 |
GO:0006511 | ubiquitin-dependent protein catabolic process | TAS | -- |
GO:0007049 | cell cycle | IEA | -- |
GO:0007080 | mitotic metaphase plate congression | IDA | 14657031 |
GO:0007091 | metaphase/anaphase transition of mitotic cell cycle | TAS,IBA | 21873635 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: |
ExUns: | 17a | · | 17b |
---|---|---|---|
SP1: | |||
SP2: | |||
SP3: | |||
SP4: | |||
SP5: | |||
SP6: | |||
SP7: | |||
SP8: | |||
SP9: | |||
SP10: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CDC23 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CDC23 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CDC23 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CDC23 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cdc23 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cdc23 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CDC23 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CDC23 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CDC23 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cdc23 30 |
|
||
Str.8410 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | cdc23 30 31 |
|
OneToOne | |
zgc56013 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | cdc23 30 31 |
|
OneToMany | |
CG2508 32 |
|
|
|||
CG31687 31 |
|
OneToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009880 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | mat-3 31 32 |
|
OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A05258g 30 |
|
||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ABR206W 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CDC23 30 31 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | APC8 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os02g0656300 30 |
|
||
Os.22624 30 |
|
||||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU01174 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | cut23 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8976 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.5916 30 |
|
SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2231477 | Benign: not provided | 138,192,259(-) |
C/T NM_004661.4(CDC23):c.1286+10G>A |
INTRON | |
rs2231480 | Benign: not provided | 138,189,633(-) |
A/G NM_004661.4(CDC23):c.1623T>C (p.Asp541=) |
SYNONYMOUS | |
rs17228304 | - |
p.Glu78Gln |
|||
rs2231471 | - |
p.Pro9Leu |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2670577 | CNV | deletion | 23128226 |
esv3606919 | CNV | loss | 21293372 |
Disorder | Aliases | PubMed IDs |
---|---|---|
neurotic excoriation |
|
|