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Aliases for CDC23 Gene

Aliases for CDC23 Gene

  • Cell Division Cycle 23 2 3 5
  • Anaphase-Promoting Complex Subunit 8 3 4
  • Cyclosome Subunit 8 3 4
  • ANAPC8 3 4
  • APC8 3 4
  • CDC23 (Cell Division Cycle 23, Yeast, Homolog) 2
  • Cell Division Cycle 23 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle Protein 23 Homolog 3
  • Anaphase Promoting Complex Subunit 8 2
  • Cell Division Cycle 23 Homolog 3
  • CUT23 3

External Ids for CDC23 Gene

Previous GeneCards Identifiers for CDC23 Gene

  • GC05M137398
  • GC05M137554
  • GC05M137599
  • GC05M137552
  • GC05M132714

Summaries for CDC23 Gene

Entrez Gene Summary for CDC23 Gene

  • The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC23 Gene

CDC23 (Cell Division Cycle 23) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for CDC23 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Wiki entry for CDC23 Gene

Additional gene information for CDC23 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC23 Gene

Genomics for CDC23 Gene

GeneHancer (GH) Regulatory Elements for CDC23 Gene

Promoters and enhancers for CDC23 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J138212 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 660.3 -0.1 -57 2 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B CDC23 ETF1 HNRNPA0 KDM3B GC05M138210
GH05J138463 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 51.7 -251.9 -251906 4.1 CLOCK IRF4 YY1 E2F8 ZNF143 SP3 SSRP1 ZNF610 ZNF585B GLIS1 EGR1 HNRNPA0 CDC23 BRD8 KDM3B RPL7P19 ETF1 FAM13B FAM53C REEP2
GH05J138350 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 60.3 -140.0 -139992 4.7 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 IRF4 YY1 SLC30A9 KDM3B CDC23 BRD8 HNRNPA0 FAM53C RPL7P19 FAM13B KIF20A GFRA3 REEP2
GH05J138335 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 44.5 -124.2 -124197 5 CLOCK ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 CDC25C FAM53C HNRNPA0 KDM3B CDC23 RPL7P19 REEP2 MATR3 BRD8 NME5
GH05J138540 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 27.4 -330.3 -330335 7 CLOCK DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 ETF1 LOC105379193 GC05P138544 CDC23 HNRNPA0 BRD8 ENSG00000232174 KDM3B WNT8A FAM53C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CDC23 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDC23 gene promoter:

Genomic Locations for CDC23 Gene

Genomic Locations for CDC23 Gene
chr5:138,187,648-138,213,343
(GRCh38/hg38)
Size:
25,696 bases
Orientation:
Minus strand
chr5:137,523,337-137,549,032
(GRCh37/hg19)

Genomic View for CDC23 Gene

Genes around CDC23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC23 Gene

Proteins for CDC23 Gene

  • Protein details for CDC23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJX2-CDC23_HUMAN
    Recommended name:
    Cell division cycle protein 23 homolog
    Protein Accession:
    Q9UJX2
    Secondary Accessions:
    • A8K6E5
    • B4E3A2
    • B7WP05
    • D3DQB7
    • O75433
    • Q53FN2
    • Q9BS73

    Protein attributes for CDC23 Gene

    Size:
    597 amino acids
    Molecular mass:
    68834 Da
    Quaternary structure:
    • The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.
    SequenceCaution:
    • Sequence=AAC70920.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH05258.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH10944.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH17713.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAS99353.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA75628.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96970.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF84299.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDC23 Gene

    Alternative splice isoforms for CDC23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC23 Gene

Post-translational modifications for CDC23 Gene

  • Phosphorylated. Phosphorylation on Thr-562 occurs specifically during mitosis.
  • Ubiquitination at Lys547, posLast=453453, and posLast=445445
  • Modification sites at PhosphoSitePlus

Other Protein References for CDC23 Gene

No data available for DME Specific Peptides for CDC23 Gene

Domains & Families for CDC23 Gene

Protein Domains for CDC23 Gene

Suggested Antigen Peptide Sequences for CDC23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJX2

UniProtKB/Swiss-Prot:

CDC23_HUMAN :
  • Belongs to the APC8/CDC23 family.
Family:
  • Belongs to the APC8/CDC23 family.
genes like me logo Genes that share domains with CDC23: view

Function for CDC23 Gene

Molecular function for CDC23 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.
GENATLAS Biochemistry:
cell division cycle (CDC)23,S cerevisiae homolog,component of the anaphase promoting complex,involved in ubiquitin mediated proteolysis,commonly deleted in myeloid leukemias,but unlikely to be involved in the pathogenesis of this disease

Phenotypes From GWAS Catalog for CDC23 Gene

Gene Ontology (GO) - Molecular Function for CDC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS 12629511
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CDC23: view
genes like me logo Genes that share phenotypes with CDC23: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC23

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC23 Gene

Localization for CDC23 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC23 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
endoplasmic reticulum 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CDC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA,TAS 14657031
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CDC23: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CDC23 Gene

Pathways & Interactions for CDC23 Gene

SuperPathways for CDC23 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.60
5 Cellular Senescence (REACTOME)
genes like me logo Genes that share pathways with CDC23: view

UniProtKB/Swiss-Prot Q9UJX2-CDC23_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for CDC23 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CDC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IDA 14657031
GO:0006511 ubiquitin-dependent protein catabolic process TAS 9790767
GO:0007049 cell cycle IEA --
GO:0007080 mitotic metaphase plate congression IDA 14657031
GO:0007091 metaphase/anaphase transition of mitotic cell cycle TAS 9790767
genes like me logo Genes that share ontologies with CDC23: view

Drugs & Compounds for CDC23 Gene

No Compound Related Data Available

Transcripts for CDC23 Gene

mRNA/cDNA for CDC23 Gene

Unigene Clusters for CDC23 Gene

Cell division cycle 23:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC23

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC23 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^
SP1: - - - - - -
SP2: - - -
SP3:
SP4: -
SP5: - -
SP6: - - - - -
SP7: - - - -
SP8:
SP9:
SP10:

ExUns: 17a · 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CDC23 Gene

GeneLoc Exon Structure for
CDC23
ECgene alternative splicing isoforms for
CDC23

Expression for CDC23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDC23 Gene

Protein differential expression in normal tissues from HIPED for CDC23 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (53.2) and Breast (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDC23 Gene



Protein tissue co-expression partners for CDC23 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDC23 Gene:

CDC23

SOURCE GeneReport for Unigene cluster for CDC23 Gene:

Hs.73625

Evidence on tissue expression from TISSUES for CDC23 Gene

  • Nervous system(4.8)
  • Bone marrow(4.2)
  • Intestine(4.2)
  • Liver(4.2)
  • Stomach(4.2)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with CDC23: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC23 Gene

Orthologs for CDC23 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC23 34 33
  • 99.66 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDC23 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDC23 34 33
  • 92.91 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CDC23 34 33
  • 92.41 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc23 33
  • 88.67 (n)
mouse
(Mus musculus)
Mammalia Cdc23 16 34 33
  • 88.55 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDC23 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC23 34 33
  • 80.29 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC23 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc23 33
  • 77.62 (n)
Str.8410 33
zebrafish
(Danio rerio)
Actinopterygii cdc23 34 33
  • 71.33 (n)
OneToOne
zgc56013 33
fruit fly
(Drosophila melanogaster)
Insecta cdc23 34 33
  • 54.75 (n)
OneToMany
CG2508 35
  • 48 (a)
CG31687 34
  • 44 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009880 33
  • 52.89 (n)
worm
(Caenorhabditis elegans)
Secernentea mat-3 34 35
  • 29 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05258g 33
  • 49.92 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR206W 33
  • 47.97 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC23 34 33
  • 47.2 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons APC8 33
  • 53.55 (n)
rice
(Oryza sativa)
Liliopsida Os02g0656300 33
  • 55.71 (n)
Os.22624 33
bread mold
(Neurospora crassa)
Ascomycetes NCU01174 33
  • 49.33 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cut23 33
  • 48.73 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8976 34
  • 43 (a)
OneToOne
Cin.5916 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5916 33
Species where no ortholog for CDC23 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC23 Gene

ENSEMBL:
Gene Tree for CDC23 (if available)
TreeFam:
Gene Tree for CDC23 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDC23: view image

Paralogs for CDC23 Gene

No data available for Paralogs for CDC23 Gene

Variants for CDC23 Gene

Sequence variations from dbSNP and Humsavar for CDC23 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000001862 -- 138,208,691(-) T/C intron_variant
rs1000035697 -- 138,211,387(-) G/C intron_variant
rs1000101623 -- 138,201,280(-) T/A intron_variant
rs1000256745 -- 138,192,726(-) G/T intron_variant
rs1000370993 -- 138,202,067(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CDC23 Gene

Variant ID Type Subtype PubMed ID
esv2670577 CNV deletion 23128226
esv3606919 CNV loss 21293372

Variation tolerance for CDC23 Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDC23 Gene

Human Gene Mutation Database (HGMD)
CDC23
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC23

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC23 Gene

Disorders for CDC23 Gene

Additional Disease Information for CDC23

No disorders were found for CDC23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC23 Gene

Publications for CDC23 Gene

  1. Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias. (PMID: 9790767) Zhao N … Le Beau MM (Genomics 1998) 2 3 4 22 58
  2. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang LF … Barford D (Nature 2014) 3 4 58
  3. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PMID: 18485873) Jin L … Rape M (Cell 2008) 3 4 58
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  5. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PMID: 16364912) Dube P … Stark H (Molecular cell 2005) 3 4 58

Products for CDC23 Gene

Sources for CDC23 Gene

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