Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugat... See more...
Aliases for CDC23 Gene
Aliases for CDC23 Gene
External Ids for CDC23 Gene
- HGNC: 1724
- NCBI Entrez Gene: 8697
- Ensembl: ENSG00000094880
- OMIM®: 603462
- UniProtKB/Swiss-Prot: Q9UJX2
Previous GeneCards Identifiers for CDC23 Gene
- GC05M137398
- GC05M137554
- GC05M137599
- GC05M137552
- GC05M132714
Summaries for CDC23 Gene
-
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDC23 Gene
CDC23 (Cell Division Cycle 23) is a Protein Coding gene. Diseases associated with CDC23 include Neurotic Excoriation. Among its related pathways are Activation of cAMP-Dependent PKA and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is CDC27.
UniProtKB/Swiss-Prot Summary for CDC23 Gene
-
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Additional gene information for CDC23 Gene
- HGNC (1724)
- NCBI Entrez Gene (8697)
- Ensembl (ENSG00000094880)
- OMIM® (603462)
- UniProtKB/Swiss-Prot (Q9UJX2)
- Open Targets Platform(ENSG00000094880)
- Search for CDC23 at DataMed
- Search for CDC23 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDC23 Gene
Genomics for CDC23 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CDC23 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CDC23 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDC23
- Top Transcription factor binding sites by QIAGEN in the CDC23 gene promoter:
-
- AP-1
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- Nkx6-1
Genomic Locations for CDC23 Gene
Latest Assembly
- chr5:138,187,650-138,213,343
- (GRCh38/hg38)
- Size:
- 25,694 bases
- Orientation:
- Minus strand
Previous Assembly
- chr5:137,523,339-137,549,012
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 25,674 bases
- Orientation:
- Minus strand
- chr5:137,523,339-137,549,032
- (GRCh37/hg19 by Ensembl)
- Size:
- 25,694 bases
- Orientation:
- Minus strand
Genomic View for CDC23 Gene
Genes around CDC23 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.2 by HGNC
- 5q31.2 by Entrez Gene
- 5q31.2 by Ensembl
CDC23 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CDC23 Gene
Proteins for CDC23 Gene
-
Protein details for CDC23 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UJX2-CDC23_HUMAN
- Recommended name:
- Cell division cycle protein 23 homolog
- Protein Accession:
- Q9UJX2
- A8K6E5
- B4E3A2
- B7WP05
- D3DQB7
- O75433
- Q53FN2
- Q9BS73
Protein attributes for CDC23 Gene
- Size:
- 597 amino acids
- Molecular mass:
- 68834 Da
- Quaternary structure:
-
- The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5.
- SequenceCaution:
-
- Sequence=AAC70920.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH05258.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH10944.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH17713.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAS99353.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA75628.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96970.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF84299.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for CDC23 Gene
Protein Expression for CDC23 Gene
Post-translational modifications for CDC23 Gene
- Phosphorylated. Phosphorylation on Thr-562 occurs specifically during mitosis.
-
Ubiquitination at Lys445, Lys453, Lys467, and Lys547
- NX_Q9UJX2 (NX_Q9UJX2-1)
- Modification sites at PhosphoSitePlus
Other Protein References for CDC23 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences CDC23 Antibody
- G Biosciences Immunotagā¢ APC8 Antibody
- Novus Biologicals Antibodies for CDC23
-
Abcam antibodies for CDC23
- Invitrogen Antibodies for CDC23 (AFLGC-Cdc23)
-
Biorbyt antibodies for CDC23
-
Santa Cruz Biotechnology (SCBT) Antibodies for CDC23
- Sino Biological Antibodies for CDC23
Protein products for research
-
OriGene Purified Proteins for CDC23
- Search Origene for MassSpec and Protein Over-expression Lysates for CDC23
- Origene Custom Protein Services for CDC23
-
Abcam proteins for CDC23
No data available for DME Specific Peptides for CDC23 Gene
Domains & Families for CDC23 Gene
Gene Families for CDC23 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CDC23 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CDC23 Gene
- GenScript: Design optimal peptide antigens:
-
- Cyclosome subunit 8 (CDC23_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UJX2- Family:
-
- Belongs to the APC8/CDC23 family.
Function for CDC23 Gene
Molecular function for CDC23 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
- GENATLAS Biochemistry:
- cell division cycle (CDC)23,S cerevisiae homolog,component of the anaphase promoting complex,involved in ubiquitin mediated proteolysis,commonly deleted in myeloid leukemias,but unlikely to be involved in the pathogenesis of this disease
Phenotypes From GWAS Catalog for CDC23 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS | 12629511 |
| GO:0005515 | protein binding | IEA,IPI | 16189514 |
Phenotypes for CDC23 Gene
- MGI mutant phenotypes for CDC23:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CDC23:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased ionizing radiation sensitivity
- Decreased viability
- Mildly decreased CFP-tsO45G cell surface transport
- Reduced mammosphere formation
- Decreased viability ratio
- shRNA abundance <= 25%
- Effect on mitosis
- No cells
- Increased cell number in S
- Increased cell death HMECs cells
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Increased ionizing radiation sensitivity
- Increased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Increased cell death in HCC-1954 cells
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CDC23 - Starting at $85 >
- * CDC23 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CDC23
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDC23
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDC23
miRNA for CDC23 Gene
- miRTarBase miRNAs that target CDC23
-
- hsa-miR-340-5p (MIRT019590)
- hsa-miR-29c-3p (MIRT020394)
- hsa-miR-34a-5p (MIRT025367)
- hsa-miR-98-5p (MIRT027586)
- hsa-miR-16-5p (MIRT031557)
- hsa-miR-4777-5p (MIRT095308)
- hsa-miR-204-5p (MIRT095328)
- hsa-miR-211-5p (MIRT095329)
- hsa-miR-623 (MIRT095331)
- hsa-miR-6832-3p (MIRT095335)
- hsa-miR-5006-3p (MIRT558843)
- hsa-miR-4755-5p (MIRT558844)
- hsa-miR-519e-5p (MIRT558845)
- hsa-miR-515-5p (MIRT558846)
- hsa-miR-4777-3p (MIRT558847)
- hsa-miR-767-5p (MIRT558848)
- hsa-miR-145-3p (MIRT558849)
- hsa-miR-3663-3p (MIRT558850)
- hsa-miR-5695 (MIRT558851)
- hsa-miR-519d-5p (MIRT558852)
- hsa-miR-6891-3p (MIRT558853)
- hsa-miR-6072 (MIRT558854)
- hsa-miR-335-5p (MIRT558855)
- hsa-miR-3938 (MIRT558856)
- hsa-miR-29b-3p (MIRT558857)
- hsa-miR-29a-3p (MIRT558858)
- hsa-miR-580-5p (MIRT558859)
- mmu-miR-544-5p (MIRT595033)
- mmu-miR-335-3p (MIRT595034)
- mmu-miR-5097 (MIRT595035)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDC23
- Browse OriGene Inhibitory RNA Products For CDC23
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC23
Clone products for research
- Applied Biological Materials (abm): Clones for CDC23 - Starting at $45 >
- * CDC23 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CDC23
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDC23
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC23 Gene
Localization for CDC23 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| plasma membrane | 1 |
| peroxisome | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005680 | anaphase-promoting complex | IBA,IDA | 14657031 |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CDC23 Gene
Pathways & Interactions for CDC23 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 | ||
| 2 | APC-Cdc20 mediated degradation of Nek2A | ||
| 3 | Class I MHC mediated antigen processing and presentation | ||
| 4 | Cell Cycle, Mitotic |
.83
|
.60
|
| 5 | Cellular Senescence (REACTOME) | ||
Pathways by source for CDC23 Gene
31 Reactome pathways for CDC23 Gene
5 KEGG pathways for CDC23 Gene
7 GeneGo (Thomson Reuters) pathways for CDC23 Gene
- Cell cycle Regulation of G1/S transition (part 1)
- Cell cycle Role of SCF complex in cell cycle regulation
- Cell cycle_Role of APC in cell cycle regulation
- Cell cycle_Spindle assembly and chromosome separation
- Development_TGF-beta receptor signaling
6 Qiagen pathways for CDC23 Gene
- Activation of PKA through GPCR
- cAMP Pathway
- CDC42 Pathway
- Epithelial Adherens Junctions
- Mitotic Roles of Polo Like Kinases
1 Cell Signaling Technology pathway for CDC23 Gene
UniProtKB/Swiss-Prot Q9UJX2-CDC23_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for CDC23 Gene
Selected Interacting proteins:
Q9UJX2-CDC23_HUMAN
ENSP00000378350
for CDC23 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CDC23
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000278 | mitotic cell cycle | TAS,IDA | 14657031 |
| GO:0006511 | ubiquitin-dependent protein catabolic process | TAS | -- |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007080 | mitotic metaphase plate congression | IDA | 14657031 |
| GO:0007091 | metaphase/anaphase transition of mitotic cell cycle | TAS,IBA | 21873635 |
Transcripts for CDC23 Gene
mRNA/cDNA for CDC23 Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000394884 1079 nts (view in UCSC)
- ENST00000394886 3133 nts (view in UCSC)
- ENST00000464806 562 nts (view in UCSC)
- ENST00000471692 1104 nts (view in UCSC)
- ENST00000475021 473 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CDC23 - Starting at $85 >
- * CDC23 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CDC23
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDC23
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDC23
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDC23
- Browse OriGene Inhibitory RNA Products For CDC23
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC23
Clone products for research
- Applied Biological Materials (abm): Clones for CDC23 - Starting at $45 >
- * CDC23 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CDC23
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDC23
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
| ExUns: | 17a | · | 17b |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: | |||
| SP10: |
Relevant External Links for CDC23 Gene
- GeneLoc Exon Structure for
- CDC23
Expression for CDC23 Gene
This gene is overexpressed in Bone marrow mesenchymal stem cell (53.2) and Breast (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDC23 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDC23
SOURCE GeneReport for Unigene cluster for CDC23 Gene:
Hs.73625Evidence on tissue expression from TISSUES for CDC23 Gene
- Nervous system(4.8)
- Intestine(4.4)
- Liver(4.4)
- Stomach(4.2)
- Bone marrow(4.2)
- Pancreas(4.1)
- Skin(2.1)
Primer products for research
-
OriGene qPCR primer pairs for CDC23
-
OriGene qPCR primer pairs and template standards for CDC23
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC23 Gene
Orthologs for CDC23 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CDC23 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CDC23 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CDC23 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CDC23 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cdc23 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Cdc23 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CDC23 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CDC23 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CDC23 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cdc23 30 |
|
||
| Str.8410 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | cdc23 30 31 |
|
OneToOne | |
| zgc56013 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | cdc23 30 31 |
|
OneToMany | |
| CG2508 32 |
|
|
|||
| CG31687 31 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009880 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | mat-3 31 32 |
|
OneToOne | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A05258g 30 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ABR206W 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CDC23 30 31 |
|
OneToOne | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | APC8 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os02g0656300 30 |
|
||
| Os.22624 30 |
|
||||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU01174 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | cut23 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8976 31 |
|
OneToOne | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.5916 30 |
|
- Species where no ortholog for CDC23 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CDC23 Gene
- ENSEMBL:
- Gene Tree for CDC23 (if available)
- TreeFam:
- Gene Tree for CDC23 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CDC23: view image
Paralogs for CDC23 Gene
Variants for CDC23 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDC23 Gene
| SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2231477 | Benign: not provided | 138,192,259(-) |
C/T NM_004661.4(CDC23):c.1286+10G>A |
INTRON | |
| rs2231480 | Benign: not provided | 138,189,633(-) |
A/G NM_004661.4(CDC23):c.1623T>C (p.Asp541=) |
SYNONYMOUS | |
| rs17228304 | - |
p.Glu78Gln |
|||
| rs2231471 | - |
p.Pro9Leu |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2670577 | CNV | deletion | 23128226 |
| esv3606919 | CNV | loss | 21293372 |
Residual Variation Intolerance Score:
16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.54;
44.32% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CDC23 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC23 Gene
Disorders for CDC23 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| neurotic excoriation |
|
|
Search CDC23 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CDC23
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CDC23 Gene
Publications for CDC23 Gene
- Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias. (PMID: 9790767) Zhao N ā¦ Le Beau MM (Genomics 1998) 2 3 4 23
- Atomic structure of the APC/C and its mechanism of protein ubiquitination. (PMID: 26083744) Chang L ā¦ Barford D (Nature 2015) 3 4
- Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang LF ā¦ Barford D (Nature 2014) 3 4
- Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PMID: 18485873) Jin L ā¦ Rape M (Cell 2008) 3 4
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA ā¦ Gygi SP (Nature biotechnology 2006) 3 4
ExternalLinks
Products for CDC23 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CDC23
- Search Origene for MassSpec and Protein Over-expression Lysates for CDC23
- Origene Custom Protein Services for CDC23
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDC23
- Browse OriGene Inhibitory RNA Products For CDC23
- OriGene qPCR primer pairs for CDC23
- OriGene qPCR primer pairs and template standards for CDC23
- OriGene CRISPR knockouts for CDC23
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CDC23
- Sino Biological Human cDNA Clone for CDC23
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for CDC23
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CDC23
- Novus Biologicals proteins and lysates for CDC23
- Novus Biologicals ELISA Kits for CDC23
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CDC23
- Abcam proteins for CDC23
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for CDC23 (AFLGC-Cdc23)
- VectorBuilder Custom and pre-made DNA vectors for CDC23 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CDC23 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CDC23 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CDC23 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CDC23
- antibodies-online: Show 17 available CDC23 Antibodies ranked by validation data
- Compare Top CDC23 Antibodies
- antibodies-online: Show 28 available CDC23 Elisa Kits ranked by validation data
- Compare Top CDC23 Elisa Kits
- antibodies-online: Show 7 available CDC23 Proteins ranked by validation data
- Compare Top CDC23 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CDC23
- Search Santa Cruz Biotechnology (SCBT) for CDC23 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CDC23
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDC23
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDC23
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CDC23
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC23
- Biorbyt antibodies for CDC23
Sources for CDC23 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150)