The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugat... See more...

Aliases for CDC23 Gene

Aliases for CDC23 Gene

  • Cell Division Cycle 23 2 3 5
  • ANAPC8 2 3 4
  • APC8 2 3 4
  • Cell Division Cycle Protein 23 Homolog 3 4
  • Anaphase-Promoting Complex Subunit 8 3 4
  • Cyclosome Subunit 8 3 4
  • CUT23 2 3
  • CDC23 (Cell Division Cycle 23, Yeast, Homolog) 2
  • Cell Division Cycle 23 Homolog (S. Cerevisiae) 2
  • Anaphase Promoting Complex Subunit 8 2
  • Cell Division Cycle 23 Homolog 3
  • CDC23 5

External Ids for CDC23 Gene

Previous GeneCards Identifiers for CDC23 Gene

  • GC05M137398
  • GC05M137554
  • GC05M137599
  • GC05M137552
  • GC05M132714

Summaries for CDC23 Gene

Entrez Gene Summary for CDC23 Gene

  • The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC23 Gene

CDC23 (Cell Division Cycle 23) is a Protein Coding gene. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Signal transduction_PKA signaling. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is CDC27.

UniProtKB/Swiss-Prot Summary for CDC23 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Gene Wiki entry for CDC23 Gene

Additional gene information for CDC23 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDC23 Gene

Genomics for CDC23 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDC23 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDC23 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDC23

Top Transcription factor binding sites by QIAGEN in the CDC23 gene promoter:
  • AP-1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Nkx6-1

Genomic Locations for CDC23 Gene

Genomic Locations for CDC23 Gene
chr5:138,187,650-138,213,343
(GRCh38/hg38)
Size:
25,694 bases
Orientation:
Minus strand
chr5:137,523,337-137,549,032
(GRCh37/hg19)
Size:
25,696 bases
Orientation:
Minus strand

Genomic View for CDC23 Gene

Genes around CDC23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC23 Gene

Proteins for CDC23 Gene

  • Protein details for CDC23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJX2-CDC23_HUMAN
    Recommended name:
    Cell division cycle protein 23 homolog
    Protein Accession:
    Q9UJX2
    Secondary Accessions:
    • A8K6E5
    • B4E3A2
    • B7WP05
    • D3DQB7
    • O75433
    • Q53FN2
    • Q9BS73

    Protein attributes for CDC23 Gene

    Size:
    597 amino acids
    Molecular mass:
    68834 Da
    Quaternary structure:
    • The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5.
    SequenceCaution:
    • Sequence=AAC70920.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH05258.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH10944.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH17713.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAS99353.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA75628.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96970.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF84299.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDC23 Gene

    Alternative splice isoforms for CDC23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC23 Gene

Post-translational modifications for CDC23 Gene

  • Phosphorylated. Phosphorylation on Thr-562 occurs specifically during mitosis.
  • Ubiquitination at Lys445, Lys453, Lys467, and Lys547
  • Modification sites at PhosphoSitePlus

Other Protein References for CDC23 Gene

No data available for DME Specific Peptides for CDC23 Gene

Domains & Families for CDC23 Gene

Gene Families for CDC23 Gene

Protein Domains for CDC23 Gene

Suggested Antigen Peptide Sequences for CDC23 Gene

GenScript: Design optimal peptide antigens:
  • Cyclosome subunit 8 (CDC23_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UJX2

UniProtKB/Swiss-Prot:

CDC23_HUMAN :
  • Belongs to the APC8/CDC23 family.
Family:
  • Belongs to the APC8/CDC23 family.
genes like me logo Genes that share domains with CDC23: view

Function for CDC23 Gene

Molecular function for CDC23 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
GENATLAS Biochemistry:
cell division cycle (CDC)23,S cerevisiae homolog,component of the anaphase promoting complex,involved in ubiquitin mediated proteolysis,commonly deleted in myeloid leukemias,but unlikely to be involved in the pathogenesis of this disease

Phenotypes From GWAS Catalog for CDC23 Gene

Gene Ontology (GO) - Molecular Function for CDC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS 12629511
GO:0005515 protein binding IEA,IPI 16189514
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with CDC23: view
genes like me logo Genes that share phenotypes with CDC23: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC23

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC23 Gene

Localization for CDC23 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC23 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
plasma membrane 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CDC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005623 cell IEA --
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IBA,IDA 14657031
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with CDC23: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CDC23 Gene

Pathways & Interactions for CDC23 Gene

PathCards logo

SuperPathways for CDC23 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
2 APC-Cdc20 mediated degradation of Nek2A
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.60
5 Cellular Senescence (REACTOME)
genes like me logo Genes that share pathways with CDC23: view

Pathways by source for CDC23 Gene

7 GeneGo (Thomson Reuters) pathways for CDC23 Gene
  • Cell cycle Regulation of G1/S transition (part 1)
  • Cell cycle Role of SCF complex in cell cycle regulation
  • Cell cycle_Role of APC in cell cycle regulation
  • Cell cycle_Spindle assembly and chromosome separation
  • Development_TGF-beta receptor signaling
6 Qiagen pathways for CDC23 Gene
  • Activation of PKA through GPCR
  • cAMP Pathway
  • CDC42 Pathway
  • Epithelial Adherens Junctions
  • Mitotic Roles of Polo Like Kinases
1 Cell Signaling Technology pathway for CDC23 Gene

UniProtKB/Swiss-Prot Q9UJX2-CDC23_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for CDC23 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CDC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS,IDA 14657031
GO:0006511 ubiquitin-dependent protein catabolic process TAS --
GO:0007049 cell cycle IEA --
GO:0007080 mitotic metaphase plate congression IDA 14657031
GO:0007091 metaphase/anaphase transition of mitotic cell cycle TAS,IBA 21873635
genes like me logo Genes that share ontologies with CDC23: view

Drugs & Compounds for CDC23 Gene

No Compound Related Data Available

Transcripts for CDC23 Gene

mRNA/cDNA for CDC23 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC23

Alternative Splicing Database (ASD) splice patterns (SP) for CDC23 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^
SP1: - - - - - -
SP2: - - -
SP3:
SP4: -
SP5: - -
SP6: - - - - -
SP7: - - - -
SP8:
SP9:
SP10:

ExUns: 17a · 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CDC23 Gene

GeneLoc Exon Structure for
CDC23

Expression for CDC23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDC23 Gene

Protein differential expression in normal tissues from HIPED for CDC23 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (53.2) and Breast (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDC23 Gene



Protein tissue co-expression partners for CDC23 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDC23

SOURCE GeneReport for Unigene cluster for CDC23 Gene:

Hs.73625

Evidence on tissue expression from TISSUES for CDC23 Gene

  • Nervous system(4.8)
  • Intestine(4.4)
  • Liver(4.4)
  • Stomach(4.2)
  • Bone marrow(4.2)
  • Pancreas(4.1)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with CDC23: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC23 Gene

Orthologs for CDC23 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC23 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDC23 30 31
  • 99.66 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CDC23 31
  • 93 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia CDC23 30 31
  • 92.91 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CDC23 30 31
  • 92.41 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cdc23 30
  • 88.67 (n)
Mouse
(Mus musculus)
Mammalia Cdc23 30 17 31
  • 88.55 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CDC23 31
  • 62 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CDC23 30 31
  • 80.29 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CDC23 31
  • 89 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cdc23 30
  • 77.62 (n)
Str.8410 30
Zebrafish
(Danio rerio)
Actinopterygii cdc23 30 31
  • 71.33 (n)
OneToOne
zgc56013 30
Fruit Fly
(Drosophila melanogaster)
Insecta cdc23 30 31
  • 54.75 (n)
OneToMany
CG2508 32
  • 48 (a)
CG31687 31
  • 44 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009880 30
  • 52.89 (n)
Worm
(Caenorhabditis elegans)
Secernentea mat-3 31 32
  • 29 (a)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05258g 30
  • 49.92 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ABR206W 30
  • 47.97 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC23 30 31
  • 47.2 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons APC8 30
  • 53.55 (n)
Rice
(Oryza sativa)
Liliopsida Os02g0656300 30
  • 55.71 (n)
Os.22624 30
Bread mold
(Neurospora crassa)
Ascomycetes NCU01174 30
  • 49.33 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cut23 30
  • 48.73 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8976 31
  • 43 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.5916 30
Species where no ortholog for CDC23 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CDC23 Gene

ENSEMBL:
Gene Tree for CDC23 (if available)
TreeFam:
Gene Tree for CDC23 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDC23: view image

Paralogs for CDC23 Gene

Paralogs for CDC23 Gene

genes like me logo Genes that share paralogs with CDC23: view

Variants for CDC23 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDC23 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
770357 Benign: not provided 138,192,259(-) C/T INTRON_VARIANT
783396 Benign: not provided 138,189,633(-) A/G SYNONYMOUS_VARIANT
rs17228304 - p.Glu78Gln
rs2231471 - p.Pro9Leu

Additional dbSNP identifiers (rs#s) for CDC23 Gene

Structural Variations from Database of Genomic Variants (DGV) for CDC23 Gene

Variant ID Type Subtype PubMed ID
esv2670577 CNV deletion 23128226
esv3606919 CNV loss 21293372

Variation tolerance for CDC23 Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDC23 Gene

Human Gene Mutation Database (HGMD)
CDC23
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC23

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC23 Gene

Disorders for CDC23 Gene

No disorders were found for CDC23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC23 Gene

Publications for CDC23 Gene

  1. Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias. (PMID: 9790767) Zhao N … Le Beau MM (Genomics 1998) 2 3 4 23
  2. Atomic structure of the APC/C and its mechanism of protein ubiquitination. (PMID: 26083744) Chang L … Barford D (Nature 2015) 3 4
  3. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang LF … Barford D (Nature 2014) 3 4
  4. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PMID: 18485873) Jin L … Rape M (Cell 2008) 3 4
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4

Products for CDC23 Gene

Sources for CDC23 Gene