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Aliases for CDC20B Gene

Aliases for CDC20B Gene

  • Cell Division Cycle 20B 2 3 5
  • CDC20 Cell Division Cycle 20 Homolog B (S. Cerevisiae) 2
  • Cell Division Cycle 20 Homolog B (S. Cerevisiae) 2
  • Cell Division Cycle Protein 20 Homolog B 3
  • CDC20 Cell Division Cycle 20 Homolog B 3
  • Cell Division Cycle 20 Homolog B 3
  • CDC20-Like Protein 3
  • G6VTS76519 3

External Ids for CDC20B Gene

Previous GeneCards Identifiers for CDC20B Gene

  • GC05M054445
  • GC05M051381

Summaries for CDC20B Gene

GeneCards Summary for CDC20B Gene

CDC20B (Cell Division Cycle 20B) is a Protein Coding gene. Among its related pathways are DNA Damage Response. An important paralog of this gene is CDC20.

Additional gene information for CDC20B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC20B Gene

Genomics for CDC20B Gene

GeneHancer (GH) Regulatory Elements for CDC20B Gene

Promoters and enhancers for CDC20B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J055172 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 662.8 -0.3 -315 1 HDAC1 PKNOX1 ATF1 RB1 SIN3A BMI1 ZNF2 ZNF335 GLIS2 CREM CDC20B GC05M055174 MIR449C ENSG00000240535 LOC105378973 CCNO PIR47804 GC05P055180
GH05J055173 Enhancer 0.8 ENCODE 650.7 +0.9 909 0.2 RB1 ZSCAN4 ARID4B SIN3A BMI1 KLF14 ZNF2 RAD21 RFX5 ZEB1 CDC20B GC05M055174 MIR449C MIR449B MIR449A
GH05J054900 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +271.0 270998 2.7 PKNOX1 MAX STAT5A EBF1 BATF IRF4 RELA NFATC1 EED ETV6 GPX8 LOC100130990 ENSG00000249016 GZMK MIR449A MIR449B CDC20B MIR449C ENSG00000240535 SNX18
GH05J055159 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 5.4 +12.4 12386 2.4 FOXA2 INSM2 MZF1 SIN3A BRCA1 ZNF2 RAD21 YY1 RFX5 ZNF335 GPX8 CCNO LOC105378973 ENSG00000249016 LOC100130990 SNX18 CDC20B MIR449A
GH05J055101 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 8.3 +71.0 71034 1.8 PKNOX1 RUNX3 GZMA CDC20B GZMAP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CDC20B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDC20B gene promoter:

Genomic Locations for CDC20B Gene

Genomic Locations for CDC20B Gene
chr5:55,112,971-55,173,177
(GRCh38/hg38)
Size:
60,207 bases
Orientation:
Minus strand
chr5:54,408,799-54,469,005
(GRCh37/hg19)

Genomic View for CDC20B Gene

Genes around CDC20B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC20B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC20B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC20B Gene

Proteins for CDC20B Gene

  • Protein details for CDC20B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y33-CD20B_HUMAN
    Recommended name:
    Cell division cycle protein 20 homolog B
    Protein Accession:
    Q86Y33
    Secondary Accessions:
    • B7WNV8
    • B9EGL8
    • C9J6X8
    • C9JHE9
    • C9JKL5
    • Q86Y31
    • Q86Y32
    • Q8IUZ8
    • Q8N1S1
    • Q8NG56

    Protein attributes for CDC20B Gene

    Size:
    519 amino acids
    Molecular mass:
    57335 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB97393.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CDC20B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC20B Gene

Post-translational modifications for CDC20B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDC20B Gene

No data available for DME Specific Peptides for CDC20B Gene

Domains & Families for CDC20B Gene

Gene Families for CDC20B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CDC20B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86Y33

UniProtKB/Swiss-Prot:

CD20B_HUMAN :
  • Belongs to the WD repeat CDC20/Fizzy family.
Family:
  • Belongs to the WD repeat CDC20/Fizzy family.
genes like me logo Genes that share domains with CDC20B: view

Function for CDC20B Gene

Gene Ontology (GO) - Molecular Function for CDC20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0010997 anaphase-promoting complex binding IEA --
GO:0097027 ubiquitin-protein transferase activator activity IEA --
genes like me logo Genes that share ontologies with CDC20B: view
genes like me logo Genes that share phenotypes with CDC20B: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDC20B Gene

Localization for CDC20B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC20B gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CDC20B Gene

Pathways & Interactions for CDC20B Gene

SuperPathways for CDC20B Gene

SuperPathway Contained pathways
1 DNA Damage Response
genes like me logo Genes that share pathways with CDC20B: view

Pathways by source for CDC20B Gene

1 BioSystems pathway for CDC20B Gene

Gene Ontology (GO) - Biological Process for CDC20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1904668 positive regulation of ubiquitin protein ligase activity IEA --
genes like me logo Genes that share ontologies with CDC20B: view

No data available for SIGNOR curated interactions for CDC20B Gene

Drugs & Compounds for CDC20B Gene

No Compound Related Data Available

Transcripts for CDC20B Gene

mRNA/cDNA for CDC20B Gene

(18) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(4) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDC20B Gene

Cell division cycle 20B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC20B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - -
SP6:

Relevant External Links for CDC20B Gene

GeneLoc Exon Structure for
CDC20B
ECgene alternative splicing isoforms for
CDC20B

Expression for CDC20B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDC20B Gene

mRNA differential expression in normal tissues according to GTEx for CDC20B Gene

This gene is overexpressed in Testis (x30.7), Lung (x9.9), and Kidney - Cortex (x4.7).

Protein differential expression in normal tissues from HIPED for CDC20B Gene

This gene is overexpressed in Bone marrow stromal cell (28.9), Fetal ovary (26.1), and Saliva (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDC20B Gene



NURSA nuclear receptor signaling pathways regulating expression of CDC20B Gene:

CDC20B

SOURCE GeneReport for Unigene cluster for CDC20B Gene:

Hs.669184

Evidence on tissue expression from TISSUES for CDC20B Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with CDC20B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC20B Gene

Orthologs for CDC20B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDC20B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC20B 34 33
  • 98.9 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CDC20B 34 33
  • 85.56 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CDC20B 34 33
  • 84.67 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc20b 16 34 33
  • 78.98 (n)
oppossum
(Monodelphis domestica)
Mammalia CDC20B 34
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 13 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CDC20B 34 33
  • 60.64 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC20B 34
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc20b 33
  • 57.14 (n)
Str.16369 33
zebrafish
(Danio rerio)
Actinopterygii si:ch73-182a11.1 34
  • 25 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta fzy 34
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fzy-1 34
  • 17 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDH1 34
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10505 34
  • 26 (a)
OneToMany
Species where no ortholog for CDC20B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC20B Gene

ENSEMBL:
Gene Tree for CDC20B (if available)
TreeFam:
Gene Tree for CDC20B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDC20B: view image

Paralogs for CDC20B Gene

Paralogs for CDC20B Gene

(2) SIMAP similar genes for CDC20B Gene using alignment to 1 proteins:

  • CD20B_HUMAN
genes like me logo Genes that share paralogs with CDC20B: view

Variants for CDC20B Gene

Sequence variations from dbSNP and Humsavar for CDC20B Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000008120 -- 55,169,268(-) A/T intron_variant
rs1000013840 -- 55,124,488(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000032277 -- 55,154,524(-) A/G intron_variant
rs1000064221 -- 55,161,974(-) G/A intron_variant
rs1000079331 -- 55,117,900(-) A/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CDC20B Gene

Variant ID Type Subtype PubMed ID
nsv477405 CNV novel sequence insertion 20440878
nsv4833 CNV deletion 18451855
nsv823075 CNV loss 20364138
nsv823077 CNV loss 20364138
nsv830301 CNV gain 17160897
nsv830302 CNV gain 17160897

Variation tolerance for CDC20B Gene

Residual Variation Intolerance Score: 80.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.96; 79.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDC20B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC20B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC20B Gene

Disorders for CDC20B Gene

Additional Disease Information for CDC20B

No disorders were found for CDC20B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC20B Gene

Publications for CDC20B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for CDC20B Gene

Sources for CDC20B Gene

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