Aliases for CDC20B Gene

Aliases for CDC20B Gene

  • Cell Division Cycle 20B 2 3 5
  • Cell Division Cycle Protein 20 Homolog B 3 4
  • CDC20 Cell Division Cycle 20 Homolog B (S. Cerevisiae) 2
  • Cell Division Cycle 20 Homolog B (S. Cerevisiae) 2
  • CDC20 Cell Division Cycle 20 Homolog B 3
  • Cell Division Cycle 20 Homolog B 3
  • CDC20-Like Protein 3
  • G6VTS76519 3
  • FLJ37927 2
  • CDC20B 5

External Ids for CDC20B Gene

Previous GeneCards Identifiers for CDC20B Gene

  • GC05M054445
  • GC05M051381

Summaries for CDC20B Gene

GeneCards Summary for CDC20B Gene

CDC20B (Cell Division Cycle 20B) is a Protein Coding gene. Among its related pathways are DNA Damage Response. An important paralog of this gene is CDC20.

Additional gene information for CDC20B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDC20B Gene

Genomics for CDC20B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDC20B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDC20B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDC20B

Top Transcription factor binding sites by QIAGEN in the CDC20B gene promoter:
  • AREB6
  • Evi-1
  • HNF-3beta
  • LyF-1
  • MIF-1
  • Olf-1
  • POU3F2
  • RSRFC4
  • SRY
  • TBP

Genomic Locations for CDC20B Gene

Genomic Locations for CDC20B Gene
chr5:55,112,971-55,173,177
(GRCh38/hg38)
Size:
60,207 bases
Orientation:
Minus strand
chr5:54,408,799-54,469,005
(GRCh37/hg19)
Size:
60,207 bases
Orientation:
Minus strand

Genomic View for CDC20B Gene

Genes around CDC20B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC20B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC20B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC20B Gene

Proteins for CDC20B Gene

  • Protein details for CDC20B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y33-CD20B_HUMAN
    Recommended name:
    Cell division cycle protein 20 homolog B
    Protein Accession:
    Q86Y33
    Secondary Accessions:
    • B7WNV8
    • B9EGL8
    • C9J6X8
    • C9JHE9
    • C9JKL5
    • Q86Y31
    • Q86Y32
    • Q8IUZ8
    • Q8N1S1
    • Q8NG56

    Protein attributes for CDC20B Gene

    Size:
    519 amino acids
    Molecular mass:
    57335 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB97393.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CDC20B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC20B Gene

Post-translational modifications for CDC20B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDC20B Gene

No data available for DME Specific Peptides for CDC20B Gene

Domains & Families for CDC20B Gene

Gene Families for CDC20B Gene

Protein Domains for CDC20B Gene

Suggested Antigen Peptide Sequences for CDC20B Gene

GenScript: Design optimal peptide antigens:
  • Cell division cycle protein 20 homolog B (CD20B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86Y33

UniProtKB/Swiss-Prot:

CD20B_HUMAN :
  • Belongs to the WD repeat CDC20/Fizzy family.
Family:
  • Belongs to the WD repeat CDC20/Fizzy family.
genes like me logo Genes that share domains with CDC20B: view

Function for CDC20B Gene

Phenotypes From GWAS Catalog for CDC20B Gene

Gene Ontology (GO) - Molecular Function for CDC20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0010997 anaphase-promoting complex binding IEA,IBA 21873635
GO:0097027 ubiquitin-protein transferase activator activity IEA --
GO:1990757 ubiquitin ligase activator activity IBA 21873635
genes like me logo Genes that share ontologies with CDC20B: view
genes like me logo Genes that share phenotypes with CDC20B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC20B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDC20B Gene

Localization for CDC20B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC20B gene
Compartment Confidence
nucleus 3
plasma membrane 1
extracellular 1
cytoskeleton 1
cytosol 1
lysosome 0

Gene Ontology (GO) - Cellular Components for CDC20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005680 anaphase-promoting complex IBA 21873635
genes like me logo Genes that share ontologies with CDC20B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CDC20B Gene

Pathways & Interactions for CDC20B Gene

PathCards logo

SuperPathways for CDC20B Gene

SuperPathway Contained pathways
1 DNA Damage Response
genes like me logo Genes that share pathways with CDC20B: view

Pathways by source for CDC20B Gene

1 BioSystems pathway for CDC20B Gene

Gene Ontology (GO) - Biological Process for CDC20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031145 anaphase-promoting complex-dependent catabolic process IBA 21873635
GO:1904668 positive regulation of ubiquitin protein ligase activity IEA --
GO:1905786 positive regulation of anaphase-promoting complex-dependent catabolic process IBA 21873635
genes like me logo Genes that share ontologies with CDC20B: view

No data available for SIGNOR curated interactions for CDC20B Gene

Drugs & Compounds for CDC20B Gene

No Compound Related Data Available

Transcripts for CDC20B Gene

mRNA/cDNA for CDC20B Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC20B

Alternative Splicing Database (ASD) splice patterns (SP) for CDC20B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - -
SP6:

Relevant External Links for CDC20B Gene

GeneLoc Exon Structure for
CDC20B

Expression for CDC20B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDC20B Gene

mRNA differential expression in normal tissues according to GTEx for CDC20B Gene

This gene is overexpressed in Testis (x30.7), Lung (x9.9), and Kidney - Cortex (x4.7).

Protein differential expression in normal tissues from HIPED for CDC20B Gene

This gene is overexpressed in Bone marrow stromal cell (28.9), Fetal ovary (26.1), and Saliva (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDC20B Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDC20B

SOURCE GeneReport for Unigene cluster for CDC20B Gene:

Hs.669184

Evidence on tissue expression from TISSUES for CDC20B Gene

  • Lung(4.3)
genes like me logo Genes that share expression patterns with CDC20B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC20B Gene

Orthologs for CDC20B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDC20B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDC20B 30 31
  • 98.9 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CDC20B 30 31
  • 85.56 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CDC20B 30 31
  • 84.67 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cdc20b 30 17 31
  • 78.98 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CDC20B 31
  • 54 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 13 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves CDC20B 30 31
  • 60.64 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CDC20B 31
  • 40 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cdc20b 30
  • 57.14 (n)
Str.16369 30
Zebrafish
(Danio rerio)
Actinopterygii si:ch73-182a11.1 31
  • 25 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta fzy 31
  • 27 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea fzy-1 31
  • 17 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDH1 31
  • 22 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10505 31
  • 26 (a)
OneToMany
Species where no ortholog for CDC20B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CDC20B Gene

ENSEMBL:
Gene Tree for CDC20B (if available)
TreeFam:
Gene Tree for CDC20B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDC20B: view image

Paralogs for CDC20B Gene

Paralogs for CDC20B Gene

(2) SIMAP similar genes for CDC20B Gene using alignment to 1 proteins:

  • CD20B_HUMAN
genes like me logo Genes that share paralogs with CDC20B: view

Variants for CDC20B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDC20B Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
785122 Benign: not provided 55,161,140(-) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT
rs1021580 - p.Arg121Cys
rs173042 - p.Thr8Pro
rs3104230 - p.Ser496Ala
rs34132993 - p.Thr97Ser

Additional dbSNP identifiers (rs#s) for CDC20B Gene

Structural Variations from Database of Genomic Variants (DGV) for CDC20B Gene

Variant ID Type Subtype PubMed ID
nsv477405 CNV novel sequence insertion 20440878
nsv4833 CNV deletion 18451855
nsv823075 CNV loss 20364138
nsv823077 CNV loss 20364138
nsv830301 CNV gain 17160897
nsv830302 CNV gain 17160897

Variation tolerance for CDC20B Gene

Residual Variation Intolerance Score: 80.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.96; 79.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDC20B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC20B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC20B Gene

Disorders for CDC20B Gene

No disorders were found for CDC20B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC20B Gene

Publications for CDC20B Gene

  1. CDC20B is required for deuterosome-mediated centriole production in multiciliated cells. (PMID: 30405130) Revinski DR … Barbry P (Nature communications 2018) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for CDC20B Gene

Sources for CDC20B Gene