Aliases for CDC20 Gene
External Ids for CDC20 Gene
Previous GeneCards Identifiers for CDC20 Gene
CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDC20 Gene
CDC20 (Cell Division Cycle 20) is a Protein Coding gene. Diseases associated with CDC20 include Mosaic Variegated Aneuploidy Syndrome 1 and Ceroid Lipofuscinosis, Neuronal, 2. Among its related pathways are Class I MHC mediated antigen processing and presentation and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include enzyme binding and protein C-terminus binding. An important paralog of this gene is FZR1.
UniProtKB/Swiss-Prot Summary for CDC20 Gene
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.