Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDC20 Gene

Aliases for CDC20 Gene

  • Cell Division Cycle 20 2 3 5
  • P55CDC 3 4
  • CDC20 (Cell Division Cycle 20, S. Cerevisiae, Homolog) 2
  • CDC20 Cell Division Cycle 20 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle 20 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle Protein 20 Homolog 3
  • CDC20 Cell Division Cycle 20 Homolog 3
  • Cell Division Cycle 20 Homolog 3
  • BA276H19.3 3
  • CDC20A 3

External Ids for CDC20 Gene

Previous GeneCards Identifiers for CDC20 Gene

  • GC01P043767
  • GC01P042825
  • GC01P043254
  • GC01P043237
  • GC01P043208
  • GC01P043493
  • GC01P043597
  • GC01P043824
  • GC01P041944

Summaries for CDC20 Gene

Entrez Gene Summary for CDC20 Gene

  • CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC20 Gene

CDC20 (Cell Division Cycle 20) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include enzyme binding and protein C-terminus binding. An important paralog of this gene is FZR1.

UniProtKB/Swiss-Prot for CDC20 Gene

  • Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.

Gene Wiki entry for CDC20 Gene

Additional gene information for CDC20 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC20 Gene

Genomics for CDC20 Gene

GeneHancer (GH) Regulatory Elements for CDC20 Gene

Promoters and enhancers for CDC20 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J043357 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.7 691 4.1 PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B CDC20 LOC105378687 GC01P043360 MED8 SZT2 P3H1 PPIH HYI KDM4A-AS1 ENSG00000229431
GH01J043283 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 10.7 -73.7 -73658 3.2 FOXA2 SIN3A RAD21 RARA ZNF121 EGR1 PRPF4 SP5 CEBPB ELF1 C1orf210 CFAP57 SZT2 MPL ENSG00000229431 MED8 CDC20 LOC105378687 ELOVL1 TMEM125
GH01J043293 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -63.9 -63882 3.8 HDGF FOXA2 KLF17 RAD21 YY1 ATF7 ETV6 IKZF2 RUNX3 RXRA MED8 EBNA1BP2 MPL CDC20 LOC105378687 ELOVL1 ENSG00000229431 SZT2 FAM183A ATP6V0B
GH01J043471 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.5 +115.6 115611 6.8 ELF3 ATF1 INSM2 SIN3A RARA ETS1 ZEB1 RCOR1 FOS ATF7 MED8 SZT2 PTPRF ELOVL1 LOC105378687 CDC20 MPL ST3GAL3 EBNA1BP2 CFAP57
GH01J043404 Enhancer 0.9 ENCODE 11.2 +46.5 46454 1.1 SMAD1 ATF1 ARNT NCOA2 TCF12 ZNF766 GATA2 ATF7 NCOA1 SNIP1 MED8 SZT2 PPIH HYI P3H1 ENSG00000229431 ELOVL1 CDC20 LOC105378687 KDM4A-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CDC20 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDC20 gene promoter:

Genomic Locations for CDC20 Gene

Genomic Locations for CDC20 Gene
chr1:43,358,955-43,363,203
(GRCh38/hg38)
Size:
4,249 bases
Orientation:
Plus strand
chr1:43,824,626-43,828,874
(GRCh37/hg19)

Genomic View for CDC20 Gene

Genes around CDC20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC20 Gene

Proteins for CDC20 Gene

  • Protein details for CDC20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12834-CDC20_HUMAN
    Recommended name:
    Cell division cycle protein 20 homolog
    Protein Accession:
    Q12834
    Secondary Accessions:
    • B2R6Z6
    • D3DPJ1
    • Q5JUY4
    • Q9BW56
    • Q9UQI9

    Protein attributes for CDC20 Gene

    Size:
    499 amino acids
    Molecular mass:
    54723 Da
    Quaternary structure:
    • Found in a complex with CDC20, CDC27, SPATC1 and TUBG1. Interacts with NEUROD2 and SPATC1 (By similarity). Interacts with MAD2L1 and BUB1B. The phosphorylated form interacts with APC/C. Interacts with NINL. May interact with MAD2L2. Interacts with CDK5RAP2 and SIRT2. Interacts with isoform 1 of NEK2. Interacts with HSF1 (via phosphorylated form); this interaction occurs in mitosis in a MAD2L1-dependent manner and prevents PLK1-stimulated degradation of HSF1 by blocking the recruitment of the SCF(BTRC) ubiquitin ligase complex (PubMed:18794143).

    Three dimensional structures from OCA and Proteopedia for CDC20 Gene

neXtProt entry for CDC20 Gene

Post-translational modifications for CDC20 Gene

  • Acetylated. Deacetylated at Lys-66 by SIRT2; deacetylation enhances the interaction of CDC20 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C).
  • Phosphorylated during mitosis, probably by maturation promoting factor (MPF). Phosphorylated by BUB1 at Ser-41; Ser-72; Ser-92; Ser-153; Thr-157 and Ser-161. Phosphorylated by NEK2.
  • Dephosphorylated by CTDP1.
  • Ubiquitinated and degraded by the proteasome during spindle assembly checkpoint. Deubiquitinated by USP44, leading to stabilize the MAD2L1-CDC20-APC/C ternary complex, thereby preventing premature activation of the APC/C. Ubiquitinated at Lys-490 during prometaphase. Ubiquitination at Lys-485 and Lys-490 has no effect on its ability to bind the APC/C complex.
  • Ubiquitination at posLast=490490, posLast=485485, Lys259, posLast=155155, Lys149, Lys136, posLast=129129, posLast=114114, and posLast=9797
  • Modification sites at PhosphoSitePlus

Other Protein References for CDC20 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDC20 Gene

Domains & Families for CDC20 Gene

Gene Families for CDC20 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CDC20 Gene

Graphical View of Domain Structure for InterPro Entry

Q12834

UniProtKB/Swiss-Prot:

CDC20_HUMAN :
  • Belongs to the WD repeat CDC20/Fizzy family.
Family:
  • Belongs to the WD repeat CDC20/Fizzy family.
genes like me logo Genes that share domains with CDC20: view

Function for CDC20 Gene

Molecular function for CDC20 Gene

UniProtKB/Swiss-Prot Function:
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
GENATLAS Biochemistry:
cell division cycle 20,involved in ubiquitin mediated proteolysis,highly expressed in proliferating cells,homolog to S cerevisiae Cdc20p,mediating the association of the mitotic spindle checkpoint protein MAD1L1 with the cyclosome/anaphase-promoting complex

Phenotypes From GWAS Catalog for CDC20 Gene

Gene Ontology (GO) - Molecular Function for CDC20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11030144
GO:0008022 protein C-terminus binding IPI 10700282
GO:0010997 anaphase-promoting complex binding IEA --
GO:0019899 enzyme binding IPI 17443180
GO:0042826 histone deacetylase binding IEA --
genes like me logo Genes that share ontologies with CDC20: view
genes like me logo Genes that share phenotypes with CDC20: view

Animal Models for CDC20 Gene

MGI Knock Outs for CDC20:
  • Cdc20 Cdc20<tm1.2Mama>
  • Cdc20 Cdc20<tm1.1(KOMP)Vlcg>

Animal Model Products

Clone Products

  • Addgene plasmids for CDC20

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDC20 Gene

Localization for CDC20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC20 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC20 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDC20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005680 colocalizes_with anaphase-promoting complex IDA 11459825
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CDC20: view

Pathways & Interactions for CDC20 Gene

SuperPathways for CDC20 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.60
5 Mitotic Metaphase and Anaphase
genes like me logo Genes that share pathways with CDC20: view

UniProtKB/Swiss-Prot Q12834-CDC20_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for CDC20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007062 sister chromatid cohesion TAS --
GO:0007064 mitotic sister chromatid cohesion IEA --
GO:0007399 nervous system development IEA --
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with CDC20: view

No data available for SIGNOR curated interactions for CDC20 Gene

Drugs & Compounds for CDC20 Gene

(3) Drugs for CDC20 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CDC20: view

Transcripts for CDC20 Gene

mRNA/cDNA for CDC20 Gene

(540) Selected AceView cDNA sequences:
(20) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDC20 Gene

Cell division cycle 20:
Representative Sequences:

Clone Products

  • Addgene plasmids for CDC20

Alternative Splicing Database (ASD) splice patterns (SP) for CDC20 Gene

No ASD Table

Relevant External Links for CDC20 Gene

GeneLoc Exon Structure for
CDC20
ECgene alternative splicing isoforms for
CDC20

Expression for CDC20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDC20 Gene

mRNA differential expression in normal tissues according to GTEx for CDC20 Gene

This gene is overexpressed in Testis (x9.1) and Esophagus - Mucosa (x4.8).

Protein differential expression in normal tissues from HIPED for CDC20 Gene

This gene is overexpressed in Lung (67.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDC20 Gene



Protein tissue co-expression partners for CDC20 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDC20 Gene:

CDC20

SOURCE GeneReport for Unigene cluster for CDC20 Gene:

Hs.524947

Evidence on tissue expression from TISSUES for CDC20 Gene

  • Intestine(4.7)
  • Liver(4.5)
  • Skin(4.4)
  • Spleen(4.2)
  • Muscle(4)
  • Nervous system(2.8)
  • Blood(2.3)
genes like me logo Genes that share expression patterns with CDC20: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC20 Gene

Orthologs for CDC20 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC20 34 33
  • 99.8 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CDC20 34 33
  • 92.25 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CDC20 34 33
  • 91.45 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc20 33
  • 89.25 (n)
mouse
(Mus musculus)
Mammalia Cdc20 16 34 33
  • 88.31 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDC20 34
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDC20 34
  • 25 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC20 34 33
  • 77 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC20 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc20 33
  • 70.49 (n)
MGC75919 33
zebrafish
(Danio rerio)
Actinopterygii cdc20 34 33
  • 63.35 (n)
OneToOne
Dr.26337 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3615 33
fruit fly
(Drosophila melanogaster)
Insecta fzy 34 35 33
  • 56.55 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009338 33
  • 54.65 (n)
worm
(Caenorhabditis elegans)
Secernentea fzy-1 34
  • 23 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL014C 33
  • 48.38 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC20 36 33
  • 47.37 (n)
CDH1 34
  • 29 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F10791g 33
  • 46.22 (n)
rice
(Oryza sativa)
Liliopsida Os02g0700100 33
  • 54.53 (n)
Os.26575 33
barley
(Hordeum vulgare)
Liliopsida Hv.7030 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes slp1 33
  • 51.66 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02616 33
  • 50.04 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10505 34
  • 49 (a)
OneToMany
Species where no ortholog for CDC20 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC20 Gene

ENSEMBL:
Gene Tree for CDC20 (if available)
TreeFam:
Gene Tree for CDC20 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDC20: view image

Paralogs for CDC20 Gene

Paralogs for CDC20 Gene

(2) SIMAP similar genes for CDC20 Gene using alignment to 1 proteins:

  • CDC20_HUMAN

Pseudogenes.org Pseudogenes for CDC20 Gene

genes like me logo Genes that share paralogs with CDC20: view

Variants for CDC20 Gene

Sequence variations from dbSNP and Humsavar for CDC20 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000360474 -- 43,357,355(+) A/T upstream_transcript_variant
rs1000928572 -- 43,363,685(+) G/C downstream_transcript_variant
rs1001902533 -- 43,358,018(+) C/G upstream_transcript_variant
rs1002108476 -- 43,363,206(+) T/C downstream_transcript_variant
rs1002269644 -- 43,357,726(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CDC20 Gene

Variant ID Type Subtype PubMed ID
nsv546128 CNV loss 21841781

Variation tolerance for CDC20 Gene

Residual Variation Intolerance Score: 11.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDC20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC20

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC20 Gene

Disorders for CDC20 Gene

Additional Disease Information for CDC20

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CDC20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC20 Gene

Publications for CDC20 Gene

  1. HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression. (PMID: 18794143) Lee YJ … Lee YS (Cancer research 2008) 3 4 22 58
  2. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. (PMID: 17443180) Stegmeier F … Elledge SJ (Nature 2007) 3 4 22 58
  3. Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. (PMID: 15525512) Tang Z … Yu H (Molecular cell 2004) 3 4 22 58
  4. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PMID: 14657031) Kraft C … Peters JM (The EMBO journal 2003) 3 4 22 58
  5. MAD2B is an inhibitor of the anaphase-promoting complex. (PMID: 11459826) Chen J … Fang G (Genes & development 2001) 3 4 22 58

Products for CDC20 Gene

  • Addgene plasmids for CDC20

Sources for CDC20 Gene

Content
Loading form....