CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008] See more...

Aliases for CDC20 Gene

Aliases for CDC20 Gene

  • Cell Division Cycle 20 2 3 5
  • P55CDC 2 3 4
  • Cell Division Cycle Protein 20 Homolog 3 4
  • CDC20A 2 3
  • CDC20 (Cell Division Cycle 20, S. Cerevisiae, Homolog) 2
  • CDC20 Cell Division Cycle 20 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle 20 Homolog (S. Cerevisiae) 2
  • CDC20 Cell Division Cycle 20 Homolog 3
  • Cell Division Cycle 20 Homolog 3
  • BA276H19.3 3
  • CDC20 5

External Ids for CDC20 Gene

Previous GeneCards Identifiers for CDC20 Gene

  • GC01P043767
  • GC01P042825
  • GC01P043254
  • GC01P043237
  • GC01P043208
  • GC01P043493
  • GC01P043597
  • GC01P043824
  • GC01P041944

Summaries for CDC20 Gene

Entrez Gene Summary for CDC20 Gene

  • CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC20 Gene

CDC20 (Cell Division Cycle 20) is a Protein Coding gene. Diseases associated with CDC20 include Mosaic Variegated Aneuploidy Syndrome 1 and Ceroid Lipofuscinosis, Neuronal, 2. Among its related pathways are Class I MHC mediated antigen processing and presentation and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include enzyme binding and protein C-terminus binding. An important paralog of this gene is FZR1.

UniProtKB/Swiss-Prot Summary for CDC20 Gene

  • Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.

Gene Wiki entry for CDC20 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDC20 Gene

Genomics for CDC20 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDC20 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J043357 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +0.7 665 4.1 BCLAF1 SP1 MYC IKZF1 ZNF600 POLR2A ZNF10 BRCA1 YY1 MXD4 CDC20 ENSG00000234694 HSALNG0003090 LOC105378687 MED8 SZT2 PPIH P3H1 HYI KDM4A-AS1
GH01J042949 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13 -402.1 -402098 15.5 MYC NCOR1 ZNF600 IKZF1 ZNF580 ZNF592 ZMYM3 ATF2 KLF9 POLR2A SLC2A1-AS1 SLC2A1 SZT2 ARTN PPIH CDC20 P3H1 MED8 RNU6-880P ERMAP
GH01J042678 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 13 -676.1 -676094 7.8 SP1 ZNF207 MYC NCOR1 ZNF600 ZNF580 ZNF592 POLR2A CEBPA NFIC ENSG00000285728 YBX1 SZT2 PPIH P3H1 FOXJ3 SVBP CDC20 MED8 ZNF691
GH01J042845 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 13 -512.2 -512208 2.7 SP1 NCOR1 ZNF600 MYC IKZF1 SIX5 POLR2A NFIC YY1 CTCF ZNF691 ENSG00000228192 SVBP SZT2 YBX1 CDC20 PPIH P3H1 MED8 FOXJ3
GH01J043171 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 13.1 -187.1 -187080 2.6 BCLAF1 SP1 ZNF207 MYC SIX5 ZNF580 ZNF592 POLR2A ZNF10 NFIC CFAP57 MIR6733 piR-48325-002 SZT2 KDM4A MED8 KDM4A-AS1 P3H1 CDC20 PPIH
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDC20 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDC20

Top Transcription factor binding sites by QIAGEN in the CDC20 gene promoter:
  • AML1a
  • CUTL1
  • HTF
  • MZF-1
  • p53

Genomic Locations for CDC20 Gene

Latest Assembly
chr1:43,358,981-43,363,203
(GRCh38/hg38)
Size:
4,223 bases
Orientation:
Plus strand

Previous Assembly
chr1:43,824,652-43,828,874
(GRCh37/hg19 by Entrez Gene)
Size:
4,223 bases
Orientation:
Plus strand

chr1:43,824,626-43,828,874
(GRCh37/hg19 by Ensembl)
Size:
4,249 bases
Orientation:
Plus strand

Genomic View for CDC20 Gene

Genes around CDC20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC20 Gene

Proteins for CDC20 Gene

  • Protein details for CDC20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12834-CDC20_HUMAN
    Recommended name:
    Cell division cycle protein 20 homolog
    Protein Accession:
    Q12834
    Secondary Accessions:
    • B2R6Z6
    • D3DPJ1
    • Q5JUY4
    • Q9BW56
    • Q9UQI9

    Protein attributes for CDC20 Gene

    Size:
    499 amino acids
    Molecular mass:
    54723 Da
    Quaternary structure:
    • Component of a complex with CDC20, CDC27, SPATC1 and TUBG1 (By similarity). Interacts with NEUROD2 (By similarity). Interacts with dimeric MAD2L1 in its closed conformation form (PubMed:9811605, PubMed:9637688, PubMed:15525512, PubMed:19098431, PubMed:29162720). Interacts with BUB1B (PubMed:15525512, PubMed:18997788, PubMed:19098431). The phosphorylated form interacts with APC/C (PubMed:9811605, PubMed:9734353, PubMed:9637688). Interacts with NINL (PubMed:17403670). May interact with MAD2L2 (PubMed:11459826). Interacts with CDK5RAP2 (PubMed:19282672). Interacts with SIRT2 (PubMed:22014574). Interacts with isoform 1 of NEK2 (PubMed:20034488). Interacts with HSF1 (via phosphorylated form); this interaction occurs in mitosis in a MAD2L1-dependent manner and prevents PLK1-stimulated degradation of HSF1 by blocking the recruitment of the SCF(BTRC) ubiquitin ligase complex (PubMed:18794143). Interacts (via the N-terminal substrate-binding domain) with FBXO5 (By similarity).

    Three dimensional structures from OCA and Proteopedia for CDC20 Gene

neXtProt entry for CDC20 Gene

Post-translational modifications for CDC20 Gene

  • Acetylated. Deacetylated at Lys-66 by SIRT2; deacetylation enhances the interaction of CDC20 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C).
  • Phosphorylated during mitosis, probably by maturation promoting factor (MPF). Phosphorylated by BUB1 at Ser-41; Ser-72; Ser-92; Ser-153; Thr-157 and Ser-161. Phosphorylated by NEK2.
  • Dephosphorylated by CTDP1.
  • Ubiquitinated and degraded by the proteasome during spindle assembly checkpoint. Deubiquitinated by USP44, leading to stabilize the MAD2L1-CDC20-APC/C ternary complex, thereby preventing premature activation of the APC/C. Ubiquitinated at Lys-490 during prometaphase. Ubiquitination at Lys-485 and Lys-490 has no effect on its ability to bind the APC/C complex.
  • Ubiquitination at Lys97, Lys114, Lys129, Lys136, Lys149, Lys155, Lys259, Lys485, and Lys490
  • Modification sites at PhosphoSitePlus

Other Protein References for CDC20 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDC20 Gene

Domains & Families for CDC20 Gene

Gene Families for CDC20 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CDC20 Gene

InterPro:
Blocks:
  • G-protein beta WD-40 repeat signature
  • Cdc20/Fizzy

Suggested Antigen Peptide Sequences for CDC20 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51449, highly similar to Cell division cycle protein 20 homolog (B4E1H5_HUMAN)
  • p55CDC (CDC20_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q12834

UniProtKB/Swiss-Prot:

CDC20_HUMAN :
  • Belongs to the WD repeat CDC20/Fizzy family.
Family:
  • Belongs to the WD repeat CDC20/Fizzy family.
genes like me logo Genes that share domains with CDC20: view

Function for CDC20 Gene

Molecular function for CDC20 Gene

UniProtKB/Swiss-Prot Function:
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
GENATLAS Biochemistry:
cell division cycle 20,involved in ubiquitin mediated proteolysis,highly expressed in proliferating cells,homolog to S cerevisiae Cdc20p,mediating the association of the mitotic spindle checkpoint protein MAD1L1 with the cyclosome/anaphase-promoting complex

Phenotypes From GWAS Catalog for CDC20 Gene

Gene Ontology (GO) - Molecular Function for CDC20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11030144
GO:0008022 protein C-terminus binding IPI 10700282
GO:0010997 anaphase-promoting complex binding IBA 21873635
GO:0019899 enzyme binding IPI 17443180
GO:0042826 histone deacetylase binding IEA --
genes like me logo Genes that share ontologies with CDC20: view
genes like me logo Genes that share phenotypes with CDC20: view

Animal Models for CDC20 Gene

MGI Knock Outs for CDC20:
  • Cdc20 Cdc20<tm1.1(KOMP)Vlcg>
  • Cdc20 Cdc20<tm1.2Mama>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC20

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDC20 Gene

Localization for CDC20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC20 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC20 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDC20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005654 nucleoplasm TAS --
GO:0005680 colocalizes_with anaphase-promoting complex IDA 11459825
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IEA --
genes like me logo Genes that share ontologies with CDC20: view

Pathways & Interactions for CDC20 Gene

PathCards logo

SuperPathways for CDC20 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.60
5 Mitotic Metaphase and Anaphase
genes like me logo Genes that share pathways with CDC20: view

Pathways by source for CDC20 Gene

2 GeneGo (Thomson Reuters) pathways for CDC20 Gene
  • Cell cycle_Role of APC in cell cycle regulation
  • Cell cycle_Spindle assembly and chromosome separation
1 Qiagen pathway for CDC20 Gene
  • Mitotic Roles of Polo Like Kinases
2 Cell Signaling Technology pathways for CDC20 Gene

UniProtKB/Swiss-Prot Q12834-CDC20_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for CDC20 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for CDC20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process TAS --
GO:0007049 cell cycle IEA --
GO:0007064 mitotic sister chromatid cohesion IEA --
GO:0007094 mitotic spindle assembly checkpoint TAS --
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with CDC20: view

Drugs & Compounds for CDC20 Gene

(3) Drugs for CDC20 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CDC20: view

Transcripts for CDC20 Gene

mRNA/cDNA for CDC20 Gene

1 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC20

Alternative Splicing Database (ASD) splice patterns (SP) for CDC20 Gene

No ASD Table

Relevant External Links for CDC20 Gene

GeneLoc Exon Structure for
CDC20

Expression for CDC20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDC20 Gene

mRNA differential expression in normal tissues according to GTEx for CDC20 Gene

This gene is overexpressed in Testis (x9.1) and Esophagus - Mucosa (x4.8).

Protein differential expression in normal tissues from HIPED for CDC20 Gene

This gene is overexpressed in Lung (67.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDC20 Gene



Protein tissue co-expression partners for CDC20 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDC20

SOURCE GeneReport for Unigene cluster for CDC20 Gene:

Hs.524947

Evidence on tissue expression from TISSUES for CDC20 Gene

  • Intestine(4.8)
  • Liver(4.6)
  • Skin(4.6)
  • Spleen(4.4)
  • Muscle(4.3)
  • Nervous system(3.3)
  • Blood(2.9)
  • Lymph node(2.3)
  • Bone marrow(2.3)
  • Stomach(2.2)
  • Kidney(2.1)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with CDC20: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC20 Gene

Orthologs for CDC20 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC20 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDC20 29 30
  • 99.8 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CDC20 29 30
  • 92.25 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CDC20 29 30
  • 91.45 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cdc20 29
  • 89.25 (n)
Mouse
(Mus musculus)
Mammalia Cdc20 29 16 30
  • 88.31 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CDC20 30
  • 78 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CDC20 30
  • 25 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CDC20 29 30
  • 77 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CDC20 30
  • 77 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cdc20 29
  • 70.49 (n)
MGC75919 29
Zebrafish
(Danio rerio)
Actinopterygii cdc20 29 30
  • 63.35 (n)
OneToOne
Dr.26337 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3615 29
Fruit Fly
(Drosophila melanogaster)
Insecta fzy 29 30 31
  • 56.55 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009338 29
  • 54.65 (n)
Worm
(Caenorhabditis elegans)
Secernentea fzy-1 30
  • 23 (a)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AFL014C 29
  • 48.38 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC20 29 32 32
  • 47.37 (n)
CDH1 30
  • 29 (a)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F10791g 29
  • 46.22 (n)
Rice
(Oryza sativa)
Liliopsida Os02g0700100 29
  • 54.53 (n)
Os.26575 29
Barley
(Hordeum vulgare)
Liliopsida Hv.7030 29
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes slp1 29
  • 51.66 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU02616 29
  • 50.04 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10505 30
  • 49 (a)
OneToMany
Species where no ortholog for CDC20 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CDC20 Gene

ENSEMBL:
Gene Tree for CDC20 (if available)
TreeFam:
Gene Tree for CDC20 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDC20: view image
Alliance of Genome Resources:
Additional Orthologs for CDC20

Paralogs for CDC20 Gene

Paralogs for CDC20 Gene

(2) SIMAP similar genes for CDC20 Gene using alignment to 1 proteins:

  • CDC20_HUMAN

Pseudogenes.org Pseudogenes for CDC20 Gene

genes like me logo Genes that share paralogs with CDC20: view

Variants for CDC20 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDC20 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1801456 Benign: not provided 43,361,123(+) G/A
NM_001255.3(CDC20):c.1081G>A (p.Val361Ile)
MISSENSE
rs2069388 Benign: not provided 43,363,081(+) G/A
NM_001255.3(CDC20):c.1452G>A (p.Glu484=)
SYNONYMOUS
rs45443196 -- p.Val402Met
rs45461499 -- p.Arg479Gln

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CDC20 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CDC20 Gene

Variant ID Type Subtype PubMed ID
nsv546128 CNV loss 21841781

Variation tolerance for CDC20 Gene

Residual Variation Intolerance Score: 11.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDC20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC20
Leiden Open Variation Database (LOVD)
CDC20

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC20 Gene

Disorders for CDC20 Gene

MalaCards: The human disease database

(7) MalaCards diseases for CDC20 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards
Search CDC20 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CDC20

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CDC20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDC20 Gene

Publications for CDC20 Gene

  1. HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression. (PMID: 18794143) Lee YJ … Lee YS (Cancer research 2008) 3 4 22
  2. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. (PMID: 17443180) Stegmeier F … Elledge SJ (Nature 2007) 3 4 22
  3. Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. (PMID: 15525512) Tang Z … Yu H (Molecular cell 2004) 3 4 22
  4. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PMID: 14657031) Kraft C … Peters JM (The EMBO journal 2003) 3 4 22
  5. MAD2B is an inhibitor of the anaphase-promoting complex. (PMID: 11459826) Chen J … Fang G (Genes & development 2001) 3 4 22

Products for CDC20 Gene

Sources for CDC20 Gene