The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, a... See more...

Aliases for CDC16 Gene

Aliases for CDC16 Gene

  • Cell Division Cycle 16 2 3 5
  • ANAPC6 2 3 4
  • APC6 2 3 4
  • Cell Division Cycle Protein 16 Homolog 3 4
  • Anaphase-Promoting Complex, Subunit 6 2 3
  • Cyclosome Subunit 6 3 4
  • CDC16Hs 3 4
  • CUT9 2 3
  • CDC16 (Cell Division Cycle 16, S. Cerevisiae, Homolog) 2
  • CDC16 Cell Division Cycle 16 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle 16 Homolog (S. Cerevisiae) 2
  • Anaphase-Promoting Complex Subunit 6 4
  • Cell Division Cycle 16 Homolog 3
  • CDC16 Homolog 4
  • CDC16 5

External Ids for CDC16 Gene

Previous GeneCards Identifiers for CDC16 Gene

  • GC13P113361
  • GC13P111188
  • GC13P114022
  • GC13P112918
  • GC13P114018
  • GC13P115000
  • GC13P095262

Summaries for CDC16 Gene

Entrez Gene Summary for CDC16 Gene

  • The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016]

GeneCards Summary for CDC16 Gene

CDC16 (Cell Division Cycle 16) is a Protein Coding gene. Diseases associated with CDC16 include Epileptic Encephalopathy, Early Infantile, 16 and Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation, And Seizures Syndrome. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Signal transduction_PKA signaling. An important paralog of this gene is CDC27.

UniProtKB/Swiss-Prot Summary for CDC16 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Gene Wiki entry for CDC16 Gene

Additional gene information for CDC16 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDC16 Gene

Genomics for CDC16 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDC16 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDC16 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDC16

Top Transcription factor binding sites by QIAGEN in the CDC16 gene promoter:
  • ATF
  • ATF-2
  • c-Myc
  • HSF2
  • Max1
  • Nkx5-1
  • S8
  • Sox5
  • Sox9
  • TGIF

Genomic Locations for CDC16 Gene

Genomic Locations for CDC16 Gene
chr13:114,234,845-114,272,723
(GRCh38/hg38)
Size:
37,879 bases
Orientation:
Plus strand
chr13:115,000,362-115,038,198
(GRCh37/hg19)
Size:
37,837 bases
Orientation:
Plus strand

Genomic View for CDC16 Gene

Genes around CDC16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC16 Gene

Proteins for CDC16 Gene

  • Protein details for CDC16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13042-CDC16_HUMAN
    Recommended name:
    Cell division cycle protein 16 homolog
    Protein Accession:
    Q13042
    Secondary Accessions:
    • A2A365
    • Q5T8C8
    • Q7Z651
    • Q96AE6
    • Q9Y564

    Protein attributes for CDC16 Gene

    Size:
    620 amino acids
    Molecular mass:
    71656 Da
    Quaternary structure:
    • V-shaped homodimer. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5 (PubMed:26083744, PubMed:25043029). Interacts with PPP5C and CDC20 (PubMed:9628895, PubMed:9405394). Interacts with CDC26 (PubMed:19668213).

    Three dimensional structures from OCA and Proteopedia for CDC16 Gene

    Alternative splice isoforms for CDC16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC16 Gene

Post-translational modifications for CDC16 Gene

  • Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis.
  • Ubiquitination at Lys106, Lys154, and Lys423
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDC16 Gene

Domains & Families for CDC16 Gene

Gene Families for CDC16 Gene

Protein Domains for CDC16 Gene

Suggested Antigen Peptide Sequences for CDC16 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56731, highly similar to Cell division cycle protein 16 homolog (B4DK74_HUMAN)
  • Cyclosome subunit 6 (CDC16_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13042

UniProtKB/Swiss-Prot:

CDC16_HUMAN :
  • TPR repeats 1-7 mediate homodimerization, while the C-terminal TPR repeats bind to CDC26, burying its hydrophobic N-terminus.
  • Belongs to the APC6/CDC16 family.
Domain:
  • TPR repeats 1-7 mediate homodimerization, while the C-terminal TPR repeats bind to CDC26, burying its hydrophobic N-terminus.
Family:
  • Belongs to the APC6/CDC16 family.
genes like me logo Genes that share domains with CDC16: view

Function for CDC16 Gene

Molecular function for CDC16 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Phenotypes From GWAS Catalog for CDC16 Gene

Gene Ontology (GO) - Molecular Function for CDC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 20360068
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with CDC16: view
genes like me logo Genes that share phenotypes with CDC16: view

Animal Model Products

CRISPR Products

miRNA for CDC16 Gene

miRTarBase miRNAs that target CDC16

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC16

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC16 Gene

Localization for CDC16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC16 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC16 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 2
mitochondrion 2
endosome 2
lysosome 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CDC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IBA,IDA 16364912
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 7736578
genes like me logo Genes that share ontologies with CDC16: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CDC16 Gene

Pathways & Interactions for CDC16 Gene

PathCards logo

SuperPathways for CDC16 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
2 APC-Cdc20 mediated degradation of Nek2A
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.60
5 Cellular Senescence (REACTOME)
genes like me logo Genes that share pathways with CDC16: view

Pathways by source for CDC16 Gene

7 GeneGo (Thomson Reuters) pathways for CDC16 Gene
  • Cell cycle Regulation of G1/S transition (part 1)
  • Cell cycle Role of SCF complex in cell cycle regulation
  • Cell cycle_Role of APC in cell cycle regulation
  • Cell cycle_Spindle assembly and chromosome separation
  • Development_TGF-beta receptor signaling
6 Qiagen pathways for CDC16 Gene
  • Activation of PKA through GPCR
  • cAMP Pathway
  • CDC42 Pathway
  • Epithelial Adherens Junctions
  • Mitotic Roles of Polo Like Kinases
1 Cell Signaling Technology pathway for CDC16 Gene

UniProtKB/Swiss-Prot Q13042-CDC16_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for CDC16 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CDC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process TAS --
GO:0007049 cell cycle IEA --
GO:0007091 metaphase/anaphase transition of mitotic cell cycle IBA 21873635
GO:0016567 protein ubiquitination IBA 21873635
GO:0031145 anaphase-promoting complex-dependent catabolic process IBA,TAS --
genes like me logo Genes that share ontologies with CDC16: view

Drugs & Compounds for CDC16 Gene

No Compound Related Data Available

Transcripts for CDC16 Gene

mRNA/cDNA for CDC16 Gene

7 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC16

Alternative Splicing Database (ASD) splice patterns (SP) for CDC16 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - -
SP8: -
SP9: -
SP10: - - -
SP11: -
SP12:
SP13:
SP14:

ExUns: 17b · 17c · 17d ^ 18a · 18b ^ 19a · 19b · 19c · 19d ^ 20
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: -
SP6: - -
SP7: - - -
SP8:
SP9: - -
SP10: - -
SP11: - -
SP12: -
SP13: - -
SP14:

Relevant External Links for CDC16 Gene

GeneLoc Exon Structure for
CDC16

Expression for CDC16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDC16 Gene

Protein differential expression in normal tissues from HIPED for CDC16 Gene

This gene is overexpressed in Breast (14.9), NK cells (8.2), and Lung (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDC16 Gene



Protein tissue co-expression partners for CDC16 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDC16

SOURCE GeneReport for Unigene cluster for CDC16 Gene:

Hs.374127

Evidence on tissue expression from TISSUES for CDC16 Gene

  • Nervous system(4.8)
  • Skin(4.6)
  • Lung(4.5)
  • Intestine(2.5)
  • Kidney(2.4)
  • Muscle(2.4)
  • Liver(2.3)
  • Thyroid gland(2.1)
  • Heart(2)
  • Lymph node(2)
  • Pancreas(2)
  • Spleen(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with CDC16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC16 Gene

Orthologs for CDC16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC16 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDC16 30 31
  • 99.3 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CDC16 31
  • 95 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 95 (a)
OneToMany
-- 31
  • 92 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia CDC16 30 31
  • 91.34 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CDC16 30 31
  • 90.75 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cdc16 30 17 31
  • 88.23 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cdc16 30
  • 87.1 (n)
Chicken
(Gallus gallus)
Aves CDC16 30 31
  • 83.23 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CDC16 31
  • 86 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cdc16 30
  • 79.61 (n)
Str.17391 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.23806 30
Zebrafish
(Danio rerio)
Actinopterygii cdc16 30 31
  • 72.29 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004623 30
  • 54.95 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta cdc16 30 31 32
  • 51.54 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea emb-27 31 32
  • 21 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC16 30 31 33
  • 46.27 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ACR168W 30
  • 46.11 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E08009g 30
  • 45.35 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons APC6 30
  • 52.01 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cut9 30
  • 48.75 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU01377 30
  • 44.96 (n)
Species where no ortholog for CDC16 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CDC16 Gene

ENSEMBL:
Gene Tree for CDC16 (if available)
TreeFam:
Gene Tree for CDC16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDC16: view image

Paralogs for CDC16 Gene

Paralogs for CDC16 Gene

genes like me logo Genes that share paralogs with CDC16: view

Variants for CDC16 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDC16 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
722878 Likely Benign: not provided 114,236,808(+) A/G MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT
773720 Benign: not provided 114,242,135(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for CDC16 Gene

Structural Variations from Database of Genomic Variants (DGV) for CDC16 Gene

Variant ID Type Subtype PubMed ID
dgv1745n100 CNV gain 25217958
dgv1746n100 CNV gain 25217958
dgv1747n100 CNV gain 25217958
dgv1748n100 CNV gain 25217958
esv25715 CNV gain+loss 19812545
esv3582871 CNV gain 25503493
esv3633642 CNV gain 21293372
esv3633643 CNV gain 21293372
esv3633644 CNV gain 21293372
nsv1043111 CNV gain 25217958
nsv1050622 CNV gain 25217958
nsv1120434 CNV deletion 24896259
nsv456143 CNV gain 19166990
nsv521609 CNV gain 19592680
nsv563532 CNV gain 21841781
nsv563533 CNV loss 21841781
nsv563534 CNV gain 21841781
nsv832728 CNV gain 17160897

Variation tolerance for CDC16 Gene

Residual Variation Intolerance Score: 24.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDC16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC16

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC16 Gene

Disorders for CDC16 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CDC16 Gene - From: DISEASES

Additional Disease Information for CDC16

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CDC16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDC16 Gene

Publications for CDC16 Gene

  1. CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. (PMID: 7736578) Tugendreich S … Hieter P (Cell 1995) 2 3 4 23
  2. The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex. (PMID: 9405394) Ollendorff V … Donoghue DJ (The Journal of biological chemistry 1997) 3 4 23
  3. Atomic structure of the APC/C and its mechanism of protein ubiquitination. (PMID: 26083744) Chang L … Barford D (Nature 2015) 3 4
  4. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang LF … Barford D (Nature 2014) 3 4
  5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 41

Products for CDC16 Gene

Sources for CDC16 Gene