Aliases for CDC16 Gene
External Ids for CDC16 Gene
Previous GeneCards Identifiers for CDC16 Gene
The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016]
GeneCards Summary for CDC16 Gene
CDC16 (Cell Division Cycle 16) is a Protein Coding gene. Diseases associated with CDC16 include Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation, And Seizures Syndrome and Deafness, Autosomal Dominant 65. Among its related pathways are Cellular Senescence (REACTOME) and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is CDC27.
UniProtKB/Swiss-Prot Summary for CDC16 Gene
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.