This gene represents a retrogene of cell division cycle 14B (CDC14B), which is located on chromosome 9. The introns in the coding sequence have been processed out relative to the CDC14B locus, but there is an intact open reading frame that is missing only some sequence at the N-terminus, including the nuclear localiztion signal, relative to proteins encoded by the CDC14B gene. ... See more...

Aliases for CDC14C Gene

Aliases for CDC14C Gene

  • Cell Division Cycle 14C 2 3 5
  • CDC14Bretro 2 3 4
  • CDC14B2 2 3 4
  • Dual Specificity Protein Phosphatase CDC14C 3 4
  • CDC14 Cell Division Cycle 14 Homolog C 3 4
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • MGC26484 2
  • CDC14CP 2
  • CDC14C 5

External Ids for CDC14C Gene

Previous GeneCards Identifiers for CDC14C Gene

  • GC07P048737
  • GC07P048934
  • GC07P049007
  • GC07P048960

Summaries for CDC14C Gene

Entrez Gene Summary for CDC14C Gene

  • This gene represents a retrogene of cell division cycle 14B (CDC14B), which is located on chromosome 9. The introns in the coding sequence have been processed out relative to the CDC14B locus, but there is an intact open reading frame that is missing only some sequence at the N-terminus, including the nuclear localiztion signal, relative to proteins encoded by the CDC14B gene. There is a difference in the subcellular localization of the protein encoded by this gene, relative to its parental gene product. While the parental gene product displays microtubular localization, GFP chimeras of the protein encoded by this gene localize to the endoplasmic reticulum, indicating a possible new functional role for this gene. [provided by RefSeq, Nov 2017]

GeneCards Summary for CDC14C Gene

CDC14C (Cell Division Cycle 14C) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is CDC14B.

UniProtKB/Swiss-Prot Summary for CDC14C Gene

  • Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity).

Additional gene information for CDC14C Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDC14C Gene

Genomics for CDC14C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDC14C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J049022 Enhancer 0.8 Ensembl ENCODE dbSUPER 9.2 +104.0 103962 1.5 TEAD4 POLR2A YY1 TAF1 POU5F1 CDC14C HSALNG0057896 piR-36588-405 VWC2
GH07J049001 Enhancer 0.8 Ensembl ENCODE 8.7 +82.0 82036 0.4 CTCF ZNF143 RAD21 TRIM22 PKNOX1 TCF12 SMC3 YY1 ELF1 GATA3 CDC14C piR-48553-287 piR-61157-047 VWC2
GH07J049036 Enhancer 0.7 Ensembl ENCODE dbSUPER 6.8 +117.5 117536 3.4 SMARCA4 NANOG CTCF CDC14C ENSG00000225705 HSALNG0057896 piR-36588-405 VWC2
GH07J049486 Enhancer 0.6 Ensembl ENCODE 4.5 +567.6 567636 1.6 CTCF ETS1 RAD21 NANOG CDC14C HSALNG0057912 piR-47162-161 VWC2
GH07J049023 Enhancer 0.3 dbSUPER 7 +102.8 102822 0.6 CEBPG ATF4 CDC14C HSALNG0057896 piR-36588-405 VWC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDC14C on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the CDC14C gene promoter:
  • LCR-F1
  • Pax-4a
  • POU2F1
  • POU2F1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • POU6F1 (c2)
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for CDC14C Gene

Genomic Locations for CDC14C Gene
chr7:48,919,765-48,927,454
(GRCh38/hg38)
Size:
7,690 bases
Orientation:
Plus strand
chr7:48,959,361-48,967,049
(GRCh37/hg19)
Size:
7,689 bases
Orientation:
Plus strand

Genomic View for CDC14C Gene

Genes around CDC14C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC14C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC14C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC14C Gene

Proteins for CDC14C Gene

  • Protein details for CDC14C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D256-CC14C_HUMAN
    Recommended name:
    Dual specificity protein phosphatase CDC14C
    Protein Accession:
    A4D256
    Secondary Accessions:
    • Q2VIP7
    • Q6NUS3
    • Q8NCT2

    Protein attributes for CDC14C Gene

    Size:
    447 amino acids
    Molecular mass:
    51614 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=ABB92421.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=EAL23906.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
    Miscellaneous:
    • May act as an autosomal functional substitute.

neXtProt entry for CDC14C Gene

Post-translational modifications for CDC14C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDC14C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDC14C Gene

Domains & Families for CDC14C Gene

Suggested Antigen Peptide Sequences for CDC14C Gene

GenScript: Design optimal peptide antigens:
  • CDC14 cell division cycle 14 homolog C (CC14C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A4D256

UniProtKB/Swiss-Prot:

CC14C_HUMAN :
  • Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
Domain:
  • Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
genes like me logo Genes that share domains with CDC14C: view

No data available for Gene Families for CDC14C Gene

Function for CDC14C Gene

Molecular function for CDC14C Gene

UniProtKB/Swiss-Prot Function:
Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16;.

Enzyme Numbers (IUBMB) for CDC14C Gene

Phenotypes From GWAS Catalog for CDC14C Gene

Gene Ontology (GO) - Molecular Function for CDC14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity IBA 21873635
GO:0004725 protein tyrosine phosphatase activity IEA,IBA 21873635
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CDC14C: view
genes like me logo Genes that share phenotypes with CDC14C: view

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDC14C Gene

Localization for CDC14C Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC14C Gene

Endoplasmic reticulum membrane. Single-pass membrane protein. Note=Retains its endoplasmic reticulum localization during mitosis. {ECO:0000269 PubMed:18547142}.

Gene Ontology (GO) - Cellular Components for CDC14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IBA 21873635
GO:0005730 nucleolus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with CDC14C: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for CDC14C Gene

Pathways & Interactions for CDC14C Gene

PathCards logo

SuperPathways for CDC14C Gene

No Data Available

Interacting Proteins for CDC14C Gene

Gene Ontology (GO) - Biological Process for CDC14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA 21873635
GO:0000278 mitotic cell cycle IBA 21873635
GO:0006470 protein dephosphorylation IEA --
GO:0007096 regulation of exit from mitosis IBA 21873635
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with CDC14C: view

No data available for Pathways by source and SIGNOR curated interactions for CDC14C Gene

Drugs & Compounds for CDC14C Gene

(2) Drugs for CDC14C Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with CDC14C: view

Transcripts for CDC14C Gene

mRNA/cDNA for CDC14C Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CDC14C Gene

No ASD Table

Relevant External Links for CDC14C Gene

GeneLoc Exon Structure for
CDC14C

Expression for CDC14C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDC14C Gene

mRNA differential expression in normal tissues according to GTEx for CDC14C Gene

This gene is overexpressed in Testis (x18.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDC14C

SOURCE GeneReport for Unigene cluster for CDC14C Gene:

Hs.567757
genes like me logo Genes that share expression patterns with CDC14C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC14C Gene

Orthologs for CDC14C Gene

Evolution for CDC14C Gene

ENSEMBL:
Gene Tree for CDC14C (if available)
TreeFam:
Gene Tree for CDC14C (if available)

No data available for Orthologs for CDC14C Gene

Paralogs for CDC14C Gene

Paralogs for CDC14C Gene

(3) SIMAP similar genes for CDC14C Gene using alignment to 1 proteins:

  • CC14C_HUMAN
genes like me logo Genes that share paralogs with CDC14C: view

Variants for CDC14C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDC14C Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs1615556 - p.Pro131Ser
rs421206 - p.Ile189Leu

Additional dbSNP identifiers (rs#s) for CDC14C Gene

Structural Variations from Database of Genomic Variants (DGV) for CDC14C Gene

Variant ID Type Subtype PubMed ID
esv33916 CNV gain 17666407
nsv1021166 CNV loss 25217958
nsv292 OTHER inversion 15895083
nsv7396 OTHER inversion 18451855
nsv970829 CNV duplication 23825009

Additional Variant Information for CDC14C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC14C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CDC14C Gene

Disorders for CDC14C Gene

Additional Disease Information for CDC14C

No disorders were found for CDC14C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC14C Gene

Publications for CDC14C Gene

  1. Birth and rapid subcellular adaptation of a hominoid-specific CDC14 protein. (PMID: 18547142) Rosso L … Kaessmann H (PLoS biology 2008) 2 3 4
  2. Emergence of young human genes after a burst of retroposition in primates. (PMID: 16201836) Marques AC … Kaessmann H (PLoS biology 2005) 2 3 4
  3. Cdc14: a highly conserved family of phosphatases with non-conserved functions? (PMID: 20720150) Mocciaro A … Schiebel E (Journal of cell science 2010) 2 3
  4. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PMID: 23400010) Del-Aguila JL … Boerwinkle E (The pharmacogenomics journal 2014) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for CDC14C Gene

Sources for CDC14C Gene