The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephospho... See more...

Aliases for CDC14B Gene

Aliases for CDC14B Gene

  • Cell Division Cycle 14B 2 3 5
  • Dual Specificity Protein Phosphatase CDC14B 3 4
  • CDC14 Cell Division Cycle 14 Homolog B 3 4
  • CDC14B3 2 3
  • Cdc14B1 2 3
  • Cdc14B2 2 3
  • HCDC14B 2 3
  • CDC14 (Cell Division Cycle 14, S. Cerevisiae) Homolog B 2
  • CDC14 Cell Division Cycle 14 Homolog B (S. Cerevisiae) 2
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • CDC14B 5

External Ids for CDC14B Gene

Previous GeneCards Identifiers for CDC14B Gene

  • GC09M090066
  • GC09M090996
  • GC09M092709
  • GC09M094632
  • GC09M096332
  • GC09M098292
  • GC09M099252

Summaries for CDC14B Gene

Entrez Gene Summary for CDC14B Gene

  • The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC14B Gene

CDC14B (Cell Division Cycle 14B) is a Protein Coding gene. Diseases associated with CDC14B include Adrenal Gland Pheochromocytoma. Among its related pathways are Signaling by GPCR and Regulation of activated PAK-2p34 by proteasome mediated degradation. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is CDC14C.

UniProtKB/Swiss-Prot Summary for CDC14B Gene

  • Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.

Gene Wiki entry for CDC14B Gene

Additional gene information for CDC14B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDC14B Gene

Genomics for CDC14B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDC14B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDC14B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDC14B

Top Transcription factor binding sites by QIAGEN in the CDC14B gene promoter:
  • AhR
  • AML1a
  • Arnt
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • Elk-1
  • FOXO4
  • POU6F1 (c2)

Genomic Locations for CDC14B Gene

Genomic Locations for CDC14B Gene
chr9:96,490,241-96,619,843
(GRCh38/hg38)
Size:
129,603 bases
Orientation:
Minus strand
chr9:99,252,523-99,382,112
(GRCh37/hg19)
Size:
129,590 bases
Orientation:
Minus strand

Genomic View for CDC14B Gene

Genes around CDC14B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC14B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC14B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC14B Gene

Proteins for CDC14B Gene

  • Protein details for CDC14B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60729-CC14B_HUMAN
    Recommended name:
    Dual specificity protein phosphatase CDC14B
    Protein Accession:
    O60729
    Secondary Accessions:
    • A6N5X8
    • A8MQ20
    • B1AL31
    • B1AL32
    • O43183
    • O60730
    • Q5JU08

    Protein attributes for CDC14B Gene

    Size:
    498 amino acids
    Molecular mass:
    56802 Da
    Quaternary structure:
    • Interacts with FZR1/CDH1.

    Three dimensional structures from OCA and Proteopedia for CDC14B Gene

    Alternative splice isoforms for CDC14B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC14B Gene

Post-translational modifications for CDC14B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for CDC14B
  • Boster Bio Antibodies for CDC14B

No data available for DME Specific Peptides for CDC14B Gene

Domains & Families for CDC14B Gene

Gene Families for CDC14B Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CDC14B Gene

Suggested Antigen Peptide Sequences for CDC14B Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ44424 fis, clone UTERU2005621, highly similar to Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (A8MQ20_HUMAN)
  • CDC14 cell division cycle 14 homolog B (CC14B_HUMAN)
  • CDC14 cell division cycle 14 homolog B (S. cerevisiae) (Q5JU06_HUMAN)
  • CDC14 cell division cycle 14 homolog B (S. cerevisiae) (Q5JU07_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60729

UniProtKB/Swiss-Prot:

CC14B_HUMAN :
  • Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
Domain:
  • Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
genes like me logo Genes that share domains with CDC14B: view

Function for CDC14B Gene

Molecular function for CDC14B Gene

UniProtKB/Swiss-Prot Function:
Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044, ECO:0000269|PubMed:12134069};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:12134069};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:12134069};.

Enzyme Numbers (IUBMB) for CDC14B Gene

Phenotypes From GWAS Catalog for CDC14B Gene

Gene Ontology (GO) - Molecular Function for CDC14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity IDA,TAS --
GO:0004725 protein tyrosine phosphatase activity IBA,IDA 9367992
GO:0005515 protein binding IPI 12697818
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with CDC14B: view
genes like me logo Genes that share phenotypes with CDC14B: view

Animal Models for CDC14B Gene

MGI Knock Outs for CDC14B:

Animal Model Products

  • Taconic Biosciences Mouse Models for CDC14B

CRISPR Products

miRNA for CDC14B Gene

miRTarBase miRNAs that target CDC14B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC14B

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDC14B Gene

Localization for CDC14B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC14B Gene

Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC14B gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CDC14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IBA 21873635
GO:0005634 nucleus IEA,IDA 9367992
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IBA,IDA 18662541
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with CDC14B: view

Pathways & Interactions for CDC14B Gene

genes like me logo Genes that share pathways with CDC14B: view

Pathways by source for CDC14B Gene

2 BioSystems pathways for CDC14B Gene
1 KEGG pathway for CDC14B Gene

SIGNOR curated interactions for CDC14B Gene

Activates:
Inactivates:
Other effect:

Gene Ontology (GO) - Biological Process for CDC14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA 21873635
GO:0000278 mitotic cell cycle IBA 21873635
GO:0006281 DNA repair IEA --
GO:0006470 protein dephosphorylation NAS 9367992
GO:0006974 cellular response to DNA damage stimulus IEA --
genes like me logo Genes that share ontologies with CDC14B: view

Drugs & Compounds for CDC14B Gene

(3) Drugs for CDC14B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Calcium Nutra 6556

(1) Additional Compounds for CDC14B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with CDC14B: view

Transcripts for CDC14B Gene

mRNA/cDNA for CDC14B Gene

8 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDC14B

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC14B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: - - - -

Relevant External Links for CDC14B Gene

GeneLoc Exon Structure for
CDC14B

Expression for CDC14B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDC14B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDC14B Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDC14B

SOURCE GeneReport for Unigene cluster for CDC14B Gene:

Hs.40582

Evidence on tissue expression from TISSUES for CDC14B Gene

  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with CDC14B: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC14B Gene

Orthologs for CDC14B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDC14B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDC14B 30 31
  • 99.63 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CDC14B 30 31
  • 92.44 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CDC14B 30 31
  • 91.9 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cdc14b 30
  • 88.15 (n)
Mouse
(Mus musculus)
Mammalia Cdc14b 30 17 31
  • 87.29 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 67 (a)
OneToMany
-- 31
  • 43 (a)
OneToMany
Chicken
(Gallus gallus)
Aves CDC14B 30 31
  • 71.49 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CDC14B 31
  • 64 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cdc14b 30
  • 68.31 (n)
Str.19310 30
Zebrafish
(Danio rerio)
Actinopterygii cdc14b 31
  • 51 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG7134 32
  • 59 (a)
cdc14 31
  • 20 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea cdc-14 31
  • 16 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC14 31
  • 21 (a)
OneToMany
Species where no ortholog for CDC14B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CDC14B Gene

ENSEMBL:
Gene Tree for CDC14B (if available)
TreeFam:
Gene Tree for CDC14B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDC14B: view image

Paralogs for CDC14B Gene

Paralogs for CDC14B Gene

(4) SIMAP similar genes for CDC14B Gene using alignment to 5 proteins:

  • CC14B_HUMAN
  • H0Y577_HUMAN
  • H7C3U8_HUMAN
  • L8E9I0_HUMAN
  • Q5JU07_HUMAN

Pseudogenes.org Pseudogenes for CDC14B Gene

genes like me logo Genes that share paralogs with CDC14B: view

Variants for CDC14B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDC14B Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs16911075 - p.Ile341Thr
rs16911114 - p.Ile302Thr

Additional dbSNP identifiers (rs#s) for CDC14B Gene

Structural Variations from Database of Genomic Variants (DGV) for CDC14B Gene

Variant ID Type Subtype PubMed ID
esv2089533 CNV deletion 18987734
esv2306628 CNV deletion 18987734
esv3621166 CNV loss 21293372
esv3621167 CNV loss 21293372
esv6348 CNV gain 19470904
nsv1147999 OTHER inversion 26484159
nsv1148415 CNV insertion 26484159
nsv415660 CNV deletion 16902084
nsv522838 CNV loss 19592680
nsv824999 CNV gain 20364138
nsv968737 CNV duplication 23825009
nsv982325 CNV duplication 23825009

Variation tolerance for CDC14B Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.15; 51.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDC14B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC14B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC14B Gene

Disorders for CDC14B Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDC14B Gene - From: DISEASES

Disorder Aliases PubMed IDs
adrenal gland pheochromocytoma
  • pheochromocytoma
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with CDC14B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDC14B Gene

Publications for CDC14B Gene

  1. A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. (PMID: 9367992) Li L … Dixon JE (The Journal of biological chemistry 1997) 2 3 4
  2. The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. (PMID: 18662541) Bassermann F … Pagano M (Cell 2008) 3 4
  3. Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication. (PMID: 18458157) Wu J … Wang Y (The Journal of cell biology 2008) 3 23
  4. Functional homology among human and fission yeast Cdc14 phosphatases. (PMID: 15911625) Vázquez-Novelle MD … Sacristán MP (The Journal of biological chemistry 2005) 3 23
  5. The dual-specificity phosphatase CDC14B bundles and stabilizes microtubules. (PMID: 15899858) Cho HP … Wang Y (Molecular and cellular biology 2005) 3 23

Products for CDC14B Gene

Sources for CDC14B Gene