The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor su... See more...

Aliases for CDC14A Gene

Aliases for CDC14A Gene

  • Cell Division Cycle 14A 2 3 5
  • CDC10 (Cell Division Cycle 10, S. Cerevisiae, Homolog) 2 3
  • Dual Specificity Protein Phosphatase CDC14A 3 4
  • CDC14 Cell Division Cycle 14 Homolog A 3 4
  • CDC14 Cell Division Cycle 14 Homolog A (S. Cerevisiae) 2
  • Deafness, Autosomal Recessive 32 2
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • DFNB105 3
  • DFNB35 3
  • HCDC14 3
  • DFNB32 3
  • Cdc14 3

External Ids for CDC14A Gene

Previous HGNC Symbols for CDC14A Gene

  • DFNB32

Previous GeneCards Identifiers for CDC14A Gene

  • GC01P101608
  • GC01P099999
  • GC01P100108
  • GC01P100280
  • GC01P100530
  • GC01P100590
  • GC01P100817
  • GC01P098941

Summaries for CDC14A Gene

Entrez Gene Summary for CDC14A Gene

  • The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC14A Gene

CDC14A (Cell Division Cycle 14A) is a Protein Coding gene. Diseases associated with CDC14A include Deafness, Autosomal Recessive 32, With Or Without Immotile Sperm and Autosomal Recessive Nonsyndromic Deafness 32. Among its related pathways are RET signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is CDC14B.

UniProtKB/Swiss-Prot Summary for CDC14A Gene

  • Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958).

Gene Wiki entry for CDC14A Gene

Additional gene information for CDC14A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDC14A Gene

Genomics for CDC14A Gene

GeneHancer (GH) Regulatory Elements for CDC14A Gene

Promoters and enhancers for CDC14A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J100348 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 535.9 +7.2 7189 7.2 FOXK2 HNRNPK ZBTB40 CTCF ZSCAN5C SIN3A NRF1 MYC POLR2G NCOR1 CDC14A lnc-DBT-7 MFSD14A BRI3P1 SASS6 SLC30A7 HNRNPA1P68 ENSG00000235795 TRMT13 FRRS1
GH01J100343 Enhancer 0.4 Ensembl 500.7 -0.8 -771 0.5 HNF4A RXRA SP1 CDC14A ENSG00000223906 LOC646970
GH01J100443 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 27.8 +99.9 99879 3.3 ZBTB40 TRIM28 RFX1 CTCF GABPA ZNF184 PBX2 KLF8 FOSL1 FOS CDC14A GPR88 MFSD14A SLC35A3 lnc-DBT-6 lnc-GPR88-1
GH01J100452 Enhancer 1 FANTOM5 ENCODE dbSUPER 25.3 +107.9 107899 1.8 EP300 RELA ATF2 ZBTB33 TCF7 TCF7L2 ATF7 NFIC CEBPB ARID3A CDC14A GPR88 SASS6 TRMT13 MFSD14A SLC35A3 lnc-DBT-6 lnc-GPR88-1
GH01J100362 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.8 +18.3 18279 1 NRF1 GTF2E2 AFF1 TOE1 MYC RUNX1 CTBP1 NFRKB TAF9B POLR2A CDC14A MIR553 SASS6 lnc-DBT-7 BCAS2P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDC14A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDC14A

Top Transcription factor binding sites by QIAGEN in the CDC14A gene promoter:
  • AP-1
  • ATF-2
  • c-Jun

Genomic Locations for CDC14A Gene

Genomic Locations for CDC14A Gene
chr1:100,345,001-100,520,277
(GRCh38/hg38)
Size:
175,277 bases
Orientation:
Plus strand
chr1:100,810,584-100,985,833
(GRCh37/hg19)
Size:
175,250 bases
Orientation:
Plus strand

Genomic View for CDC14A Gene

Genes around CDC14A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC14A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC14A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC14A Gene

Proteins for CDC14A Gene

  • Protein details for CDC14A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNH5-CC14A_HUMAN
    Recommended name:
    Dual specificity protein phosphatase CDC14A
    Protein Accession:
    Q9UNH5
    Secondary Accessions:
    • A6MA65
    • B1AQ14
    • B1AQ15
    • O43171
    • O60727
    • O60728
    • Q52LH9
    • Q8IXX0

    Protein attributes for CDC14A Gene

    Size:
    594 amino acids
    Molecular mass:
    66574 Da
    Quaternary structure:
    • Interacts with KIF20A, which is required to localize CDC14 to the midzone of the mitotic spindle.
    SequenceCaution:
    • Sequence=AAB88277.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for CDC14A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC14A Gene

Post-translational modifications for CDC14A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CDC14A Gene

Domains & Families for CDC14A Gene

Gene Families for CDC14A Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for CDC14A Gene

Suggested Antigen Peptide Sequences for CDC14A Gene

GenScript: Design optimal peptide antigens:
  • CDC14 cell division cycle 14 homolog A (CC14A_HUMAN)
  • CDC14 cell division cycle 14 homolog A (S. cerevisiae), isoform CRA_a (Q52LH9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UNH5

UniProtKB/Swiss-Prot:

CC14A_HUMAN :
  • Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
Domain:
  • Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
genes like me logo Genes that share domains with CDC14A: view

Function for CDC14A Gene

Molecular function for CDC14A Gene

UniProtKB/Swiss-Prot Function:
Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16;.
GENATLAS Biochemistry:
cell division cycle 14A,dual specificity serine/threonine-tyrosine phosphatase,involved in cell cycle function and in tumorigenesis,with homology to PTEN

Enzyme Numbers (IUBMB) for CDC14A Gene

Phenotypes From GWAS Catalog for CDC14A Gene

Gene Ontology (GO) - Molecular Function for CDC14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity TAS --
GO:0004725 protein tyrosine phosphatase activity IBA 21873635
GO:0005515 protein binding IPI 16221885
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with CDC14A: view
genes like me logo Genes that share phenotypes with CDC14A: view

Human Phenotype Ontology for CDC14A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CDC14A Gene

MGI Knock Outs for CDC14A:
  • Cdc14a Cdc14a<tm1e.1(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for CDC14A Gene

Localization for CDC14A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC14A Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Cell projection, kinocilium. Cell projection, stereocilium. Note=Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the mitotic spindle pole and at the central spindle (PubMed:12134069, PubMed:11901424, PubMed:15263015). Present along both the transient kinocilia of developing cochlear hair cells and the persistent kinocilia of vestibular hair cells (By similarity). {ECO:0000250 UniProtKB:Q6GQT0, ECO:0000269 PubMed:11901424, ECO:0000269 PubMed:12134069, ECO:0000269 PubMed:15263015}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC14A gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDC14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IBA 21873635
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with CDC14A: view

Pathways & Interactions for CDC14A Gene

genes like me logo Genes that share pathways with CDC14A: view

Pathways by source for CDC14A Gene

1 KEGG pathway for CDC14A Gene
1 GeneGo (Thomson Reuters) pathway for CDC14A Gene
  • Cell cycle_Role of APC in cell cycle regulation

SIGNOR curated interactions for CDC14A Gene

Activates:
Inactivates:
Other effect:

Gene Ontology (GO) - Biological Process for CDC14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA 21873635
GO:0000278 mitotic cell cycle IBA 21873635
GO:0006470 protein dephosphorylation IEA --
GO:0007049 cell cycle IEA --
GO:0007096 regulation of exit from mitosis IBA 21873635
genes like me logo Genes that share ontologies with CDC14A: view

Drugs & Compounds for CDC14A Gene

(3) Drugs for CDC14A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Calcium Approved Nutra 7884

(1) Additional Compounds for CDC14A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with CDC14A: view

Transcripts for CDC14A Gene

mRNA/cDNA for CDC14A Gene

6 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC14A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b
SP1: - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - - -
SP6: -
SP7:

Relevant External Links for CDC14A Gene

GeneLoc Exon Structure for
CDC14A

Expression for CDC14A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDC14A Gene

mRNA differential expression in normal tissues according to GTEx for CDC14A Gene

This gene is overexpressed in Testis (x4.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDC14A

SOURCE GeneReport for Unigene cluster for CDC14A Gene:

Hs.127411

Evidence on tissue expression from TISSUES for CDC14A Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with CDC14A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC14A Gene

Orthologs for CDC14A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDC14A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC14A 31 30
  • 99.38 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CDC14A 31 30
  • 92.62 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CDC14A 31 30
  • 90.9 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc14a 30
  • 87.57 (n)
mouse
(Mus musculus)
Mammalia Cdc14a 17 31 30
  • 87.01 (n)
oppossum
(Monodelphis domestica)
Mammalia CDC14A 31
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC14A 31
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC14A 31 30
  • 73.29 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC14A 31
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc14a 30
  • 66.25 (n)
zebrafish
(Danio rerio)
Actinopterygii cdc14ab 31 30
  • 67.97 (n)
OneToMany
cdc14aa 31
  • 56 (a)
OneToMany
zgc63654 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4997 30
fruit fly
(Drosophila melanogaster)
Insecta CG7134 32
  • 63 (a)
cdc14 31
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdc-14 31 30
  • 48.15 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC14 33 31
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8008 31
  • 51 (a)
OneToOne
Cin.1797 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1797 30
Species where no ortholog for CDC14A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC14A Gene

ENSEMBL:
Gene Tree for CDC14A (if available)
TreeFam:
Gene Tree for CDC14A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDC14A: view image

Paralogs for CDC14A Gene

Paralogs for CDC14A Gene

(4) SIMAP similar genes for CDC14A Gene using alignment to 3 proteins:

  • CC14A_HUMAN
  • C9JSP6_HUMAN
  • F5H7B3_HUMAN
genes like me logo Genes that share paralogs with CDC14A: view

Variants for CDC14A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDC14A Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
638289 Likely Pathogenic: Deafness, autosomal recessive 32 100,468,076(+) A/C MISSENSE_VARIANT
638290 Pathogenic: Deafness, autosomal recessive 32 100,439,959(+) C/G NONSENSE,FIVE_PRIME_UTR_VARIANT
666801 Uncertain Significance: not specified 100,424,286(+) C/G MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT
666802 Uncertain Significance: not specified 100,352,982(+) G/C MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
667038 Benign: not specified 100,499,372(+) C/G MISSENSE_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for CDC14A Gene

Structural Variations from Database of Genomic Variants (DGV) for CDC14A Gene

Variant ID Type Subtype PubMed ID
esv3373317 CNV insertion 20981092
nsv1133882 CNV deletion 24896259
nsv473052 CNV novel sequence insertion 20440878
nsv546889 CNV gain 21841781
nsv830815 CNV gain 17160897
nsv830826 CNV gain 17160897
nsv950522 CNV duplication 24416366

Variation tolerance for CDC14A Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDC14A Gene

Human Gene Mutation Database (HGMD)
CDC14A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC14A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC14A Gene

Disorders for CDC14A Gene

MalaCards: The human disease database

(8) MalaCards diseases for CDC14A Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CC14A_HUMAN
  • Deafness, autosomal recessive, 32, with or without immotile sperm (DFNB32) [MIM:608653]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNB32 is characterized by prelingual, progressive, moderate to profound sensorineural deafness. Some affected men are infertile. {ECO:0000269 PubMed:27259055, ECO:0000269 PubMed:29293958}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for CDC14A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CDC14A: view

No data available for Genatlas for CDC14A Gene

Publications for CDC14A Gene

  1. A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. (PMID: 9367992) Li L … Dixon JE (The Journal of biological chemistry 1997) 2 3 4 23 54
  2. CDC14A phosphatase is essential for hearing and male fertility in mouse and human. (PMID: 29293958) Imtiaz A … Friedman TB (Human molecular genetics 2018) 2 3 4 54
  3. Mutations in CDC14A, Encoding a Protein Phosphatase Involved in Hair Cell Ciliogenesis, Cause Autosomal-Recessive Severe to Profound Deafness. (PMID: 27259055) Delmaghani S … Petit C (American journal of human genetics 2016) 2 3 4 54
  4. Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene. (PMID: 10409437) Wong AK … Teng DH (Genomics 1999) 2 3 4 54
  5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 41 54

Products for CDC14A Gene

Sources for CDC14A Gene