Aliases for CDC14A Gene
External Ids for CDC14A Gene
Previous HGNC Symbols for CDC14A Gene
Previous GeneCards Identifiers for CDC14A Gene
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDC14A Gene
CDC14A (Cell Division Cycle 14A) is a Protein Coding gene. Diseases associated with CDC14A include Deafness, Autosomal Recessive 32, With Or Without Immotile Sperm and Autosomal Recessive Nonsyndromic Deafness 32. Among its related pathways are RET signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is CDC14B.
UniProtKB/Swiss-Prot Summary for CDC14A Gene
Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958).